AutismKB 2.0

Annotation Detail for NEK2


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Basic Information Top
Gene Symbol:NEK2 ( HsPK21,NEK2A,NLK1 )
Gene Full Name: NIMA (never in mitosis gene a)-related kinase 2
Band: 1q32.3
Quick LinksEntrez ID:4751; OMIM: 604043; Uniprot ID:NEK2_HUMAN; ENSEMBL ID: ENSG00000117650; HGNC ID: 7745
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Pathway IDPathway Name
200120FOXM1 transcription factor network
No data
Pathway IDPathway Name
500369APC-Cdc20 mediated degradation of Nek2A
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NEK2 mRNAincreases expression 19031421
D000082 Acetaminophen Acetaminophen results in decreased expression of NEK2 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NEK2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEK2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of NEK2 mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NEK2 mRNAdecreases expression 17942131
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NEK2 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NEK2 mRNAdecreases expression 20382639
20018196
C053541 bicalutamide bicalutamide results in decreased expression of NEK2 mRNAdecreases expression 15638997
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of NEK2 mRNAdecreases expression 17942131
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NEK2 mRNAaffects expression 17484886
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NEK2 mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine results in decreased expression of NEK2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of NEK2 mRNAdecreases expression 17942131
C014347 decitabine decitabine results in decreased expression of NEK2 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of NEK2 mRNA]affects reaction|decreases expression 19363521
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NEK2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NEK2 mRNA]decreases reaction|increases expression 17854601
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of NEK2 mRNA]affects reaction|decreases expression 15016801
C051890 irinotecan irinotecan metabolite results in decreased expression of NEK2 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of NEK2 mRNAdecreases expression 15956246
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of NEK2 mRNAincreases expression 20713471
D009532 Nickel Nickel results in increased expression of NEK2 mRNAincreases expression 19031421
C030110 oxaliplatin oxaliplatin results in decreased expression of NEK2 mRNAdecreases expression 17762391
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NEK2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NEK2 mRNAincreases expression 19363144
19482888
C006253 pirinixic acid pirinixic acid results in increased expression of NEK2 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of NEK2 mRNA]increases expression|increases reaction 17950772
C059514 resveratrol resveratrol results in decreased expression of NEK2 mRNAdecreases expression 15767336
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of NEK2 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of NEK2 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of NEK2 mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NEK2 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NEK2 mRNAdecreases expression 11007951
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of NEK2 mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of NEK2 mRNAincreases expression 19031421
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of NEK2 mRNAdecreases expression 17951470
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of NEK2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of NEK2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D058186 Acute Kidney Injury resveratrol 3.6216538975
MESH:D055371 Acute Lung Injury Nickel 8.4416166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.4418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1720127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.1717638652
MESH:D000236 Adenoma Benzo(a)pyrene 14.776695378
MESH:D000236 Adenoma Diethylnitrosamine 14.7710737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 14.7710545420 6695378
MESH:D000236 Adenoma resveratrol 14.7715688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6819052882 17620307 19061943 18056438 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.6817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6417306315 16712894
MESH:D000544 Alzheimer Disease resveratrol 2.5116162502 16183991
MESH:D000740 Anemia Fluorouracil 7.9317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9311748828
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001169 Arthritis, Experimental resveratrol 3.3417115116
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4511922910
MESH:D050197 Atherosclerosis resveratrol 6.4517967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D002545 Brain Ischemia resveratrol 4.0217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5620146248 17474063
MESH:D001943 Breast Neoplasms decitabine 5.5618320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5617474063
MESH:D001943 Breast Neoplasms Fluorouracil 5.5615136595 19217205 16595493 16557594 18608205 18357371 16110121
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.5617474063
MESH:D001943 Breast Neoplasms Nickel 5.5615986119
MESH:D001943 Breast Neoplasms resveratrol 5.5616393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5620435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 5.5615986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.0816050911 16097048 16227642 15700767 16124888 15721981 16011737 18705752 10355542 3786805 16192424 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.0816050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4016051944
MESH:D002277 Carcinoma Fluorouracil 12.8017121937
