AutismKB 2.0

Annotation Detail for NFYA


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Basic Information Top
Gene Symbol:NFYA ( CBF-A,CBF-B,FLJ11236,HAP2,NF-YA )
Gene Full Name: nuclear transcription factor Y, alpha
Band: 6p21.1
Quick LinksEntrez ID:4800; OMIM: 189903; Uniprot ID:NFYA_HUMAN; ENSEMBL ID: ENSG00000001167; HGNC ID: 7804
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04612Antigen processing and presentation
No data
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200101Direct p53 effectors
No data
Pathway IDPathway Name
500131Activation of Chaperones by IRE1alpha
500130Activation of Chaperones by ATF6-alpha
500129Unfolded Protein Response
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NFYA mRNAincreases expression 18648102
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNAaffects cotreatment|decreases expression 16443354
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NFYA mRNAincreases expression 20064835
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]decreases reaction|increases expression 20360939
D003474 Curcumin Curcumin results in decreased expression of NFYA mRNAdecreases expression 15713895
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]decreases reaction|increases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NFYA mRNAincreases expression 20360939
D005038 Ethylnitrosourea Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]affects binding|increases reaction 16271038
D005038 Ethylnitrosourea Ethylnitrosourea results in increased activity of NFYA proteinincreases activity 16271038
D008748 Methylcholanthrene Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]affects binding|increases reaction 16271038
D008748 Methylcholanthrene Methylcholanthrene results in increased activity of NFYA proteinincreases activity 16271038
D016685 Mitomycin Mitomycin results in increased expression of NFYA mRNAincreases expression 12760830
D016685 Mitomycin NFYA protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C022838 nickel chloride nickel chloride results in increased expression of NFYA mRNAincreases expression 17547211
D019800 Phenol Phenol results in increased expression of NFYA mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NFYA mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin Quercetin inhibits the reaction [NFYA protein binds to CCNB1 promoter]affects binding|decreases reaction 19009557
C099150 trabectedin trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein]affects activity|affects binding 15961672
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNAaffects cotreatment|decreases expression 16443354
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 21.213712494
MESH:D000236 Adenoma Benzo(a)pyrene 21.216695378
MESH:D000236 Adenoma Diethylnitrosamine 21.2110737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 21.216695378
MESH:D000236 Adenoma Methylcholanthrene 21.216695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2617162532 18056438 16434500 19052882 19061943 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.2616434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1417887948
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000544 Alzheimer Disease Curcumin 2.6215590663
MESH:D000743 Anemia, Hemolytic Quercetin 4.2717084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7516807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7516292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0315336622
MESH:D050197 Atherosclerosis Curcumin 7.0418704882
MESH:D050197 Atherosclerosis Methylcholanthrene 7.0411922910
MESH:D001327 Autoimmune Diseases Curcumin 11.0119761891
MESH:D001327 Autoimmune Diseases Quercetin 11.0119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.0716197459 16206674
MESH:D001859 Bone Neoplasms Phenol 5.2410556009
MESH:D001913 Bowen's Disease Phenol 5.8119293009
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D002545 Brain Ischemia Curcumin 4.3816770732
MESH:D001932 Brain Neoplasms Curcumin 9.2317596214
MESH:D001932 Brain Neoplasms Ethylnitrosourea 9.2318412241 15144691 16357521 16651633 16436596
MESH:D001943 Breast Neoplasms Ascorbic Acid 3.8016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.8017474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 3.8018593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.8017474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.8017474063
MESH:D001943 Breast Neoplasms Quercetin 3.8018628248
MESH:D001943 Breast Neoplasms Tretinoin 3.8016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002105 Cadmium Poisoning Quercetin 5.6116962696
MESH:D002277 Carcinoma Curcumin 8.7918593918
MESH:D002277 Carcinoma Methylcholanthrene 8.7910545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.637296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6320512989 19701751 19418558 18785209 19208518 16288022 16698587 16569478 20101231 17978847 17162532 3084413 20524982 17428255 19383236 16807293 19107877 10672840 16502159 19171122 20432363 20514400 18494052 18210153 18691550 18393292 18056438 17173139 16540662 17761372 16779866 11831363 19822196 19919837 16681979 20727157 16830150 20084675 18978308 19539802 18971187 19394651 10737359 18788625 3581430 17138121 20007298 18506893 19335982 19052882 16328049 16878318 18665156 20214788 21159647 17055752 20935162 16935385 19519916
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.6312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.631917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9818414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0017234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.6118462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.6116051514 16096774
MESH:D006332 Cardiomegaly Quercetin 3.3319794523
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.277505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.272727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 16.2716003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.2716192471
