Annotation Detail for NHS
Basic Information
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| Gene Symbol: | NHS ( DKFZp781F2016,DKFZp781L0254,FLJ22511,SCML1 ) |
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| Gene Full Name: | Nance-Horan syndrome (congenital cataracts and dental anomalies) |
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| Band: | Xp22.2-p22.13 |
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| Quick Links | Entrez ID:4810; OMIM: 300457; Uniprot ID:NHS_HUMAN; ENSEMBL ID: ENSG00000188158; HGNC ID: 7820 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease Name |
|---|
| Cataract, congenital, X-linked |
| Nance-Horan syndrome |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D017638 |
Asbestos, Crocidolite |
Asbestos, Crocidolite results in increased expression of NHS mRNA | increases expression | 18687144
|
| D002117 |
Calcitriol |
Calcitriol results in increased expression of NHS mRNA | increases expression | 16002434
|
| D006830 |
Hydralazine |
[Hydralazine co-treated with Valproic Acid] results in increased expression of NHS mRNA | affects cotreatment|increases expression | 17183730
|
| D014635 |
Valproic Acid |
[Hydralazine co-treated with Valproic Acid] results in increased expression of NHS mRNA | affects cotreatment|increases expression | 17183730
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.11 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.35 | 19490988 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
5.96 | 17688650 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.90 | 17497229 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 17688650 18396377 17157402 19232924 16609825 19460635 18775368 18558336 18177632 18985861 18940202 17507914 18316065 15238991 20603192 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.24 | 20046352 17594078 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.63 | 8888407 |
| MESH:D001943 |
Breast Neoplasms |
|
Calcitriol |
2.56 | 11237771 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Calcitriol |
2.71 | 11237771 |
| OMIM:302200 |
CATARACT, CONGENITAL, X-LINKED |
marker/mechanism |
|
| |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.82 | 20734317 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.91 | 17688650 8888407 16575769 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.25 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.51 | 1851702 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Calcitriol |
4.44 | 15138306 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.71 | 17275665 3659116 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.64 | 16628512 3922381 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.11 | 18234410 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
3.96 | 6254150 6426943 7562514 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.86 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.69 | 3659116 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
3.72 | 19224547 14986274 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.61 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.64 | 18558336 8888407 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.50 | 17688650 |
| MESH:D046110 |
Hypertension, Pregnancy-Induced |
|
Hydralazine |
5.19 | 16612254 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.20 | 16294345 17596541 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
4.98 | 17228818 |
| MESH:D055370 |
Lung Injury |
|
Asbestos, Crocidolite |
4.58 | 17365036 |
| MESH:D008654 |
Mesothelioma |
|
Asbestos, Crocidolite |
3.31 | 18303189 16966607 16166281 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.47 | 18765137 18803445 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.45 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.35 | 17596541 |
| MESH:C538336 |
Nance-Horan syndrome |
marker/mechanism |
|
| |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.37 | 16359493 8888407 |
| MESH:D010995 |
Pleural Diseases |
|
Asbestos, Crocidolite |
5.45 | 10923243 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.46 | 20603192 |
| MESH:D011470 |
Prostatic Hyperplasia |
|
Calcitriol |
5.41 | 15572423 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Calcitriol |
3.48 | 16289102 16644109 15754350 18247401 12479363 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.26 | 11422049 12752131 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Asbestos, Crocidolite |
3.15 | 17365031 15814490 17322281 17975199 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.64 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.10 | 15737665 19110320 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
2.99 | 1511512 11738929 3137016 16876388 14763951 15475178 11044598 17978042 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.09 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.26 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
5.96 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.15 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.20 | 8888407 |
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