AutismKB 2.0

Annotation Detail for NEFL


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Basic Information Top
Gene Symbol:NEFL ( CMT1F,CMT2E,FLJ53642,NF-L,NF68,NFL )
Gene Full Name: neurofilament, light polypeptide
Band: 8p21.2
Quick LinksEntrez ID:4747; OMIM: 162280; Uniprot ID:NFL_HUMAN; ENSEMBL ID: ENSG00000104725; HGNC ID: 7739
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05014Amyotrophic lateral sclerosis (ALS)
Pathway IDPathway Name
Synaptic Transmission
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1726Charcot-Marie-Tooth disease
1809HIV infection
1982Myopathy
2062Neurodegenerative disorder
2134Amyotrophic lateral sclerosis
2223Central nervous system disease
No data
No data
Desease Name
Charcot-Marie-Tooth disease, type 1F
Charcot-Marie-Tooth disease, type 2E
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of NEFL mRNAincreases expression 20406850
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of NEFL mRNAdecreases expression 15982314
D020106 Acrylamide Acrylamide results in increased expression of NEFL mRNAincreases expression 10678756
D020106 Acrylamide Acrylamide results in increased expression of NEFL proteinincreases expression 10678756
D020106 Acrylamide NGF protein promotes the reaction [Acrylamide results in increased expression of NEFL protein]increases expression|increases reaction 10678756
C103303 alitretinoin alitretinoin results in decreased expression of NEFL mRNAdecreases expression 15982314
C041524 aluminum sulfate aluminum sulfate results in decreased expression of NEFL mRNAdecreases expression 15961160
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEFL mRNAaffects expression 16483693
D001151 Arsenic Arsenic metabolite affects the expression of NEFL mRNAaffects expression 17553662
C015001 arsenite arsenite results in decreased expression of NEFL proteindecreases expression 18242949
D002118 Calcium calpeptin inhibits the reaction [Calcium results in increased degradation of NEFL protein]decreases reaction|increases degradation 11071371
D002118 Calcium Indomethacin inhibits the reaction [Calcium results in increased degradation of NEFL protein]decreases reaction|increases degradation 11071371
C058076 calpain inhibitor III calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein]decreases reaction|increases degradation 15275793
C071482 calpeptin calpeptin inhibits the reaction [Calcium results in increased degradation of NEFL protein]decreases reaction|increases degradation 11071371
D002246 Carbon Disulfide Carbon Disulfide results in decreased expression of NEFL proteindecreases expression 17120161
16474999
D002246 Carbon Disulfide Carbon Disulfide results in increased expression of NEFL mRNAincreases expression 17120161
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of NEFL mRNAincreases expression 18812211
D003513 Cycloheximide Cycloheximide results in decreased expression of NEFL mRNAdecreases expression 19146868
D004006 Dichlorvos Dichlorvos results in decreased expression of NEFL mRNAdecreases expression 19146868
D004026 Dieldrin Dieldrin results in increased expression of NEFL mRNAincreases expression 18812211
D002117 Calcitriol Calcitriol results in decreased expression of NEFL mRNAdecreases expression 16002434
D000431 Ethanol Ethanol affects the expression of NEFL mRNAaffects expression 15513904
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEFL mRNAaffects cotreatment|increases expression 17942748
C511402 Grape Seed Proanthocyanidins Grape Seed Proanthocyanidins affects the expression of NEFL proteinaffects expression 16414080
D007213 Indomethacin Indomethacin inhibits the reaction [Calcium results in increased degradation of NEFL protein]decreases reaction|increases degradation 11071371
C032854 leupeptin leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein]decreases reaction|increases degradation 11071371
C014655 methamidophos methamidophos affects the expression of NEFL proteinaffects expression 15938848
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of NEFL promoteraffects acetylation|affects methylation 18448484
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of NEFL mRNAdecreases expression 18448484
D010269 Paraquat Paraquat results in decreased expression of NEFL mRNAdecreases expression 19146868
D010278 Parathion Parathion results in decreased expression of NEFL mRNAdecreases expression 19146868
D020849 Raloxifene Raloxifene affects the expression of NEFL mRNAaffects expression 14699072
D015474 Isotretinoin Isotretinoin results in decreased expression of NEFL mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of NEFL mRNAincreases expression 20308225
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of NEFL promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite sodium arsenite results in decreased expression of NEFL mRNAdecreases expression 18448484
