AutismKB 2.0

Annotation Detail for NEUROD1


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Basic Information Top
Gene Symbol:NEUROD1 ( BETA2,BHF-1,MODY6,NEUROD,bHLHa3 )
Gene Full Name: neurogenic differentiation 1
Band: 2q31.3
Quick LinksEntrez ID:4760; OMIM: 601724; Uniprot ID:NDF1_HUMAN; ENSEMBL ID: ENSG00000162992; HGNC ID: 7762
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04950Maturity onset diabetes of the young
Pathway IDPathway Name
Regulation of beta-cell development
No data
No data
Pathway IDPathway Name
500522Regulation of gene expression in beta cells
500521Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
500518Regulation of beta-cell development
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00410Maturity onset diabetes of the young (MODY)
Desease IDDesease Name
1848Embryoma
1879Glucose intolerance
1904Diabetes mellitus
1944Breast cancer
2169Pituitary tumor
Desease Name
diabetes, type 1
glucose tolerance
beta-cell function
IMMUNE
METABOLIC
diabetes, type 2
No data
Desease Name
Diabetes mellitus, noninsulin-dependent
Maturity-onset diabetes of the young 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEUROD1 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEUROD1 mRNAincreases expression 15212814
D005472 Fluorouracil Fluorouracil affects the expression of NEUROD1 mRNAaffects expression 16584549
D007529 Isoflavones Isoflavones affects the expression of NEUROD1 mRNAaffects expression 18522411
D009151 Mustard Gas Mustard Gas results in increased expression of NEUROD1 mRNAincreases expression 15674843
D010634 Phenobarbital Phenobarbital results in increased expression of NEUROD1 mRNAincreases expression 12832660
D028321 Plant Preparations Plant Preparations affects the expression of NEUROD1 mRNAaffects expression 18522411
D013619 Tacrine Tacrine results in increased expression of NEUROD1 mRNAincreases expression 12832660
D014212 Tretinoin Tretinoin affects the expression of NEUROD1 mRNAaffects expression 16211290
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4914692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4917638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.2617620307
MESH:D000505 Alopecia Isoflavones 10.1317569567
MESH:D000505 Alopecia Tretinoin 10.1315955085
MESH:D000544 Alzheimer Disease Tacrine 3.9612725862
MESH:D000740 Anemia Fluorouracil 3.9016511603 17963324 15504547
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Mustard Gas 5.1610378619
MESH:D001249 Asthma Tretinoin 5.1616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116197459 16206674
MESH:D001943 Breast Neoplasms Fluorouracil 2.1215136595 16595493 18608205 16110121 19217205 16557594 18357371
MESH:D001943 Breast Neoplasms Plant Preparations 2.1217398067
MESH:D001943 Breast Neoplasms Tretinoin 2.1216166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2910378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8017045692 17088986 16332177 16799960 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8020007298 17173139 6705139 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.801917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 8.0416280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 8.0417418620
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0416051514 16096774
MESH:D002318 Cardiovascular Diseases Isoflavones 8.6217689850
MESH:D002318 Cardiovascular Diseases Plant Preparations 8.6216862667
MESH:D016893 Carotid Stenosis Plant Preparations 6.4215158307
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0215861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616340194 15001691 17169374 17018589 17172411 17725105 17287894 16510598 18772588 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9718509181 16524972 16303861 18288408 17695437 17594712 17401013 17016601 18383874 16391804 14970324 17094418 15148649 15289873 20501625 18949393 17454858 16282729 17255274 18448328 16331619 18802399
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9717116718
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0515158307
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 16925845 9664655 17551590 9224671 10589399 9142499 14991402 9211117 9125849
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D004362 Drug Toxicity Plant Preparations 4.8211033412
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema Mustard Gas 3.519260866 11402378 11428631 11428647
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.2217638652 16481741 15173087 16337965 16785472
MESH:D004938 Esophageal Neoplasms Plant Preparations 5.2216510608
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0215345470
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2415102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.999664655 14991402
MESH:D006529 Hepatomegaly Phenobarbital 3.7416109766
MESH:D019584 Hot Flashes Isoflavones 5.3017290160 14716179
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Mustard Gas 2.8811428647 9357497 9260866 17524151 8975870 11402378 11428620 11428631 16001271
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1115992940 17551590
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817506722 16891316 15748426 16788101 17217047 16935935 19225113 17339181 16140955 9834237 19029980 17361223 17368321 17712046 12679006 17649720 16331271 17107899 16766008 16823087 17294898 19035177 19642359 19075265 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0021047994
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.0617724770
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.0616248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008113 Liver Neoplasms Fluorouracil 4.9317045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 4.9319812893 19073162 21047994 8742319 15975961 19482888
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.8218308698 17172636 6150874 1399818 2563599
MESH:D008171 Lung Diseases Mustard Gas 3.5818702808 18161513
MESH:D008175 Lung Neoplasms Fluorouracil 2.7415246190
MESH:D008175 Lung Neoplasms Mustard Gas 2.748781369 3148597
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
OMIM:606394 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6 marker/mechanism
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009062 Mouth Neoplasms Fluorouracil 9.6416757204 18986760
MESH:D009062 Mouth Neoplasms Plant Preparations 9.6417418620
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009369 Neoplasms Fluorouracil 5.4616928823 18600527 18239605
MESH:D009369 Neoplasms Tretinoin 5.4616594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009503 Neutropenia Mustard Gas 4.1916761898 7688884
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010024 Osteoporosis Isoflavones 4.2216562857
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.0219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.0216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.0215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.6719082440 18626508
MESH:D011471 Prostatic Neoplasms Isoflavones 3.6717571952 17219775 16365062 17374662
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011537 Pruritus Ethinyl Estradiol 10.4915861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.4918058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9910334151 17894541 17720292 17266442 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1916160472 15538739 18286688 18722050
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012640 Seizures Phenobarbital 2.8211442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5517522103 16951190 16424979 19015929 19084572 17172411 17498489 18567086 18396642 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 2.5517261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.721399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7216026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.4816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.4816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 3.8311251952
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.1116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
KEGG:04950 Maturity onset diabetes of the young
REACT:13641 Regulation of Beta-Cell Development
REACT:13698 Regulation of beta-cell development
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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