AutismKB 2.0

Annotation Detail for NOS1


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Basic Information Top
Gene Symbol:NOS1 ( IHPS1,N-NOS,NC-NOS,NOS,bNOS,nNOS )
Gene Full Name: nitric oxide synthase 1 (neuronal)
Band: 12q24.22
Quick LinksEntrez ID:4842; OMIM: 163731; Uniprot ID:NOS1_HUMAN; ENSEMBL ID: ENSG00000089250; HGNC ID: 7872
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4983citrulline-nitric oxide cycle
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04145Phagosome
hsa04730Long-term depression
hsa04970Salivary secretion
hsa00330Arginine and proline metabolism
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa01100Metabolic pathways
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
cystic fibrosis
bipolar disorder
infantile hypertrophic pyloric stenosis.
Parkinson's disease
nitric oxide
Alzheimer's disease
PSYCH
slow transit constipation
sickle cell disease
neuronal NO synthase (NOS1) gene polymorphism
Asthma
asthma IgE
suicide
IMMUNE
NEUROLOGICAL
EO
tIgE
schizophrenia
atopy
nitric oxide, exhaled
cognitive trait
No data
Desease Name
Pyloric stenosis, infantile hypertrophic 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C069243 1,2,4-trimethylcyclohexane NOS1 protein affects the reaction [1,2,4-trimethylcyclohexane results in increased abundance of Reactive Nitrogen Species]affects reaction|increases abundance 11377403
C069243 1,2,4-trimethylcyclohexane NOS1 protein affects the reaction [1,2,4-trimethylcyclohexane results in increased abundance of Reactive Oxygen Species]affects reaction|increases abundance 11377403
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]decreases expression|decreases reaction 17585341
C109986 2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C109986 2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C109602 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of NOS1 proteindecreases activity 17098364
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of NOS1 proteinincreases expression 12482207
C478738 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester results in decreased expression of NOS1 mRNAdecreases expression 16172162
C080122 7-nitroindazole 7-nitroindazole results in decreased activity of NOS1 proteindecreases activity 15686955
17854383
C080122 7-nitroindazole 7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C080122 7-nitroindazole 7-nitroindazole inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C080122 7-nitroindazole 7-nitroindazole binds to and results in decreased activity of NOS1 proteinaffects binding|decreases activity 15245872
C080122 7-nitroindazole 7-nitroindazole results in decreased activity of NOS1 proteindecreases activity 16023617
D000082 Acetaminophen Acetaminophen results in decreased expression of NOS1 mRNAdecreases expression 16172162
C010395 acetylsalicylic acid lysinate acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]decreases reaction|increases expression 15154853
D020106 Acrylamide Acrylamide results in decreased expression of NOS1 proteindecreases expression 15977197
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of NOS1 mRNAdecreases expression 11585554
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of NOS1 mRNAincreases expression 11585554
C004984 apocarotenal apocarotenal results in increased expression of NOS1 mRNAincreases expression 17034753
D019207 beta Carotene beta Carotene results in increased expression of NOS1 mRNAincreases expression 17034753
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C086539 BQ 788 BQ 788 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C086539 BQ 788 BQ 788 inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
D002104 Cadmium Cadmium results in increased expression of NOS1 mRNAincreases expression 16948784
D002104 Cadmium Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16948784
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of NOS1 mRNAincreases expression 16948784
D019256 Cadmium Chloride Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16948784
D002118 Calcium [Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]affects binding|increases chemical synthesis|increases reaction 17098364
D002118 Calcium [Calcium binds to CALM1 protein] which binds to and affects the folding of and results in increased activity of NOS1 proteinaffects binding|affects folding|increases activity 17098364
D002122 Calcium Chloride Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene]increases reaction|increases reduction 15223068
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the localization of NOS1 proteinaffects localization 16325526
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NOS1 mRNAincreases expression 16325526
16644059
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NOS1 proteinincreases expression 16325526
D010133 p-Chloroamphetamine NOS1 protein results in increased susceptibility to p-Chloroamphetamineincreases response to substance 16054768
D010133 p-Chloroamphetamine p-Chloroamphetamine results in decreased expression of NOS1 mRNAdecreases expression 16054768
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of NOS1 mRNAaffects cotreatment|increases expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NOS1 protein alternative formincreases expression 16791854
D020111 Chlorodiphenyl (54% Chlorine) Egtazic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of NOS1 protein alternative form]decreases reaction|increases expression 16791854
D003300 Copper Copper results in increased expression of NOS1 mRNAincreases expression 16962711
D003300 Copper Copper results in increased expression of NOS1 proteinincreases expression 16962711
D003300 Copper Plant Extracts inhibits the reaction [Copper results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16962711
D003300 Copper Plant Extracts inhibits the reaction [Copper results in increased expression of NOS1 protein]decreases reaction|increases expression 16962711
D003474 Curcumin Curcumin promotes the reaction [sildenafil results in increased expression of NOS1 mRNA]increases expression|increases reaction 17627722
D003907 Dexamethasone [Dexamethasone co-treated with Indomethacin] results in decreased expression of NOS1 proteinaffects cotreatment|decreases expression 18030227
D003907 Dexamethasone Dexamethasone results in decreased expression of NOS1 proteindecreases expression 18030227
C121718 dicyclanil dicyclanil results in increased expression of NOS1 mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in decreased expression of NOS1 mRNAdecreases expression 18042831
C056189 di-n-butyltin CALM1 protein inhibits the reaction [di-n-butyltin results in decreased activity of NOS1 protein]decreases activity|decreases reaction 15464999
C056189 di-n-butyltin di-n-butyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 15464999
C056189 di-n-butyltin di-n-butyltin results in decreased activity of NOS1 proteindecreases activity 15464999
C031291 diphenyliodonium diphenyliodonium inhibits the reaction [Paraquat promotes the reaction [NOS1 protein affects the secretion of Superoxides]]affects secretion|decreases reaction|increases reaction 11113575
D004280 Dobutamine NOS1 protein affects the susceptibility to Dobutamineaffects response to substance 16344403
