AutismKB 2.0

Annotation Detail for NFX1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NFX1 ( DKFZp779G2416,MGC20369,NFX2 )
Gene Full Name: nuclear transcription factor, X-box binding 1
Band: 9p12
Quick LinksEntrez ID:4799; OMIM: 603255; Uniprot ID:NFX1_HUMAN; ENSEMBL ID: ENSG00000086102; HGNC ID: 7803
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NFX1 mRNAincreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of NFX1 mRNAdecreases expression 12419474
D000638 Amiodarone Amiodarone affects the expression of NFX1 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of NFX1 mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NFX1 mRNAdecreases expression 19150397
D002994 Clofibrate Clofibrate affects the expression of NFX1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of NFX1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NFX1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFX1 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of NFX1 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of NFX1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of NFX1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of NFX1 mRNAaffects expression 19483382
C017947 sodium arsenite sodium arsenite results in increased expression of NFX1 mRNAincreases expression 12760830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFX1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NFX1 mRNAincreases expression 15328365
D013853 Thioacetamide Thioacetamide affects the expression of NFX1 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.773712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9617306315 16712894
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1210965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8318218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9219698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 59.4219483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 59.4219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 59.4219483382
MESH:D001778 Blood Coagulation Disorders Ethionine 59.4219483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 59.4219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 59.4219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 59.4219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 59.4212125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 59.4219483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.697296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.691701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.6917997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1318974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.327505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.3220889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 21.321399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.3212371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.3219524636 20056578
MESH:D002637 Chest Pain Omeprazole 5.1715447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.6318291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.399022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.3919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.3917681005 16105132 17333356 11677210 16919318 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 19.3919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 8697196 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8412868966 18759878 11906362 2524372 8156756 11298694 14531868 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.0818289764 18692083 16192314 6679447 9022650 8291058 9328219 6482804 18648102 11289319 1440618 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.0818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.0812963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3617151854 16613094 21218061 15991576
MESH:D050171 Dyslipidemias Clofibrate 4.0916707586
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.413581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.7816456712
MESH:D005234 Fatty Liver Amiodarone 25.0014986274
MESH:D005234 Fatty Liver Clofibrate 25.0019224547
MESH:D005234 Fatty Liver Cyclosporine 25.0019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.0015345470
MESH:D005234 Fatty Liver pirinixic acid 25.0019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6018665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.576705139
MESH:D006505 Hepatitis Thioacetamide 9.5716456712
MESH:D006529 Hepatomegaly Amiodarone 14.6715265979
MESH:D006529 Hepatomegaly pirinixic acid 14.6718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.6715340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116354765 8697196 18606429 16959395 15340226
MESH:D006937 Hypercholesterolemia Amiodarone 3.909751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.7517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.758137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7017937319
MESH:D007248 Infertility, Male sodium arsenite 6.7012646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 6.0718776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 6.0720008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.356582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1219248655
MESH:D008064 Lipidoses Amiodarone 3.5315342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4911172339 15474484 17629604 11682029 12557150 15078482 18606216 15288472 17127702 16343077 18615449 16126171 18416461 15716488 16098781 15158331 10677585 18031379 11481614 18380797 15288473 17355460 12891558 16248980 12679928 15465738 15075984 17292413 12085344 15095483 15334695 18458672 15316131 18295389 12531686 16489207 12175628 16097051 14739098 17050028 16511523 18395095 15362042 18263696 18032466
MESH:D008107 Liver Diseases Thioacetamide 2.7118374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.3415633222 17276928 15313186 12479984
MESH:D008113 Liver Neoplasms pirinixic acid 7.4115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.4116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.78598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6011989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 7.5812587719
MESH:D008171 Lung Diseases sodium arsenite 7.5819095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5418516814
MESH:D008175 Lung Neoplasms sodium arsenite 2.3116712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3111884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009181 Mycoses Amiodarone 4.9617974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009369 Neoplasms pirinixic acid 4.9817405874
MESH:D009369 Neoplasms sodium arsenite 4.9811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.326679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.3212854658
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.989802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.454026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4417306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 13.216228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 13.2111550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3016039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8612832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1318724381
MESH:D012878 Skin Neoplasms sodium arsenite 5.6318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013272 Stomach Diseases Omeprazole 4.6618545984
MESH:D013276 Stomach Ulcer Amiodarone 7.6718087811
MESH:D013276 Stomach Ulcer Omeprazole 7.6716755016 15991576 10750652 18237397 11906479 17977527
MESH:D013610 Tachycardia Amiodarone 4.3211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Amiodarone 12.2619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.2612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.456582329 7505956 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.4515710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.2411989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.128074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1216712894 17306315 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved