AutismKB 2.0

Annotation Detail for NFIB


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Basic Information Top
Gene Symbol:NFIB ( HMGIC/NFIB,NFI-RED,NFIB2,NFIB3 )
Gene Full Name: nuclear factor I/B
Band: 9p23-p22.3
Quick LinksEntrez ID:4781; OMIM: 600728; Uniprot ID:NFIB_HUMAN; ENSEMBL ID: ENSG00000147862; HGNC ID: 7785
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
500585RNA Polymerase III Transcription Termination
500578RNA Polymerase III Transcription
500579RNA Polymerase III Abortive And Retractive Initiation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NFIB mRNAaffects expression 21346803
C026114 2-xylene 2-xylene results in increased expression of NFIB mRNAincreases expression 20359517
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NFIB mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NFIB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NFIB mRNAaffects expression 16483693
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of NFIB mRNAincreases expression 15305145
D001554 Benzene Benzene results in increased expression of NFIB mRNAincreases expression 20359517
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NFIB mRNAdecreases expression 19150397
20018196
20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NFIB mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of NFIB mRNAdecreases expression 18178546
D016572 Cyclosporine Cyclosporine results in decreased expression of NFIB mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of NFIB mRNAdecreases expression 19638242
D004317 Doxorubicin Doxorubicin results in decreased expression of NFIB mRNAdecreases expression 17888722
D004958 Estradiol Estradiol affects the expression of NFIB mRNAaffects expression 14699072
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of NFIB mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NFIB mRNAdecreases expression 12655037
C004912 ethylbenzene ethylbenzene results in increased expression of NFIB mRNAincreases expression 20359517
D005472 Fluorouracil Fluorouracil results in decreased expression of NFIB mRNAdecreases expression 16557594
D001556 Lindane Lindane results in decreased expression of NFIB mRNAdecreases expression 17785943
D008345 Manganese Manganese results in increased expression of NFIB mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of NFIB mRNAincreases expression 17175027
D008701 Methapyrilene Methapyrilene results in decreased expression of NFIB mRNAdecreases expression 16393664
D008713 Methimazole Methimazole results in decreased expression of NFIB mRNAdecreases expression 17403546
D008752 Methylene Chloride Methylene Chloride results in increased expression of NFIB mRNAincreases expression 20359517
D009151 Mustard Gas Mustard Gas affects the expression of NFIB mRNAaffects expression 15651846
C494474 perchlorate perchlorate results in decreased expression of NFIB mRNAdecreases expression 17403546
C006253 pirinixic acid pirinixic acid results in decreased expression of NFIB mRNAdecreases expression 18445702
16221962
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of NFIB mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of NFIB mRNAincreases expression 17404688
D011441 Propylthiouracil Propylthiouracil results in decreased expression of NFIB mRNAdecreases expression 17403546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NFIB mRNAincreases expression 16922920
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFIB mRNAaffects cotreatment|affects expression 16979875
D014050 Toluene Toluene results in increased expression of NFIB mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of NFIB mRNAincreases expression 20359517
C025643 vinclozolin vinclozolin affects the expression of NFIB mRNAaffects expression 19015723
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFIB mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.367525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D000169 Acrodermatitis Zinc 5.0617202136 16889938 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Doxorubicin 9.4017418594
MESH:D000230 Adenocarcinoma Estradiol 9.4011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4014692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.4017638652
MESH:D000236 Adenoma Diethylnitrosamine 2.656695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.3019061943 18056438 17620307 16434500 19052882 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.3016835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0412661182
MESH:D000419 Albuminuria Doxorubicin 4.2221441931
MESH:D000544 Alzheimer Disease Zinc 2.6816580781 17119284 16410023 16325427
MESH:D000740 Anemia Fluorouracil 7.7117963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7111748828
MESH:D000741 Anemia, Aplastic Benzene 4.1111369114 14761424 17661222
MESH:D000755 Anemia, Sickle Cell Zinc 4.5816916123
MESH:D000756 Anemia, Sideroblastic Manganese 10.0216910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.0216910769
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3719015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001249 Asthma Mustard Gas 4.8310378619
MESH:D001249 Asthma Zinc 4.8317085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001768 Blister Mustard Gas 4.8219167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6012125929
