AutismKB 2.0

Annotation Detail for NFATC4


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Basic Information Top
Gene Symbol:NFATC4 ( NF-ATc4,NFAT3 )
Gene Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Band: 14q12
Quick LinksEntrez ID:4776; OMIM: 602699; Uniprot ID:NFAC4_HUMAN; ENSEMBL ID: ENSG00000100968; HGNC ID: 7778
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
No data
Pathway IDPathway Name
200119ErbB2/ErbB3 signaling events
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P00010B cell activation
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
Desease Name
CARDIOVASCULAR
cardiomyopathy
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid 20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 proteinincreases localization 16055480
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid 20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 proteinincreases localization 16055480
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NFATC4 mRNAincreases expression 19933214
D003078 Colchicine Colchicine results in decreased localization of NFATC4 proteindecreases localization 17044076
D016572 Cyclosporine Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016572 Cyclosporine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016572 Cyclosporine Cyclosporine inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016572 Cyclosporine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D015638 Cytochalasin D Cytochalasin D results in decreased localization of NFATC4 proteindecreases localization 17044076
C093973 PD 98059 PD 98059 inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]affects localization|decreases reaction 11044444
D010656 Phenylephrine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D010656 Phenylephrine Phenylephrine results in increased localization of NFATC4 proteinincreases localization 16055480
D010656 Phenylephrine Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D010656 Phenylephrine Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D010656 Phenylephrine PD 98059 inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]affects localization|decreases reaction 11044444
D010656 Phenylephrine Phenylephrine affects the localization of NFATC4 proteinaffects localization 11044444
D010656 Phenylephrine Phenylephrine results in increased localization of NFATC4 proteinincreases localization 16055480
D010656 Phenylephrine Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
C017947 sodium arsenite NFATC4 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]increases expression|increases reaction 16809336
C017947 sodium arsenite sodium arsenite results in increased activity of NFATC4 proteinincreases activity 16809336
D016559 Tacrolimus Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016559 Tacrolimus Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016559 Tacrolimus Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D016559 Tacrolimus Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]decreases reaction|increases localization 16055480
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NFATC4 mRNAincreases expression 19933214
18691609
D014747 Vinblastine Vinblastine results in decreased localization of NFATC4 proteindecreases localization 17044076
D015032 Zinc Zinc results in increased localization of NFATC4 proteinincreases localization 17044076
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000169 Acrodermatitis Zinc 5.5617190629 16889938 17202136
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000544 Alzheimer Disease Zinc 2.7716325427 16580781 17119284 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2117460149
MESH:D001249 Asthma Zinc 2.9817085522
MESH:D001528 Behcet Syndrome Colchicine 6.2415870978
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001919 Bradycardia Phenylephrine 4.7015306635
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9916507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.831485588
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0118572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.0116543248
MESH:D006332 Cardiomegaly Phenylephrine 7.0717124262 11179087 11754973 17287366 15728586 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0716120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Tacrolimus 8.3117703430
MESH:D002318 Cardiovascular Diseases Zinc 8.3116936243
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9012371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9019524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 12621046 8697196 15668235 16354765
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.7019302082
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004381 Duodenal Ulcer Tacrolimus 5.2717202747
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms Zinc 2.8816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Zinc 4.9717241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006086 Graft vs Host Disease Tacrolimus 6.0116376943
MESH:D006130 Growth Disorders Tacrolimus 9.3111041285
MESH:D006130 Growth Disorders Zinc 9.3117217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure Zinc 3.6717162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 8.0312676792
MESH:D006689 Hodgkin Disease Vinblastine 8.0318501091 18180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 16959395 15340226 8697196 16354765
MESH:D006973 Hypertension Cyclosporine 8.8310903974
MESH:D006973 Hypertension Phenylephrine 8.838949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8318670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6612791704 18502941
MESH:C537153 Hypomagnesemia primary Tacrolimus 6.3111041285
MESH:D007022 Hypotension Tacrolimus 5.2311041285
MESH:D007248 Infertility, Male sodium arsenite 3.0612646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 15.0618776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 15.0620008137
MESH:D007674 Kidney Diseases Tacrolimus 15.0611041285
MESH:D007674 Kidney Diseases Zinc 15.0616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007859 Learning Disorders Colchicine 5.6411749816
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.3816972261
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.5715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3316712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3311884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.3612773700
MESH:D008545 Melanoma sodium arsenite 3.7516487513 19082730
MESH:D008545 Melanoma Vinblastine 3.7518505091 12374674 16248763 18332650 17761969 15577323 16432458 18176117 15577320 16809738
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms sodium arsenite 2.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2112854658
MESH:D019636 Neurodegenerative Diseases Tacrolimus 5.0415081597
MESH:D009503 Neutropenia Vinblastine 4.6917378895
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4617306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4716039940
MESH:D011471 Prostatic Neoplasms Zinc 3.4712429649 16606632 16517595 16700911
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012852 Sinusitis Phenylephrine 4.867327846
MESH:D012878 Skin Neoplasms sodium arsenite 5.7518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5417306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1815577323
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04660 T cell receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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