AutismKB 2.0

Annotation Detail for ATP1B1


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Basic Information Top
Gene Symbol:ATP1B1 ( ATP1B,MGC1798 )
Gene Full Name: ATPase, Na+/K+ transporting, beta 1 polypeptide
Band: 1q24.2
Quick LinksEntrez ID:481; OMIM: 182330; Uniprot ID:AT1B1_HUMAN; ENSEMBL ID: ENSG00000143153; HGNC ID: 804
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04973Carbohydrate digestion and absorption
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
hsa04960Aldosterone-regulated sodium reabsorption
hsa04964Proximal tubule bicarbonate reclamation
hsa04971Gastric acid secretion
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2151Neuroblastoma
Desease Name
CARDIOVASCULAR
QT interval
Desease Name
QT interval
Desease Name
Blood pressure regulation QTL
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ATP1B1 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of ATP1B1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of ATP1B1 mRNAdecreases expression 16648578
D000638 Amiodarone Amiodarone results in decreased expression of ATP1B1 proteindecreases expression 8071999
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP1B1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ATP1B1 mRNAdecreases expression 15761015
D016589 Astemizole Astemizole results in increased expression of ATP1B1 mRNAincreases expression 20221588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATP1B1 mRNAdecreases expression 20018196
C095105 bexarotene bexarotene results in decreased expression of ATP1B1 mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of ATP1B1 mRNAdecreases expression 16474171
D002118 Calcium Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]affects reaction|increases expression 11204457
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ATP1B1 mRNAincreases expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATP1B1 mRNAaffects cotreatment|affects expression 17602206
C009160 cyclonite cyclonite results in increased expression of ATP1B1 mRNAincreases expression 19417177
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of ATP1B1 mRNAaffects cotreatment|affects expression 17330099
D004041 Dietary Fats Dietary Fats results in increased expression of ATP1B1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATP1B1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ATP1B1 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of ATP1B1 mRNAdecreases expression 16474171
D019833 Genistein Genistein results in decreased expression of ATP1B1 mRNAdecreases expression 16474171
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]decreases reaction|increases expression 11204457
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased expression of ATP1B1 mRNAdecreases expression 11204457
D006220 Haloperidol Haloperidol results in increased expression of ATP1B1 mRNAincreases expression 15860345
D007529 Isoflavones Isoflavones results in increased expression of ATP1B1 mRNAincreases expression 17374662
C029938 nickel sulfate nickel sulfate results in decreased expression of ATP1B1 mRNAdecreases expression 16100012
D010100 Oxygen Oxygen deficiency results in increased expression of ATP1B1 mRNAincreases expression 11713096
C041786 palm oil palm oil results in increased expression of ATP1B1 mRNAincreases expression 18042831
D010269 Paraquat Paraquat affects the expression of ATP1B1 mRNAaffects expression 16854511
D010269 Paraquat Paraquat results in increased expression of ATP1B1 mRNAincreases expression 16555045
D010656 Phenylephrine Phenylephrine results in increased expression of ATP1B1 mRNAincreases expression 11204457
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ATP1B1 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of ATP1B1 mRNAincreases expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of ATP1B1 mRNAdecreases expression 16474171
D011374 Progesterone Progesterone results in decreased expression of ATP1B1decreases expression 17510236
D010042 Ouabain 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]decreases reaction|increases expression 11204457
D010042 Ouabain Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]affects reaction|increases expression 11204457
D010042 Ouabain Ouabain results in increased expression of ATP1B1 mRNAincreases expression 11204457
D010042 Ouabain W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]decreases reaction|increases expression 11204457
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ATP1B1 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ATP1B1 mRNAdecreases expression 18691609
18796159
19933214
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of ATP1B1 mRNAincreases expression 11204457
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of ATP1B1 mRNAaffects cotreatment|affects expression 17330099
C017967 W 7 W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]decreases reaction|increases expression 11204457
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1918287403
MESH:D055371 Acute Lung Injury nickel sulfate 13.4416100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury Oxygen 13.4416759491
MESH:D055371 Acute Lung Injury pirinixic acid 13.4418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.5211798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.5211473722
MESH:D000230 Adenocarcinoma Genistein 6.5211473722
MESH:D000236 Adenoma Diethylnitrosamine 2.6410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.1417620307 19061943 19052882 16434500 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.1416835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4011874814