D013726 Terbutaline Terbutaline results in increased expression of NEFL proteinincreases expression 14610225
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEFL mRNAaffects cotreatment|increases expression 17942748
D013750 Tetrachloroethylene Tetrachloroethylene results in decreased expression of NEFL proteindecreases expression 8372046
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFL proteinaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin metabolite results in decreased expression of NEFL mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of NEFL mRNAdecreases expression 15982314
D014501 Uranium Uranium affects the expression of NEFL mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of NEFL mRNAaffects expression 15672453
D015054 Zymosan calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein]decreases reaction|increases degradation 15275793
D015054 Zymosan Zymosan results in decreased expression of NEFL proteindecreases expression 15275793
D015054 Zymosan Zymosan results in increased degradation of NEFL proteinincreases degradation 15275793
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 17.4517676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 17.4518769834
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 17.4514610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.4515322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.6518769834
MESH:D000138 Acidosis Ammonium Chloride 9.2518287403
MESH:D000138 Acidosis Ethanol 9.2511192467
MESH:D017486 Acneiform Eruptions Isotretinoin 5.9116232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.7517505938
MESH:D000152 Acne Vulgaris Isotretinoin 10.7516185265 18769834
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1314692618
MESH:D000230 Adenocarcinoma Indomethacin 4.1316537180
MESH:D000236 Adenoma Indomethacin 3.2411497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3215276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.5417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.5417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 17.5417119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Dichlorvos 17.5417119214 16611668 12661182
MESH:D000382 Agricultural Workers' Diseases Paraquat 17.5411874814
MESH:D000382 Agricultural Workers' Diseases Parathion 17.5411874814 17119214
MESH:D000419 Albuminuria Raloxifene 4.2517308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9415451039 15451040
MESH:D000505 Alopecia Tretinoin 3.3315955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0017225004
MESH:D000544 Alzheimer Disease Indomethacin 4.1617627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 4.1615800139
MESH:D000686 Amyloidosis Terbutaline 5.287986221
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9411748828
MESH:D000740 Anemia Zymosan 7.9418664788
MESH:D000853 Anophthalmos Ethanol 4.4615513904
MESH:D001008 Anxiety Disorders Ethanol 3.7211141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.5010231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.5110388637
MESH:D020261 Arsenic Poisoning Arsenic 2.7616835338 16251483 12569548 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1111256880
MESH:D018771 Arthralgia Indomethacin 4.792160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.0315885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.0316412693
MESH:D001169 Arthritis, Experimental Zymosan 11.0315944321 17659584 15142272 15188379 16872482
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.4411248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4416292516
MESH:D001249 Asthma Tretinoin 2.2316456186
MESH:D050197 Atherosclerosis Arsenic 6.7612928151 19371607
MESH:D050197 Atherosclerosis Carbon Disulfide 6.7610658303 10367350
MESH:D001321 Autistic Disorder Terbutaline 3.4717400887 16417856
MESH:D001342 Autonomic Nervous System Diseases methamidophos 6.4011527224
MESH:D001471 Barrett Esophagus Tretinoin 4.0516935849
MESH:D001477 Bartter Syndrome Indomethacin 4.6210684365
MESH:D001480 Basal Ganglia Diseases Dichlorvos 5.6115303389
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.8516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D001929 Brain Edema Indomethacin 4.6511481608
MESH:D001930 Brain Injuries Raloxifene 4.1216580743
MESH:D002545 Brain Ischemia Indomethacin 4.0512524144
MESH:D001943 Breast Neoplasms Acrylamide 7.7918183576 16253758
MESH:D001943 Breast Neoplasms alitretinoin 7.7916344269
MESH:D001943 Breast Neoplasms Calcitriol 7.7911237771
MESH:D001943 Breast Neoplasms Dieldrin 7.7915770527 11859874
MESH:D001943 Breast Neoplasms Grape Seed Proanthocyanidins 7.7920146248
MESH:D001943 Breast Neoplasms Indomethacin 7.7917401462
MESH:D001943 Breast Neoplasms Parathion 7.7912762645
MESH:D001943 Breast Neoplasms Raloxifene 7.7916912660 17049068 15758505 15775269 17952589 16837676 15572757 17440819 17261762 17242785 17893378 17595753
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.7920435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 7.7915986119
MESH:D001943 Breast Neoplasms Tretinoin 7.7916873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2216813970
MESH:D002056 Burns Ethanol 10.1816374292
MESH:D002056 Burns Indomethacin 10.1810459503
MESH:D002100 Cachexia Indomethacin 4.6411239499 15625704 15141370 16537180
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.4811713377 9428835
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3815504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.5016705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 10.5016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.5018788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 10.5016391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.5017306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.501917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9818791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2017341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 16.5517687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 16.5511237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 16.5512636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 16.5511237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.5518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.5516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.6118640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6117572228
MESH:D006332 Cardiomegaly Ethanol 6.1519332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 6.7115738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 6.7115775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.0016973168 18022660
MESH:D002386 Cataract Tretinoin 2.8817460283
MESH:D002418 Cattle Diseases Acrylamide 10.7012510666
MESH:D002418 Cattle Diseases Dichlorvos 10.7014651886
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.896135515
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 9.8919716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.8919524636 20056578
MESH:D002493 Central Nervous System Diseases Dichlorvos 5.3912670839
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2216129372
MESH:C537987 Charcot-Marie-Tooth disease, Type 1F marker/mechanism
MESH:C537994 Charcot-Marie-Tooth disease, Type 2E marker/mechanism
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8516835633
MESH:D002764 Cholecystitis Indomethacin 4.7911181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6017681005 11677210 16105132 17110522 17333356 16919318 15861022
MESH:D002822 Choriocarcinoma Tretinoin 4.7816461808
MESH:D002971 Cleft Lip Ethanol 3.3915513904
MESH:D002972 Cleft Palate Ethanol 8.9015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9016354765 15340226 8697196 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 8.909407595
MESH:D003072 Cognition Disorders Raloxifene 4.2615800139
MESH:D003092 Colitis Tretinoin 3.3517035595
MESH:D003110 Colonic Neoplasms arsenite 3.8415037631
MESH:D003110 Colonic Neoplasms Indomethacin 3.8415637740 15625704 15936596 15786552 11260862 15963497
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3512606626 17054584 11197048 18059344
MESH:D003128 Coma Dichlorvos 5.6215303389
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7514669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.3417302372
MESH:D003371 Cough Terbutaline 5.1919679606
MESH:D019465 Craniofacial Abnormalities Ethanol 5.0815513904 10194807 15451039 19302082 15451040 11873399 11198716
MESH:D019465 Craniofacial Abnormalities Isotretinoin 5.089879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.089142499 17551590 9224671 10589399 9664655 8800419 9125849 16925845 9211117 14991402
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6618551238
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8517474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.6315920148 17308373 17451421
MESH:D003967 Diarrhea Indomethacin 3.457907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.5611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4911462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7818446180 12774134 18043480 16326151 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.7911535926 17351913 17151854 11595431 17045617 11991626 17329845 10671773 16699067 17202747 11595415
MESH:D004487 Edema Indomethacin 13.8616100529 8273558 7907874 10653021 19703484 7990266 8985016
MESH:D004487 Edema Raloxifene 13.8615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.8612711302 11000095
MESH:D004487 Edema Zymosan 13.867907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.3915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.3915845917