D004533 Egtazic Acid Egtazic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of NOS1 protein alternative form]decreases reaction|increases expression 16791854
D004533 Egtazic Acid Egtazic Acid results in decreased expression of NOS1 protein alternative formdecreases expression 16791854
C074283 estradiol 3-benzoate [Progesterone co-treated with estradiol 3-benzoate] results in increased expression of NOS1 proteinaffects cotreatment|increases expression 15347845
D004958 Estradiol Estradiol affects the expression of NOS1 mRNAaffects expression 12810170
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of NOS1 geneincreases mutagenesis 16495775
D005839 Gentamicins DMD protein affects the reaction [Gentamicins results in increased expression of NOS1 protein]affects reaction|increases expression 14751810
D005839 Gentamicins Gentamicins results in increased expression of NOS1 proteinincreases expression 14751810
D005947 Glucose Glucose deficiency results in decreased expression of NOS1 proteindecreases expression 17855661
D005947 Glucose Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS1 protein]decreases expression|decreases reaction 17855661
D006861 Hydrogen Peroxide [NOS1 protein results in increased susceptibility to Trinitrotoluene] which results in increased abundance of Hydrogen Peroxideincreases abundance|increases response to substance 15223068
D016627 Oxidopamine N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of NOS1 protein]decreases reaction|increases expression 17855475
D016627 Oxidopamine Oxidopamine results in increased expression of NOS1 proteinincreases expression 17855475
D007052 Ibuprofen Ibuprofen affects the expression of NOS1 mRNAaffects expression 17070997
C056599 icariin icariin results in increased expression of NOS1 mRNAincreases expression 16281085
D007213 Indomethacin [Dexamethasone co-treated with Indomethacin] results in decreased expression of NOS1 proteinaffects cotreatment|decreases expression 18030227
D007608 Kainic Acid 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]decreases expression|decreases reaction 17585341
D007608 Kainic Acid Kainic Acid results in decreased expression of NOS1 proteindecreases expression 17585341
C063302 KN 62 KN 62 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C063302 KN 62 KN 62 inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C057416 KT 5720 KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17438462
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of NOS1 proteinincreases expression 17855475
D008070 Lipopolysaccharides N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS1 protein]decreases reaction|increases expression 17855475
C015329 lycopene lycopene results in decreased expression of NOS1 mRNAdecreases expression 16886892
D008345 Manganese Manganese results in decreased expression of NOS1 mRNAdecreases expression 16476481
C039798 manganese sulfate manganese sulfate results in decreased expression of NOS1 mRNAdecreases expression 16476481
C037500 mastoparan mastoparan results in decreased activity of NOS1 proteindecreases activity 17098364
D008550 Melatonin Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16948784
D008550 Melatonin Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16948784
D008550 Melatonin Melatonin results in decreased expression of NOS1 mRNAdecreases expression 16948784
D008555 Melitten Melitten results in decreased activity of NOS1 proteindecreases activity 17098364
C054938 methoctramine methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17395621
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NOS1 mRNAdecreases expression 16054768
D018817 N-Methyl-3,4-methylenedioxyamphetamine NOS1 protein results in increased susceptibility to N-Methyl-3,4-methylenedioxyamphetamineincreases response to substance 16054768
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS1 proteinincreases expression 17555550
D008799 Mevinphos KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17438462
D008799 Mevinphos methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17395621
D008799 Mevinphos Mevinphos results in increased expression of NOS1 proteinincreases expression 17438462
17395621
D008799 Mevinphos N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17438462
D008799 Mevinphos Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17395621
C516409 mono-n-butyltin CALM1 protein inhibits the reaction [mono-n-butyltin results in decreased activity of NOS1 protein]decreases activity|decreases reaction 15464999
C516409 mono-n-butyltin mono-n-butyltin binds to and results in decreased activity of NOS1 proteinaffects binding|decreases activity 17098364
C516409 mono-n-butyltin mono-n-butyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 15464999
17098364
C516409 mono-n-butyltin mono-n-butyltin results in decreased activity of NOS1 proteindecreases activity 15464999
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]affects binding|decreases reaction|increases activity 15245872
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17438462
C080418 N-(4-O-glycerol-3-methoxybenzyl)nonivamide N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS1 protein]decreases reaction|increases expression 17855475
C080418 N-(4-O-glycerol-3-methoxybenzyl)nonivamide N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of NOS1 protein]decreases reaction|increases expression 17855475
D009569 Nitric Oxide [Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]affects binding|increases chemical synthesis|increases reaction 17098364
D009569 Nitric Oxide [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxideincreases abundance|increases activity 16380457
D009569 Nitric Oxide NOS1 protein results in increased chemical synthesis of Nitric Oxideincreases chemical synthesis 17098364
D009569 Nitric Oxide [NOS1 protein results in increased reduction of Trinitrotoluene] which results in decreased chemical synthesis of Nitric Oxidedecreases chemical synthesis|increases reduction 15223068
D005996 Nitroglycerin acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]decreases reaction|increases expression 15154853
D005996 Nitroglycerin Nitroglycerin results in increased expression of NOS1 proteinincreases expression 15154853
14510930
D005996 Nitroglycerin Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]decreases reaction|increases expression 14510930
D009599 Nitroprusside Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS1 protein]decreases expression|decreases reaction 17855661
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of NOS1 mRNAaffects cotreatment|increases expression 18636392
C041786 palm oil palm oil results in decreased expression of NOS1 mRNAdecreases expression 18042831
D010269 Paraquat diphenyliodonium inhibits the reaction [Paraquat promotes the reaction [NOS1 protein affects the secretion of Superoxides]]affects secretion|decreases reaction|increases reaction 11113575
D010269 Paraquat Paraquat affects the activity of NOS1 proteinaffects activity 11113575
D010269 Paraquat Paraquat promotes the reaction [NOS1 protein affects the secretion of Superoxides]affects secretion|increases reaction 11113575
D019800 Phenol Phenol results in decreased expression of NOS1decreases expression 12160195
