AutismKB 2.0

Annotation Detail for NKX3-1


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Basic Information Top
Gene Symbol:NKX3-1 ( BAPX2,NKX3,NKX3.1,NKX3A )
Gene Full Name: NK3 homeobox 1
Band: 8p21.2
Quick LinksEntrez ID:4824; OMIM: 602041; Uniprot ID:NKX31_HUMAN; ENSEMBL ID: ENSG00000167034; HGNC ID: 7838
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05215Prostate cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200194FOXA1 transcription factor network
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the urinary system and male genital organs
H00024Prostate cancer
No data
Desease Name
prostate cancer
CANCER
Desease Name
Prostate cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C103303 alitretinoin alitretinoin results in increased expression of NKX3-1 mRNAincreases expression 16763719
C103303 alitretinoin alitretinoin results in increased expression of NKX3-1 proteinincreases expression 16763719
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of NKX3-1 mRNAdecreases expression 12711008
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of NKX3-1 mRNAincreases expression 17131305
D013196 Dihydrotestosterone PD 98059 inhibits the reaction [Dihydrotestosterone results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
D000728 Androgens Androgens results in increased expression of NKX3-1 mRNAincreases expression 17202838
16817226
D000728 Androgens TP53 protein inhibits the reaction [Androgens results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17202838
D000728 Androgens Androgens affects the expression of NKX3-1 mRNAaffects expression 17288544
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NKX3-1 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NKX3-1 mRNAincreases expression 19150397
C053541 bicalutamide bicalutamide results in decreased expression of NKX3-1 mRNAdecreases expression 15638997
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of NKX3-1 mRNAincreases expression 15336504
D003474 Curcumin Curcumin results in decreased expression of NKX3-1 mRNAdecreases expression 18719366
17303007
D003474 Curcumin Curcumin results in decreased expression of NKX3-1 proteindecreases expression 17303007
18719366
C004742 daidzein daidzein results in decreased expression of NKX3-1 mRNAdecreases expression 16865672
C014347 decitabine decitabine results in increased expression of NKX3-1 mRNAincreases expression 18174752
C115058 difenoconazole difenoconazole results in decreased expression of NKX3-1 mRNAdecreases expression 12711008
C007610 equol equol results in decreased expression of NKX3-1 mRNAdecreases expression 16865672
D004958 Estradiol AR protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA]affects reaction|increases expression 17131305
D004958 Estradiol ESR2 protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA]affects reaction|increases expression 17131305
D004958 Estradiol Estradiol results in increased expression of NKX3-1 mRNAincreases expression 17131305
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
D004958 Estradiol PD 98059 inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
D005485 Flutamide [Flutamide binds to and results in decreased activity of AR protein] which results in decreased expression of NKX3-1 proteinaffects binding|decreases activity|decreases expression 17303007
D005485 Flutamide Flutamide results in decreased expression of NKX3-1 proteindecreases expression 17303007
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
C106014 gedunin gedunin results in decreased expression of NKX3-1 mRNAdecreases expression 17010675
D019833 Genistein Genistein results in decreased expression of NKX3-1 mRNAdecreases expression 15378649
16865672
D007213 Indomethacin Indomethacin results in increased expression of NKX3-1 mRNAincreases expression 16984733
D007529 Isoflavones Isoflavones results in decreased expression of NKX3-1 mRNAdecreases expression 17374662
C533894 LG 100815 LG 100815 results in increased expression of NKX3-1 mRNAincreases expression 16951191
C008493 methylselenic acid methylselenic acid affects the expression of NKX3-1 mRNAaffects expression 14617803
D015741 Metribolone Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]affects binding|increases reaction 16603237
D015741 Metribolone Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone promotes the reaction [JMJD1A protein binds to NKX3-1 enhancer]affects binding|increases reaction 16603237
