Annotation Detail for ATP1A4
Basic Information Top
| Gene Symbol: | ATP1A4 ( ATP1A1,ATP1AL2,MGC25056 ) |
|---|---|
| Gene Full Name: | ATPase, Na+/K+ transporting, alpha 4 polypeptide |
| Band: | 1q23.2 |
| Quick Links | Entrez ID:480; OMIM: 607321; Uniprot ID:AT1A4_HUMAN; ENSEMBL ID: ENSG00000132681; HGNC ID: 14073 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04973 | Carbohydrate digestion and absorption |
| hsa04970 | Salivary secretion |
| hsa04972 | Pancreatic secretion |
| hsa04974 | Protein digestion and absorption |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
| hsa04964 | Proximal tubule bicarbonate reclamation |
| hsa04971 | Gastric acid secretion |
| hsa04260 | Cardiac muscle contraction |
| No data |
| No data |
| No data |
| No data |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of ATP1A4 mRNA | affects expression | 16483693 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in decreased expression of ATP1A4 mRNA | decreases expression | 20360939 |
| C025589 | ochratoxin A | ochratoxin A results in decreased expression of ATP1A4 mRNA | decreases expression | 16251485 |
| D018038 | Sodium Selenite | Sodium Selenite results in increased expression of ATP1A4 mRNA | increases expression | 18175754 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.19 | 18287403 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.05 | 10737359 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.53 | 17620307 19052882 18056438 19061943 16434500 17162532 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.65 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | ochratoxin A | 2.65 | 11921183 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.88 | 16698587 19418558 20084675 19383236 3581430 20214788 19335982 19107877 19394651 18210153 18978308 16935385 18785209 19919837 17428255 18494052 16807293 17162532 20935162 18691550 16540662 18971187 16830150 17055752 11831363 20512989 20524982 18665156 19519916 20101231 17138121 20727157 3084413 18393292 17173139 20514400 20007298 10672840 19701751 16502159 16779866 10737359 18506893 16328049 17978847 16878318 16288022 19208518 19822196 16681979 19539802 20432363 19171122 17761372 21159647 18788625 19052882 16569478 18056438 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.12 | 21159647 7505956 2727394 17174075 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.05 | 19052882 | |
| MESH:D019457 | Chromosome Breakage | Sodium Selenite | 5.31 | 15894690 | |
| MESH:D019465 | Craniofacial Abnormalities | ochratoxin A | 3.22 | 20036863 | |
| MESH:D003920 | Diabetes Mellitus | Sodium Selenite | 4.15 | 16285004 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.26 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 4.31 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | Sodium Selenite | 4.31 | 15131321 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 5.84 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.61 | 20387270 21071580 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 2.55 | 18785209 | |
| MESH:D007333 | Insulin Resistance | Sodium Selenite | 3.52 | 14714311 | |
| MESH:D007674 | Kidney Diseases | ochratoxin A | 4.30 | 11409539 | |
| MESH:D007680 | Kidney Neoplasms | ochratoxin A | 4.84 | 16251485 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 3.01 | 18665156 19638242 20032147 18407596 18522880 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.17 | 17034775 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 2.35 | 19690152 2862719 19499222 21047994 21278145 19642983 19073162 21071580 19426721 21167192 19833225 9163691 19427195 2422723 12112319 19256749 18644402 19996281 16942905 19255062 19638242 20583210 20137499 20405173 18754104 20492335 12771043 10737359 18648771 18977376 20434301 19551842 20101389 19090486 19294768 20501860 19254457 15885732 15175105 18978307 19850985 20118626 20452335 19812893 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.85 | 16842330 19539802 9362446 18079962 17942915 2563599 18308698 18544905 3124819 17854601 19519916 19004024 18282651 17174075 18164116 19009564 18253720 16267830 18775883 21159647 18093689 19126423 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.77 | 20512841 20970405 21163286 6695378 | |
| MESH:D016393 | Lymphoma, B-Cell | Sodium Selenite | 4.52 | 14737004 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | ochratoxin A | 4.31 | 11921183 | |
| MESH:D008850 | Microphthalmos | ochratoxin A | 6.30 | 20036863 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.69 | 3581430 9029167 | |
| MESH:D009436 | Neural Tube Defects | ochratoxin A | 4.68 | 20036863 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.69 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 5.84 | 20387270 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.53 | 16540662 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 3.92 | 2563599 | |
| MESH:D011471 | Prostatic Neoplasms | Sodium Selenite | 3.33 | 18760546 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.29 | 7505956 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04960 | Aldosterone-regulated sodium reabsorption |
| KEGG:04976 | Bile secretion |
| KEGG:04973 | Carbohydrate digestion and absorption |
| KEGG:04260 | Cardiac muscle contraction |
| KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04971 | Gastric acid secretion |
| KEGG:04978 | Mineral absorption |
| KEGG:04972 | Pancreatic secretion |
| KEGG:04974 | Protein digestion and absorption |
| KEGG:04964 | Proximal tubule bicarbonate reclamation |
| KEGG:04970 | Salivary secretion |
| REACT:15518 | Transmembrane transport of small molecules |