D019800 Phenol tempol inhibits the reaction [Phenol results in decreased expression of NOS1 mRNA]decreases expression|decreases reaction 16785328
D010936 Plant Extracts Plant Extracts inhibits the reaction [Copper results in increased expression of NOS1 mRNA]decreases reaction|increases expression 16962711
D010936 Plant Extracts Plant Extracts inhibits the reaction [Copper results in increased expression of NOS1 protein]decreases reaction|increases expression 16962711
D010936 Plant Extracts Plant Extracts results in decreased expression of NOS1 mRNAdecreases expression 16962711
D010936 Plant Extracts Plant Extracts results in decreased expression of NOS1 proteindecreases expression 16962711
D011374 Progesterone [Progesterone co-treated with estradiol 3-benzoate] results in increased expression of NOS1 proteinaffects cotreatment|increases expression 15347845
D026361 Reactive Nitrogen Species NOS1 protein affects the reaction [1,2,4-trimethylcyclohexane results in increased abundance of Reactive Nitrogen Species]affects reaction|increases abundance 11377403
D017382 Reactive Oxygen Species NOS1 protein affects the reaction [1,2,4-trimethylcyclohexane results in increased abundance of Reactive Oxygen Species]affects reaction|increases abundance 11377403
C116926 rofecoxib rofecoxib affects the expression of NOS1 mRNAaffects expression 17070997
C101426 sildenafil Curcumin promotes the reaction [sildenafil results in increased expression of NOS1 mRNA]increases expression|increases reaction 17627722
C101426 sildenafil [sildenafil co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNAaffects cotreatment|increases expression 17627722
C101426 sildenafil sildenafil results in increased expression of NOS1 mRNAincreases expression 17627722
C071262 SK&F 82958 SK&F 82958 results in decreased expression of NOS1 mRNAdecreases expression 11585554
C071262 SK&F 82958 SK&F 82958 results in increased expression of NOS1 mRNAincreases expression 11585554
C086717 S-methylthiocitrulline S-methylthiocitrulline results in decreased activity of NOS1 proteindecreases activity 12511180
C086717 S-methylthiocitrulline [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodiumaffects abundance|decreases activity 12511180
C086717 S-methylthiocitrulline S-methylthiocitrulline results in decreased activity of NOS1 proteindecreases activity 16380457
D012964 Sodium [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodiumaffects abundance|decreases activity 12511180
D012964 Sodium Sodium affects the expression of NOS1 mRNAaffects expression 12424424
D012964 Sodium Sodium results in increased expression of NOS1 proteinincreases expression 10894794
C017947 sodium arsenite sodium arsenite results in decreased expression of NOS1 proteindecreases expression 19409443
D018170 Sumatriptan Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]decreases reaction|increases expression 14510930
D013481 Superoxides diphenyliodonium inhibits the reaction [Paraquat promotes the reaction [NOS1 protein affects the secretion of Superoxides]]affects secretion|decreases reaction|increases reaction 11113575
D013481 Superoxides Paraquat promotes the reaction [NOS1 protein affects the secretion of Superoxides]affects secretion|increases reaction 11113575
D013629 Tamoxifen Tamoxifen binds to and results in decreased activity of NOS1 proteinaffects binding|decreases activity 17098364
D013629 Tamoxifen Tamoxifen inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 17098364
C001803 tempol tempol inhibits the reaction [Phenol results in decreased expression of NOS1 mRNA]decreases expression|decreases reaction 16785328
D013864 Thioglycolates NOS1 protein affects the susceptibility to Thioglycolatesaffects response to substance 10362674
C011559 tributyltin CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]decreases activity|decreases reaction 15464999
C011559 tributyltin tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 15464999
C011559 tributyltin tributyltin results in decreased activity of NOS1 proteindecreases activity 15464999
D014303 Trinitrotoluene Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene]increases reaction|increases reduction 15223068
D014303 Trinitrotoluene NOS1 protein results in increased reduction of Trinitrotolueneincreases reduction 15223068
D014303 Trinitrotoluene [NOS1 protein results in increased reduction of Trinitrotoluene] which results in decreased chemical synthesis of Nitric Oxidedecreases chemical synthesis|increases reduction 15223068
D014303 Trinitrotoluene [NOS1 protein results in increased susceptibility to Trinitrotoluene] which results in increased abundance of Hydrogen Peroxideincreases abundance|increases response to substance 15223068
D014303 Trinitrotoluene Trinitrotoluene results in decreased activity of NOS1 proteindecreases activity 15223068
D014303 Trinitrotoluene Trinitrotoluene results in increased expression of NOS1 mRNAincreases expression 15223068
C030665 triphenyltin CALM1 protein inhibits the reaction [triphenyltin results in decreased activity of NOS1 protein]decreases activity|decreases reaction 15464999
C030665 triphenyltin triphenyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 15464999
C030665 triphenyltin triphenyltin results in decreased activity of NOS1 proteindecreases activity 15464999
D014331 Tropicamide Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]decreases reaction|increases expression 17395621
C017967 W 7 W 7 binds to and results in decreased activity of NOS1 proteinaffects binding|decreases activity 17098364
C017967 W 7 W 7 inhibits the reaction [CALM1 protein binds to NOS1 protein]affects binding|decreases reaction 17098364
C063449 zileuton [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1decreases activity|decreases expression 11694324
C017803 zinc protoporphyrin [sildenafil co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNAaffects cotreatment|increases expression 17627722
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7214745880
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 3.407525203
MESH:D000152 Acne Vulgaris zileuton 4.9420436887
MESH:D058186 Acute Kidney Injury Gentamicins 10.6211274264
MESH:D058186 Acute Kidney Injury Ibuprofen 10.626375363
MESH:D058186 Acute Kidney Injury Superoxides 10.6218460982
MESH:D055371 Acute Lung Injury Chlorine 11.2420601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 11.2411850527 18653653
MESH:D055371 Acute Lung Injury zileuton 11.2417118201
MESH:D000210 Acute-Phase Reaction Thioglycolates 5.549464241
MESH:D000230 Adenocarcinoma Estradiol 5.5711473722
MESH:D000230 Adenocarcinoma Ibuprofen 5.5710697514
MESH:D000230 Adenocarcinoma Indomethacin 5.5716537180
MESH:D000236 Adenoma Ethylnitrosourea 8.456695378
MESH:D000236 Adenoma Indomethacin 8.4511497255
MESH:D000236 Adenoma Melatonin 8.4517195641
MESH:D018248 Adenoma, Liver Cell dicyclanil 4.2817162532
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.0816712894 17306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 2.9811874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.2617887948
MESH:D016301 Alveolar Bone Loss Indomethacin 4.5417225004
MESH:D000544 Alzheimer Disease Copper 18.1016886094 16962711 16410023 16325427 16866297 17119284
MESH:D000544 Alzheimer Disease Curcumin 18.1015590663
MESH:D000544 Alzheimer Disease Ibuprofen 18.1018351690
