AutismKB 2.0

Annotation Detail for NFIL3


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Basic Information Top
Gene Symbol:NFIL3 ( E4BP4,IL3BP1,NF-IL3A,NFIL3A )
Gene Full Name: nuclear factor, interleukin 3 regulated
Band: 9q22.31
Quick LinksEntrez ID:4783; OMIM: 605327; Uniprot ID:NFIL3_HUMAN; ENSEMBL ID: ENSG00000165030; HGNC ID: 7787
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NFIL3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of NFIL3 mRNAincreases expression 11264010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NFIL3 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NFIL3 mRNAincreases expression 18687144
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NFIL3 mRNAaffects cotreatment|decreases expression 18164116
C027561 butylbenzyl phthalate butylbenzyl phthalate results in increased expression of NFIL3 mRNAincreases expression 15728792
D016572 Cyclosporine Cyclosporine results in increased expression of NFIL3 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of NFIL3 mRNAincreases expression 12782123
D004041 Dietary Fats Dietary Fats results in decreased expression of NFIL3 mRNAdecreases expression 18042831
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of NFIL3 mRNAincreases expression 15728792
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NFIL3 mRNAaffects cotreatment|decreases expression 18164116
D004958 Estradiol Estradiol results in increased expression of NFIL3 mRNAincreases expression 20106945
D007501 Iron Iron deficiency results in increased expression of NFIL3 mRNAincreases expression 20368581
C011890 kojic acid kojic acid results in increased expression of NFIL3 mRNAincreases expression 16595896
C008493 methylselenic acid methylselenic acid affects the expression of NFIL3 mRNAaffects expression 14617803
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of NFIL3 mRNAincreases expression 20024957
C029938 nickel sulfate nickel sulfate results in increased expression of NFIL3 mRNAincreases expression 16780908
D009638 Norepinephrine Norepinephrine results in increased expression of NFIL3 mRNAincreases expression 12729908
D010126 Ozone Ozone results in increased expression of NFIL3 mRNAincreases expression 17095637
19555225
C041786 palm oil palm oil results in decreased expression of NFIL3 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NFIL3 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of NFIL3 mRNAdecreases expression 19270015
19482888
D010656 Phenylephrine U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA]decreases reaction|increases expression 12729908
C006253 pirinixic acid pirinixic acid results in decreased expression of NFIL3 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of NFIL3 mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in decreased expression of NFIL3decreases expression 17510236
D020849 Raloxifene Raloxifene affects the expression of NFIL3 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNAaffects cotreatment|decreases expression 19059307
C009250 sevoflurane sevoflurane affects the expression of NFIL3 mRNAaffects expression 15967596
D013467 Sulindac Sulindac results in increased expression of NFIL3 mRNAincreases expression 11906190
D013629 Tamoxifen Tamoxifen affects the expression of NFIL3 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NFIL3 mRNAdecreases expression 17101203
C024746 tobacco tar tobacco tar results in decreased expression of NFIL3 mRNAdecreases expression 19559774
D014415 Tunicamycin Tunicamycin results in increased expression of NFIL3 mRNAincreases expression 17127020
C113580 U 0126 U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA]decreases reaction|increases expression 12729908
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.9714745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.9714745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 12.546734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.546195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.5414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.1717694057
MESH:D058186 Acute Kidney Injury Sulindac 4.047897758
MESH:D055371 Acute Lung Injury nickel sulfate 8.1912718980 19131640 16100012 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 8.1918653653
MESH:D000230 Adenocarcinoma Estradiol 4.4211473722
MESH:D000230 Adenocarcinoma Sulindac 4.4211910360
MESH:D000236 Adenoma beta-Naphthoflavone 10.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.316695378 10737359
MESH:D000236 Adenoma Sulindac 10.3110223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.2918056438 19052882 19061943 16434500 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.2917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.2916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.2916835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3315623613 11874996 17611924 11535846 16460482 12394442 19003578
MESH:D000419 Albuminuria Raloxifene 4.3017451421 17308373
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.3416640825
MESH:D000544 Alzheimer Disease Iron 6.3216563566 16640825
MESH:D000544 Alzheimer Disease Ozone 6.3215513908
MESH:D000544 Alzheimer Disease Raloxifene 6.3215800139
MESH:D000740 Anemia Iron 8.0316566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0311748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.3816569441 17163184 17162259 17147795 17375513
