AutismKB 2.0

Annotation Detail for NFIA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NFIA ( DKFZp434L0422,DKFZp686J23256,FLJ39164,KIAA1439,NFI-L )
Gene Full Name: nuclear factor I/A
Band: 1p31.3
Quick LinksEntrez ID:4774; OMIM: 600727; Uniprot ID:NFIA_HUMAN; ENSEMBL ID: ENSG00000162599; HGNC ID: 7784
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
500585RNA Polymerase III Transcription Termination
500578RNA Polymerase III Transcription
500579RNA Polymerase III Abortive And Retractive Initiation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2159Hydrocephalus
Desease Name
Celiac Disease
IMMUNE
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of NFIA mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NFIA mRNAaffects expression 21346803
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of NFIA mRNAincreases expression 19643169
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NFIA mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NFIA mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NFIA proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NFIA mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of NFIA mRNAincreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NFIA mRNAdecreases expression 20106945
20064835
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of NFIA mRNAincreases expression 17720352
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NFIA mRNAaffects cotreatment|decreases expression 20360939
D016572 Cyclosporine Cyclosporine results in decreased expression of NFIA mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NFIA mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of NFIA mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NFIA mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NFIA mRNAdecreases expression 17351261
17557909
D005419 Flavonoids Flavonoids results in decreased expression of NFIA mRNAdecreases expression 18035473
D001556 Lindane Lindane results in decreased expression of NFIA mRNAdecreases expression 17785943
C005219 methyl cellosolve methyl cellosolve results in increased expression of NFIA mRNAincreases expression 19643169
D009151 Mustard Gas Mustard Gas affects the expression of NFIA mRNAaffects expression 15651846
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of NFIA mRNAdecreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of NFIA mRNAdecreases expression 19363144
C006253 pirinixic acid pirinixic acid results in increased expression of NFIA mRNAincreases expression 18301758
C045950 propiconazole propiconazole results in decreased expression of NFIA mRNAdecreases expression 19363144
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NFIA mRNAdecreases expression 16054898
D014212 Tretinoin Tretinoin inhibits the reaction [NFIA protein binds to MIR223 promoter]affects binding|decreases reaction 16325577
C032910 triadimefon triadimefon results in decreased expression of NFIA mRNAdecreases expression 19363144
C025643 vinclozolin vinclozolin affects the expression of NFIA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 24.466499820 6499796 7151721 6499823 6499812
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 24.467525203
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 24.463652986 6499812 6474471
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 24.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 24.4615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.433712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.436695378
MESH:D000236 Adenoma Diethylnitrosamine 10.436695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.1218056438 19061943 17162532 17620307 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.1217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.1216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.1216835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1612661182
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.143699323
MESH:D001008 Anxiety Disorders vinclozolin 3.4819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.906499823 10689203 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 11.903987992
MESH:D001249 Asthma Mustard Gas 4.7610378619
MESH:D001249 Asthma Tretinoin 4.7616456186
MESH:D001259 Ataxia 2-ethoxyethanol 5.267151721
MESH:D001284 Atrophy 2-ethoxyethanol 10.7415850284 6499799
MESH:D001284 Atrophy methyl cellosolve 10.743699323 2626667 6705890
MESH:D053713 Azoospermia 2-ethoxyethanol 5.376499807 6492198
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.811440618 11289319
MESH:D001724 Birth Weight 2-ethoxyethanol 6.306499823 2884743
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.3919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.3912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.3916206674 16197459
MESH:D001836 Body Weight Changes 2-ethoxyethanol 11.327151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8620146248 17474063
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.8617474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8617474063
MESH:D001943 Breast Neoplasms Lindane 2.8614688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8616873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.553581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.5512619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.5514691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5516878318 19519916 19919837 19171122 19052882 19539802 19418558 17162532 20514400 16288022 18056438 17428255 16328049 20101231 3084413 16830150 16502159 11831363 18691550 18494052 16569478 16779866 17055752 20935162 18393292 17138121 19208518 17978847 16681979 16540662 16935385 18978308 18210153 20512989 19701751 21159647 18665156 19822196 10737359 16807293 20214788 18785209 18971187 20007298 20432363 19383236 18788625 19394651 18506893 19335982 20727157 16698587 10672840 3581430 17761372 19107877 17173139 20084675 20524982
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.551701930 20935162 6705139 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.551917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3620419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.3616051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2114694615