MESH:D000544 Alzheimer Disease icariin 18.1019782061 19858766
MESH:D000544 Alzheimer Disease Indomethacin 18.1015579461 17627676
MESH:D000544 Alzheimer Disease Nitric Oxide 18.1017556102
MESH:D000544 Alzheimer Disease Ozone 18.1015513908
MESH:D000544 Alzheimer Disease Plant Extracts 18.1016962711
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.7410694572
MESH:D000707 Anaphylaxis Ibuprofen 4.459532969
MESH:D018798 Anemia, Iron-Deficiency Copper 4.1616614410
MESH:D000756 Anemia, Sideroblastic Manganese 8.8216910769
MESH:D000756 Anemia, Sideroblastic Superoxides 8.8216910769
MESH:D000799 Angioedema Acetaminophen 3.0210982225
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 4.6015146954
MESH:D001014 Aortic Aneurysm Indomethacin 4.0710231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.0810388637
MESH:D001161 Arteriosclerosis Dietary Fats 3.1015238619
MESH:D018771 Arthralgia Indomethacin 4.342160914
MESH:D001169 Arthritis, Experimental Dexamethasone 9.3717659584
MESH:D001169 Arthritis, Experimental Plant Extracts 9.3714686799
MESH:D001169 Arthritis, Experimental rofecoxib 9.3716690336
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.8716807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.8711248219
MESH:D001172 Arthritis, Rheumatoid Ozone 5.8715570426
MESH:D001249 Asthma Ozone 4.3616373670 17854713
MESH:D001249 Asthma zileuton 4.3617944539 9620945 19214143 20332717 10181070 10764316 8598621
MESH:D001250 Asthma, Exercise-Induced zileuton 4.7810984370
MESH:D050197 Atherosclerosis Cadmium 5.2515687053
MESH:D050197 Atherosclerosis Curcumin 5.2518704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.0614699433
MESH:D001321 Autistic Disorder Acetaminophen 2.4118445737
MESH:D001321 Autistic Disorder Melatonin 2.4116897403 16919138
MESH:D001327 Autoimmune Diseases Curcumin 3.7019761891
MESH:D001477 Bartter Syndrome Indomethacin 4.1910684365
MESH:D001847 Bone Diseases icariin 5.5918295595
MESH:D001859 Bone Neoplasms Phenol 4.4510556009
MESH:D001913 Bowen's Disease Phenol 4.9319293009
MESH:D001927 Brain Diseases Ethylnitrosourea 4.1614991843
MESH:D001929 Brain Edema Indomethacin 10.1411481608
MESH:D001929 Brain Edema zileuton 10.1419309543
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.5117868700
MESH:D001930 Brain Injuries Nitroprusside 8.7914637104
MESH:D001930 Brain Injuries Progesterone 8.7915665606 15845082 15380490
MESH:D002545 Brain Ischemia beta Carotene 29.1016157235
MESH:D002545 Brain Ischemia Curcumin 29.1016770732
MESH:D002545 Brain Ischemia Ibuprofen 29.1015837124
MESH:D002545 Brain Ischemia icariin 29.1019303870
MESH:D002545 Brain Ischemia Indomethacin 29.1012524144
MESH:D002545 Brain Ischemia Plant Extracts 29.1016041641
MESH:D001932 Brain Neoplasms Copper 10.7517079463
MESH:D001932 Brain Neoplasms Curcumin 10.7517596214
MESH:D001932 Brain Neoplasms Ethylnitrosourea 10.7516651633 16436596 16357521 18412241 15144691
MESH:D001943 Breast Neoplasms Acrylamide 4.4916253758 18183576
MESH:D001943 Breast Neoplasms Copper 4.4915986119 17079463
MESH:D001943 Breast Neoplasms Curcumin 4.4919250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 4.4920435547
MESH:D001943 Breast Neoplasms Estradiol 4.4918497071 12948864 17018787 19861407 14630087 17261762 16675129 17289903
MESH:D001943 Breast Neoplasms Indomethacin 4.4917401462
MESH:D001943 Breast Neoplasms Nitric Oxide 4.4915631943
MESH:D001943 Breast Neoplasms Progesterone 4.4917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.4921138602 18984771 11161223 19059307 16202921 19289846 15565566 18425577 20390343 17440819 18629630 16818667 19189212 19244106 19189210 19487384 17261762 19066611 17893378 17049068 19115204 20065188 20135344 18821012 19155303 18997820 18815881 19103187 19084267 20005174 20544844 19200415 19288272 16273361 19011961 16873071 19410462 18351453 19142967 18855134 19221464 21152245 15668708 20859285 17242785
MESH:D016535 Bronchial Hyperreactivity Ozone 6.8019059883 18417511 18315731 15516495 14754758 17626835 16777450
MESH:D016535 Bronchial Hyperreactivity zileuton 6.8012794006 12388339 12654629
MESH:D002056 Burns Indomethacin 3.9110459503
MESH:D002057 Burns, Chemical Plant Extracts 4.519625245
MESH:D002100 Cachexia Ibuprofen 16.4715141370
MESH:D002100 Cachexia Indomethacin 16.4715141370 16537180 11239499 15625704
MESH:D002100 Cachexia Ozone 16.4716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 7.8215721981 16124888 10355542 3786805 15673190 16011737 16227642 16097048 15700767 16192424 16050911 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 7.8215700767
MESH:D002277 Carcinoma Curcumin 3.1818593918
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.183084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.1818788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 13.1817162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.1816924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.1816391822
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 13.1818834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.1817306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.1816924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 3.9211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.5414736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.6318414057
MESH:D002292 Carcinoma, Renal Cell Indomethacin 2.9317341418
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.7618462866
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 5.7615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.7618572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.9017572228
MESH:D006332 Cardiomegaly Copper 5.8617327471
MESH:D006332 Cardiomegaly Plant Extracts 5.8617645561
MESH:D009202 Cardiomyopathies sildenafil 4.5915811867
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 2.9216936243
MESH:D002386 Cataract Acetaminophen 5.7010977129
MESH:D002386 Cataract Trinitrotoluene 5.7014694615 15817613
MESH:D002418 Cattle Diseases Acrylamide 4.6312510666
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.8117332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.8118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 14.8116003739
MESH:D002471 Cell Transformation, Neoplastic manganese sulfate 14.818243401
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.8119524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.1617160924
MESH:D002764 Cholecystitis Indomethacin 4.3411181007
MESH:D002779 Cholestasis Nitric Oxide 3.8216919318
MESH:D003092 Colitis Curcumin 3.3918200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 3.8118809619
MESH:D003110 Colonic Neoplasms Curcumin 8.5719359593 16340194
MESH:D003110 Colonic Neoplasms Dexamethasone 8.5715824018
MESH:D003110 Colonic Neoplasms Indomethacin 8.5715936596 15786552 11260862 15963497 15625704 15637740
MESH:D003110 Colonic Neoplasms rofecoxib 8.5712902858
MESH:D003110 Colonic Neoplasms zileuton 8.5718927292
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 18059344 17054584
MESH:D000013 Congenital Abnormalities Trinitrotoluene 3.7015095906
MESH:D016510 Corneal Neovascularization Curcumin 4.1018497527
MESH:D018352 Coronavirus Infections Indomethacin 4.8917302372
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.9217728286
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 2.9215736158
