AutismKB 2.0

Annotation Detail for NHP2L1


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Basic Information Top
Gene Symbol:NHP2L1 ( 15.5K,FA-1,FA1,NHPX,OTK27,SNRNP15-5,SNU13,SPAG12,SSFA1 )
Gene Full Name: NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Band: 22q13
Quick LinksEntrez ID:4809; OMIM: 601304; Uniprot ID:NH2L1_HUMAN; ENSEMBL ID: ENSG00000100138; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NHP2L1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of NHP2L1 mRNAaffects expression 18414638
D004642 Emodin Emodin results in decreased expression of NHP2L1 mRNAdecreases expression 15612046
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NHP2L1 mRNAaffects cotreatment|increases expression 17183730
D015125 Oxyquinoline Oxyquinoline results in decreased expression of NHP2L1 mRNAdecreases expression 15612046
D012643 Selenium Selenium results in increased expression of NHP2L1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of NHP2L1 mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NHP2L1 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of NHP2L1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5317306315
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9116835338 12569548 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3619371607 12928151
MESH:D001321 Autistic Disorder Valproic Acid 1.9918558336 18396377 15238991 16609825 17507914 17157402 20603192 18177632 18316065 19460635 18985861 17688650 18775368 18940202 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6915504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3016507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7415504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2718640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4918022660 16973168
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7716575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7719769572
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6315131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6315131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6319641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D005234 Fatty Liver Valproic Acid 3.5019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005355 Fibrosis Emodin 5.0619474275
MESH:D005534 Foot Diseases Arsenic 5.886392382
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6517050553
MESH:D006973 Hypertension Arsenic 2.9316076760 9931084 11953799
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D006987 Hypesthesia Arsenic 5.8816093927
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007642 Keratosis Arsenic 5.2816930632 12749816
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.2317077332
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6817339181
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.0715288473
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.0716169303
MESH:D008107 Liver Diseases Arsenic 2.5811134558
MESH:D008113 Liver Neoplasms Arsenic 2.7416368122
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Arsenic 2.7117976673 17306315 19168569
MESH:D008175 Lung Neoplasms Vitamin E 2.7111062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D017202 Myocardial Ischemia Arsenic 4.1515371236
MESH:D009436 Neural Tube Defects Arsenic 7.8816620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.888888407 16359493
MESH:D020078 Neurogenic Inflammation Arsenic 4.6017056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2816905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms Arsenic 2.6216140617
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6218760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6215084515
MESH:D011507 Proteinuria Arsenic 4.2221343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8714763951 17978042 3137016 11738929 16876388 15475178 11044598 1511512
MESH:D012871 Skin Diseases Arsenic 5.1919834688 15952646 17050553 17938729 16759981 6392382 17453740 18709164 16353154 16702368 17548696
MESH:D012871 Skin Diseases Vitamin E 5.1918709164
MESH:D012878 Skin Neoplasms Arsenic 3.0915504454 16251483 19538983 17050553 17976673 17029826
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8818640142 15987713 19322015 17306315 19429237 17976673 11144890
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014652 Vascular Diseases Arsenic 5.0217056641
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02494 - Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 - ANISOMYCIN
DB08437 - PUROMYCIN
DB08769 - N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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