AutismKB 2.0

Annotation Detail for NELL2


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Basic Information Top
Gene Symbol:NELL2 ( NRP2 )
Gene Full Name: NEL-like 2 (chicken)
Band: 12q12
Quick LinksEntrez ID:4753; OMIM: 602320; Uniprot ID:NELL2_HUMAN; ENSEMBL ID: ENSG00000184613; HGNC ID: 7751
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of NELL2 mRNAincreases expression 20406850
D002713 Chlorine Chlorine results in increased expression of NELL2 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of NELL2 mRNAaffects cotreatment|increases expression 18636392
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of NELL2 mRNAdecreases expression 17005392
D002117 Calcitriol Calcitriol results in increased expression of NELL2 mRNAincreases expression 16002434
D019833 Genistein Genistein results in decreased expression of NELL2 mRNAdecreases expression 15257099
C004925 methylmercuric chloride methylmercuric chloride results in increased expression of NELL2 mRNAincreases expression 19465457
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of NELL2 mRNAaffects cotreatment|increases expression 18636392
D014635 Valproic Acid Valproic Acid results in increased expression of NELL2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 10.156734493
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.158875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury Chlorine 4.5820601635
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 16609825 17688650 18316065 18396377 18558336 19232924 18775368 17157402 18985861 17507914 15238991 19460635 18177632 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Calcitriol 2.0411237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0417129689 15324884
MESH:D001943 Breast Neoplasms Genistein 2.0417200150 16541309 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8717626835 15516495 16777450 18417511 19059883 18315731 14754758
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8616705839
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8615948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8616924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6811237771
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8412952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1319641884 1733752
MESH:D004417 Dyspnea Chlorine 5.0020016425
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.0516402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.0516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.1816804899 15700306
MESH:D016889 Endometrial Neoplasms Genistein 8.1811473722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005234 Fatty Liver Valproic Acid 3.5414986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916534752 16002989 15751030 16611131 16513791
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7412960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.2216762066 14681315 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D007938 Leukemia Genistein 3.1318980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.977678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.9716712894 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876786 2876784 6135515
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0812929590 14578162
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms Diethylstilbestrol 2.8715313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.9011399458
MESH:D009421 Nervous System Malformations Genistein 10.9016427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.278888407 16359493
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9816977796 15687265
MESH:D011014 Pneumonia Ozone 4.7318929643 18381685 18007984
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.9517184923
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.9520603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6518247401 15754350 12479363 16289102 16644109
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6517136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Genistein 2.6516925846 15256057 15378649
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.473137016 1511512 17978042 14763951 16876388 11738929 15475178 11044598
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916002989 16709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4616049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4616712894 16452187 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416513791 16002989
Pathway ID Pathway Name
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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