MESH:D000756 Anemia, Sideroblastic Iron 4.5316910769
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001145 Arrhythmias, Cardiac Iron 8.4616604332
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.4617460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.5915238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3517659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4815570426
MESH:D001249 Asthma Ozone 2.5416373670 17854713
MESH:D001260 Ataxia Telangiectasia Iron 5.1415336622
MESH:D050197 Atherosclerosis Iron 3.5316632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.3318445737
MESH:D001321 Autistic Disorder Iron 2.3317352947
MESH:D001321 Autistic Disorder Norepinephrine 2.338570775
MESH:D001424 Bacterial Infections Iron 4.8816640825
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001913 Bowen's Disease Sulindac 5.0411207687
MESH:D001919 Bradycardia Phenylephrine 4.2315306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 9.9515665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.9516580743
MESH:D001943 Breast Neoplasms Dietary Fats 4.4620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4617474063
MESH:D001943 Breast Neoplasms Estradiol 4.4612948864 18497071 16675129 14630087 17289903 17018787 17261762 19861407
MESH:D001943 Breast Neoplasms Progesterone 4.4616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 4.4617261762 15572757 17049068 17242785 15775269 15758505 17440819 17595753 17952589 17893378 16837676 16912660
MESH:D001943 Breast Neoplasms Sulindac 4.4616642371
MESH:D001943 Breast Neoplasms Tamoxifen 4.4618425577 19155303 17242785 18855134 19200415 18351453 20859285 20135344 16818667 19221464 19288272 15565566 20390343 18815881 18984771 17893378 16873071 19011961 20005174 19487384 17261762 19410462 21152245 17440819 18821012 19084267 20065188 17049068 16202921 20544844 21138602 19189210 19103187 15668708 18629630 19115204 16273361 11161223 19066611 19189212 18997820 19142967 19059307 19244106 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4418315731 16777450 18417511 17626835 15516495 19059883 14754758
MESH:D002100 Cachexia Ozone 4.4316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.273084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.2718056438 19701751 17162532 20727157 20514400 19171122 19107877 19394651 19822196 19919837 20007298 18785209 18691550 19208518 19383236 20084675 16540662 16502159 18665156 18393292 20935162 20214788 20432363 20524982 16830150 18788625 20512989 17761372 18971187 16569478 10737359 3084413 18494052 18506893 3581430 16328049 19335982 19052882 20101231 18210153 17055752 19539802 21159647 17978847 16698587 17138121 10672840 19519916 18978308 11831363 16779866 17173139 16681979 16288022 19418558 16878318 17428255 16935385 16807293
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.2716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.2717173139 20935162 1701930 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.2716924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6117572228
MESH:D006332 Cardiomegaly Norepinephrine 15.0211179087
MESH:D006332 Cardiomegaly Phenylephrine 15.0211754973 15728586 16170337 11179087 17287366 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 15.0218670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 15.0219597038
MESH:D009202 Cardiomyopathies Iron 7.8216640825
MESH:D009202 Cardiomyopathies valsartan 7.8216247790
MESH:D002311 Cardiomyopathy, Dilated Iron 3.3516604332
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1615775269
MESH:D002318 Cardiovascular Diseases valsartan 7.1611230374
MESH:D002375 Catalepsy Norepinephrine 5.238216760
MESH:D002386 Cataract Acetaminophen 2.4010977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.8712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.872727394 21159647 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.8718566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 18.8719716837
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 18.8719559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.954080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4616835633
MESH:D002779 Cholestasis Cyclosporine 7.0019486331
MESH:D002779 Cholestasis pirinixic acid 7.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 15668235 15340226 12621046 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.3115800139
MESH:D003110 Colonic Neoplasms Dexamethasone 5.7015824018
MESH:D003110 Colonic Neoplasms Iron 5.7016640825
MESH:D003110 Colonic Neoplasms Sulindac 5.7012902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6810666051 11197048 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8014669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.7817719468
MESH:D003384 Coxsackievirus Infections valsartan 5.5320392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5117728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9017474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.3712438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.3716780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.4916882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.4918249437