MESH:D001836 Body Weight Changes 2-xylene 10.957457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.9515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D001855 Bone Marrow Diseases Benzene 4.8816183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3514601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 9.9415380490 15845082 15665606
MESH:D001930 Brain Injuries Zinc 9.9417109824
MESH:D001932 Brain Neoplasms Doxorubicin 3.5217150277
MESH:D001943 Breast Neoplasms Ascorbic Acid 7.8516443354
MESH:D001943 Breast Neoplasms Benzene 7.8517162533 11921183
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.8517474063
MESH:D001943 Breast Neoplasms Doxorubicin 7.8519526202 18234424 16096432 16115903 16264153 17426702 15692762 15668708 15993339 16935488 16826403 17369602 15136595 18382427 18695136 15634643 15939500 17983394 15994142 18628466 11325840 15567936 16322301 16595493
MESH:D001943 Breast Neoplasms Estradiol 7.8516675129 19861407 17289903 17261762 12948864 17018787 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 7.8518608205 16110121 15136595 16557594 19217205 18357371 16595493
MESH:D001943 Breast Neoplasms Lindane 7.8514688026
MESH:D001943 Breast Neoplasms Methylene Chloride 7.8515986119
MESH:D001943 Breast Neoplasms Progesterone 7.8516175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.8520435547
MESH:D001943 Breast Neoplasms Trichloroethylene 7.8515986119
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6317687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4518705752 16227642 16097048 15700767 16124888 3786805 10355542 15721981 16011737 15673190 16192424 16050911
MESH:D002276 Carcinoid Tumor Doxorubicin 11.2016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.2016051944
MESH:D002277 Carcinoma Fluorouracil 7.3017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.133084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.1318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.1319919837 19539802 20007298 18210153 16681979 20727157 18056438 19052882 17055752 16569478 3581430 3084413 18785209 17173139 19208518 16878318 20432363 21159647 19107877 19171122 17428255 16779866 20512989 16288022 19335982 20214788 20101231 16935385 16807293 17138121 18494052 18506893 10737359 17978847 20935162 19822196 18691550 20514400 19519916 11831363 18978308 16502159 16540662 17761372 20084675 19701751 16830150 18393292 19383236 16328049 18971187 18788625 17162532 18665156 19394651 10672840 16698587 19418558 20524982
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.1316234567 16023760 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.1316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.1317088986 17045692 18930000 16332177 16799960 17971768
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.131485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1318695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.996189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.9916757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.9918922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 9.9916543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1818850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3117382496 17351982 16952015 17308081 17329180 16731534 16278810 17519947 16364871 17974986 17007740 17924179 16612575 17928571 15792986 16269455 17131338 15476868 16455267 18627295 16242529 16651473 15811867 15505089 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8317334414 16243910
MESH:D002318 Cardiovascular Diseases Zinc 3.4316936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.7514694615
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.0912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.0917174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.0918566989
MESH:D002547 Cerebral Palsy Toluene 5.519294310
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8916919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9615340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1816340194 17016597 17287894 16510598 17172411 17018589 18772588 17725105 17169374 15001691
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5618802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5617454858 18448328 14970324 17016601 18383874 16524972 15148649 17094418 18802399 17594712 17255274 15289873 20501625 18949393 17695437 16391804 16331619 16282729 18509181 18288408 17401013 16303861
MESH:D003139 Common Cold Ascorbic Acid 5.1317323712
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.2415095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 5.1515643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Toluene 5.159294310
MESH:D019465 Craniofacial Abnormalities Zinc 5.1519302082
MESH:D003456 Cryptorchidism vinclozolin 4.0214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6818551238
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D003643 Death Toluene 5.326431079
MESH:D003872 Dermatitis Benzene 4.4315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003920 Diabetes Mellitus Zinc 3.9216479319
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.6416506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 23.7621346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.7617562736 12705907 11834606 19739265 14550746 17906064 15619225 16109766 16227642 14725611 10774834 18071297 14986274 12958197 2444490 15968718 12153990 18713872 16393943 11287661 11529661 16081117 19164858 17522070 11743745 16781746 12594235 10915739 12392966 19416960 11739529 11461765 19923254 11421492 16485898 16177239 12540782 19085960 19370779 10663392 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.767440962 6623471 16227642 7120509 2869522 6884620 17522070 19336974 15968718 10092053 9327722 10915739 19085960 3786805 11566570 15998439 4309450 21278145 16177239 3732212 15027814 7179309