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8716569247
MESH:D004715 Endometriosis Indomethacin 8.0115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0110568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.1318509659
MESH:D004751 Enteritis Indomethacin 4.3717763956 16328016 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6217980183
MESH:D004802 Eosinophilia Indomethacin 3.7011298111
MESH:D004938 Esophageal Neoplasms Ethanol 4.5416704527
MESH:D004938 Esophageal Neoplasms Indomethacin 4.5411005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.939664655 16938888
MESH:D005234 Fatty Liver arsenite 16.1618296743
MESH:D005234 Fatty Liver Ethanol 16.1616409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.1615345470
MESH:D005234 Fatty Liver Raloxifene 16.1617473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9310194807 15451040 16946407 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005334 Fever Indomethacin 3.8011852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.5310962813
MESH:D005355 Fibrosis arsenite 23.9618296743
MESH:D005355 Fibrosis Indomethacin 23.9617994277
MESH:D005355 Fibrosis Terbutaline 23.9615467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.9620067830
MESH:D005355 Fibrosis Tretinoin 23.9617994277
MESH:D005499 Folliculitis Indomethacin 4.7911298111
MESH:D005517 Foodborne Diseases methamidophos 6.7611527224
MESH:D005534 Foot Diseases Arsenic 5.186392382
MESH:D005756 Gastritis Ethanol 10.2715046732
MESH:D005756 Gastritis Indomethacin 10.2715046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3116452187
MESH:D005909 Glioblastoma Indomethacin 6.5212870263
MESH:D005909 Glioblastoma Tretinoin 6.5217312396
MESH:D005910 Glioma Indomethacin 3.0816487511 18371953
MESH:D005911 Gliosis Paraquat 4.7911124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9911849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006073 Gout Indomethacin 4.9811248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.1015482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.8714991402 9664655
MESH:D006331 Heart Diseases Grape Seed Proanthocyanidins 7.5612587719
MESH:D006331 Heart Diseases Raloxifene 7.5611110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2415633222
MESH:D006505 Hepatitis Zymosan 4.3519110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3315135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5415340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 2.8512676792
MESH:D006734 Horse Diseases Dichlorvos 5.6216402567
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6716959395 18606429 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Ethanol 11.5518783367
MESH:D006930 Hyperalgesia Indomethacin 11.5512727271
MESH:D006930 Hyperalgesia Tretinoin 11.5516870215
MESH:D034321 Hyperamylasemia Indomethacin 5.3417883296
MESH:D006940 Hyperemia Indomethacin 4.6412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2116778211
MESH:D006941 Hyperesthesia Dichlorvos 6.3212563396
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1417050553
MESH:D006949 Hyperlipidemias Indomethacin 3.8317546600
MESH:D006973 Hypertension Arsenic 7.829931084 16076760 11953799
MESH:D006973 Hypertension Raloxifene 7.8217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8218850075 18670907
MESH:D006985 Hyperventilation Terbutaline 5.7110895896
MESH:D006987 Hypesthesia Arsenic 5.1816093927
MESH:D007008 Hypokalemia Terbutaline 5.7217292646
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4516569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.6518306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9810651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.0016133044
MESH:D007247 Infertility, Female Acrylamide 15.3311020651
MESH:D007247 Infertility, Female Dieldrin 15.3310630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 15.3312013081
MESH:D007248 Infertility, Male Acrylamide 23.2012507653 11020651 15355880 15749267
MESH:D007248 Infertility, Male Ethinyl Estradiol 23.2017937319
MESH:D007248 Infertility, Male methamidophos 23.2010828210
MESH:D007248 Infertility, Male Paraquat 23.204850670
MESH:D007248 Infertility, Male Parathion 23.2016029889
MESH:D007248 Infertility, Male sodium arsenite 23.2012646999 15346721
MESH:D007249 Inflammation calpain inhibitor III 10.5215275793
MESH:D007249 Inflammation Indomethacin 10.523291741 12568917 7812673
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.5212878042 12200463
MESH:D007249 Inflammation Zymosan 10.528014878 11289658
MESH:D007410 Intestinal Diseases Indomethacin 8.6917994277 11713966 10210152 15831440 18236018 17329856 11855677 11686837 15610444
MESH:D007410 Intestinal Diseases Tretinoin 8.6917994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.0015241188