MESH:D003490 Cyanosis Trinitrotoluene 4.1318551238
MESH:D003550 Cystic Fibrosis sildenafil 4.6819747007
MESH:D003665 Decompression Sickness zileuton 5.4018309904
MESH:D015140 Dementia, Vascular Nitric Oxide 5.1517556102
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5719031437
MESH:D003866 Depressive Disorder marker/mechanism 17854383
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.6812438553
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.4618403477
MESH:D003928 Diabetic Nephropathies Curcumin 15.7418204486
MESH:D003928 Diabetic Nephropathies Estradiol 15.7419279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 15.7419706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.7419279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.7017187935
MESH:D003967 Diarrhea Dexamethasone 5.757237001
MESH:D003967 Diarrhea Indomethacin 5.757907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5114725611 11743745 16781746 2444490 18071297 19164858 14550746 19923254 12705907 16393943 12540782 19085960 14986274 18713872 11529661 16485898 16081117 16177239 17522070 10774834 19739265 17562736 10915739 19420014 17906064 10663392 11834606 19370779 11421492 12594235 11287661 15619225 16109766 15968718 11461765 12392966 12958197 12153990 19416960 11739529 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5119336974 10915739 7179309 7120509 15027814 9327722 11566570 17522070 6623471 16227642 10092053 15968718 15998439 7440962 6884620 3732212 3786805 21278145 4309450 16177239 2869522 19085960
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.5117851650
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 8.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury zileuton 8.5117944539
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2719426721
MESH:D004362 Drug Toxicity Gentamicins 3.8111033412 15033597
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 10.5418450898 18446180 16133044
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 10.5416326151 12774134 17190690 16133044 18446180 18043480
MESH:D004381 Duodenal Ulcer Curcumin 6.8717351913
MESH:D004381 Duodenal Ulcer Indomethacin 6.8717202747 11991626 17045617 11595415 11595431 16699067 17151854 17351913 10671773 11535926 17329845
MESH:D050171 Dyslipidemias Dietary Fats 2.8318367378
MESH:D004417 Dyspnea Chlorine 3.8120016425
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.1618357618
MESH:D004485 Eczema Dexamethasone 3.6912438553
MESH:D004487 Edema bisindolylmaleimide I 14.118273558
MESH:D004487 Edema Dexamethasone 14.1119703484
MESH:D004487 Edema Indomethacin 14.118273558 16100529 19703484 8985016 7990266 7907874 10653021
MESH:D004487 Edema Plant Extracts 14.1112787963
MESH:D004487 Edema zileuton 14.117812673 9831321 8273558 11698051 7990266 19703484 17118201
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 6.6117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 6.6119031437
MESH:D016889 Endometrial Neoplasms Estradiol 5.4518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.4519155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Ibuprofen 16.1115652904
MESH:D004715 Endometriosis Indomethacin 16.1115652904
MESH:D004715 Endometriosis Progesterone 16.1116134523
MESH:D004715 Endometriosis rofecoxib 16.1115652904
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.8515268973
MESH:D019446 Endotoxemia Ibuprofen 18.5011545620
MESH:D019446 Endotoxemia Indomethacin 18.5018509659
MESH:D019446 Endotoxemia Lipopolysaccharides 18.5015821434 15328337 17637181
MESH:D019446 Endotoxemia zileuton 18.5015328337
MESH:D004751 Enteritis Indomethacin 3.9217763956 16328016 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.1917980183
MESH:D004802 Eosinophilia Indomethacin 6.8911298111
MESH:D004802 Eosinophilia zileuton 6.8910764316 8621850
MESH:D004827 Epilepsy Plant Extracts 3.2519700373 19439326
MESH:D007172 Erectile Dysfunction icariin 8.6116281085 15329286
MESH:D007172 Erectile Dysfunction sildenafil 8.6116368379
MESH:D004938 Esophageal Neoplasms Indomethacin 2.5511005569
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.9915959796 61145 16239168 16045604 12795759 12631006 17595544 19224547
MESH:D005234 Fatty Liver Curcumin 16.9919297423
MESH:D005234 Fatty Liver Dietary Fats 16.9919004024 19551842 17967931 18296743
MESH:D005234 Fatty Liver Plant Extracts 16.9915975614
MESH:D005234 Fatty Liver Tamoxifen 16.9919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6816709447
MESH:D005334 Fever Ibuprofen 11.2616997862
MESH:D005334 Fever Indomethacin 11.2617627676 11852909 10431976
MESH:D005334 Fever Lipopolysaccharides 11.269205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.3719069698
MESH:D005354 Fibrosarcoma Indomethacin 4.0810962813
MESH:D005355 Fibrosis Carbon Tetrachloride 14.8018705752
MESH:D005355 Fibrosis Curcumin 14.8018705752
MESH:D005355 Fibrosis Dietary Fats 14.8018296743
MESH:D005355 Fibrosis Indomethacin 14.8017994277
MESH:D005499 Folliculitis Indomethacin 4.3411298111
MESH:D005596 Fractures, Closed zileuton 5.0419544365
MESH:D005739 Gas Poisoning Chlorine 4.1920016425
MESH:D005756 Gastritis Acetaminophen 8.4116983495
MESH:D005756 Gastritis Indomethacin 8.4115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 3.9018462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.8716452187
MESH:D005909 Glioblastoma Curcumin 12.2917596214
MESH:D005909 Glioblastoma Ethylnitrosourea 12.2916436596
MESH:D005909 Glioblastoma Indomethacin 12.2912870263
MESH:D005909 Glioblastoma Manganese 12.2917043766
MESH:D005910 Glioma Ethylnitrosourea 5.1216651633 16357521 18412241
MESH:D005910 Glioma Indomethacin 5.1218371953 16487511
MESH:D005911 Gliosis Paraquat 4.3411124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.6111849393
MESH:D006073 Gout Indomethacin 4.5411248219
MESH:D006261 Headache Nitric Oxide 13.7211284996 11554966
MESH:D006261 Headache Nitroglycerin 13.7211554966 11284996
MESH:D006261 Headache Sumatriptan 13.7215240983
MESH:D006258 Head and Neck Neoplasms Curcumin 6.1118462866 18829502
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.1115482327
MESH:D034381 Hearing Loss Gentamicins 4.1819130971 15968427 17868369 18024279
MESH:D006333 Heart Failure Dobutamine 6.0917440445
MESH:D006333 Heart Failure Plant Extracts 6.0918097624
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.6616366002
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.8315633222
MESH:D006505 Hepatitis Carbon Tetrachloride 2.8319900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.9115135802
MESH:D006521 Hepatitis, Chronic Copper 4.4517338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.3817276780 17109627 19888908 16607473 17182432
MESH:D006529 Hepatomegaly Trinitrotoluene 6.8515817613
MESH:D006529 Hepatomegaly zileuton 6.858661344
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.2417701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.717520565
MESH:D006558 Herpes Genitalis Estradiol 4.2015709030
MESH:D006561 Herpes Simplex Plant Extracts 3.8310715843
MESH:D015658 HIV Infections beta Carotene 5.5816960176
MESH:D015658 HIV Infections Plant Extracts 5.5812878215
MESH:D006689 Hodgkin Disease sodium arsenite 2.4912676792
MESH:D019584 Hot Flashes Estradiol 7.6117088409
MESH:D019584 Hot Flashes Plant Extracts 7.6117454163 16566672 14716179