MESH:D003920 Diabetes Mellitus Iron 4.1916640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.3511508273
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2616506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 6.7016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 19.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 19.3415920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 19.3419279558
MESH:D003928 Diabetic Nephropathies valsartan 19.3411427623 18630688
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.8812861449 17621415
MESH:D003967 Diarrhea Dexamethasone 3.417237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5616177239 19923254 16227642 19164858 11834606 11421492 18713872 12540782 17906064 19420014 12958197 12392966 18071297 11529661 11739529 19370779 16081117 12153990 16781746 14550746 15968718 2444490 19085960 16393943 14725611 16485898 12705907 15619225 19416960 10774834 19739265 17522070 11287661 10663392 16109766 17562736 11743745 12594235 11461765 14986274 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.5619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2318367378
MESH:D004421 Dystonia Phenobarbital 3.721851702
MESH:D004485 Eczema Dexamethasone 4.1612438553
MESH:D004487 Edema Dexamethasone 14.1919703484
MESH:D004487 Edema pirinixic acid 14.1912083418
MESH:D004487 Edema Raloxifene 14.1915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.7217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.7215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.7219031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.7219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7219155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Progesterone 13.7916134523
MESH:D004715 Endometriosis Sulindac 13.7915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.7910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.803659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.563922381 11558140
MESH:D004827 Epilepsy Norepinephrine 6.63821787
MESH:D004827 Epilepsy Phenobarbital 6.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.286401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.713659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms Sulindac 3.0612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005234 Fatty Liver Cyclosporine 32.7119224547
MESH:D005234 Fatty Liver Dietary Fats 32.7119551842 18296743 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 32.7121071580 20387270
MESH:D005234 Fatty Liver Iron 32.7116640825
MESH:D005234 Fatty Liver pirinixic acid 32.7120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 32.7117473493
MESH:D005234 Fatty Liver Tamoxifen 32.7114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.9114745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.9114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.6019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6019069698
MESH:D005355 Fibrosis Cyclosporine 18.6912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 18.6918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.6920067830
MESH:D005355 Fibrosis valsartan 18.6916893502
MESH:D005621 Friedreich Ataxia Iron 5.1216640825 16604332
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7111910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.2516928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1711294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3211110106
MESH:D006333 Heart Failure pirinixic acid 6.7520558911
MESH:D006333 Heart Failure valsartan 6.7519027736
MESH:D006432 Hemochromatosis Iron 4.2717236123 17255318 16604332 16640825 16574947 17053826
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006486 Hemosiderosis Iron 4.9016604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.1516640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.6317182432
MESH:D006529 Hepatomegaly Iron 18.2016890145
MESH:D006529 Hepatomegaly Phenobarbital 18.2016109766
MESH:D006529 Hepatomegaly pirinixic acid 18.2019176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.2015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.967520565
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D015658 HIV Infections Iron 3.5116597321
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.738697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3221332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3321332399
MESH:D006973 Hypertension Cyclosporine 19.0110903974
MESH:D006973 Hypertension Dexamethasone 19.0117042910
MESH:D006973 Hypertension Phenylephrine 19.0112717712 8949925
MESH:D006973 Hypertension Raloxifene 19.0117577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 19.0118850075 18670907
MESH:D006973 Hypertension valsartan 19.0120102058 18390891 10903974 11427623 12692753 16475468 18344623 12850387
MESH:D006974 Hypertension, Malignant valsartan 6.0911560862
MESH:D006984 Hypertrophy Phenylephrine 4.2812791704 18502941
MESH:D007006 Hypogonadism Iron 4.1916640825
MESH:D007022 Hypotension Norepinephrine 4.716740701
MESH:D007037 Hypothyroidism Iron 4.7816640825
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1015869954
MESH:D007249 Inflammation Dexamethasone 21.738960868 11099482
MESH:D007249 Inflammation Dietary Fats 21.7320412841
MESH:D007249 Inflammation Diethylnitrosamine 21.7318785209
MESH:D007249 Inflammation Progesterone 21.7315869954
