AutismKB 2.0

Annotation Detail for NFATC1


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Basic Information Top
Gene Symbol:NFATC1 ( MGC138448,NF-ATC,NFAT2,NFATc )
Gene Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Band: 18q23
Quick LinksEntrez ID:4772; OMIM: 600489; Uniprot ID:NFAC1_HUMAN; ENSEMBL ID: ENSG00000131196; HGNC ID: 7775
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
No data
Pathway IDPathway Name
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200184Downstream signaling in naive CD8+ T cells
200005BCR signaling pathway
200077Glucocorticoid receptor regulatory network
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
Pathway IDPathway Name
P00053T cell activation
P00010B cell activation
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1944Breast cancer
2053Colon cancer
2094Ulcerative colitis
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NFATC1 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of NFATC1 mRNAaffects expression 17562736
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NFATC1 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NFATC1 mRNAdecreases expression 12419474
D016572 Cyclosporine Cyclosporine inhibits the reaction [Oxygen deficiency affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D016572 Cyclosporine Cyclosporine inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D016572 Cyclosporine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]decreases reaction|increases activity|increases localization 19349967
C014347 decitabine decitabine results in decreased expression of NFATC1 mRNAdecreases expression 17785578
D017313 Fenretinide Fenretinide results in decreased expression of NFATC1 mRNAdecreases expression 16467112
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [Ionomycin results in decreased phosphorylation of NFATC1 protein]decreases phosphorylation|decreases reaction 12203019
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased activity of NFATC1 proteindecreases activity 12203019
D019271 Hypoxanthine Hypoxanthine results in decreased activity of NFATC1 proteindecreases activity 12203019
D015759 Ionomycin Hydrogen Peroxide inhibits the reaction [Ionomycin results in decreased phosphorylation of NFATC1 protein]decreases phosphorylation|decreases reaction 12203019
D015759 Ionomycin Ionomycin results in decreased phosphorylation of NFATC1 proteindecreases phosphorylation 12203019
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of NFATC1 mRNAdecreases expression 16467112
D010100 Oxygen Cyclosporine inhibits the reaction [Oxygen deficiency affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D010100 Oxygen Oxygen deficiency affects the localization of NFATC1 proteinaffects localization 19028555
D010656 Phenylephrine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]decreases reaction|increases activity|increases localization 19349967
D010656 Phenylephrine KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]decreases reaction|increases activity 12403671
D010656 Phenylephrine Phenylephrine results in increased localization of and results in increased activity of NFATC1 proteinincreases activity|increases localization 19349967
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 19495926
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNAaffects cotreatment|decreases expression 19059307
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]affects cotreatment|decreases reaction|increases expression 16267019
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen results in increased expression of NFATC1 mRNAincreases expression 19031437
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D013749 Tetrachlorodibenzodioxin Cyclosporine inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]affects localization|decreases reaction 19028555
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the localization of NFATC1 proteinaffects localization 19028555
D019284 Thapsigargin Thapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein]decreases phosphorylation|increases reaction 10898953
D014212 Tretinoin Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
D014212 Tretinoin Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
C011559 tributyltin Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
C011559 tributyltin tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
C030665 triphenyltin triphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D058186 Acute Kidney Injury resveratrol 3.6816538975
MESH:D055371 Acute Lung Injury Oxygen 4.3516759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4920464547 20127859
MESH:D000230 Adenocarcinoma Fenretinide 4.4910697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.563712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.566695378
MESH:D000236 Adenoma resveratrol 10.5615688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D000419 Albuminuria Raloxifene 4.4117308373 17451421
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease Raloxifene 4.2715800139
MESH:D000544 Alzheimer Disease resveratrol 4.2716183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9810965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D000860 Anoxia Oxygen 4.8620872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001169 Arthritis, Experimental resveratrol 7.1317115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.1316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D050197 Atherosclerosis Oxygen 6.7216391483
MESH:D050197 Atherosclerosis resveratrol 6.7216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.831440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D002545 Brain Ischemia resveratrol 4.0917600658
MESH:D001932 Brain Neoplasms Fenretinide 4.1816187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8220146248 17474063
MESH:D001943 Breast Neoplasms decitabine 6.8218320071 19208741
MESH:D001943 Breast Neoplasms Fenretinide 6.8216601279
MESH:D001943 Breast Neoplasms Oxygen 6.8217263869
MESH:D001943 Breast Neoplasms Quercetin 6.8218628248
MESH:D001943 Breast Neoplasms Raloxifene 6.8217242785 16912660 17952589 17440819 15775269 17893378 17261762 15758505 17049068 15572757 16837676 17595753
MESH:D001943 Breast Neoplasms resveratrol 6.8216393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 6.8219059307 19155303 21138602 15565566 15668708 11161223 17242785 16818667 17261762 18821012 19200415 20135344 19289846 18351453 19103187 19221464 21152245 18855134 16273361 20544844 20390343 19244106 20859285 19115204 19084267 19066611 19410462 19011961 19487384 16202921 18984771 19189212 19288272 18629630 17440819 19189210 20005174 19142967 16873071 20065188 17049068 18997820 18425577 17893378 18815881
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 6.8216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.613581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.613084413
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.6116270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.6112508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.6116227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.611917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.7520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.7519215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.7516274795