MESH:D002277 Carcinoma Methylcholanthrene 12.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.133084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.1321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.1318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.1321159647 17055752 20007298 16878318 19383236 19208518 10737359 16830150 18978308 10672840 19418558 17761372 18665156 20514400 3084413 17138121 20432363 19171122 19394651 20727157 11831363 16328049 19701751 17978847 19052882 19539802 20084675 16698587 18494052 16935385 19822196 20214788 17162532 18506893 17428255 16540662 20935162 16502159 16807293 19919837 20512989 16288022 20524982 16569478 18971187 17173139 16779866 18788625 18691550 18210153 3581430 16681979 19107877 19519916 18393292 18785209 19335982 20101231 18056438
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.1316799960 17045692 17088986 17971768 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.1317173139 6705139 20935162 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.1316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.1316507464 17306315 15276417
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3316675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 17.0520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 17.0519215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 17.0518986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell resveratrol 17.0516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 17.0518572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 17.0518922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2216120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.3015458977
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.2020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.2012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.2017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.2016192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.2019524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002779 Cholestasis Cyclosporine 7.1219486331
MESH:D002779 Cholestasis pirinixic acid 7.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 8697196 16354765 15340226 15668235
MESH:D003092 Colitis resveratrol 8.8016474422
MESH:D003092 Colitis Selenium 8.8017936198
MESH:D003110 Colonic Neoplasms arsenite 13.4315037631
MESH:D003110 Colonic Neoplasms decitabine 13.4317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 13.4317172411 17725105 17287894 15001691 17169374 16510598 18772588 16340194 17018589 17016597
MESH:D003110 Colonic Neoplasms irinotecan 13.4317725105 17287894
MESH:D003110 Colonic Neoplasms oxaliplatin 13.4316024531 16004971 16510598
MESH:D003110 Colonic Neoplasms resveratrol 13.4316338953
MESH:D015179 Colorectal Neoplasms decitabine 6.2118981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.2117454858 18949393 20501625 15289873 17401013 17016601 15148649 16391804 17695437 17094418 18509181 14970324 16331619 17594712 16524972 18288408 18383874 17255274 18802399 18448328 16282729 16303861
MESH:D015179 Colorectal Neoplasms irinotecan 6.2116303861 16391804 17454858 18259882 15273666 18509181 17159606
MESH:D015179 Colorectal Neoplasms oxaliplatin 6.2117594712 17401013 17255274 17695437 18448328 18509181
MESH:D015179 Colorectal Neoplasms resveratrol 6.2116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.5916507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4019769572
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7019470301 17244072 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact Nickel 4.392952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5616873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7416286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.1312153990 19416960 10663392 19923254 18713872 19370779 11529661 17522070 11743745 11287661 12540782 16781746 12392966 11461765 11739529 16081117 17906064 16227642 12594235 11421492 14550746 14725611 19164858 2444490 15619225 18071297 10774834 17562736 19420014 19739265 19085960 14986274 11834606 10915739 15968718 16393943 16485898 12958197 16177239 16109766 12705907
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.137179309 16227642 7120509 9327722 3786805 10915739 15027814 21278145 4309450 2869522 11566570 15968718 17522070 6884620 19336974 7440962 3732212 19085960 6623471 16177239 10092053 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.1319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 11.1315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:C538011 Eales disease Vitamin E 4.449068938
MESH:D004487 Edema pirinixic acid 14.5412083418
MESH:D004487 Edema resveratrol 14.548985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5412711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 14.547812673 8273558 11698051 15177302 16716910 9599246 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7817872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8519294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8010568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5917923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.613922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.8115173087 16785472 16337965 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver arsenite 22.1518296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.1519224547 16045604 17595544 12795759 61145 12631006 16239168 15959796
MESH:D005234 Fatty Liver Cyclosporine 22.1519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.1520387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 22.1520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6810962813 14633661
MESH:D005355 Fibrosis arsenite 19.0318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 19.0318705752
MESH:D005355 Fibrosis Cyclosporine 19.0312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0320067830
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.3219215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.3215162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.3016080930
MESH:D006333 Heart Failure pirinixic acid 6.4220558911