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 23.7617851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.7619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 23.7617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.7620420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 23.767120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.2818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2811462148
MESH:C538011 Eales disease Ascorbic Acid 5.139068938
MESH:D004487 Edema Mustard Gas 13.999260866 11428647 11428631 11402378
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9911000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.997812673 16716910 9599246 15177302 8273558 11698051 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5615322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.9617692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.8017359293
MESH:D016889 Endometrial Neoplasms Estradiol 6.8019148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 7.9516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.959294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8118037988
MESH:D004890 Erythema Mustard Gas 4.829357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7816785472 16481741 17638652 16337965 15173087
MESH:D004938 Esophageal Neoplasms Zinc 6.7816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.4212631006 17595544 15959796 12795759 61145 16045604 19224547 16239168
MESH:D005234 Fatty Liver Cyclosporine 21.4219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 21.4220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.4215345470
MESH:D005234 Fatty Liver pirinixic acid 21.4219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 12.7918705752
MESH:D005355 Fibrosis Cyclosporine 12.7912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.7920067830
MESH:D005756 Gastritis Acetaminophen 10.0116983495
MESH:D005756 Gastritis Zinc 10.0117241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Doxorubicin 6.8417150277
MESH:D005909 Glioblastoma Manganese 6.8417043766
MESH:D005910 Glioma Fluorouracil 2.7316145905
MESH:D006042 Goiter perchlorate 4.9918801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006130 Growth Disorders Zinc 3.7417217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1615162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 6.2516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2511294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2516244371 18006777 16144979 17875725 16707910 16244372 18674790 16495754 16330681 14766674 17888722 12587719 16879835
MESH:D006333 Heart Failure Doxorubicin 10.6617481944
MESH:D006333 Heart Failure pirinixic acid 10.6620558911
MESH:D006333 Heart Failure Zinc 10.6617162251
MESH:D006335 Heart Injuries Zinc 5.4217074742
MESH:D016481 Helicobacter Infections Zinc 4.2217241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6015692506
MESH:D006402 Hematologic Diseases Benzene 4.3416183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3617276780
MESH:D006529 Hepatomegaly 2-xylene 12.677457028 7457013
MESH:D006529 Hepatomegaly pirinixic acid 12.6716221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.6715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3516490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.1318501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006973 Hypertension Benzene 7.8217940673
MESH:D006973 Hypertension Cyclosporine 7.8210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D006980 Hyperthyroidism Methimazole 5.2914678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007037 Hypothyroidism Methimazole 10.8418031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.848137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9117937319
MESH:D007248 Infertility, Male vinclozolin 5.9116467254
MESH:D007249 Inflammation Diethylnitrosamine 13.9518785209
MESH:D007249 Inflammation Mustard Gas 13.9511428647 11428631 11428620 9357497 8975870 17524151 16001271 11402378 9260866
MESH:D007249 Inflammation Progesterone 13.9515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.9512878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 13.9511698051 7812673 7562506 8273558 15177302
MESH:D007333 Insulin Resistance Estradiol 6.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.4616306350
MESH:D007511 Ischemia Zinc 4.3016584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Acetaminophen 16.9515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 16.9518776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 16.9516775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 16.9515618244
MESH:D007674 Kidney Diseases Zinc 16.9516960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.1716707910
MESH:D007676 Kidney Failure, Chronic Zinc 9.1716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.5116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.5112371664
MESH:D007680 Kidney Neoplasms Estradiol 15.5115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.5116985049