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.7516227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.7516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Phenylephrine 10.8715728586 11754973 11179087 17287366 17124262 16170337
MESH:D006332 Cardiomegaly Quercetin 10.8719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.8718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.5216936243
MESH:D002318 Cardiovascular Diseases Raloxifene 11.5215775269
MESH:D002318 Cardiovascular Diseases resveratrol 11.5215458977
MESH:D002386 Cataract Acetaminophen 6.8610977129
MESH:D002386 Cataract Tretinoin 6.8617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.147505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1412371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.3316154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.3316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.419022650 19486331
MESH:D002779 Cholestasis Cyclosporine 7.4119486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5012621046 15668235 8697196 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D003092 Colitis resveratrol 9.0016474422
MESH:D003092 Colitis Tretinoin 9.0017035595
MESH:D003110 Colonic Neoplasms decitabine 5.7117616700
MESH:D003110 Colonic Neoplasms Quercetin 5.7117191121 17148506 11134977 15741050 19056647 16640504 19440933
MESH:D003110 Colonic Neoplasms resveratrol 5.7116338953
MESH:D015179 Colorectal Neoplasms decitabine 4.7118981723
MESH:D015179 Colorectal Neoplasms Fenretinide 4.7117273769
MESH:D015179 Colorectal Neoplasms Quercetin 4.7118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 4.7116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6316507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3910589399 9142499 17551590 16925845 9125849 9211117 8800419 9224671 14991402 9664655
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6218759878 11298694 2524372 11906362 14531868 8970840 8156756 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.313621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.0419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.0416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Raloxifene 14.1617451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 14.1616286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.1619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.7818289764 6482804 7440962 11289319 16192314 18648102 9022650 6679447 1440618 9328219 18692083 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7812540782 14986274 2444490 19164858 11743745 10915739 19739265 19420014 11739529 11421492 14725611 12705907 16393943 19085960 16781746 12958197 10663392 16227642 11529661 17522070 10774834 15968718 19923254 12594235 16485898 11287661 18713872 11834606 15619225 16081117 19370779 17906064 17562736 18071297 12153990 16177239 19416960 16109766 14550746 11461765 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004417 Dyspnea Oxygen 4.6420016425
MESH:D004487 Edema Raloxifene 10.5515860553
MESH:D004487 Edema resveratrol 10.558985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3015322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.4015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.4017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.4019031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9219294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0316202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.193581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.379664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 12.1619224547
MESH:D005234 Fatty Liver Raloxifene 12.1617473493
MESH:D005234 Fatty Liver Tamoxifen 12.1614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Cyclosporine 19.5912639820 12168785
MESH:D005355 Fibrosis Quercetin 19.5919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.5920067830
MESH:D005355 Fibrosis Tretinoin 19.5917994277
MESH:D005739 Gas Poisoning Oxygen 5.0320016425
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Fenretinide 11.3116187019
MESH:D005909 Glioblastoma Quercetin 11.3119804834
MESH:D005909 Glioblastoma Tretinoin 11.3117312396
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.4119215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.5114991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.4011110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.336705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7115340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 3.9916876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8518606429 15340226 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006937 Hypercholesterolemia resveratrol 3.8317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia Quercetin 9.6011834736 18262572
MESH:D006943 Hyperglycemia triphenyltin 9.6010522495
MESH:D006949 Hyperlipidemias resveratrol 3.8516873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension Cyclosporine 15.6210903974
MESH:D006973 Hypertension Phenylephrine 15.6212717712 8949925
MESH:D006973 Hypertension Quercetin 15.6218356687
MESH:D006973 Hypertension Raloxifene 15.6217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.6218670907 18850075
MESH:D015228 Hypertriglyceridemia triphenyltin 5.7910522495
MESH:D006984 Hypertrophy Phenylephrine 4.3818502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4617600658
MESH:D007246 Infertility triphenyltin 5.8415205045
MESH:D007248 Infertility, Male decitabine 3.0817581917
MESH:D007249 Inflammation resveratrol 7.7616366677
MESH:D007249 Inflammation Tamoxifen 7.7619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7612200463 12878042
MESH:D007251 Influenza, Human Quercetin 10.5516624496
MESH:D007251 Influenza, Human resveratrol 10.5516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.839022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3615992940 17551590
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.418314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 9.4116962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.476582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.4712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 11.4718625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D007938 Leukemia decitabine 10.0019235587 18980019
MESH:D007938 Leukemia Quercetin 10.0017468513
MESH:D007938 Leukemia Tretinoin 10.0017143497
MESH:D007951 Leukemia, Myeloid decitabine 8.9919117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8517679729 18704418 19010910 18206229 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8519850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2718055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.3616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.3616331271 19029980 19035177 16891316 17649720 16935935 16766008 19075265 17712046 16140955 19642359 17368321 16823087 17361223 17294898 17301526 17339181 17506722 15748426 12679006 9834237 17217047 16788101 19225113 17107899
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8516707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.7712741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.5912969438 11587558 19784758 16611625 19014921 12587719 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.4720195826 21137059