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone results in decreased expression of NKX3-1 mRNAdecreases expression 12711008
D015741 Metribolone Metribolone results in increased expression of NKX3-1 mRNAincreases expression 17131305
17010675
19318562
17202838
D015741 Metribolone Metribolone results in increased expression of NKX3-1 proteinincreases expression 17303007
D015741 Metribolone TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17202838
D015741 Metribolone UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]affects reaction|increases expression 19318562
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of NKX3-1 mRNAincreases expression 16951191
C093973 PD 98059 PD 98059 inhibits the reaction [Dihydrotestosterone results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
C093973 PD 98059 PD 98059 inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]decreases reaction|increases expression 17131305
C011978 phentin acetate phentin acetate results in decreased expression of NKX3-1 mRNAdecreases expression 12711008
D011794 Quercetin Quercetin results in decreased expression of NKX3-1 mRNAdecreases expression 11238180
C009424 tetramethrin tetramethrin results in decreased expression of NKX3-1 mRNAdecreases expression 12711008
D014212 Tretinoin Tretinoin results in increased expression of NKX3-1 mRNAincreases expression 16817226
D014212 Tretinoin Tretinoin results in increased expression of NKX3-1 proteinincreases expression 16817226
C050414 tripterine tripterine results in decreased expression of NKX3-1 mRNAdecreases expression 17010675
C025643 vinclozolin vinclozolin affects the expression of NKX3-1 mRNAaffects expression 18220299
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma daidzein 9.6511473722
MESH:D000230 Adenocarcinoma Estradiol 9.6511473722
MESH:D000230 Adenocarcinoma Genistein 9.6511473722
MESH:D000230 Adenocarcinoma Indomethacin 9.6516537180
MESH:D000236 Adenoma Indomethacin 3.2911497255
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8017887948
MESH:D000505 Alopecia Isoflavones 8.8517569567
MESH:D000505 Alopecia Tretinoin 8.8515955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0917225004
MESH:D000544 Alzheimer Disease Androgens 6.5117182789 17917157
MESH:D000544 Alzheimer Disease Curcumin 6.5115590663
MESH:D000544 Alzheimer Disease Indomethacin 6.5117627676 15579461
MESH:D000743 Anemia, Hemolytic Quercetin 3.9917084956
MESH:D001008 Anxiety Disorders vinclozolin 3.4219015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.5810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.6010388637
MESH:D018771 Arthralgia Indomethacin 4.882160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.9116412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.0816807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 7.0811248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.0816292516
MESH:D001249 Asthma Tretinoin 2.2616456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7015336622
MESH:D050197 Atherosclerosis Curcumin 3.1618704882
MESH:D001284 Atrophy fulvestrant 4.5811514358
MESH:D001327 Autoimmune Diseases Curcumin 9.9519761891
MESH:D001327 Autoimmune Diseases Quercetin 9.9519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001477 Bartter Syndrome Indomethacin 4.7110684365
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3616206674 16197459
MESH:D001929 Brain Edema Indomethacin 4.7411481608
MESH:D002545 Brain Ischemia Curcumin 9.4416770732
MESH:D002545 Brain Ischemia Indomethacin 9.4412524144
MESH:D001932 Brain Neoplasms Curcumin 3.7017596214
MESH:D001943 Breast Neoplasms alitretinoin 7.9616344269
MESH:D001943 Breast Neoplasms Androgens 7.9617018787
MESH:D001943 Breast Neoplasms Curcumin 7.9618462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms decitabine 7.9619208741 18320071
MESH:D001943 Breast Neoplasms equol 7.9616898868
MESH:D001943 Breast Neoplasms Estradiol 7.9617289903 14630087 17261762 12948864 19861407 18497071 17018787 16675129
MESH:D001943 Breast Neoplasms fulvestrant 7.9618984771
MESH:D001943 Breast Neoplasms Genistein 7.9616541309 16873071 17200150
MESH:D001943 Breast Neoplasms Indomethacin 7.9617401462
MESH:D001943 Breast Neoplasms Quercetin 7.9618628248
MESH:D001943 Breast Neoplasms Tretinoin 7.9616166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002056 Burns Indomethacin 4.4310459503