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4717553498
MESH:D007569 Jaw Abnormalities Ethanol 15.2815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.2816580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.2815992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.6516133968 10574470 18306037
MESH:D007642 Keratosis Arsenic 4.6216930632 12749816
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2716144296
MESH:D007674 Kidney Diseases Dichlorvos 12.8816798900
MESH:D007674 Kidney Diseases Grape Seed Proanthocyanidins 12.8812587719
MESH:D007674 Kidney Diseases Indomethacin 12.8817190690
MESH:D007674 Kidney Diseases sodium arsenite 12.8820008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.6916705839
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6716316344
MESH:D007859 Learning Disorders Ethanol 3.8515451040
MESH:D007889 Leiomyoma Raloxifene 4.1616973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6110320625 12228301 11703811
MESH:D053609 Lethargy Terbutaline 5.9410895896
MESH:D007938 Leukemia Tretinoin 2.5817143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6510785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.8118360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 6.9517339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.9516891316 16935935 17649720 16140955 17361223 12679006 9834237 17368321 17712046 16788101 16823087 17506722 16766008 19075265 17107899 19225113 19642359 17301526 17294898 19029980 19035177 15748426 17339181 16331271 17217047
MESH:D007964 Leukocytosis Indomethacin 5.0016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3417980183
MESH:D017880 Limb Deformities, Congenital Ethanol 7.4417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.449224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3411479899
MESH:D008103 Liver Cirrhosis arsenite 6.3518296743
MESH:D008103 Liver Cirrhosis Ethanol 6.3515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7318295389
MESH:D008106 Liver Cirrhosis, Experimental calpain inhibitor III 6.2315316131
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.2318166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.2318194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2318397230 16248980
MESH:D008107 Liver Diseases Arsenic 8.7511134558
MESH:D008107 Liver Diseases Chlorpyrifos 8.7515991261
MESH:D008107 Liver Diseases Grape Seed Proanthocyanidins 8.7512587719
MESH:D008107 Liver Diseases Tetrachloroethylene 8.7517267091
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2917347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.677678174
MESH:D008113 Liver Neoplasms Arsenic 12.6716368122
MESH:D008113 Liver Neoplasms Dieldrin 12.679539021 8742319
MESH:D008113 Liver Neoplasms sodium arsenite 12.6715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.662876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6612151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 8.667955063
MESH:D008171 Lung Diseases Grape Seed Proanthocyanidins 7.2812587719
MESH:D008171 Lung Diseases sodium arsenite 7.2819095001
MESH:D008175 Lung Neoplasms alitretinoin 9.8916413115
MESH:D008175 Lung Neoplasms Arsenic 9.8919168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenite 9.8916809336
MESH:D008175 Lung Neoplasms Indomethacin 9.8916537180 11497255 11053908
MESH:D008175 Lung Neoplasms Isotretinoin 9.8915899809
MESH:D008175 Lung Neoplasms sodium arsenite 9.8917077188 17306315 15276417 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8919555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Isotretinoin 4.8217237267
MESH:D008545 Melanoma sodium arsenite 4.8216487513 19082730
MESH:D008545 Melanoma Tretinoin 4.8216752155
MESH:D008569 Memory Disorders Ethanol 3.8415451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.0616940565
MESH:D008881 Migraine Disorders Indomethacin 3.4111903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1815863610
MESH:D016472 Motor Neuron Disease Dichlorvos 5.9611282359
MESH:D009062 Mouth Neoplasms Indomethacin 3.7112636206
MESH:D009101 Multiple Myeloma Raloxifene 3.1816497877
MESH:D009102 Multiple Organ Failure Zymosan 4.8712130978 15259001 18160304 10890648 12879239 10479408 15241586 15834315 15213630 17724436
MESH:D018908 Muscle Weakness methamidophos 6.4017849254
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8717596541
MESH:D017202 Myocardial Ischemia Arsenic 8.0415371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0412213967
MESH:D009232 Myxoma Raloxifene 5.1816343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.497678174 18551238
MESH:D009349 Nematode Infections Dichlorvos 5.7716402567
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0216537180 11239499 11053908
MESH:D009369 Neoplasms alitretinoin 13.7816946489
MESH:D009369 Neoplasms Dieldrin 13.788820588
