AutismKB 2.0

Annotation Detail for NFIX


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Basic Information Top
Gene Symbol:NFIX ( NF1A )
Gene Full Name: nuclear factor I/X (CCAAT-binding transcription factor)
Band: 19p13.13
Quick LinksEntrez ID:4784; OMIM: 164005; Uniprot ID:NFIX_HUMAN; ENSEMBL ID: ENSG00000008441; HGNC ID: 7788
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
500585RNA Polymerase III Transcription Termination
500578RNA Polymerase III Transcription
500579RNA Polymerase III Abortive And Retractive Initiation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of NFIX mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NFIX mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NFIX mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of NFIX mRNAdecreases expression 12419474
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of NFIX mRNA]decreases reaction|increases expression 19228888
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NFIX mRNAdecreases expression 12419474
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNAaffects cotreatment|increases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNAaffects cotreatment|increases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNAaffects cotreatment|increases expression 12634122
C014347 decitabine decitabine results in decreased expression of NFIX mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of NFIX mRNA]affects reaction|decreases expression 19363521
D004958 Estradiol Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NFIX mRNA]decreases reaction|increases expression 16977382
D000431 Ethanol Ethanol results in decreased expression of NFIX mRNAdecreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NFIX mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in decreased expression of NFIX mRNAdecreases expression 15954086
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of NFIX mRNAdecreases expression 12419474
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNAaffects cotreatment|increases expression 12634122
D001556 Lindane Lindane results in increased expression of NFIX mRNAincreases expression 17785943
D008070 Lipopolysaccharides Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NFIX mRNA]decreases reaction|increases expression 16977382
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of NFIX mRNAincreases expression 16977382
D008345 Manganese Manganese results in decreased expression of NFIX mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of NFIX mRNAdecreases expression 17175027
C006253 pirinixic acid pirinixic acid results in decreased expression of NFIX mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NFIX mRNA]decreases expression|increases reaction 20059764
C035988 procymidone procymidone results in increased expression of NFIX mRNAincreases expression 15686871
D011374 Progesterone Progesterone affects the expression of NFIX mRNAaffects expression 17251523
C059514 resveratrol resveratrol results in increased expression of NFIX mRNAincreases expression 12002526
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNAaffects cotreatment|increases expression 12634122
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of NFIX mRNA]decreases reaction|increases expression 19228888
D014284 Triiodothyronine Triiodothyronine results in increased expression of NFIX mRNAincreases expression 19228888
D013629 Tamoxifen Tamoxifen results in decreased expression of NFIX mRNAdecreases expression 15849065
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in decreased expression of NFIX mRNAdecreases expression 20056577
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NFIX mRNAdecreases expression 16054898
C025643 vinclozolin vinclozolin affects the expression of NFIX mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in increased methylation of NFIX intronincreases methylation 16973722
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.5418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5415322242 11752688 14514962
MESH:D000138 Acidosis Ethanol 4.2211192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6016538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.1918653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.1918653653
MESH:D000230 Adenocarcinoma Estradiol 3.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.403712494
MESH:D000236 Adenoma Ethylnitrosourea 10.406695378
MESH:D000236 Adenoma resveratrol 10.4015688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6217306315 16712894
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1012661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0315451040 15451039
MESH:D000544 Alzheimer Disease resveratrol 2.5116183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9310965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000756 Anemia, Sideroblastic Manganese 10.2016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.2016910769
MESH:D000853 Anophthalmos Ethanol 4.5515513904
MESH:D001008 Anxiety Disorders Ethanol 8.2911141031
MESH:D001008 Anxiety Disorders vinclozolin 8.2919015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7915885639
MESH:D001169 Arthritis, Experimental resveratrol 6.7917115116
MESH:D050197 Atherosclerosis resveratrol 3.1116873680 17967414
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 3.4019211157
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.731440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6414991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 4.0017600658
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0516651633 16357521 16436596 18412241 15144691
MESH:D001943 Breast Neoplasms bisphenol A 4.4917123778
MESH:D001943 Breast Neoplasms decitabine 4.4919208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 4.4914630087 17289903 16675129 17018787 17261762 18497071 19861407 12948864
MESH:D001943 Breast Neoplasms Lindane 4.4914688026
MESH:D001943 Breast Neoplasms Progesterone 4.4915562024 16175315 17614352
MESH:D001943 Breast Neoplasms resveratrol 4.4917534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 4.4920544844 18984771 18351453 19066611 19289846 16273361 18629630 19244106 19189212 17049068 19221464 19487384 15668708 16818667 19115204 19200415 15565566 16873071 20135344 18821012 18855134 17242785 17893378 19103187 18425577 21138602 18815881 17261762 19155303 19288272 19142967 20005174 11161223 19410462 19189210 20390343 16202921 18997820 20859285 19011961 19084267 21152245 20065188 17440819 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4920435547
MESH:D002056 Burns Ethanol 4.3816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.3416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.347296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3416924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.3415289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.3416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.3415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.1419215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.1416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1418572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3717572228