MESH:D002100 Cachexia Indomethacin 4.7215141370 16537180 11239499 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.2616962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002277 Carcinoma Curcumin 3.6218593918
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.3716924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.3716391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.3719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.371917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0718791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8818414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6817234771
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2417341418
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.1518462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.1519215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.1515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.1516096774 16051514
MESH:D006332 Cardiomegaly Quercetin 3.1719794523
MESH:D002318 Cardiovascular Diseases daidzein 11.3516332659
MESH:D002318 Cardiovascular Diseases Genistein 11.3516332659
MESH:D002318 Cardiovascular Diseases Isoflavones 11.3517689850
MESH:D002386 Cataract Tretinoin 2.9317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.0220889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.0218566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D002764 Cholecystitis Indomethacin 4.8811181007
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002869 Chromosome Aberrations phentin acetate 6.9510477351
MESH:D002972 Cleft Palate Tretinoin 2.559407595
MESH:D003092 Colitis Curcumin 8.7318200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 8.7317035595
MESH:D003103 Coloboma Curcumin 4.3018809619
MESH:D003110 Colonic Neoplasms Curcumin 10.5116340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 10.5117616700
MESH:D003110 Colonic Neoplasms Genistein 10.5117182828
MESH:D003110 Colonic Neoplasms Indomethacin 10.5115963497 15786552 11260862 15936596 15637740 15625704
MESH:D003110 Colonic Neoplasms Quercetin 10.5115741050 17191121 17148506 11134977 16640504 19056647 19440933
MESH:D015179 Colorectal Neoplasms decitabine 4.6518981723
MESH:D015179 Colorectal Neoplasms Indomethacin 4.6518059344 17054584 11197048 12606626
MESH:D015179 Colorectal Neoplasms Isoflavones 4.6517116718
MESH:D015179 Colorectal Neoplasms Quercetin 4.6518852136 18095365
MESH:D016510 Corneal Neovascularization Curcumin 4.6218497527
MESH:D018352 Coronavirus Infections Indomethacin 5.4317302372
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8116925845 9664655 10589399 9125849 17551590 9211117 9142499 8800419 14991402 9224671
MESH:D016638 Critical Illness Androgens 5.7816670151
MESH:D003456 Cryptorchidism vinclozolin 4.0714966744
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5119496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.9818403477
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9816647724
MESH:D003928 Diabetic Nephropathies Curcumin 8.2618204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.2619279558
MESH:D003967 Diarrhea Indomethacin 3.537237001 7907874
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.8718446180 12774134 17190690 16326151 18043480 16133044
MESH:D004381 Duodenal Ulcer Curcumin 8.5417351913
MESH:D004381 Duodenal Ulcer Indomethacin 8.5417202747 17329845 11595431 17045617 11595415 17351913 11991626 17151854 16699067 11535926 10671773
MESH:D004487 Edema Indomethacin 3.2616100529 7990266 7907874 8273558 19703484 8985016 10653021
MESH:D004489 Edema, Cardiac Tretinoin 4.1818230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8319294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.3116402032
MESH:D016889 Endometrial Neoplasms daidzein 16.3511473722
MESH:D016889 Endometrial Neoplasms Estradiol 16.3518566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.3511473722
MESH:D016889 Endometrial Neoplasms Tretinoin 16.3516569247
MESH:D004715 Endometriosis Indomethacin 3.9015652904
MESH:D019446 Endotoxemia Indomethacin 4.2218509659
MESH:D004751 Enteritis Indomethacin 4.4617763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7117980183
MESH:D004802 Eosinophilia Indomethacin 3.7811298111
MESH:D007172 Erectile Dysfunction daidzein 4.7514972507
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.3911005569
MESH:D005124 Eye Abnormalities Tretinoin 3.379664655 16938888
MESH:D005234 Fatty Liver Curcumin 3.4519297423
