AutismKB 2.0

Annotation Detail for NME4


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Basic Information Top
Gene Symbol:NME4 ( NDPK-D,NM23H4,nm23-H4 )
Gene Full Name: non-metastatic cells 4, protein expressed in
Band: 16p13.3
Quick LinksEntrez ID:4833; OMIM: 601818; Uniprot ID:NDKM_HUMAN; ENSEMBL ID: ENSG00000103202; HGNC ID: 7852
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5687pyrimidine ribonucleotides interconversion
PWY0-163salvage pathways of pyrimidine ribonucleotides
PWY0-162pyrimidine ribonucleotides de novo biosynthesis
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02739De novo pyrimidine deoxyribonucleotide biosynthesis
P02740De novo pyrimidine ribonucleotides biosythesis
P02738De novo purine biosynthesis
Pathway IDPathway Name
500233Synthesis and interconversion of nucleotide di- and triphosphates
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NME4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NME4 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of NME4 mRNAdecreases expression 20106945
D004391 Dust Dust results in decreased expression of NME4 mRNAdecreases expression 17805423
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NME4 mRNAdecreases expression 17557909
D005472 Fluorouracil NME4 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005492 Folic Acid Folic Acid affects the expression of NME4 mRNAaffects expression 16361273
C008493 methylselenic acid methylselenic acid results in decreased expression of NME4 mRNAdecreases expression 18548127
D011794 Quercetin Quercetin results in decreased expression of NME4 mRNAdecreases expression 15309432
D011794 Quercetin Quercetin results in decreased expression of NME4 proteindecreases expression 15221776
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NME4 mRNAincreases expression 16267337
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.5017003819 16316344 16595132
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4614692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4617638652
MESH:D000236 Adenoma Folic Acid 3.8816963246
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease Folic Acid 3.0817116317
MESH:D000740 Anemia Fluorouracil 9.2315504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0318357371 18608205 19217205 16557594 16110121 16595493 15136595
MESH:D001943 Breast Neoplasms Folic Acid 2.0316777985
MESH:D001943 Breast Neoplasms Quercetin 2.0318628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7517045692 17088986 17971768 18930000 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7512508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5316280240 16757204 18986760 17066447
MESH:D006332 Cardiomegaly Quercetin 7.0919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0616755160
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2016919318 11677210 15861022 17681005 16105132 17333356 17110522
MESH:D002971 Cleft Lip Folic Acid 4.0621254359
MESH:D002972 Cleft Palate Folic Acid 6.3121254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.3112621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9918772588 17725105 17287894 16510598 17169374 15001691 17172411 16340194 17018589 17016597
MESH:D003110 Colonic Neoplasms Quercetin 3.9919056647 19440933 11134977 15741050 17148506 17191121 16640504
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6715289873 17695437 15148649 17454858 14970324 18802399 17094418 18383874 16391804 18509181 18288408 20501625 18448328 16331619 18949393 16524972 17255274 17401013 17594712 16282729 17016601 16303861
MESH:D015179 Colorectal Neoplasms Folic Acid 3.6717116713 17087956 17245555 16963246 16985020
MESH:D015179 Colorectal Neoplasms Quercetin 3.6718095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.6916886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7019085960 11461765 15968718 12153990 18071297 11739529 12705907 12594235 10915739 19416960 16081117 16485898 17522070 16393943 11421492 11529661 16109766 10774834 12958197 11743745 15619225 14550746 17906064 18713872 19923254 16781746 11834606 12540782 16227642 19164858 11287661 10663392 2444490 12392966 14986274 19370779 16177239 19420014 19739265 17562736 14725611
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1117301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4816785472 16337965 16481741 15173087 17638652
MESH:D017889 Exfoliation Syndrome Folic Acid 5.7316504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 8.1519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 16.0812168785 12639820
MESH:D005355 Fibrosis Quercetin 16.0819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0820067830
MESH:D005756 Gastritis Acetaminophen 12.1816983495
MESH:D005756 Gastritis Folic Acid 12.1817171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005901 Glaucoma Folic Acid 5.2616504073
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Fluorouracil 6.3816145905
MESH:D005910 Glioma Quercetin 6.3817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Folic Acid 7.1417286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006679 HIV Seropositivity Folic Acid 5.7317209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia Quercetin 4.1918262572 11834736
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6516755160 16395265 16397167 16865747 16433478
MESH:D006973 Hypertension Cyclosporine 8.9210903974
MESH:D006973 Hypertension Quercetin 8.9218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.598314463 18776723 10903974
MESH:D007674 Kidney Diseases Quercetin 10.5916962696
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D007938 Leukemia Quercetin 3.2317468513
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.4912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4912878042
MESH:D008107 Liver Diseases Acetaminophen 4.3819014921 19784758 19460945 16611625 16610002 12969438 11587558 12587719
MESH:D008107 Liver Diseases Folic Acid 4.3816877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 7.8218383874 16603448 17045692 15113037
MESH:D008113 Liver Neoplasms Quercetin 7.8218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8216984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.2619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2612151625
MESH:D008175 Lung Neoplasms Fluorouracil 3.5515246190
MESH:D008175 Lung Neoplasms Quercetin 3.5516280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3817718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.9316832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7618986760 16757204
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D009369 Neoplasms Fluorouracil 5.5516928823 18239605 18600527
MESH:D009369 Neoplasms Quercetin 5.5515185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Folic Acid 4.0617438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009503 Neutropenia Folic Acid 4.6916322990
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7819005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6616929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.6212371664
MESH:D011230 Precancerous Conditions Quercetin 9.6219056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7018626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7016205645
MESH:D011471 Prostatic Neoplasms Quercetin 2.7014715546 17292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Folic Acid 4.9915728788
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012559 Schizophrenia Folic Acid 2.9116641680
MESH:D012871 Skin Diseases Folic Acid 3.2818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.7316361298
MESH:D013274 Stomach Neoplasms Fluorouracil 2.8817522103 16424979 18567086 17172411 18396642 17498489 15786421 16951190 19084572 19015929
MESH:D013274 Stomach Neoplasms Folic Acid 2.8817171786
MESH:D020521 Stroke Folic Acid 4.4616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.8616720314
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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