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.919022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.9119176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tretinoin 2.689407595
MESH:D003092 Colitis Curcumin 9.7816782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 9.7817035595
MESH:D003103 Coloboma Curcumin 4.5818809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0219359593 16340194
MESH:D003110 Colonic Neoplasms Quercetin 4.0217191121 11134977 19440933 15741050 16640504 19056647 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 5.5417323712
MESH:D016510 Corneal Neovascularization Curcumin 4.9418497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829125849 9224671 8800419 16925845 9142499 9211117 10589399 9664655 14991402 17551590
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8411906362 12868966 11298694 18759878 14531868 2524372 8156756 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7519496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 7.3716506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.3718403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3720387270
MESH:D003928 Diabetic Nephropathies Curcumin 4.0318204486
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.917440962 8291058 6482804 18648102 11289319 18692083 16192314 18289764 9328219 9653073 1440618 6679447 9022650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9119107877
MESH:D004381 Duodenal Ulcer Curcumin 4.0817351913
MESH:C538011 Eales disease Ascorbic Acid 5.549068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1216569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.383581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3816530937
MESH:D005124 Eye Abnormalities Tretinoin 3.609664655 16938888
MESH:D005234 Fatty Liver Curcumin 13.3419297423
MESH:D005234 Fatty Liver Diethylnitrosamine 13.3421071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.3419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9914633661 10962813
MESH:D005355 Fibrosis Curcumin 15.2218705752
MESH:D005355 Fibrosis Quercetin 15.2219474275
MESH:D005355 Fibrosis Tretinoin 15.2217994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7418462866
MESH:D005909 Glioblastoma Curcumin 17.1617596214
MESH:D005909 Glioblastoma Ethylnitrosourea 17.1616436596
MESH:D005909 Glioblastoma Quercetin 17.1619804834
MESH:D005909 Glioblastoma Tretinoin 17.1617312396
MESH:D005910 Glioma Ethylnitrosourea 6.4518412241 16357521 16651633
MESH:D005910 Glioma Quercetin 6.4517643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006258 Head and Neck Neoplasms Curcumin 7.9518462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 11.3716080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3720471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.3714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0416221962 18467677 19772884 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0817701891
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4816863852 16490937
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D006937 Hypercholesterolemia Curcumin 4.0818704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006943 Hyperglycemia pirinixic acid 9.3320558911
MESH:D006943 Hyperglycemia Quercetin 9.3318262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Quercetin 2.8718356687
MESH:D007249 Inflammation Curcumin 5.3218403477 17151092 16956363
MESH:D007249 Inflammation Diethylnitrosamine 5.3218785209
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2218200517 18596194
MESH:D007251 Influenza, Human Quercetin 4.5716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 10.1910783313
MESH:D007414 Intestinal Neoplasms Curcumin 10.1910783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.089022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.9317551590 15992940
MESH:D007627 Keloid Quercetin 5.0017086741
MESH:D055623 Keratosis, Actinic Phenol 6.5119293009
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.6215369732
MESH:D007674 Kidney Diseases Quercetin 6.6216962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.796582329
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 7.7917379185
MESH:D007889 Leiomyoma Curcumin 4.6018555241
MESH:D007938 Leukemia Curcumin 10.6518462866
MESH:D007938 Leukemia Quercetin 10.6517468513
MESH:D007938 Leukemia Tretinoin 10.6517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2316106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.9816766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9816891316 16331271 17712046 17368321 19075265 17107899 16788101 17301526 19035177 17217047 16823087 19029980 17649720 17339181 17294898 16140955 9834237 17506722 17361223 19225113 15748426 16935935 12679006 19642359 16766008
MESH:D015458 Leukemia, T-Cell Curcumin 4.8016106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8418665156 18407596 18522880 19638242 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0212741479
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0216248980 18397230
MESH:D008107 Liver Diseases Curcumin 4.2916956363
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2917034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.3820195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.3819499222 19427195 18644402 19833225 19638242 20501860 19812893 21071580 19690152 18978307 12771043 15175105 19256749 20118626 19426721 19255062 19294768 2862719 21278145 20101389 20137499 15885732 20492335 18648771 9163691 19073162 12112319 19254457 18754104 2422723 18977376 19642983 20405173 19090486 10737359 19850985 20452335 20583210 16942905 19996281 20434301 21167192 19551842 21047994
MESH:D008113 Liver Neoplasms Mitomycin 14.3815113037
MESH:D008113 Liver Neoplasms pirinixic acid 14.3820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 14.3818980244
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.886587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 18.8818544905