MESH:D009369 Neoplasms sodium arsenite 13.7811559025
MESH:D009369 Neoplasms Tetrachloroethylene 13.7811911487
MESH:D009369 Neoplasms Tretinoin 13.7816946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 8.0915625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.0920056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.0515738583
MESH:D009410 Nerve Degeneration Acrylamide 12.7812387367 12387366 11264303
MESH:D009410 Nerve Degeneration Dichlorvos 12.7817850875 11282359
MESH:D009410 Nerve Degeneration Paraquat 12.7816893418
MESH:D009422 Nervous System Diseases Acrylamide 14.6412164553 12507653
MESH:D009422 Nervous System Diseases Carbon Disulfide 14.6410669001
MESH:D009422 Nervous System Diseases methamidophos 14.642238440 15938848
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3514600291
MESH:D009421 Nervous System Malformations Tretinoin 8.359125849
MESH:D009436 Neural Tube Defects Arsenic 10.8016620997
MESH:D009436 Neural Tube Defects sodium arsenite 10.8012854658
MESH:D009436 Neural Tube Defects Tretinoin 10.809142499
MESH:D009447 Neuroblastoma Isotretinoin 3.8517368321
MESH:D019636 Neurodegenerative Diseases Dichlorvos 8.1716635102
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.1712349958
MESH:D020078 Neurogenic Inflammation Arsenic 4.0417056641
MESH:D020258 Neurotoxicity Syndromes Carbon Disulfide 12.3815315294
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 12.3815081274
MESH:D020258 Neurotoxicity Syndromes Dichlorvos 12.3812186780
MESH:D007752 Obstetric Labor, Premature Indomethacin 12.236374098
MESH:D007752 Obstetric Labor, Premature Terbutaline 12.2314998686
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1216049721
MESH:D010003 Osteoarthritis Indomethacin 3.447009135
MESH:D010024 Osteoporosis Calcium 6.7617882678
MESH:D010024 Osteoporosis Raloxifene 6.7617882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8915579764 17893378 15758505 17823083
MESH:D010051 Ovarian Neoplasms Arsenic 7.2117306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.2115276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 7.2116936753
MESH:D010146 Pain Indomethacin 6.0117627676 13679232 17440234 3291741
MESH:D010146 Pain Tretinoin 6.0116870215
MESH:D010149 Pain, Postoperative Indomethacin 4.3112538197 18702446
MESH:D010190 Pancreatic Neoplasms Ethanol 4.9812384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9815976015
MESH:D010195 Pancreatitis Dichlorvos 7.9716258382
MESH:D010195 Pancreatitis Indomethacin 7.9717883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3511578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3416537180
MESH:D010300 Parkinson Disease Dieldrin 5.3011445065 16809432 11181820 16112328 17291500
MESH:D010300 Parkinson Disease Paraquat 5.3012911755 16510128 11445065 16140633 15451049 11181820 15824117 11124998
MESH:D010302 Parkinson Disease, Secondary Dichlorvos 10.2512645970
MESH:D010302 Parkinson Disease, Secondary Paraquat 10.2516190885
MESH:D020734 Parkinsonian Disorders Carbon Disulfide 8.9015019297
MESH:D020734 Parkinsonian Disorders Indomethacin 8.9012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3411903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7811148446
MESH:D010518 Periodontitis Indomethacin 4.5417225004
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 14.9011510240
MESH:D010523 Peripheral Nervous System Diseases Arsenic 14.9016093927
MESH:D010523 Peripheral Nervous System Diseases methamidophos 14.902170085 7654138 10447555
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.626392382 16905509 15371236
MESH:D010538 Peritonitis Zymosan 4.5219641140 18760300 18557954 14761945 19088179 18977430 17826846 15259001 17371808 15979727 11985352
MESH:D011014 Pneumonia Paraquat 4.0912504350
MESH:D011041 Poisoning Dichlorvos 8.7215303389 18072136 17157343 12460839 16036766 17603234
MESH:D011041 Poisoning methamidophos 8.7217849254 16119251
MESH:D011115 Polyneuropathies Dichlorvos 10.8912563396
MESH:D011115 Polyneuropathies methamidophos 10.897654138
MESH:D017499 Porokeratosis alitretinoin 5.6316144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D047928 Premature Birth Indomethacin 4.7717000239
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 8.6318769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6311399792 11222880 11118676 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4115572423
MESH:D011471 Prostatic Neoplasms Arsenic 1.9416140617
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9412479363 15754350 16644109 18247401 16289102
MESH:D011471 Prostatic Neoplasms Dichlorvos 1.9412661182
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9416220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9416039940
MESH:D011507 Proteinuria Arsenic 13.5521343184
MESH:D011507 Proteinuria Indomethacin 13.5511849393