MESH:D012001 Hyperacusis Sumatriptan 6.2615240983
MESH:D006930 Hyperalgesia 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 9.5716870215
MESH:D006930 Hyperalgesia Acetaminophen 9.5716870215
MESH:D006930 Hyperalgesia Indomethacin 9.5712727271
MESH:D034321 Hyperamylasemia Indomethacin 4.8917883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.7216899240
MESH:D053565 Hypercalciuria Gentamicins 4.9017652376
MESH:D006937 Hypercholesterolemia Curcumin 6.8018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 6.8021332399
MESH:D006940 Hyperemia Indomethacin 10.0312524144
MESH:D006940 Hyperemia Nitric Oxide 10.0311156591
MESH:D006943 Hyperglycemia triphenyltin 4.9510522495
MESH:D020138 Hyperhomocysteinemia Plant Extracts 7.7016484555
MESH:D020138 Hyperhomocysteinemia Superoxides 7.7012615666
MESH:D006949 Hyperlipidemias Dietary Fats 11.2321332399
MESH:D006949 Hyperlipidemias Indomethacin 11.2317546600
MESH:D006949 Hyperlipidemias Plant Extracts 11.2315268973 15975614
MESH:D006973 Hypertension Dexamethasone 2.5717042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.3015338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 6.8215838368
MESH:D006976 Hypertension, Pulmonary zileuton 6.8214726295
MESH:D015228 Hypertriglyceridemia triphenyltin 5.2310522495
MESH:D006984 Hypertrophy Ibuprofen 4.2416672835
MESH:D007077 Ileal Diseases Indomethacin 4.2010574470 18306037
MESH:D007079 Ileitis Indomethacin 4.5416133968 10651667 10647630
MESH:D007235 Infant, Premature, Diseases Ibuprofen 11.4516133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 11.4516133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.2215869954
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 9.2219309543
MESH:D007246 Infertility triphenyltin 5.2515205045
MESH:D007247 Infertility, Female Acrylamide 4.4511020651
MESH:D007248 Infertility, Male Acrylamide 11.3315355880 11020651 15749267 12507653
MESH:D007248 Infertility, Male Paraquat 11.334850670
MESH:D007248 Infertility, Male sodium arsenite 11.3315346721 12646999
MESH:D007248 Infertility, Male Trinitrotoluene 11.3312150543
MESH:D007249 Inflammation bisindolylmaleimide I 30.478273558
MESH:D007249 Inflammation Curcumin 30.4716956363 17151092 18403477
MESH:D007249 Inflammation Dexamethasone 30.4711099482 8960868
MESH:D007249 Inflammation Dietary Fats 30.4720412841
MESH:D007249 Inflammation Ibuprofen 30.473291741
MESH:D007249 Inflammation Indomethacin 30.473291741 7812673 12568917
MESH:D007249 Inflammation Lipopolysaccharides 30.4717963957 12878042 17237260 9205823 17255318
MESH:D007249 Inflammation Plant Extracts 30.4716366677 12787963 19332304 15997105
MESH:D007249 Inflammation Progesterone 30.4715869954
MESH:D007249 Inflammation Tamoxifen 30.4719457130
MESH:D007249 Inflammation zileuton 30.4718059327 18309904 9831321 17118201 8960868 7812673 18295198 8621850
MESH:D015212 Inflammatory Bowel Diseases Curcumin 5.5318596194 18200517
MESH:D015212 Inflammatory Bowel Diseases zileuton 5.5315339030
MESH:D007333 Insulin Resistance Dietary Fats 5.4318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 5.4316627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 17.1415610444 17329856 10210152 18236018 11855677 17994277 11686837 11713966 15831440
MESH:D007410 Intestinal Diseases Nitric Oxide 17.1410210152 11713966 11574821
MESH:D007410 Intestinal Diseases rofecoxib 17.1415831440
MESH:D007410 Intestinal Diseases Superoxides 17.1410210152
MESH:D007414 Intestinal Neoplasms Curcumin 7.7210783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 7.7212628509 12351151 12584176
MESH:D007416 Intestinal Perforation marker/mechanism 18030227
MESH:D007417 Intestinal Polyps rofecoxib 4.6111245490
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.2819381132
MESH:D019586 Intracranial Hypertension Indomethacin 4.5415241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.8717255318
MESH:D007579 Jejunal Diseases Indomethacin 4.2016133968 18306037 10574470
MESH:D055623 Keratosis, Actinic Phenol 5.6219293009
MESH:D007673 Kidney Cortex Necrosis Gentamicins 4.9018842672
MESH:D007674 Kidney Diseases Acetaminophen 24.6112587719 15629191
MESH:D007674 Kidney Diseases Cadmium 24.6116322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 24.6116962696
MESH:D007674 Kidney Diseases Estradiol 24.6115618244
MESH:D007674 Kidney Diseases Gentamicins 24.6117934191 18289764 19349640
MESH:D007674 Kidney Diseases Indomethacin 24.6117190690
MESH:D007674 Kidney Diseases sodium arsenite 24.6120008137
MESH:D007674 Kidney Diseases tempol 24.6117640563
MESH:D007676 Kidney Failure, Chronic Copper 7.9516518626
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 7.9516518626
MESH:D007680 Kidney Neoplasms Estradiol 8.6315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.6317379185
MESH:D007680 Kidney Neoplasms Tamoxifen 8.6318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 9.3716316344
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 9.3711231351
MESH:D007859 Learning Disorders Copper 7.8517134702
MESH:D007859 Learning Disorders icariin 7.8519782061
MESH:D007889 Leiomyoma Curcumin 3.8118555241
MESH:D007896 Leishmaniasis Nitric Oxide 3.9617218153
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 6.6110219319
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 6.6110320625 12228301 11703811
MESH:D007938 Leukemia Curcumin 2.7818462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.4716106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 6.9316572323 10785260 15631656
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 6.9319823023 19503090
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.4618360721
MESH:D015458 Leukemia, T-Cell Curcumin 3.9916106398
MESH:D007964 Leukocytosis Indomethacin 4.5416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.8917980183
MESH:D007970 Leukopenia Lipopolysaccharides 3.8915821434
MESH:D008064 Lipidoses Tamoxifen 2.5415342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.8911479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.1321278145 17174718 16239168 16221502 17157831 11408273 17334410 16943688 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 8.1318296743
MESH:D008103 Liver Cirrhosis Plant Extracts 8.1317157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.4217761835 17640975 18054572 17721639 12649538 16011737 15730626 10355542 14512876 15996030 12546737 16116963 18277467 15123356 15925388 17565644 18472094 18251166 14716496 12609069 17869086 12958196 14748882 18376398 15650968 12445421 14620537 17976157 12898905 15362042 17481882 16027843 15893842 17900296 12666154 15057751 17698563 15052691 17557913 18156304 12632514 18279442 17805973 14716833 16136751 17714472 11481614 15959796 15338365 12586293 17708605 17525996 20821823 18705752 17922224 18205269 12445418 18263696 16638106 17631135 14724832 18317297 18006644 16192424 17823541 12632512 15370692 18395914 16248980 15876570 18210741 17944888 16015684 18187930 15931870 12667390 18472332 18420326 15673190 16097048 12389079 18166357 18395095 18429990 17766677 18339082 18418968 18481824 12741479 16033810 15818738 13678700 18412020
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 14.4218705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.4216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 14.4218194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 14.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 14.4215298665 16703270 15925388
