AutismKB 2.0

Annotation Detail for NELL1


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Basic Information Top
Gene Symbol:NELL1 ( FLJ45906,IDH3GL,NRP1 )
Gene Full Name: NEL-like 1 (chicken)
Band: 11p15.1
Quick LinksEntrez ID:4745; OMIM: 602319; Uniprot ID:NELL1_HUMAN; ENSEMBL ID: ENSG00000165973; HGNC ID: 7750
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2249Craniosynostosis
Desease Name
IMMUNE
Crohn's disease
Desease Name
Crohn's disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NELL1 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of NELL1 mRNAaffects cotreatment|increases expression 18636392
C014347 decitabine decitabine affects the methylation of NELL1 promoteraffects methylation 17452981
C014347 decitabine [decitabine affects the methylation of NELL1 promoter] which affects the expression of NELL1 mRNAaffects expression|affects methylation 17452981
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NELL1 mRNAaffects expression 17351261
D005419 Flavonoids Flavonoids results in increased expression of NELL1 mRNAincreases expression 18035473
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of NELL1 mRNAaffects cotreatment|increases expression 18636392
D014635 Valproic Acid Valproic Acid results in increased expression of NELL1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury Chlorine 4.6320601635
MESH:D000230 Adenocarcinoma marker/mechanism 17452981
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 18558336 18396377 15238991 17157402 17688650 18940202 17507914 18177632 18316065 18775368 20603192 16609825 18985861 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms decitabine 2.5519208741 18320071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9018315731 19059883 18417511 16777450 15516495 17626835 14754758
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0716105132 15861022 17110522 16919318 17681005 11677210 17333356
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003398 Craniosynostoses marker/mechanism 14672347
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.231733752 19641884
MESH:D004417 Dyspnea Chlorine 5.0720016425
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.847562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms marker/mechanism 17452981
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7015345470
MESH:D005234 Fatty Liver Valproic Acid 8.7019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005739 Gas Poisoning Chlorine 5.4520016425
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male decitabine 7.3117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3117937319
MESH:D007249 Inflammation Flavonoids 2.7717296493
MESH:D007938 Leukemia decitabine 3.1918980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1319387464 19010910 18206229 17679729 18704418 18460780
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1316294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Ozone 2.107614698 8597069
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9819157545 18608210 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9817596541
MESH:D009369 Neoplasms decitabine 2.8319470736 19116145 17925555
MESH:D009436 Neural Tube Defects Valproic Acid 3.3016359493 8888407
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918007984 18381685 18929643
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D012120 Respiration Disorders Chlorine 5.6518579056
MESH:D012208 Rhabdomyosarcoma decitabine 12.0119155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 12.0119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9114763951 16876388 3137016 15475178 11738929 17978042 11044598 1511512
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms decitabine 3.5417967635
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8117616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31552
    • No data
    Releated disease ID Related disease Name
    PA443755Colonic Diseases, Functional
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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