MESH:D000505 Alopecia Isoflavones 4.4317569567
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6311748828
MESH:D000799 Angioedema Acetaminophen 10.7810982225
MESH:D000799 Angioedema Astemizole 10.782883202
MESH:D000860 Anoxia Oxygen 4.6920872349
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.0918057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.0917460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.5315238619
MESH:D050197 Atherosclerosis Oxygen 3.5916391483
MESH:D001281 Atrial Fibrillation Amiodarone 3.6319698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1120106747
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1218080171 19368416
MESH:D001778 Blood Coagulation Disorders Amiodarone 19.2619483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.2616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.2619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.2612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D001862 Bone Resorption bisphenol A 3.5411985600
MESH:D001919 Bradycardia Phenylephrine 4.1815306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9617868700
MESH:D001930 Brain Injuries Progesterone 3.9015845082 15380490 15665606
MESH:D001943 Breast Neoplasms alitretinoin 9.1316344269
MESH:D001943 Breast Neoplasms bexarotene 9.1316818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 9.1317123778
MESH:D001943 Breast Neoplasms decitabine 9.1318320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 9.1320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.1317474063
MESH:D001943 Breast Neoplasms Estradiol 9.1312948864 16675129 17018787 18497071 17289903 19861407 17261762 14630087
MESH:D001943 Breast Neoplasms Genistein 9.1317200150 16541309 16873071
MESH:D001943 Breast Neoplasms Oxygen 9.1317263869
MESH:D001943 Breast Neoplasms Progesterone 9.1316175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.1320435547
MESH:D001943 Breast Neoplasms vorinostat 9.1316144943
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4216192424 16011737 16050911 16124888 16097048 10355542 18705752 15700767 3786805 16227642 15721981 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.493084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.4915553829 16217749 15073043 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.4918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.4918393292 16288022 18506893 19335982 19052882 16807293 18788625 19519916 19701751 11831363 19919837 19822196 16878318 17428255 10672840 20084675 20514400 17138121 19539802 20935162 3084413 18785209 17055752 17761372 18210153 19394651 16935385 19171122 18494052 3581430 20512989 17173139 17162532 17978847 16681979 16779866 16698587 19383236 16328049 21159647 16502159 16569478 20101231 19418558 20432363 16540662 20214788 18056438 16830150 18978308 19107877 20007298 18971187 18665156 20727157 18691550 19208518 10737359 20524982
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.4916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.4916924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1016247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8012490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6219215824
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.6218922899
MESH:D006332 Cardiomegaly Phenylephrine 6.1917287366 17124262 16170337 15728586 11179087 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7615710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 6.9216332659
MESH:D002318 Cardiovascular Diseases Isoflavones 6.9217689850
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7218974383
MESH:D002375 Catalepsy Haloperidol 4.5415215559 1977408
MESH:D002386 Cataract Acetaminophen 2.3610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.7120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.7117174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.7118566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3016835633
MESH:D002779 Cholestasis pirinixic acid 2.5619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9516354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.6317616700
MESH:D003110 Colonic Neoplasms Genistein 3.6317182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.5520501625
MESH:D015179 Colorectal Neoplasms decitabine 4.5518981723
MESH:D015179 Colorectal Neoplasms Isoflavones 4.5517116718
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.5515531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.3410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3410048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 9.8015213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.8020210726
MESH:D003704 Dementia Haloperidol 9.2411575062
MESH:D003704 Dementia Polychlorinated Biphenyls 9.2416140633
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.3311298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5120387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.5116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1317187935
MESH:D003967 Diarrhea vorinostat 4.1520479100
MESH:D004244 Dizziness Astemizole 6.093105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.7214986274 19416960 19085960 10915739 19420014 19739265 12392966 17522070 11834606 11461765 16109766 12958197 16177239 12153990 15968718 11529661 10774834 17906064 16081117 14725611 16227642 16781746 17562736 12705907 19370779 10663392 15619225 11421492 2444490 18071297 19923254 14550746 16393943 12540782 18713872 11287661 12594235 11739529 11743745 19164858 16485898