MESH:D005334 Fever Indomethacin 3.8810431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.6110962813
MESH:D005355 Fibrosis Curcumin 19.0018705752
MESH:D005355 Fibrosis Indomethacin 19.0017994277
MESH:D005355 Fibrosis Quercetin 19.0019474275
MESH:D005355 Fibrosis Tretinoin 19.0017994277
MESH:D005499 Folliculitis Indomethacin 4.8811298111
MESH:D005756 Gastritis Indomethacin 4.4615046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4218462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005909 Glioblastoma Curcumin 20.3517596214
MESH:D005909 Glioblastoma Genistein 20.3516598420
MESH:D005909 Glioblastoma Indomethacin 20.3512870263
MESH:D005909 Glioblastoma Quercetin 20.3519804834
MESH:D005909 Glioblastoma Tretinoin 20.3517312396
MESH:D005910 Glioma Indomethacin 5.9416487511 18371953
MESH:D005910 Glioma Quercetin 5.9417643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0711849393
MESH:D006073 Gout Indomethacin 5.0711248219
MESH:D006258 Head and Neck Neoplasms Curcumin 16.9518829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 16.9519215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 16.9515482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7514991402 9664655
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.3215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.4215135802
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7717701891
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006628 Hirsutism Androgens 5.7917019078 16914592
MESH:D019584 Hot Flashes Estradiol 9.4817088409
MESH:D019584 Hot Flashes Isoflavones 9.4817290160 14716179
MESH:D006930 Hyperalgesia Indomethacin 7.3012727271
MESH:D006930 Hyperalgesia Tretinoin 7.3016870215
MESH:D034321 Hyperamylasemia Indomethacin 5.4317883296
MESH:D017588 Hyperandrogenism Androgens 11.4417019078
MESH:D017588 Hyperandrogenism Flutamide 11.4415356085
MESH:D006937 Hypercholesterolemia Curcumin 3.8018704882
MESH:D006940 Hyperemia Indomethacin 4.7212524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006943 Hyperglycemia Quercetin 3.7918262572 11834736
MESH:D006949 Hyperlipidemias Indomethacin 3.9117546600
MESH:D006973 Hypertension daidzein 5.5117169123
MESH:D006973 Hypertension Quercetin 5.5118356687
MESH:D007077 Ileal Diseases Indomethacin 4.7410574470 18306037
MESH:D007079 Ileitis Indomethacin 5.0710651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.0916133044
MESH:D007248 Infertility, Male decitabine 10.3417581917
MESH:D007248 Infertility, Male fulvestrant 10.3411514358
MESH:D007248 Infertility, Male vinclozolin 10.3416467254
MESH:D007249 Inflammation Curcumin 5.0218403477 17151092 16956363
MESH:D007249 Inflammation Indomethacin 5.023291741 7812673 12568917
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.2216624496
MESH:D007333 Insulin Resistance Estradiol 2.7916393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 8.9717329856 15610444 15831440 11713966 11686837 17994277 10210152 11855677 18236018
MESH:D007410 Intestinal Diseases Tretinoin 8.9717994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9810783313
MESH:D019586 Intracranial Hypertension Indomethacin 5.0915241188
MESH:D007569 Jaw Abnormalities Tretinoin 3.6517551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.7416133968 10574470 18306037
MESH:D007627 Keloid Quercetin 4.6817086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3616144296
MESH:D007674 Kidney Diseases Estradiol 9.2915618244
MESH:D007674 Kidney Diseases Indomethacin 9.2917190690
MESH:D007674 Kidney Diseases Quercetin 9.2916962696
MESH:D007680 Kidney Neoplasms Estradiol 2.7615610895
MESH:D007889 Leiomyoma Curcumin 4.3118555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6811703811 12228301 10320625
MESH:D007938 Leukemia Curcumin 18.2218462866
MESH:D007938 Leukemia decitabine 18.2218980019 19235587
MESH:D007938 Leukemia Genistein 18.2218980019 17468513
MESH:D007938 Leukemia Quercetin 18.2217468513
MESH:D007938 Leukemia Tretinoin 18.2217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9616106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.9516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7216572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid decitabine 8.7319117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.8918704418 19010910 18460780 18206229 17679729 19387464