MESH:D007249 Inflammation Sulindac 21.733291741
MESH:D007249 Inflammation Tamoxifen 21.7319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.7312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.1211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.1216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.1216306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.3712584176 12663524 10223192 12628509 10213222 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.7011245490 12394442
MESH:D019189 Iron Metabolism Disorders Iron 4.7517163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Acetaminophen 12.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.9918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 12.9915618244
MESH:D007674 Kidney Diseases valsartan 12.9910903974 12164870 16893502
MESH:D007680 Kidney Neoplasms Cyclosporine 10.9312371664
MESH:D007680 Kidney Neoplasms Estradiol 10.9315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.9318625569
MESH:D007859 Learning Disorders sevoflurane 4.4719212262
MESH:D007889 Leiomyoma Raloxifene 4.2116973256
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.0016972261
MESH:D020961 Lewy Body Disease Iron 5.1216563566
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 14.3818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.3818665156 18522880 18407596 20032147 19638242
MESH:D008103 Liver Cirrhosis Iron 14.3816640825
MESH:D008103 Liver Cirrhosis Phenobarbital 14.3821047994
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0312468960
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.1816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.1818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1812878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 8.1815619341 16872305 15504291
MESH:D008107 Liver Diseases Acetaminophen 8.6916610002 12587719 19784758 11587558 19014921 16611625 12969438 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6917034775
MESH:D008107 Liver Diseases Phenobarbital 8.6919363144
MESH:D008107 Liver Diseases Sulindac 8.6914986274 16867024
MESH:D008108 Liver Diseases, Alcoholic Iron 4.7017207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9716871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 23.8119389873 21295105
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 23.8111940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.8120492335 2422723 10737359 19256749 19254457 19255062 19690152 19996281 19499222 20118626 20137499 18978307 21278145 16942905 15175105 20583210 18644402 15885732 18977376 19850985 18648771 20434301 20101389 19090486 19638242 20501860 20452335 2862719 12771043 21047994 20405173 19551842 19812893 19427195 18754104 19073162 19294768 21167192 19426721 21071580 12112319 19833225 19642983 9163691
MESH:D008113 Liver Neoplasms Iron 23.8116640825 20302851
MESH:D008113 Liver Neoplasms Phenobarbital 23.8119812893 21047994 19482888 19073162 15975961 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 23.8120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 23.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.8116984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.6018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.6019004024 19539802 19519916 16267830 19126423 18079962 2563599 18775883 18282651 18164116 18093689 18544905 3124819 19009564 9362446 18253720 16842330 17942915 17854601 21159647 18308698 17174075
MESH:D008114 Liver Neoplasms, Experimental kojic acid 16.6018544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.6017172636 6150874 1399818 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.6012151625
MESH:D008171 Lung Diseases Ozone 3.178266340 19066396
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.2417365036
MESH:D055370 Lung Injury Ozone 8.2420417186
MESH:D008175 Lung Neoplasms Dexamethasone 10.0511195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0520970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Iron 10.0516640825
MESH:D008175 Lung Neoplasms Ozone 10.057614698 8597069
MESH:D008175 Lung Neoplasms Sulindac 10.0515713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 10.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0511884234 19555203
MESH:D008268 Macular Degeneration Iron 3.8116640825
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8216891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.8217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.8219196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.5919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5919453300
MESH:D008545 Melanoma Sulindac 3.4216642371
MESH:D008545 Melanoma Tamoxifen 3.4219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008569 Memory Disorders sevoflurane 4.4619212262
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0616166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D008679 Metaplasia Ozone 4.7910496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2415863610
MESH:D009101 Multiple Myeloma Dexamethasone 6.8315867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 6.8316497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.3617086897
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009181 Mycoses Iron 5.1516640825
