AutismKB 2.0

Annotation Detail for NEO1


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Basic Information Top
Gene Symbol:NEO1 ( DKFZp547A066,DKFZp547B146,IGDCC2,NGN )
Gene Full Name: neogenin 1
Band: 15q24.1
Quick LinksEntrez ID:4756; OMIM: 601907; Uniprot ID:NEO1_HUMAN; ENSEMBL ID: ENSG00000067141; HGNC ID: 7754
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Myogenesis
Axon guidance
No data
No data
Pathway IDPathway Name
500088Netrin-1 signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NEO1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NEO1 mRNAincreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of NEO1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of NEO1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEO1 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NEO1 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NEO1 mRNAaffects expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NEO1 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEO1 mRNAincreases expression 17606305
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1816434500 17620307 19061943 17162532 19052882 18056438
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.2210965797
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0418705752 15721981 10355542 16227642 16011737 15673190 16124888 3786805 16050911 15700767 16097048 16192424
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.167296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.163084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.1618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1618056438 19539802 18691550 17978847 21159647 16807293 10737359 3084413 18978308 17761372 16681979 16328049 16540662 18506893 20214788 20727157 19208518 20084675 20512989 19701751 18494052 16502159 19418558 18788625 20007298 18210153 11831363 19052882 18971187 19394651 10672840 19335982 20935162 19919837 17055752 16878318 16830150 18393292 19822196 20514400 16698587 16288022 16779866 17173139 20524982 19519916 16935385 18785209 20432363 19171122 20101231 17138121 17162532 3581430 17428255 19107877 16569478 19383236 18665156
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.152727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3617110522 17681005 15861022 16105132 17333356 16919318 11677210
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0614531868 18759878 11298694 8156756 8970840 12868966 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5918289764 9022650 6482804 6679447 18648102 1440618 11289319 7440962 18692083 9653073 16192314 8291058 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5919164858 12153990 16485898 16781746 19923254 14725611 17562736 16177239 19370779 15968718 15619225 10663392 16081117 16227642 2444490 12705907 10774834 11834606 11739529 19085960 11743745 17906064 19420014 10915739 11529661 18071297 14550746 19416960 12540782 11461765 12392966 14986274 16109766 18713872 12594235 17522070 16393943 11287661 12958197 19739265 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.593732212 21278145 6884620 15998439 2869522 16177239 3786805 11566570 7120509 6623471 10092053 17522070 15027814 10915739 7179309 9327722 19336974 16227642 4309450 15968718 19085960 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.3316045604 12795759 19224547 15959796 16239168 12631006 61145 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 14.3320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3315345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7118705752
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7810783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.6012587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.6015369732
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1216766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9511408273 11903743 16943688 17157831 16239168 17334410 21278145 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9518665156 18407596 18522880 19638242 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518317297 15362042 15057751 12958196 12666154 15893842 12389079 15876570 15338365 16033810 16136751 15650968 18412020 15996030 15925388 14724832 17922224 15052691 16015684 12586293 16638106 20821823 17714472 13678700 16248980 15959796 15370692 18339082 14620537 17900296 18166357 18279442 12445418 16097048 16116963 17976157 14716496 16192424 15931870 18205269 12546737 18263696 18210741 14716833 18006644 18395095 18481824 11481614 18251166 17525996 18395914 12632512 18277467 15123356 14512876 12445421 18376398 17721639 17823541 12609069 18472094 10355542 17557913 17631135 18705752 18429990 12649538 16027843 17944888 16011737 17698563 18418968 12898905 17708605 18054572 12741479 17869086 12667390 18472332 17761835 17481882 15730626 15818738 18156304 14748882 18187930 17565644 15673190 17805973 17640975 12632514 18420326 17766677
MESH:D008107 Liver Diseases Acetaminophen 6.7411587558 12969438 16611625 19014921 12587719 19784758 16610002 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7417285989 15720792 16964402 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.8119996281 12112319 2422723 20405173 20501860 20492335 19255062 18644402 18978307 19294768 20583210 21047994 20118626 18754104 19073162 21278145 16942905 19426721 18648771 19499222 19833225 12771043 18977376 20137499 2862719 19638242 20434301 10737359 19254457 19812893 19256749 19690152 19642983 20452335 15175105 19850985 21167192 19090486 19551842 20101389 21071580 9163691 15885732 19427195
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.573712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5718079962 2563599 16267830 17854601 18775883 21159647 19009564 19519916 19539802 9362446 3124819 16842330 18544905 19004024 17942915 18164116 18093689 18253720 17174075 18308698 19126423 18282651
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.949029167 3581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.536482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 14.086228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 14.0811550810
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.643712494 6587162 6582329 1399818 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:21303 Myogenesis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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