AutismKB 2.0

Annotation Detail for NMB


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Basic Information Top
Gene Symbol:NMB ( MGC17211,MGC2277,MGC3936 )
Gene Full Name: neuromedin B
Band: 15q25.2
Quick LinksEntrez ID:4828; OMIM: 162340; Uniprot ID:NMB_HUMAN; ENSEMBL ID: ENSG00000197696; HGNC ID: 7842
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
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Related Diseases/Disorders Top
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Desease Name
Body Weight Regulation
METABOLIC
obesity
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NMB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NMB mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of NMB mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of NMB mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NMB proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of NMB mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NMB mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of NMB mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of NMB mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NMB mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in decreased expression of NMB mRNAdecreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1810965797
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9117474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Progesterone 1.9115562024 17614352 16175315
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7221507988 12907637 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.866135515
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3914550746 19085960 17562736 11834606 16393943 19416960 12705907 10774834 10663392 15968718 19370779 11287661 18713872 16177239 11743745 14986274 19164858 17522070 12392966 11461765 2444490 10915739 19923254 18071297 12594235 12958197 12540782 19420014 12153990 16081117 14725611 16227642 11529661 17906064 16485898 19739265 11739529 16109766 16781746 15619225 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D004715 Endometriosis Progesterone 3.9016134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver arsenite 14.0218296743
MESH:D005234 Fatty Liver Dietary Fats 14.0219004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 14.0220131406 19236843
MESH:D005355 Fibrosis arsenite 9.6318296743
MESH:D005355 Fibrosis Dietary Fats 9.6318296743
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Dietary Fats 5.4120412841
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D008103 Liver Cirrhosis arsenite 7.0918296743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0918296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19784758 19460945 12969438 16610002 19014921 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.097678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.092125692 18177683 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0920195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 11.0915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.242876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.248603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5914755239
MESH:D008175 Lung Neoplasms arsenite 3.5916809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5918816296 18520028 18569708 20064080 20464547 6695378 20135361 17053015 20869020
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9517203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 4.5418674790 21332399 20518802 20132043 19632207 17217161 16723640 11836018 18457598
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5617393432 16525653
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.7211550810
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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