MESH:D007938 Leukemia Benzene 3.2218335105 17119257 14694614 15935818
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8116085563
MESH:D007951 Leukemia, Myeloid Benzene 4.0217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6419478238
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3916417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.9817157831 17334410 16943688 21278145 17174718 16239168 16221502 11408273 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9818665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.2218006644 18279442 18395914 11481614 17557913 12667390 14620537 17525996 12609069 12632512 15959796 18156304 18472094 17766677 17481882 16027843 18263696 15673190 12546737 17721639 12898905 17761835 15931870 14724832 18054572 15057751 14716833 12586293 14748882 16116963 12445418 18429990 16136751 16033810 17869086 12632514 16015684 18166357 17714472 12741479 14716496 18317297 17922224 17708605 18420326 15123356 15818738 15876570 18412020 15362042 18472332 18205269 15370692 18187930 14512876 15996030 18277467 20821823 17823541 17631135 12666154 17900296 12649538 15730626 12389079 16248980 18251166 15052691 18376398 16192424 17698563 10355542 16011737 18210741 16638106 17640975 15925388 15650968 17976157 18481824 18395095 16097048 13678700 15338365 18705752 17944888 12958196 15893842 17565644 18339082 12445421 18418968 17805973
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.2216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.2214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2212878042
MESH:D008107 Liver Diseases Acetaminophen 8.6112587719 16611625 16610002 12969438 11587558 19460945 19784758 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6116964402 15830285 15720792 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6117034775
MESH:D008107 Liver Diseases Lindane 8.611715830
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4314706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.2119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.2119850985 18977376 19996281 18644402 9163691 19073162 21071580 18754104 15885732 21278145 2862719 12112319 19090486 16942905 19833225 19499222 20118626 19690152 19427195 12771043 10737359 20137499 19255062 19294768 19254457 19638242 18978307 19812893 15175105 19426721 20492335 20452335 21047994 20101389 20405173 20434301 2422723 19256749 18648771 20583210 19551842 21167192 20501860 19642983
MESH:D008113 Liver Neoplasms Fluorouracil 16.2117045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Methapyrilene 16.2115890375
MESH:D008113 Liver Neoplasms pirinixic acid 16.2120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.2116984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 25.0018544905
MESH:D008114 Liver Neoplasms, Experimental Benzene 25.0012562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.0012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.0017854601 19539802 17942915 18775883 16842330 19009564 2563599 18544905 21159647 16267830 17174075 18079962 9362446 18253720 18093689 18164116 18282651 19126423 3124819 19519916 18308698 19004024
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.0017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.0012151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 25.007955063
MESH:D008171 Lung Diseases Ascorbic Acid 7.0716863852
MESH:D008171 Lung Diseases Mustard Gas 7.0718161513 18702808
MESH:D017563 Lung Diseases, Interstitial Benzene 4.4614698565
MESH:D008175 Lung Neoplasms Ascorbic Acid 14.4716401635
MESH:D008175 Lung Neoplasms Benzene 14.4712562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.4721163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 14.476189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 14.4715246190
MESH:D008175 Lung Neoplasms Methylene Chloride 14.4715172992
MESH:D008175 Lung Neoplasms Mustard Gas 14.478781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.4719555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 14.4711807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D008223 Lymphoma Benzene 7.0417119257 17584886
MESH:D008223 Lymphoma Doxorubicin 7.0416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2315621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1012562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 20.7411921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 20.7415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.7411807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 20.7417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 20.748985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 20.7412773700
MESH:D020149 Manganese Poisoning Estradiol 11.8519453300
MESH:D020149 Manganese Poisoning Manganese 11.8519453300 16551646 16568477
MESH:D008545 Melanoma Doxorubicin 2.2416827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008607 Mental Retardation Toluene 3.539294310
MESH:D008654 Mesothelioma Doxorubicin 2.9217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1915792986
MESH:D019957 Motor Skills Disorders Toluene 4.929294310
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3716757204 18986760
MESH:D009069 Movement Disorders Manganese 4.7016551646
MESH:D052016 Mucositis Doxorubicin 4.4517415656
MESH:D009101 Multiple Myeloma Benzene 3.4317119195