MESH:D006332 Cardiomegaly Ethanol 6.3319332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3316120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9516936243
MESH:D002318 Cardiovascular Diseases resveratrol 6.9515458977
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.517505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.5118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 14.5116003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.5120056578 19524636
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7017160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.1919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 12.1916105132 16919318 15861022 17110522 11677210 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 12.1919176532
MESH:D002971 Cleft Lip Ethanol 3.4415513904
MESH:D002972 Cleft Palate Ethanol 5.5615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5615340226 8697196 12621046 16354765 15668235
MESH:D003092 Colitis resveratrol 3.8616474422
MESH:D003110 Colonic Neoplasms decitabine 3.7717616700
MESH:D003110 Colonic Neoplasms resveratrol 3.7716338953
MESH:D015179 Colorectal Neoplasms decitabine 2.6518981723
MESH:D015179 Colorectal Neoplasms resveratrol 2.6516550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8111198716 15513904 19302082 10194807 15451039 15451040 11873399
MESH:D019465 Craniofacial Abnormalities lead acetate 3.8119769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8110048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.0714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5412868966 2524372 8156756 11906362 18759878 14531868 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.232952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.6819279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.6816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.2611289319 6679447 9022650 16192314 9328219 18692083 8291058 7440962 18289764 6482804 18648102 1440618 9653073
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.2611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7018357618
MESH:D004487 Edema pirinixic acid 10.0012083418
MESH:D004487 Edema resveratrol 10.008985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.7412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.7417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 19.7417872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.7419031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8319294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.7911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7916202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.139294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1215821434 15328337 17637181
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.383581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.3816704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Ethanol 16.7219236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.7215345470
MESH:D005234 Fatty Liver pirinixic acid 16.7220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 16.7214986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3817920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0216946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.1219769572
MESH:D005334 Fever Lipopolysaccharides 3.7711852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.736705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6820067830
MESH:D005756 Gastritis Ethanol 4.4115046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005909 Glioblastoma Ethylnitrosourea 7.1516436596
MESH:D005909 Glioblastoma Manganese 7.1517043766
MESH:D005910 Glioma Ethylnitrosourea 3.3818412241 16651633 16357521
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.787505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1416366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.256705139
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 12.9716109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9719772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006561 Herpes Simplex resveratrol 3.9016876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Ethanol 3.5018783367
MESH:D006937 Hypercholesterolemia resveratrol 3.7617188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006949 Hyperlipidemias resveratrol 3.7716873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6715034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.5715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.5717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male decitabine 14.5317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.5317937319
MESH:D007248 Infertility, Male sodium arsenite 14.5315346721 12646999
MESH:D007248 Infertility, Male vinclozolin 14.5316467254
MESH:D007249 Inflammation Lipopolysaccharides 14.3117963957 12878042 17255318 9205823 17237260
MESH:D007249 Inflammation Progesterone 14.3115869954
MESH:D007249 Inflammation resveratrol 14.3116366677
MESH:D007249 Inflammation Tamoxifen 14.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.3112200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007333 Insulin Resistance bisphenol A 11.2716393666
MESH:D007333 Insulin Resistance Estradiol 11.2716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.2716306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3717255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.739022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.2915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2916580747
MESH:D007674 Kidney Diseases Cadmium Chloride 9.2816962696
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007674 Kidney Diseases sodium arsenite 9.2820008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.9616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 20.966582329
MESH:D007680 Kidney Neoplasms Estradiol 20.9615610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 20.9617379185
MESH:D007680 Kidney Neoplasms Tamoxifen 20.9618625569
MESH:D007859 Learning Disorders Ethanol 3.9415451040
MESH:D007938 Leukemia decitabine 2.9319235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.7518454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3317679729 19387464 18704418 18206229 18460780 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4016087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.4215821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6217676605
MESH:D008064 Lipidoses Tamoxifen 2.9615342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.2215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8218295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.2518166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.2512878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2512878042
MESH:D008107 Liver Diseases Lindane 3.031715830
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3817207112 17347304
MESH:D008113 Liver Neoplasms pirinixic acid 13.0715890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 13.0719073162 20405173 19812893 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.0716712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 13.0716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.0716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.16598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1612151625