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.8918360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.8916294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.979834237 19029980 19075265 17649720 19642359 16891316 15748426 16935935 16823087 19225113 17294898 16140955 16788101 17301526 17107899 12679006 16331271 17506722 17368321 16766008 17712046 17339181 17361223 17217047 19035177
MESH:D015458 Leukemia, T-Cell Curcumin 4.5016106398
MESH:D007964 Leukocytosis Indomethacin 5.0916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4317980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.119224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4311479899
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.2617355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2617823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.2618194892
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.2612741479
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2618397230 16248980
MESH:D008107 Liver Diseases Curcumin 2.5516956363
MESH:D008113 Liver Neoplasms Quercetin 2.5718980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 2.8919519916
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7517365036
MESH:D008175 Lung Neoplasms alitretinoin 4.6816413115
MESH:D008175 Lung Neoplasms Curcumin 4.6819359593 16243823 18462866
MESH:D008175 Lung Neoplasms Indomethacin 4.6811497255 16537180 11053908
MESH:D008175 Lung Neoplasms Quercetin 4.6816280456
MESH:D008223 Lymphoma Curcumin 7.1218462866
MESH:D008223 Lymphoma decitabine 7.1219470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4216173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5011408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.5012929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.2019453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Curcumin 4.8917885582 18462866
MESH:D008545 Melanoma decitabine 4.8917785578 16505122
MESH:D008545 Melanoma Tretinoin 4.8916752155
MESH:D008569 Memory Disorders Curcumin 3.8917263510
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0716966607 16166281 18303189
MESH:D008881 Migraine Disorders Indomethacin 3.4811903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.7812636206
MESH:D009101 Multiple Myeloma Curcumin 6.8719372569
MESH:D009101 Multiple Myeloma decitabine 6.8718172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6417962980
MESH:D009190 Myelodysplastic Syndromes decitabine 6.9519157545 19010910 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9517596541
MESH:D009203 Myocardial Infarction Genistein 5.6017141266
MESH:D009203 Myocardial Infarction Quercetin 5.6019595682
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0616810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0617141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.0619207477
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1018495463
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0611239499 11053908 16537180
MESH:D009369 Neoplasms alitretinoin 10.8016946489
MESH:D009369 Neoplasms decitabine 10.8019470736 19116145 17925555
MESH:D009369 Neoplasms Quercetin 10.8015185748
MESH:D009369 Neoplasms Tretinoin 10.8016946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 3.8615625704 10663608
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2512497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009421 Nervous System Malformations Estradiol 14.9016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 14.9016427766
MESH:D009421 Nervous System Malformations Tretinoin 14.909125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3518462866
MESH:D009436 Neural Tube Defects Tretinoin 2.879142499
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.7212349958
MESH:D020078 Neurogenic Inflammation Quercetin 4.1017929310
MESH:D009765 Obesity Curcumin 2.6819297423
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.886374098
MESH:D010003 Osteoarthritis Indomethacin 3.507009135
MESH:D010024 Osteoporosis Curcumin 11.0718719352
MESH:D010024 Osteoporosis Genistein 11.0719401787
MESH:D010024 Osteoporosis Isoflavones 11.0716562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.2816169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.2819495926
MESH:D010051 Ovarian Neoplasms Curcumin 17.6818462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 17.6819331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.6819401270
MESH:D010051 Ovarian Neoplasms Genistein 17.6819005980