MESH:D002386 Cataract Tretinoin 7.2117460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.327505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3217174075 7505956 21159647 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.946499794
MESH:D002764 Cholecystitis methyl cellosolve 12.946499794
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.9519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9516105132 17681005 16919318 11677210 17333356 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 17.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.4116354765 15340226 12621046 15668235 8697196
MESH:D002972 Cleft Palate Tretinoin 9.419407595
MESH:D002972 Cleft Palate triadimefon 9.4116781842
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 14.6415095906
MESH:D000013 Congenital Abnormalities methyl cellosolve 14.6412530607 6499821
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 14.6414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.2510525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.259125849 9211117 10589399 14991402 17551590 9224671 8800419 9664655 9142499 16925845
MESH:D019465 Craniofacial Abnormalities triadimefon 5.2515834900 16875885
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D003643 Death 2-ethoxyethanol 5.756499796
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.618156756 11298694 2524372 8970840 18759878 11906362 14531868 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.3318289764 8291058 16192314 9653073 7440962 9328219 1440618 9022650 18692083 11289319 18648102 6482804 6679447
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.3321346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema Mustard Gas 10.3411428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 10.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.306499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6611558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.953581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.9512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.9516530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.9515547733 15264214 15547721 16510608 16805852 15878914 15150132 16704527 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 22.6215073043
MESH:D005234 Fatty Liver Cyclosporine 22.6219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6215345470
MESH:D005234 Fatty Liver pirinixic acid 22.6220131406 19236843
MESH:D005313 Fetal Death 2-ethoxyethanol 10.152884743 7198755 6499820 7151721 6499823
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.1511858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.216499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.966499812 6499820
MESH:D005327 Fetal Resorption methyl cellosolve 11.966499821 6499812 6474471 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.947151721 6499820 2884743
MESH:D020567 Fetal Weight methyl cellosolve 12.946499812 6474471 6499821
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D005355 Fibrosis Cyclosporine 13.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.283652986
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.469664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.576499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.1920172899 10514026
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006461 Hemolysis 2-ethoxyethanol 11.6319051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 11.6317874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 31.0816109766
MESH:D006529 Hepatomegaly Phenobarbital 31.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 31.0816221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly propiconazole 31.0817178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 31.0815340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 31.0817178688 17178689
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007247 Infertility, Female 2-ethoxyethanol 9.756499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.7512013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 15.026499823
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.0217937319
MESH:D007248 Infertility, Male methyl cellosolve 15.023987992
MESH:D007248 Infertility, Male vinclozolin 15.0216467254
MESH:D007249 Inflammation Diethylnitrosamine 11.0818785209
MESH:D007249 Inflammation Flavonoids 11.0817296493
MESH:D007249 Inflammation Mustard Gas 11.0811428631 9357497 11402378 8975870 16001271 11428620 9260866 17524151 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4010783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 16.1616580747
MESH:D007569 Jaw Abnormalities Tretinoin 16.1617551590 15992940
MESH:D007569 Jaw Abnormalities triadimefon 16.1615834900 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 5.8915369732
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.3816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.386582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3812371664
MESH:D007938 Leukemia arsenic trioxide 6.0015070760
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7516968895 19850784 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.0519075265 17712046 15622746 19642359 17869043 16112521 16330433 19035177 19225113 17649720 16891316 11468182 11161223 16823087 16331271 12712474 12018890 17217047 15336539 9834237 15748426 17107899 15213294 12679006 16966277
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 12.0516766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.0515748426 19075265 9834237 17217047 19642359 19029980 19035177 17301526 17712046 16935935 17649720 17361223 16788101 16140955 17107899 17368321 16331271 19225113 17339181 12679006 16823087 17506722 16766008 16891316 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 8.076499821
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.079224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2618522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.2516248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 11.9817034775