MESH:D008171 Lung Diseases sodium arsenite 2.9919095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.7421114838
MESH:D008175 Lung Neoplasms Ethylnitrosourea 4.5817703301 16019985 16271038 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 4.5817077188 17306315 19931552 16712894 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 4.5818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5819555203 11884234
MESH:D008223 Lymphoma decitabine 7.2519470736
MESH:D008223 Lymphoma Ethylnitrosourea 7.2515790496
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7715375218
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.0715688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.0719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.9416891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 16.9410838139 10767621 18041768
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.9417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 16.9411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.9419196722 14580682 19196723 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 20.7419453300
MESH:D020149 Manganese Poisoning Manganese 20.7419453300 16568477 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 20.7419453300
MESH:D008545 Melanoma decitabine 6.8817785578 16505122
MESH:D008545 Melanoma resveratrol 6.8817992120
MESH:D008545 Melanoma sodium arsenite 6.8819082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008569 Memory Disorders Ethanol 3.9218411066 15451040
MESH:D008579 Meningioma Ethylnitrosourea 5.7017943659
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D009069 Movement Disorders Manganese 4.7516551646
MESH:D009101 Multiple Myeloma decitabine 6.8618172295
MESH:D009101 Multiple Myeloma resveratrol 6.8617049120 16490592 14749477 16267019 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2218608210 19157545 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 5.3519151258
MESH:D009203 Myocardial Infarction resveratrol 5.3517188708 16525036 17125593 16317513 16456233 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.2817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5516411023
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5818551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.313581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms decitabine 10.7619470736 19116145 17925555
MESH:D009369 Neoplasms Lindane 10.7616818664 12807735
MESH:D009369 Neoplasms pirinixic acid 10.7617405874
MESH:D009369 Neoplasms sodium arsenite 10.7611559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 13.8116707424
MESH:D009374 Neoplasms, Experimental resveratrol 13.818985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.8120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009410 Nerve Degeneration Manganese 4.0616551646
MESH:D009421 Nervous System Malformations bisphenol A 14.8111399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 14.8111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.666679447
MESH:D009436 Neural Tube Defects sodium arsenite 6.6612854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1416003739 16651423 17160924
MESH:D019636 Neurodegenerative Diseases resveratrol 3.5817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1417929310
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.086482804 4026338
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7017160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.733988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0017513867
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms decitabine 10.5519331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 10.5519401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.5517393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.5517306315 15276417
MESH:D010190 Pancreatic Neoplasms decitabine 5.2219294695
MESH:D010190 Pancreatic Neoplasms Ethanol 5.2212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.417296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.4112065085
MESH:D010300 Parkinson Disease Manganese 3.2711181820
MESH:D020734 Parkinsonian Disorders Manganese 4.2316140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.056228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.0511550810
MESH:D011014 Pneumonia Lipopolysaccharides 4.2711605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 20.9510548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 20.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.9511896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.9519015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.4517616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Lindane 1.8814688026 12661182
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817675339 15767336 17804756 17718901 17636462 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0315861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1119058328
MESH:D015427 Reperfusion Injury resveratrol 6.1116317513 17520802 17058453 16314181 15827377
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5510835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.173692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.1419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 8.9318551238
MESH:D012640 Seizures Ethanol 8.939754883
MESH:D012640 Seizures Lindane 8.937539098 12842176 15475178
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.5212065085
MESH:D012878 Skin Neoplasms resveratrol 16.5215837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 16.5218572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.528532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.5216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms decitabine 2.6619037991
MESH:D013274 Stomach Neoplasms Ethanol 2.6618456281
MESH:D013276 Stomach Ulcer Ethanol 3.299211565 17189318 17918041 16755016 9562338 11906479
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.019754883
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9215821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.8815790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.556582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms decitabine 6.5517967635
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms resveratrol 3.9716227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.6116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.618074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.6119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.6116452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.618653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0410091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.7617473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7611813266
MESH:D014591 Uterine Diseases bisphenol A 4.7214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6114692618
MESH:D014594 Uterine Neoplasms resveratrol 8.6117044934
MESH:D014604 Uveal Neoplasms decitabine 4.6317785578
MESH:D014652 Vascular Diseases sodium arsenite 4.1417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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