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.8818093689 18544905 19126423 19539802 18308698 17942915 18282651 16267830 21159647 19009564 9362446 18775883 17174075 18079962 19004024 18253720 19519916 18164116 17854601 3124819 16842330 2563599
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.881399818 598648
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.8819519916
MESH:D008171 Lung Diseases Ascorbic Acid 3.9616863852
MESH:D008175 Lung Neoplasms marker/mechanism 16271038
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.7816401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.7820135361 18816296 20869020 18569708 17053015 20464547 18520028 20064080 6695378
MESH:D008175 Lung Neoplasms Curcumin 10.7816243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.7820970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Ethylnitrosourea 10.7817703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.7816271038 11893704 15390079 17909032 9230183 21163286 1399818 20512841 7750092 6695378 16337739 10545420 20970405
MESH:D008175 Lung Neoplasms Quercetin 10.7816280456
MESH:D008223 Lymphoma Curcumin 8.0318462866
MESH:D008223 Lymphoma Ethylnitrosourea 8.0315790496
MESH:D016399 Lymphoma, T-Cell Curcumin 11.8816173963
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 11.8815375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5318041768 10767621 10838139
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Curcumin 3.5017885582 18462866
MESH:D008545 Melanoma Tretinoin 3.5016752155
MESH:D008569 Memory Disorders Curcumin 4.1917263510
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009101 Multiple Myeloma Curcumin 3.5319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.9717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.7619151258
MESH:D009203 Myocardial Infarction Quercetin 5.7619595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.5119207477
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4018495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.743581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.749029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 11.9711141357
MESH:D009369 Neoplasms pirinixic acid 11.9717405874
MESH:D009369 Neoplasms Quercetin 11.9715185748
MESH:D009369 Neoplasms Tretinoin 11.9716946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.4416707424
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6012497104
MESH:D009421 Nervous System Malformations Tretinoin 3.819125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.6918462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.296679447
MESH:D009436 Neural Tube Defects Tretinoin 7.299142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4716651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3620387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.3917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity Ascorbic Acid 7.5917217161
MESH:D009765 Obesity Curcumin 7.5919297423
MESH:D009765 Obesity pirinixic acid 7.5920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.454026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010024 Osteoporosis Curcumin 3.4918719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2519495926
MESH:D010051 Ovarian Neoplasms Curcumin 8.0519020741 18462866
MESH:D010051 Ovarian Neoplasms Quercetin 8.0519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0516936753
MESH:D010146 Pain Phenol 7.3217610455
MESH:D010146 Pain Tretinoin 7.3216870215
MESH:D010190 Pancreatic Neoplasms Curcumin 16.4519401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.4516540662
MESH:D010190 Pancreatic Neoplasms Mitomycin 16.4515113037
MESH:D010190 Pancreatic Neoplasms Quercetin 16.4516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 16.4515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010392 Pemphigus Phenol 6.5116522979 17163923
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D010864 Pilonidal Sinus Phenol 6.5119655223 15622588
MESH:D011041 Poisoning Phenol 4.758825745
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.312563599
MESH:D011230 Precancerous Conditions Quercetin 9.3119056647
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6417292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.6412497104 18769126 11398177 18226269 18156803 10851300 15129424
MESH:D011471 Prostatic Neoplasms Quercetin 2.6417292933 14715546
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.5519168576
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.3914606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0610666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316116481 16283617
MESH:D012509 Sarcoma Curcumin 4.1418462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.6116862918
MESH:D018805 Sepsis Curcumin 4.1018389075
MESH:D012871 Skin Diseases Ascorbic Acid 3.2218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013088 Spermatocele Phenol 5.7018646496
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3418456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.7818726076
MESH:D013276 Stomach Ulcer Curcumin 7.7819188055 16631530
MESH:D020521 Stroke Ascorbic Acid 4.3116517955 16403987
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2115790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.086587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.087505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.0816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014277 Trigeminal Neuralgia Phenol 6.5110223447 16527771
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.058074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.0517053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 12.0518593936
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.0516720314
MESH:D014565 Urogenital Neoplasms Curcumin 5.3118462866
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D014860 Warts Phenol 6.1619122958
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
KEGG:05152 Tuberculosis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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