MESH:D056486 Drug-Induced Liver Injury Amiodarone 10.7218218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.724309450 2869522 7440962 10915739 7120509 15027814 15998439 19336974 3732212 6884620 15968718 7179309 3786805 6623471 9327722 10092053 21278145 11566570 19085960 16177239 17522070 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.7219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.7220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1918367378
MESH:D004417 Dyspnea Oxygen 4.4620016425
MESH:D004487 Edema pirinixic acid 9.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5911000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 9.597812673 9599246 8113982 15177302 8273558 16716910 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4317692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7419294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.2216402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.7011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 6.7011473722
MESH:D004715 Endometriosis Progesterone 7.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.879294722 10568697
MESH:D004802 Eosinophilia Astemizole 4.451355641
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.1112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7411564622
MESH:D005221 Fatigue vorinostat 5.2320479100
MESH:D005234 Fatty Liver Amiodarone 26.4614986274
MESH:D005234 Fatty Liver arsenic trioxide 26.4615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.4615959796 16239168 17595544 61145 12631006 16045604 12795759 19224547
MESH:D005234 Fatty Liver Dietary Fats 26.4617967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 26.4620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 26.4619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005355 Fibrosis Carbon Tetrachloride 12.6818705752
MESH:D005355 Fibrosis Dietary Fats 12.6818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6820067830
MESH:D005499 Folliculitis Astemizole 5.541671328
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9116904648
MESH:D005739 Gas Poisoning Oxygen 4.8420016425
MESH:D005756 Gastritis Acetaminophen 3.3016983495
MESH:D005909 Glioblastoma Genistein 3.0216598420
MESH:D005911 Gliosis Paraquat 4.7911124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.2419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2519900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 12.3415265979
MESH:D006529 Hepatomegaly pirinixic acid 12.3418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.3412621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.6615709030
MESH:D019584 Hot Flashes Estradiol 9.1717088409
MESH:D019584 Hot Flashes Isoflavones 9.1717290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.678697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.4216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1616899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.089751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0821332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2821332399
MESH:D006973 Hypertension Ouabain 8.0618976649
MESH:D006973 Hypertension Phenylephrine 8.0612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0618670907 18850075
OMIM:145500 HYPERTENSION, ESSENTIAL marker/mechanism
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7315338365
MESH:D006984 Hypertrophy Phenylephrine 4.2318502941 12791704
MESH:D007037 Hypothyroidism Amiodarone 4.1518020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0415869954
MESH:D007248 Infertility, Male decitabine 6.1817581917
MESH:D007248 Infertility, Male Paraquat 6.184850670
MESH:D007249 Inflammation Dietary Fats 13.7720412841
MESH:D007249 Inflammation Diethylnitrosamine 13.7718785209
MESH:D007249 Inflammation Progesterone 13.7715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.7712200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 13.777562506 15177302 11698051 7812673 8273558
MESH:D007333 Insulin Resistance bisphenol A 15.6516393666
MESH:D007333 Insulin Resistance Dietary Fats 15.6511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 15.6516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 15.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0116580747
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2716144296
MESH:D007674 Kidney Diseases Acetaminophen 5.1715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.1715618244
MESH:D007680 Kidney Neoplasms Estradiol 2.6915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6716316344
MESH:D007938 Leukemia arsenic trioxide 9.4415070760
MESH:D007938 Leukemia decitabine 9.4418980019 19235587
MESH:D007938 Leukemia Genistein 9.4417468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.5019077051
MESH:D007951 Leukemia, Myeloid decitabine 8.5018454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7416968895 19850784 20471514 17050201 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7418206229 17679729 18704418 18460780 19010910 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9716966277 12679006 16891316 12018890 11161223 15748426 19225113 17869043 11468182 17217047 19075265 15622746 17649720 16331271 16112521 15336539 17107899 19035177 16823087 19642359 15213294 17712046 16330433 9834237 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0016882451
MESH:D017513 Lichen Nitidus Astemizole 6.092563723