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.2215857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5218551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.419029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4118259882
MESH:D009369 Neoplasms Fluorouracil 10.5418239605 18600527 16928823
MESH:D009369 Neoplasms Lindane 10.5412807735 16818664
MESH:D009369 Neoplasms pirinixic acid 10.5417405874
MESH:D009369 Neoplasms Trichloroethylene 10.5411911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009401 Nephrosis Doxorubicin 4.4416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3519348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3515640375 16889571
MESH:D009410 Nerve Degeneration Manganese 4.0216551646
MESH:D009421 Nervous System Malformations Estradiol 8.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3914600291
MESH:D009436 Neural Tube Defects Benzene 3.4515643154
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.2720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009503 Neutropenia Mustard Gas 3.6616761898 7688884
MESH:D009765 Obesity Ascorbic Acid 4.4417217161
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.5616049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.5614694615
MESH:D009784 Occupational Diseases Benzene 13.5617119257 15935809 17479406 15727169 17178637 15913788 15576619 16737584 15612468
MESH:D012516 Osteosarcoma Doxorubicin 3.8515930896
MESH:D010051 Ovarian Neoplasms Benzene 7.3012562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.3019401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.3016525653 17393432
MESH:D010146 Pain Acetaminophen 2.1316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.9716540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.9719003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.9715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.968330346 18404319 12065085 18922899
MESH:D010300 Parkinson Disease Manganese 3.2511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.1816140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8117983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8117638057
MESH:D011041 Poisoning Mustard Gas 3.4915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.002563599
MESH:D011225 Pre-Eclampsia Zinc 3.9217114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3611222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.3618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9216888761 15897917 15749863 16868541 16729912 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9218626508 19082440
MESH:D011471 Prostatic Neoplasms Lindane 1.9212661182 14688026
MESH:D011471 Prostatic Neoplasms Zinc 1.9212429649 16606632 16517595 16700911
MESH:D011472 Prostatitis vinclozolin 4.5918629315
MESH:D011537 Pruritus Ethinyl Estradiol 8.3916919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.3918058305
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.9914606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8010334151 17266442 17620002 17894541 17720292
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7316160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.8917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012162 Retinal Degeneration Zinc 3.8816584753
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2116849425
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012509 Sarcoma Doxorubicin 3.7015625365 16767912 18313854 15675481 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4517846226
MESH:D012640 Seizures 2,4-dinitrotoluene 8.7618551238
MESH:D012640 Seizures Lindane 8.7612842176 15475178 7539098
MESH:D012640 Seizures Toluene 8.766431079 9294310
MESH:D012871 Skin Diseases Ascorbic Acid 4.9918709164
MESH:D012871 Skin Diseases Mustard Gas 4.9916961503 12880345 15451306
MESH:D012878 Skin Neoplasms Doxorubicin 8.5915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.598330346 11807781 18404319 12065085 8985016
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2316767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6016709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9415862959 16503802
MESH:D013274 Stomach Neoplasms Benzene 3.2712562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2716951190 16424979 18396642 17522103 18567086 17172411 19084572 17498489 19015929 15786421
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.6018726076
MESH:D020521 Stroke Ascorbic Acid 4.0316403987 16517955
MESH:D013733 Testicular Diseases Toluene 4.6210514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013953 Thymus Neoplasms Benzene 4.6210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.627505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.6217909728 16010429
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.6215710170
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0816280240
MESH:D014062 Tongue Neoplasms Zinc 9.0816543248
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.7216049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 4.7217653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9710091137
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.5916803524
MESH:D014594 Uterine Neoplasms Benzene 8.5012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5014692618
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8916364871 17678736 17638931 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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