MESH:D006333 Heart Failure Selenium 6.4217162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 12.8916109766
MESH:D006529 Hepatomegaly pirinixic acid 12.8919772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8915340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6116490937 16863852
MESH:D006561 Herpes Simplex resveratrol 3.9216876885
MESH:D015658 HIV Infections Nickel 3.6817263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.9412676792
MESH:D019584 Hot Flashes Vitamin E 3.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7815340226 8697196 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.3616870215
MESH:D006930 Hyperalgesia oxaliplatin 7.3617418472
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia resveratrol 3.7717188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006949 Hyperlipidemias resveratrol 3.7916873680
MESH:D006973 Hypertension Cyclosporine 4.6110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0717488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3917600658
MESH:D007248 Infertility, Male decitabine 6.3317581917
MESH:D007248 Infertility, Male sodium arsenite 6.3315346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 14.4318785209
MESH:D007249 Inflammation Nickel 14.4316166738
MESH:D007249 Inflammation resveratrol 14.4316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4312200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 14.4315177302 8273558 7562506 7812673 11698051
MESH:D007251 Influenza, Human resveratrol 17.0816624496
MESH:D007251 Influenza, Human Selenium 17.0816624496
MESH:D007251 Influenza, Human Vitamin E 17.0816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.188314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 13.1820008137
MESH:D007674 Kidney Diseases Vitamin E 13.1812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6516518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 6.6916985049
MESH:D007938 Leukemia decitabine 2.9418980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.7719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3419387464 17679729 18206229 19010910 18460780 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1918055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4116087638
MESH:D008103 Liver Cirrhosis arsenite 14.5918296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.5916221502 16943688 16239168 11408273 21278145 11903743 17157831 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.5918665156 19638242 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 14.5921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6515925388 17640975 14512876 18429990 12586293 20821823 18277467 18418968 12445418 11481614 12546737 14724832 15996030 12445421 15730626 17721639 12741479 15893842 17714472 18395095 14620537 12609069 15673190 10355542 18006644 18317297 12649538 12666154 17557913 17631135 12632514 16033810 18472332 16011737 17869086 16015684 15370692 18705752 17708605 15057751 16136751 18187930 16638106 12632512 14748882 16097048 12389079 16027843 17761835 18156304 17922224 18263696 18412020 17944888 15338365 15959796 17805973 18279442 17481882 15876570 15931870 18481824 17698563 12667390 18251166 17766677 18376398 17976157 12958196 18420326 18210741 18166357 15818738 13678700 18054572 17823541 12898905 17565644 16248980 17525996 18472094 17900296 18395914 15123356 18339082 15362042 15650968 14716833 18205269 16116963 15052691 14716496 16192424
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.6516169303
MESH:D008107 Liver Diseases Acetaminophen 11.7819460945 12587719 12969438 16610002 19014921 11587558 16611625 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.7815720792 17285989 15830285 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 11.7817034775
MESH:D008107 Liver Diseases Phenobarbital 11.7819363144
MESH:D008107 Liver Diseases Tetrachloroethylene 11.7817267091
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.2818177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.2821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 32.2819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.282862719 12771043 20501860 20137499 19833225 19255062 19256749 20583210 2422723 19812893 18644402 19254457 19850985 20101389 15885732 18977376 21047994 15175105 20405173 19294768 19642983 12112319 19426721 21278145 19073162 19690152 21071580 19499222 20492335 18648771 20118626 19638242 9163691 20452335 16942905 19996281 20434301 21167192 19551842 19090486 10737359 18754104 19427195 18978307
MESH:D008113 Liver Neoplasms Fluorouracil 32.2817045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 32.2819812893 15975961 19482888 21047994 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 32.2820007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 32.2819812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 32.2816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.2816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.788603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.7818775883 18093689 18282651 18253720 18079962 16842330 19519916 21159647 19009564 19126423 16267830 3124819 19539802 9362446 18544905 18308698 17854601 2563599 18164116 19004024 17942915 17174075
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 25.781399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.7818308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.7812151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 25.787955063
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D008171 Lung Diseases Vitamin E 6.8616863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 17.2014755239
MESH:D008175 Lung Neoplasms arsenite 17.2016809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 17.2018816296 20064080 20464547 18520028 18569708 6695378 17053015 20135361 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 17.2020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 17.2015246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 17.2020970405 11893704 15390079 10545420 9230183 16337739 7750092 21163286 1399818 20512841 16271038 6695378 17909032