MESH:D008064 Lipidoses Amiodarone 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.8121278145 16943688 17174718 11408273 17334410 16239168 11903743 16221502 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 9.8118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.8118522880 18407596 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1617481882 16097048 12389079 18376398 18705752 10355542 16116963 17766677 14724832 17640975 15650968 15818738 17869086 15876570 18054572 15996030 15057751 18279442 18420326 16192424 14620537 12632512 18166357 12741479 12649538 18429990 16136751 18156304 17944888 12958196 15925388 15052691 12445418 12586293 18006644 17631135 17976157 16027843 14716833 15362042 11481614 13678700 18395095 18187930 14512876 17714472 15370692 18418968 18481824 18339082 18472094 18205269 18317297 15123356 17698563 17761835 15893842 17721639 16011737 16033810 12609069 12445421 18263696 12667390 17565644 18251166 20821823 17525996 15959796 17900296 12632514 17708605 12898905 17805973 15338365 18412020 17922224 16638106 16248980 18210741 18277467 18395914 15931870 15730626 18472332 14716496 12546737 17823541 12666154 15673190 14748882 17557913 16015684
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.1617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1612878042
MESH:D008107 Liver Diseases Acetaminophen 5.8512969438 16611625 19784758 11587558 19460945 12587719 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.8516246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 5.8517034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 16.0414682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.0419294768
MESH:D008113 Liver Neoplasms Clofibric Acid 16.0417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.0420501860 20492335 2422723 19256749 19850985 20137499 15175105 21047994 18978307 19073162 19427195 20405173 19090486 20452335 20583210 12112319 15885732 19812893 19642983 12771043 20101389 9163691 21167192 10737359 19551842 19833225 16942905 19426721 18977376 18644402 20434301 18754104 21071580 21278145 20118626 19499222 19254457 19638242 19294768 19690152 19255062 18648771 19996281 2862719
MESH:D008113 Liver Neoplasms pirinixic acid 16.0420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.0416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.1920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.1912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.1919009564 18079962 16267830 3124819 19539802 18544905 17174075 17942915 17854601 18093689 16842330 18775883 18282651 18253720 19519916 9362446 19004024 2563599 21159647 19126423 18164116 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 16.191423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.1912151625
MESH:D008133 Long QT Syndrome Amiodarone 12.1211989578 15350150 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 12.1215213294
MESH:D008133 Long QT Syndrome Astemizole 12.1211989578 18472280
MESH:D008171 Lung Diseases Amiodarone 3.1312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1018516814
MESH:D055370 Lung Injury Oxygen 4.1518339021
MESH:D008175 Lung Neoplasms alitretinoin 7.8816413115
MESH:D008175 Lung Neoplasms arsenic trioxide 7.8811798837 19825857
MESH:D008175 Lung Neoplasms bexarotene 7.8817849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.8820970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.8811807781
MESH:D008223 Lymphoma decitabine 3.1619470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 11.5411161223
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 11.5420479100
MESH:D008288 Malaria Astemizole 4.4916816845
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 16.3219196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.3217203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.3214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.3217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 16.328985016
MESH:D020149 Manganese Poisoning Estradiol 4.1119453300
MESH:D008545 Melanoma decitabine 2.2016505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2119513568
MESH:D001523 Mental Disorders Haloperidol 3.6616856516
MESH:D009101 Multiple Myeloma arsenic trioxide 6.5119549372 19417148 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma decitabine 6.5118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1516239165
MESH:D009181 Mycoses Amiodarone 4.5312754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7916882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.7918608210 19157545 19010910 16882708
MESH:D009203 Myocardial Infarction Genistein 5.1417141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.5516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.5517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.5516411023
MESH:D009325 Nausea vorinostat 5.1520479100
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6116624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.429029167 3581430
MESH:D009369 Neoplasms alitretinoin 7.2816946489
MESH:D009369 Neoplasms decitabine 7.2819116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 7.2817405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4119196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3717289903
MESH:D009410 Nerve Degeneration Paraquat 3.4416893418
MESH:D009421 Nervous System Malformations bisphenol A 20.5711399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 20.5711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.5716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.5714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.8810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7420387270
MESH:D009759 Nystagmus, Pathologic Astemizole 6.096135121
MESH:D009765 Obesity Dietary Fats 4.0917217161 16723640 19632207 18457598 18674790 20518802 21332399 20132043 11836018
MESH:D009765 Obesity pirinixic acid 4.0920558911
MESH:D010024 Osteoporosis Calcium 10.7717882678
MESH:D010024 Osteoporosis Genistein 10.7719401787