MESH:D010051 Ovarian Neoplasms Quercetin 17.6819005980
MESH:D010051 Ovarian Neoplasms Tretinoin 17.6816936753
MESH:D010146 Pain Indomethacin 6.2417440234 17627676 3291741 13679232
MESH:D010146 Pain Tretinoin 6.2416870215
MESH:D010149 Pain, Postoperative Indomethacin 4.4018702446 12538197
MESH:D010190 Pancreatic Neoplasms Curcumin 11.5317440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 11.5319294695
MESH:D010190 Pancreatic Neoplasms Quercetin 11.5316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.5315976015
MESH:D010195 Pancreatitis Indomethacin 3.6715028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4316537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4311903285
MESH:D010437 Peptic Ulcer Indomethacin 4.8711148446
MESH:D010518 Periodontitis Indomethacin 4.6317225004
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6210923243
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.7615356085
MESH:D017499 Porokeratosis alitretinoin 5.7216144296
MESH:D011230 Precancerous Conditions Quercetin 3.7519056647
MESH:D047928 Premature Birth Indomethacin 4.8517000239
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.6218042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.4517616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048 17202838 16817226
MESH:D011471 Prostatic Neoplasms Androgens 3.4316998812 15389811 17909013
MESH:D011471 Prostatic Neoplasms bicalutamide 3.4315638997 17914592 18487222 19240160 19011039
MESH:D011471 Prostatic Neoplasms Curcumin 3.4318226269 15129424 18769126 11398177 18156803 10851300 12497104
MESH:D011471 Prostatic Neoplasms equol 3.4316925846 16898868
MESH:D011471 Prostatic Neoplasms Estradiol 3.4316740699
MESH:D011471 Prostatic Neoplasms Flutamide 3.433169114
MESH:D011471 Prostatic Neoplasms Genistein 3.4315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 3.4317374662 17219775 17571952 16365062
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.4316205645
MESH:D011471 Prostatic Neoplasms Quercetin 3.4314715546 17292933
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011507 Proteinuria Indomethacin 8.4811849393
MESH:D011507 Proteinuria Tretinoin 8.4816636307
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2819168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9217365031 17975199 15814490 17322281
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7710666014 18379247
MESH:D012208 Rhabdomyosarcoma decitabine 10.0919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.0916116481 16283617
MESH:D012509 Sarcoma Curcumin 3.8818462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.2616862918
MESH:D018805 Sepsis Curcumin 3.8518389075
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.368532709
MESH:D012878 Skin Neoplasms Tretinoin 5.3616467112
MESH:D013272 Stomach Diseases Indomethacin 4.1415472012 10192188 17207306 16113693 17160473 10215738 15038085 10486359 16184426 16280098 17638125 18545984 18209964
MESH:D013274 Stomach Neoplasms decitabine 3.3219037991
MESH:D013274 Stomach Neoplasms Indomethacin 3.3215609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.3217261132
MESH:D013276 Stomach Ulcer Curcumin 6.7519188055 16631530
MESH:D013276 Stomach Ulcer Indomethacin 6.7518237397 17135157 16252198 10878458 17657623 15104355 17654042 18543354 12467913 11906479 12077510 10423059 12787963 18181030 15138204 16631530 11145282 18431645 12500499 10750652 15255614 16755016 18087811 17627676 11595415 1323529 18726076 17895592 16169175 17977527 16934674 18209962 14567935 11595431 18299717 17918041 12498302 16397915 11523592 16150113 18193104 11729361
MESH:D013964 Thyroid Neoplasms decitabine 10.8817967635
MESH:D013964 Thyroid Neoplasms Indomethacin 10.8818791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5516051514
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D014456 Ulcer Indomethacin 4.6117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.8418593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.8416720314
MESH:D014565 Urogenital Neoplasms Curcumin 4.9818462866
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4416129372
MESH:D014604 Uveal Neoplasms decitabine 11.8817785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.8816752155
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D014839 Vomiting Indomethacin 4.4611897121
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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