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 14.4215479170
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 14.4217565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.4218564211
MESH:D008107 Liver Diseases Acetaminophen 6.9216610002 19014921 11587558 19460945 12587719 19784758 16611625 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.9215720792 16246199 17285989 16964402 15830285
MESH:D008107 Liver Diseases Curcumin 6.9216956363
MESH:D008107 Liver Diseases Plant Extracts 6.9217034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.3715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.0217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.0214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.8319294768
MESH:D008113 Liver Neoplasms Copper 12.8320302851
MESH:D008113 Liver Neoplasms dicyclanil 12.8320118626
MESH:D008113 Liver Neoplasms Plant Extracts 12.8319168119
MESH:D008113 Liver Neoplasms sodium arsenite 12.8315276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 12.8316684651
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 4.5917113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.5915583823 12014681
MESH:D008133 Long QT Syndrome Dobutamine 4.1019353679
MESH:D008171 Lung Diseases Dobutamine 9.1116638327
MESH:D008171 Lung Diseases Ozone 9.118266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 9.1119095001
MESH:D055370 Lung Injury Lipopolysaccharides 10.8121114838
MESH:D055370 Lung Injury Nitric Oxide 10.8111395602
MESH:D055370 Lung Injury Ozone 10.8120417186
MESH:D008175 Lung Neoplasms beta Carotene 14.1416401635
MESH:D008175 Lung Neoplasms Curcumin 14.1416243823 18462866 19359593
MESH:D008175 Lung Neoplasms Dexamethasone 14.1411195469 15824018
MESH:D008175 Lung Neoplasms Ethylnitrosourea 14.146695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Indomethacin 14.1411497255 11053908 16537180
MESH:D008175 Lung Neoplasms Melatonin 14.1417195641
MESH:D008175 Lung Neoplasms Ozone 14.147614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 14.1420869020
MESH:D008175 Lung Neoplasms sodium arsenite 14.1417306315 17077188 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 14.1418625569
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 3.6216373423
MESH:D008223 Lymphoma Curcumin 9.2518462866
MESH:D008223 Lymphoma Ethylnitrosourea 9.2515790496
MESH:D008223 Lymphoma Nitric Oxide 9.2516166326
MESH:D016399 Lymphoma, T-Cell Curcumin 9.1116173963
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 9.1115375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.9619428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.1817203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 16.1815375486
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 16.1810838139 18041768 10767621
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 16.1810697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.1817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.1819196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 17.6419453300
MESH:D020149 Manganese Poisoning Manganese 17.6416568477 19453300 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 17.6419453300
MESH:D008545 Melanoma Curcumin 7.4118462866 17885582
MESH:D008545 Melanoma Glucose 7.4114993021
MESH:D008545 Melanoma Reactive Oxygen Species 7.4117992120
MESH:D008545 Melanoma sodium arsenite 7.4119082730 16487513
MESH:D008545 Melanoma Tamoxifen 7.4112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7819513568
MESH:D008569 Memory Disorders Curcumin 7.6017263510
MESH:D008569 Memory Disorders icariin 7.6019782061
MESH:D008579 Meningioma Ethylnitrosourea 5.1617943659
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.0717268249 17109627
MESH:D008679 Metaplasia Ozone 4.2810496685
MESH:D008708 Methemoglobinemia Nitroglycerin 3.993537620
MESH:D008881 Migraine Disorders Indomethacin 9.4511903285
MESH:D008881 Migraine Disorders Nitric Oxide 9.4511701602
MESH:D008881 Migraine Disorders Sumatriptan 9.4515240983 15689192
MESH:D020326 Migraine without Aura Nitric Oxide 8.5911304026 14659530
MESH:D020326 Migraine without Aura Nitroglycerin 8.5914659530
MESH:D009041 Motion Sickness Dextroamphetamine 4.701613127
MESH:D009062 Mouth Neoplasms Indomethacin 3.3412636206
MESH:D009069 Movement Disorders Manganese 4.2516551646
MESH:D009101 Multiple Myeloma Curcumin 5.5419372569
MESH:D009101 Multiple Myeloma Dexamethasone 5.5415744524 15867202 16118317
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.1117962980
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.4518694830
MESH:D015878 Mydriasis Tropicamide 6.5316308726
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.029809623
MESH:D009203 Myocardial Infarction Nitroglycerin 3.3814729435
MESH:D017202 Myocardial Ischemia Dobutamine 4.3612447174
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.6316810080
MESH:D009298 Nasal Polyps zileuton 5.4010665187
MESH:D009325 Nausea Sumatriptan 5.7115240983
MESH:D009336 Necrosis Melatonin 8.5912195237
MESH:D009336 Necrosis Trinitrotoluene 8.5918551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.6018495463
MESH:D009362 Neoplasm Metastasis Indomethacin 4.5811053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1819410462
MESH:D009369 Neoplasms beta Carotene 5.9017051425
MESH:D009369 Neoplasms lycopene 5.9017051425
MESH:D009369 Neoplasms sodium arsenite 5.9011559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 10.8716707424
MESH:D009374 Neoplasms, Experimental Indomethacin 10.8715625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.8720056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.1112497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.1119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Copper 7.6717308104
MESH:D009389 Neovascularization, Pathologic Estradiol 7.6717289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.176375363
MESH:D009410 Nerve Degeneration Acrylamide 14.7711264303 12387366 12387367
MESH:D009410 Nerve Degeneration Ibuprofen 14.7710961664
MESH:D009410 Nerve Degeneration Manganese 14.7716551646
MESH:D009410 Nerve Degeneration Paraquat 14.7716893418
MESH:D009422 Nervous System Diseases Acrylamide 4.2912507653 12164553
MESH:D009421 Nervous System Malformations Estradiol 2.8811399458 16427766
MESH:D009423 Nervous System Neoplasms Curcumin 4.8018462866
MESH:D009436 Neural Tube Defects sodium arsenite 2.5712854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.6016003739 16651423 17160924
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3917168769
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 14.6812349958
MESH:D019636 Neurodegenerative Diseases Acetaminophen 14.6818514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 14.6812349958
MESH:D019636 Neurodegenerative Diseases Oxidopamine 14.6818514411
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4.6516725203
MESH:D009765 Obesity Curcumin 5.8919297423
MESH:D009765 Obesity Dietary Fats 5.8921332399 20132043 17217161 20518802 18674790 16723640 19632207 11836018 18457598
MESH:D009765 Obesity Plant Extracts 5.8919056576 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.346374098