MESH:D008113 Liver Neoplasms Quercetin 13.4718980244
MESH:D008113 Liver Neoplasms resveratrol 13.4720405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 13.4716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.161399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.1619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1612151625
MESH:D055370 Lung Injury Oxygen 4.3218339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6518520028 18816296 20464547 20135361 18569708 6695378 17053015 20869020 20064080
MESH:D008175 Lung Neoplasms Quercetin 4.6516280456
MESH:D008175 Lung Neoplasms Tamoxifen 4.6518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6511884234 19555203
MESH:D008223 Lymphoma decitabine 3.2819470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 9.4410697514
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.448985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4419196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma decitabine 9.4417785578 16505122
MESH:D008545 Melanoma Fenretinide 9.4416270382
MESH:D008545 Melanoma resveratrol 9.4417992120
MESH:D008545 Melanoma Tamoxifen 9.4419393235 12393984
MESH:D008545 Melanoma Tretinoin 9.4416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.3016274795
MESH:D009101 Multiple Myeloma decitabine 11.4418172295
MESH:D009101 Multiple Myeloma Raloxifene 11.4416497877
MESH:D009101 Multiple Myeloma resveratrol 11.4414749477 17049120 16490592 17164350 17935668 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1218608210 19010910 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1217596541
MESH:D009203 Myocardial Infarction Quercetin 5.7919595682
MESH:D009203 Myocardial Infarction resveratrol 5.7917188708 16456233 16525036 16317513 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.5117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6519207477
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.443581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.7511141357
MESH:D009369 Neoplasms decitabine 14.7519116145 19470736 17925555
MESH:D009369 Neoplasms Fenretinide 14.7515958647 17353921
MESH:D009369 Neoplasms Quercetin 14.7515185748
MESH:D009369 Neoplasms Tretinoin 14.7516946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.818985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1218481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 8.909125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.826679447
MESH:D009436 Neural Tube Defects Tretinoin 6.829142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.8417652729
MESH:D020078 Neurogenic Inflammation Quercetin 10.1017929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.1017929310
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4916303764
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.256482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010024 Osteoporosis Raloxifene 3.2817882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 15.8919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 15.8917893378 17823083 15758505 15579764
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 15.8917513867
MESH:D010051 Ovarian Neoplasms decitabine 10.8619259094 19331143
MESH:D010051 Ovarian Neoplasms Fenretinide 10.8616133793
MESH:D010051 Ovarian Neoplasms Quercetin 10.8619005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.8616936753
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms decitabine 11.8419294695
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.8415580305
MESH:D010190 Pancreatic Neoplasms Quercetin 11.8416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.8415976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.697296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.6912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.356228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.3511550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5612371664
MESH:D011230 Precancerous Conditions Quercetin 8.5619056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9511896295 11222880 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.5417616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Fenretinide 1.8917024972
MESH:D011471 Prostatic Neoplasms Quercetin 1.8917292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms resveratrol 1.8917718901 17804756 15767336 17675339 16731767 17636462
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury resveratrol 3.1815827377 16314181 17058453 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.3318339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.643692021
MESH:D012162 Retinal Degeneration Fenretinide 8.6416303925
MESH:D012208 Rhabdomyosarcoma decitabine 10.3519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.3516116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 30.5410029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 30.5416467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 30.5412065085
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 30.5416467112
MESH:D012878 Skin Neoplasms resveratrol 30.5415837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 30.548532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 30.5416192470
MESH:D012878 Skin Neoplasms Tretinoin 30.5416467112
MESH:D013088 Spermatocele Tamoxifen 4.1016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2720155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.2719037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.2717261132
MESH:D020521 Stroke Raloxifene 3.6716837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D013398 Sudden Infant Death Oxygen 5.3512563064
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.166582329 1399818 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms decitabine 11.1617967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.1617045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 5.0219048282
MESH:D014062 Tongue Neoplasms resveratrol 9.3516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.3516051514
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.0017053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.0017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 23.0016720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 23.0016720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 23.0017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.0016712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.0316154183
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.0317473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.0316129372
MESH:D014594 Uterine Neoplasms resveratrol 3.9517044934
MESH:D014604 Uveal Neoplasms decitabine 12.1817785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.1816752155
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1117488730
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
KEGG:04660 T cell receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31582
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164743471adenosine triphosphate
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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