MESH:D008107 Liver Diseases Lindane 11.981715830
MESH:D008107 Liver Diseases Phenobarbital 11.9819363144
MESH:D008107 Liver Diseases propiconazole 11.9819363144
MESH:D008107 Liver Diseases triadimefon 11.9819363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.612125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 28.6114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.6121137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.6118978307 20405173 20501860 19833225 20452335 20583210 19090486 19256749 2862719 16942905 19638242 20137499 18648771 9163691 21071580 12112319 18754104 21167192 19426721 19255062 20118626 12771043 18644402 19690152 19294768 19073162 20101389 20434301 19551842 15885732 2422723 21047994 19642983 19850985 19499222 19427195 19812893 10737359 18977376 20492335 21278145 19996281 15175105 19254457
MESH:D008113 Liver Neoplasms Phenobarbital 28.6121047994 8742319 15975961 19812893 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 28.6120007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 28.6119028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.6116984957
MESH:D008113 Liver Neoplasms triadimefon 28.6119028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 31.063712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 31.068603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 31.0620377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 31.0618093689 18544905 18282651 17174075 18253720 18775883 18164116 19009564 19519916 16267830 18308698 9362446 19126423 2563599 17854601 19004024 16842330 18079962 3124819 19539802 21159647 17942915
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 31.062563599 17172636 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental propiconazole 31.0617178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 31.0612151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 31.0617178689
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008171 Lung Diseases Mustard Gas 3.3118161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2014755239
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2019825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2017053015 20064080 20464547 18816296 18520028 6695378 18569708 20869020 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 8.203148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2019555203 11884234
MESH:D008231 Lymphopenia methyl cellosolve 5.573699323
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9614977855 19417148 15949261 11468182 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0016105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.1918551238
MESH:D009336 Necrosis 2-ethoxyethanol 10.1920172899
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.423581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.423581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 11.0311141357
MESH:D009369 Neoplasms Lindane 11.0316818664 12807735
MESH:D009369 Neoplasms pirinixic acid 11.0317405874
MESH:D009369 Neoplasms Tretinoin 11.0316946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 8.849125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.346679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.3410525206
MESH:D009436 Neural Tube Defects Tretinoin 11.349142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009503 Neutropenia Mustard Gas 3.787688884 16761898
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.1016049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.106482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.1014694615
MESH:D009845 Oligospermia 2-ethoxyethanol 10.6720172899
MESH:D009845 Oligospermia methyl cellosolve 10.673987992
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6512452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6516936753
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.7015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 21.617198755 2884743 6499817
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 21.617974496 6499817 12530607
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.6111118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.6118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7317292933
MESH:D011471 Prostatic Neoplasms Lindane 2.7312661182 14688026
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.8216919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.8218058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8517720292 17894541 10334151 17266442 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.223692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012640 Seizures 2,4-dinitrotoluene 9.1418551238
MESH:D012640 Seizures Lindane 9.147539098 15475178 12842176
MESH:D012640 Seizures Phenobarbital 9.143137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012871 Skin Diseases Mustard Gas 2.6616961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.162093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.1617575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 6.1617261132
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.206499799
MESH:D013733 Testicular Diseases 2-ethoxyethanol 10.3610048760 10514026 6499806
MESH:D013733 Testicular Diseases methyl cellosolve 10.366499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 25.986582329 1399818 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 25.9819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 25.987505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 25.981399818
MESH:D013964 Thyroid Neoplasms Tretinoin 25.9816026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 25.9817178689
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.9416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.948074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.9412845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.9417053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 14.9415537745
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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