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.369809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Iron 8.3616604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 18.4416810080
MESH:D015428 Myocardial Reperfusion Injury Iron 18.4416604332
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 18.4415642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 18.4416411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1617484760
MESH:D009232 Myxoma Raloxifene 5.2416343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.303581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms pirinixic acid 1.8017405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.6219348381 18481113
MESH:D009404 Nephrotic Syndrome Iron 8.6217178036
MESH:D009421 Nervous System Malformations Estradiol 8.4816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 18.0818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 18.0820387270
MESH:D019636 Neurodegenerative Diseases Iron 18.0816604332 17296847
MESH:D019636 Neurodegenerative Diseases Sulindac 18.0817266991 16850258
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009765 Obesity Dietary Fats 4.1618457598 21332399 16723640 17217161 11836018 20132043 20518802 18674790 19632207
MESH:D009765 Obesity pirinixic acid 4.1620558911
MESH:D010003 Osteoarthritis Iron 3.7816640825
MESH:D010018 Osteomalacia Phenobarbital 4.0517016548
MESH:D010024 Osteoporosis Iron 6.9216640825 16648989
MESH:D010024 Osteoporosis Raloxifene 6.9217882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9417893378 15758505 17823083 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 7.4319401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.4316525653 17393432
MESH:D010051 Ovarian Neoplasms U 0126 7.4316211241
MESH:D010146 Pain Acetaminophen 6.0916870215
MESH:D010146 Pain Sulindac 6.093291741
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.0516965848
MESH:D010190 Pancreatic Neoplasms Sulindac 8.0516820089 11504793
MESH:D010212 Papilloma Iron 4.1812065085
MESH:D020447 Parasomnias Iron 5.7017352947
MESH:D010300 Parkinson Disease Iron 3.2116640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010538 Peritonitis Ozone 3.8316369182
MESH:D010900 Pituitary Diseases Iron 5.3616604332
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5910923243
MESH:D011014 Pneumonia Ozone 4.0818381685 18007984 18929643
MESH:D011041 Poisoning Iron 4.0116604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.0416640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.0418163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.7712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.772563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.772563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3721297632
MESH:D011225 Pre-Eclampsia Iron 4.1916640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8811222880 11399792 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1716740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1716205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1716220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1715067354
MESH:D011507 Proteinuria valsartan 4.5717664856 18344623 12164870
MESH:D011528 Protozoan Infections Iron 5.7016640825
MESH:D019310 Pseudolymphoma Phenobarbital 4.1812752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.8315814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis valsartan 5.8317241526
MESH:D011693 Purpura Raloxifene 5.2415770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7318379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012148 Restless Legs Syndrome Iron 4.3216930377
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012640 Seizures Phenobarbital 2.493137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.516407741
MESH:D012852 Sinusitis Phenylephrine 4.397327846
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3017431481
MESH:D012878 Skin Neoplasms Iron 5.3812065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3816192470
MESH:D013088 Spermatocele Tamoxifen 3.9816709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.8316503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.8319457130
MESH:D013272 Stomach Diseases Dexamethasone 4.0115472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.2215138204
MESH:D020521 Stroke Raloxifene 3.5816837676
MESH:D013398 Sudden Infant Death Iron 5.1416640825
MESH:D013610 Tachycardia Norepinephrine 5.143261545
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.417505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.411399818
MESH:D013978 Tibial Fractures Estradiol 12.6619048282
MESH:D013978 Tibial Fractures Raloxifene 12.6619048282
MESH:D014376 Tuberculosis Iron 3.8916597321
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 7.7820375083
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.7817572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7816712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D014594 Uterine Neoplasms Sulindac 4.3118645019
MESH:D014605 Uveitis Cyclosporine 10.711336536
MESH:D014605 Uveitis Dexamethasone 10.711336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8916837676
MESH:D020257 Ventricular Remodeling valsartan 5.3919027736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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