MESH:D010024 Osteoporosis Isoflavones 10.7716562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7516169203
MESH:D010049 Ovarian Diseases bisphenol A 4.6211985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.6416624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 13.6419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 13.6419401270
MESH:D010051 Ovarian Neoplasms Genistein 13.6419005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.6417393432 16525653
MESH:D010146 Pain Acetaminophen 2.1116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.2015580305
MESH:D010190 Pancreatic Neoplasms decitabine 11.2019294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.2016540662
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.2015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9418922899 8330346 18404319 12065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8219927285
MESH:D010300 Parkinson Disease Paraquat 5.2511124998 11445065 15824117 12911755 15451049 16510128 16140633 11181820
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.2516702228
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0716190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D011014 Pneumonia Paraquat 4.0912504350
MESH:D017499 Porokeratosis alitretinoin 5.6316144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.252563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.2910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2911896295 11118676 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.3717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.4620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.4620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0419131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0416740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0415256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 2.0417219775 16365062 17571952 17374662
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.0415721890
MESH:D011471 Prostatic Neoplasms vorinostat 2.0417218635
MESH:D011595 Psychomotor Agitation Haloperidol 4.6011575062
MESH:D011618 Psychotic Disorders Haloperidol 3.9911575062
MESH:D011629 Puberty, Precocious bisphenol A 4.4210548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.3412490602 11597910 12832656
MESH:D011658 Pulmonary Fibrosis Paraquat 5.3417997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.3217627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.3211700416
MESH:D012135 Respiratory Sounds Paraquat 3.7011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012162 Retinal Degeneration Paraquat 3.5916458197
MESH:D012208 Rhabdomyosarcoma decitabine 4.0619155313
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.0510822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6116646077
MESH:D012559 Schizophrenia Haloperidol 2.7518513383 20107430 1830565 19369910
MESH:D012640 Seizures cyclonite 4.2919417177
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7218724381
MESH:D012852 Sinusitis Phenylephrine 4.347327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.2118404319 12065085 8985016 11807781 8330346
MESH:D013119 Spinal Cord Injuries Progesterone 3.9116503802 15862959
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.1817007042
MESH:D013274 Stomach Neoplasms decitabine 3.1819037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1818456281
MESH:D013276 Stomach Ulcer Amiodarone 3.0018087811
MESH:D019966 Substance-Related Disorders bisphenol A 3.6216045194 16684133
MESH:D013398 Sudden Infant Death Oxygen 5.1812563064
MESH:D013610 Tachycardia Amiodarone 3.9411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 9.3719225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.3720210726
MESH:D013921 Thrombocytopenia vorinostat 4.6520479100
MESH:D013959 Thyroid Diseases Amiodarone 10.8019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.8012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.4119014326
MESH:D013964 Thyroid Neoplasms decitabine 10.4117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.417505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.5018020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3119048282
MESH:D016171 Torsades de Pointes Amiodarone 15.2417467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 15.2415213294
MESH:D016171 Torsades de Pointes Astemizole 15.248256756 9583453
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.7412973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 4.7417616700 19087683
MESH:D014581 Urticaria Acetaminophen 7.9110982225
MESH:D014581 Urticaria Astemizole 7.913080510 2565098 2147912 3134034 2568189 2568013 1683191 3097109 2885854 2859714 1976298 2883202
MESH:D014591 Uterine Diseases bisphenol A 4.6314652134
MESH:D014604 Uveal Neoplasms decitabine 4.5417785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D014717 Vertigo Astemizole 6.093105558
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D015430 Weight Gain Dietary Fats 3.4316723640
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04976 Bile secretion
KEGG:04973 Carbohydrate digestion and absorption
KEGG:04260 Cardiac muscle contraction
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04971 Gastric acid secretion
REACT:604 Hemostasis
KEGG:04978 Mineral absorption
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
KEGG:04964 Proximal tubule bicarbonate reclamation
KEGG:04970 Salivary secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA66
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA450218levonorgestrel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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