AutismKB 2.0

Annotation Detail for NME3


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Basic Information Top
Gene Symbol:NME3 ( DR-nm23,KIAA0516,NDPK-C,NDPKC,NM23-H3,NM23H3,c371H6.2 )
Gene Full Name: non-metastatic cells 3, protein expressed in
Band: 16p13.3
Quick LinksEntrez ID:4832; OMIM: 601817; Uniprot ID:NDK3_HUMAN; ENSEMBL ID: ENSG00000103024; HGNC ID: 7851
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5687pyrimidine ribonucleotides interconversion
PWY0-163salvage pathways of pyrimidine ribonucleotides
PWY0-162pyrimidine ribonucleotides de novo biosynthesis
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P02739De novo pyrimidine deoxyribonucleotide biosynthesis
P02740De novo pyrimidine ribonucleotides biosythesis
P02738De novo purine biosynthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NME3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NME3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NME3 mRNAaffects expression 17562736
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of NME3 mRNAdecreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NME3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NME3 mRNAdecreases expression 18247414
D016572 Cyclosporine Cyclosporine results in decreased expression of NME3 mRNAdecreases expression 20106945
D009538 Nicotine Nicotine results in decreased expression of NME3 mRNAdecreases expression 18247414
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NME3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NME3 mRNAdecreases expression 18445702
D018038 Sodium Selenite Sodium Selenite results in increased expression of NME3 mRNAincreases expression 18175754
D013853 Thioacetamide Thioacetamide results in decreased expression of NME3 mRNAdecreases expression 16337175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000544 Alzheimer Disease Nicotine 3.3016627626
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6519483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.6519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.7417997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.887505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8812371664
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4118291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.9919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.9919486331
MESH:D002779 Cholestasis pirinixic acid 13.9919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978970840 12868966 8156756 18759878 11298694 14531868 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.4418692083 1440618 18289764 8291058 9653073 9022650 18648102 7440962 9328219 11289319 16192314 6679447 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4411739529 19416960 15619225 11461765 17522070 19085960 11529661 14986274 19420014 18071297 11421492 11287661 12392966 16227642 10663392 11834606 18713872 10915739 16393943 16781746 2444490 14725611 12594235 12540782 15968718 17906064 19370779 14550746 19164858 12958197 19923254 16109766 11743745 12705907 10774834 16081117 16485898 16177239 17562736 19739265 12153990
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.4415131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.4412963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D020821 Dystonic Disorders Nicotine 6.1217881519
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4716530937
MESH:D005218 Fat Necrosis Thioacetamide 5.9416456712
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0320131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7115929193 18665440 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.006705139
MESH:D006505 Hepatitis Thioacetamide 10.0016456712
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.066582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5918263696 11172339 18615449 15288472 12085344 15078482 12557150 16343077 17127702 17292413 18606216 12679928 16511523 15158331 15075984 16098781 18395095 15316131 15465738 15474484 18380797 15288473 12891558 15334695 18416461 11682029 11481614 15716488 17050028 17629604 12175628 14739098 16097051 16248980 17355460 16126171 16489207 18032466 10677585 18458672 12531686 18031379 15362042 15095483 18295389
MESH:D008107 Liver Diseases Acetaminophen 4.2312969438 16611625 19014921 16610002 19784758 11587558 19460945 12587719
MESH:D008107 Liver Diseases Thioacetamide 4.2315158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 10.0815633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.5220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.616587162 1399818 3712494 598648
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618520028 18816296 17053015 18569708 6695378 20869020 20135361 20464547 20064080
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7211141357
MESH:D009369 Neoplasms Nicotine 8.7216365874
MESH:D009369 Neoplasms pirinixic acid 8.7217405874
MESH:D009389 Neovascularization, Pathologic Nicotine 5.1916365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.326482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1918760546
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6418551238
MESH:D012640 Seizures Nicotine 6.6417873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 1399818 6587162 3712494 7505956
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.8316720336 16785264 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.6215735609 18305452 17979512 18041664
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3916049721
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 12.3911144890
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.398074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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