AutismKB 2.0

Annotation Detail for GIMAP6


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Basic Information Top
Gene Symbol:GIMAP6 ( DKFZp686A01175,FLJ22690,IAN6,hIAN2 )
Gene Full Name: GTPase, IMAP family member 6
Band: 7q36.1
Quick LinksEntrez ID:474344; OMIM: NA; Uniprot ID:GIMA6_HUMAN; ENSEMBL ID: ENSG00000133561; HGNC ID: 21918
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GIMAP6 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of GIMAP6 mRNAincreases expression 15761015
D001194 Asbestos Asbestos affects the expression of GIMAP6 mRNAaffects expression 17297452
D004041 Dietary Fats Dietary Fats results in increased expression of GIMAP6 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of GIMAP6 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GIMAP6 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GIMAP6 mRNAdecreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D050197 Atherosclerosis Asbestos 4.3918795166
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7811135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7817173139 1701930 20935162 20007298 6705139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512958197 14550746 16109766 17562736 14986274 16177239 16781746 19370779 16227642 15968718 16081117 19085960 14725611 11739529 11834606 19923254 19739265 19420014 19416960 19164858 18071297 15619225 11461765 12153990 11421492 18713872 17522070 16485898 17906064 11743745 11287661 11529661 10663392 10774834 10915739 12594235 12705907 2444490 16393943 12392966 12540782
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005234 Fatty Liver arsenic trioxide 8.9915073043
MESH:D005234 Fatty Liver Dietary Fats 8.9918296743 19004024 19551842 17967931
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 19850784 20471514 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116891316 15748426 17712046 16966277 12712474 12018890 9834237 12679006 19642359 15622746 19075265 15336539 16112521 16331271 19035177 17217047 11468182 16330433 15213294 19225113 17107899 17869043 11161223 17649720 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008103 Liver Cirrhosis Dietary Fats 7.1818296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1821047994
MESH:D008107 Liver Diseases Acetaminophen 4.1516610002 19014921 12587719 12969438 11587558 19460945 16611625 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9914682389
MESH:D008113 Liver Neoplasms Phenobarbital 4.998742319 19073162 21047994 15975961 19482888 19812893
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6320377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.631399818 6150874 2563599 18308698 17172636
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.0819825857 11798837
MESH:D008175 Lung Neoplasms Asbestos 3.0812111688
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Asbestos 4.1918310086 16319530 16919927 16564556 18709470
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3215949261 19417148 14977855 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 2.3418674790 17217161 11836018 21332399 18457598 19632207 16723640 20518802 20132043
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4816624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6115580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6116965848
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures Phenobarbital 2.8911442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.031399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5812973940 20435036 12845720 11780464
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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