MESH:D008175 Lung Neoplasms sodium arsenite 17.2019931552 17077188 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.2011884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 17.2011807781
MESH:D008175 Lung Neoplasms Vitamin E 17.2011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D008223 Lymphoma decitabine 3.2319470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6614749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.1611606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1615318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.168985016
MESH:D008545 Melanoma decitabine 4.9117785578 16505122
MESH:D008545 Melanoma resveratrol 4.9117992120
MESH:D008545 Melanoma sodium arsenite 4.9116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D008659 Metabolic Diseases resveratrol 4.1417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8716757204 18986760
MESH:D052016 Mucositis irinotecan 4.7417159606
MESH:D009101 Multiple Myeloma decitabine 6.9018172295
MESH:D009101 Multiple Myeloma resveratrol 6.9017049120 16490592 17164350 14749477 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2319157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 5.3719151258
MESH:D009203 Myocardial Infarction resveratrol 5.3716317513 16525036 17188708 17125593 16456233 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.3317015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7516411023
MESH:D009205 Myocarditis resveratrol 4.5017322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.609029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.6018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 18.1111141357
MESH:D009369 Neoplasms decitabine 18.1119470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 18.1116928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 18.1117405874
MESH:D009369 Neoplasms sodium arsenite 18.1111559025
MESH:D009369 Neoplasms Tetrachloroethylene 18.1111911487
MESH:D009374 Neoplasms, Experimental resveratrol 8.378985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.3720056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.1515738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9614600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.9712854658
MESH:D009447 Neuroblastoma irinotecan 3.358761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.8318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.8320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 12.8317652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.478761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.1617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2616436463
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0117513867
MESH:D010051 Ovarian Neoplasms decitabine 4.7119331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7117306315 15276417
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms decitabine 15.3019294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.3016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3019003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.3016965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 15.3015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.0412065085 8330346 18922899 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010954 Plasmacytoma Selenium 4.6215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.002563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.002563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.7216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7211896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.4717616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bicalutamide 1.8818487222 15638997 17914592 19240160 19011039
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817718901 17675339 17804756 17636462 15767336 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7918286688 18722050 15538739 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3216325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1419058328
MESH:D015427 Reperfusion Injury resveratrol 6.1417058453 16314181 15827377 17520802 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1619155313
MESH:D012640 Seizures Phenobarbital 2.523137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.6119755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 16.6115837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 16.6118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.6116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 16.618985016 12065085 11807781 8330346 18404319
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.102093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 6.1019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1016951190 19015929 17522103 17498489 16424979 15786421 18396642 19084572 17172411 18567086
MESH:D013274 Stomach Neoplasms irinotecan 6.1015723263
MESH:D020521 Stroke Vitamin E 3.3216517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2516321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms decitabine 10.8717967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.877505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.871399818
MESH:D014062 Tongue Neoplasms Fluorouracil 9.2316280240
MESH:D014062 Tongue Neoplasms resveratrol 9.2316227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.7419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7416712894 17306315 16452187 11723127
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.6016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.6017473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.6011813266
MESH:D014594 Uterine Neoplasms resveratrol 3.8917044934
MESH:D014604 Uveal Neoplasms decitabine 4.6517785578
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31546
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07180 - 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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