MESH:D011507 Proteinuria Tretinoin 13.5516636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9515861022 16919318
MESH:D011596 Psychomotor Disorders Isotretinoin 5.5518769834
MESH:D011625 Pterygium Tretinoin 4.4216723453
MESH:D011654 Pulmonary Edema Terbutaline 5.1410903255
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7716324872 17997886
MESH:D011693 Purpura Raloxifene 5.1815770314
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.5211700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 8.522878809
MESH:D012131 Respiratory Insufficiency Dichlorvos 5.2915303389 17350689
MESH:D012135 Respiratory Sounds Chlorpyrifos 20.0717119214 16611668 11874814
MESH:D012135 Respiratory Sounds Dichlorvos 20.0717119214 16611668
MESH:D012135 Respiratory Sounds Paraquat 20.0711874814
MESH:D012135 Respiratory Sounds Parathion 20.0717119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 15.9116611668 17119214
MESH:D012140 Respiratory Tract Diseases Dichlorvos 15.9117119214 16611668
MESH:D012140 Respiratory Tract Diseases Parathion 15.9117119214
MESH:D012162 Retinal Degeneration Paraquat 3.5916458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7616283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 8.6518551238
MESH:D012640 Seizures Dichlorvos 8.6517157343 12660363
MESH:D012640 Seizures Ethanol 8.659754883
MESH:D018805 Sepsis Zymosan 4.3511441115
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.716418539
MESH:D012772 Shock, Septic Terbutaline 5.133431524
MESH:D012871 Skin Diseases Arsenic 5.0316353154 17938729 19834688 15952646 17548696 18709164 17453740 16759981 6392382 17050553 16702368
MESH:D012871 Skin Diseases monomethylarsonous acid 5.0317431481
MESH:D012878 Skin Neoplasms Arsenic 12.0917976673 17029826 17050553 19538983 16251483 15504454
MESH:D012878 Skin Neoplasms sodium arsenite 12.0918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.0916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5716709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5112854658
MESH:D013158 Splenic Diseases Grape Seed Proanthocyanidins 6.1212587719
MESH:D013272 Stomach Diseases Indomethacin 4.0518545984 10215738 17638125 16184426 18209964 17160473 10192188 16280098 16113693 17207306 10486359 15038085 15472012
MESH:D013274 Stomach Neoplasms Dichlorvos 4.5011397402
MESH:D013274 Stomach Neoplasms Ethanol 4.5018456281
MESH:D013274 Stomach Neoplasms Indomethacin 4.5015609394
MESH:D013274 Stomach Neoplasms Tretinoin 4.5017261132
MESH:D013276 Stomach Ulcer Ethanol 6.5116755016 9562338 9211565 17918041 11906479 17189318
MESH:D013276 Stomach Ulcer Indomethacin 6.5116934674 16631530 18209962 17135157 15104355 18193104 11145282 11906479 12498302 18543354 12467913 17895592 12077510 17977527 16397915 10750652 17654042 18431645 15138204 17657623 14567935 16755016 15255614 17627676 18299717 10878458 11729361 1323529 16252198 17918041 11523592 10423059 18726076 11595415 12500499 18087811 11595431 18181030 16150113 18237397 12787963 16169175
MESH:D020521 Stroke Raloxifene 3.5316837676
MESH:D013322 Strongyloidiasis Dichlorvos 5.7714651886
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.949754883
MESH:D013610 Tachycardia Terbutaline 5.1510895896
MESH:D013733 Testicular Diseases Acrylamide 4.8615864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5312697716
MESH:D013964 Thyroid Neoplasms Indomethacin 6.4718791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4716026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.8319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4716051514
MESH:D014376 Tuberculosis Tretinoin 3.0016040207
MESH:D014456 Ulcer Indomethacin 4.5317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.2016049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.2017976673 18640142 11144890 19429237 19322015 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 14.2020375083
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.2017572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.2016452187 17306315 11723127 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9510091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.3516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2416752155
MESH:D014605 Uveitis Zymosan 5.0311006244
MESH:D014652 Vascular Diseases Arsenic 10.6217056641
MESH:D014652 Vascular Diseases sodium arsenite 10.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2114671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7116761959
MESH:D014839 Vomiting Indomethacin 4.3711897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D009396 Wilms Tumor Tretinoin 3.6616287080
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
REACT:13685 Synaptic Transmission
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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