MESH:D009784 Occupational Diseases Trinitrotoluene 3.6217852074 14694615 12819281
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.1617160924
MESH:D010003 Osteoarthritis Ibuprofen 9.637009135
MESH:D010003 Osteoarthritis Indomethacin 9.637009135
MESH:D010003 Osteoarthritis rofecoxib 9.6316690336
MESH:D010024 Osteoporosis Calcium 8.9517882678
MESH:D010024 Osteoporosis Curcumin 8.9518719352
MESH:D010024 Osteoporosis icariin 8.9519747809 18236786
MESH:D010051 Ovarian Neoplasms Curcumin 8.4318462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 8.4319401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.4316525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.4317306315 15276417
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 21.6918987195
MESH:D010146 Pain 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 21.6916870215
MESH:D010146 Pain Acetaminophen 21.6916870215
MESH:D010146 Pain Ibuprofen 21.693291741
MESH:D010146 Pain Indomethacin 21.6917440234 3291741 17627676 13679232
MESH:D010146 Pain Phenol 21.6917610455
MESH:D010146 Pain zileuton 21.6915935457
MESH:D010149 Pain, Postoperative Ibuprofen 14.1816678543
MESH:D010149 Pain, Postoperative Indomethacin 14.1812538197 18702446
MESH:D010149 Pain, Postoperative rofecoxib 14.1816678543 18165598
MESH:D010190 Pancreatic Neoplasms Curcumin 6.7517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Ibuprofen 6.7512384795
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 6.7515580305
MESH:D010195 Pancreatitis Indomethacin 3.1915028970 17883296
MESH:D010212 Papilloma Hydrogen Peroxide 7.0812065085
MESH:D010212 Papilloma Plant Extracts 7.0816517061 15173996
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.8916537180
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.7611181820 15451049 16140633
MESH:D010300 Parkinson Disease Manganese 6.7611181820
MESH:D010300 Parkinson Disease Paraquat 6.7612911755 15824117 15451049 16140633 11445065 11181820 11124998 16510128
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 8.7615893579 11771942
MESH:D010302 Parkinson Disease, Secondary Paraquat 8.7616190885
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 20.8712349958
MESH:D020734 Parkinsonian Disorders Indomethacin 20.8712349958
MESH:D020734 Parkinsonian Disorders Manganese 20.8716140633
MESH:D020734 Parkinsonian Disorders Melatonin 20.8715574749
MESH:D020734 Parkinsonian Disorders Tropicamide 20.8717594079
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.8911903285
MESH:D010392 Pemphigus Phenol 5.6216522979 17163923
MESH:D010437 Peptic Ulcer Indomethacin 4.3411148446
MESH:D010518 Periodontitis Indomethacin 4.0917225004
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.3411510240
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.5715687053
MESH:D010538 Peritonitis Melatonin 17.7815707874
MESH:D010538 Peritonitis Ozone 17.7816369182
MESH:D010538 Peritonitis Thioglycolates 17.7819804847 18628355 15707874 16751407 11985352 19180231 19641140
MESH:D010538 Peritonitis zileuton 17.7817371808
MESH:D020795 Photophobia Sumatriptan 6.2615240983
MESH:D010864 Pilonidal Sinus Phenol 5.6215622588 19655223
MESH:D011014 Pneumonia Lipopolysaccharides 13.9212224865 11605937
MESH:D011014 Pneumonia Ozone 13.9218929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 13.9212504350
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.5318573544
MESH:D011041 Poisoning Phenol 3.988825745
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0321297632
MESH:D047928 Premature Birth Indomethacin 4.3317000239
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.1520887781
MESH:D011471 Prostatic Neoplasms Cadmium 2.4717075824
MESH:D011471 Prostatic Neoplasms Copper 2.4717308104 17079463
MESH:D011471 Prostatic Neoplasms Curcumin 2.4710851300 18769126 15129424 18156803 11398177 18226269 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.4716740699
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.4717409433
MESH:D011471 Prostatic Neoplasms lycopene 2.4715084515 17337101
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.4717804756 14666653
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4715067354
MESH:D011507 Proteinuria Gentamicins 11.4115033597
MESH:D011507 Proteinuria Ibuprofen 11.416375363
MESH:D011507 Proteinuria Indomethacin 11.4111849393
MESH:D011537 Pruritus zileuton 4.3419657356 17827870
MESH:D011654 Pulmonary Edema zileuton 4.6018309904
MESH:D011656 Pulmonary Emphysema Curcumin 3.8019168576
MESH:D011658 Pulmonary Fibrosis Paraquat 2.5416324872 17997886
OMIM:179010 PYLORIC STENOSIS, INFANTILE HYPERTROPHIC 1 marker/mechanism
MESH:D051437 Renal Insufficiency Gentamicins 4.2117132701 15728788
MESH:D015427 Reperfusion Injury Superoxides 6.1318460982
MESH:D015427 Reperfusion Injury zileuton 6.139865762 15266012
MESH:D012120 Respiration Disorders Chlorine 4.3918579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 10.9218379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 10.9218379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 10.9211700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.1510835634
MESH:D012135 Respiratory Sounds Paraquat 3.2711874814
MESH:D012162 Retinal Degeneration Paraquat 3.2316458197
MESH:D012173 Retinitis Gentamicins 5.4518644591
MESH:D012220 Rhinitis zileuton 4.1320332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4918045962
MESH:D012509 Sarcoma Curcumin 3.4018462866
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 4.679673227
MESH:D012559 Schizophrenia marker/mechanism 18923069
MESH:D012559 Schizophrenia Copper 2.9516842975
MESH:D012640 Seizures Kainic Acid 4.9519414003 14637104 18657176 1641125 10686065 16336964 17827730 19186208 15686955
MESH:D012640 Seizures Trinitrotoluene 4.9518551238
MESH:D018805 Sepsis Curcumin 3.3918389075
MESH:D012852 Sinusitis zileuton 4.7110665187
MESH:D012878 Skin Neoplasms Glucose 9.8914993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.8912065085
MESH:D012878 Skin Neoplasms Plant Extracts 9.8915173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 9.8918572023 19524636
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.0519118273
MESH:D012893 Sleep Disorders Kainic Acid 8.9319414003
MESH:D012893 Sleep Disorders Melatonin 8.9316919138 18182647 16897403
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 5.8118078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 4.4418078449
MESH:D013088 Spermatocele Phenol 9.4518646496
MESH:D013088 Spermatocele Tamoxifen 9.4516709447
MESH:D013119 Spinal Cord Injuries Progesterone 13.9716503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 13.9719457130
MESH:D013119 Spinal Cord Injuries zileuton 13.9718059327
MESH:D016135 Spinal Dysraphism sodium arsenite 3.1412854658
MESH:D013163 Splenomegaly Trinitrotoluene 4.4115817613
MESH:D013272 Stomach Diseases beta Carotene 17.7817638125
MESH:D013272 Stomach Diseases Dexamethasone 17.7815472012
MESH:D013272 Stomach Diseases Indomethacin 17.7815038085 10486359 10192188 10215738 18209964 17160473 16184426 15472012 18545984 17207306 16280098 17638125 16113693
MESH:D013272 Stomach Diseases sildenafil 17.7816113693
MESH:D013274 Stomach Neoplasms Indomethacin 2.3715609394
MESH:D013276 Stomach Ulcer beta Carotene 22.8312500499
MESH:D013276 Stomach Ulcer Curcumin 22.8316631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 22.8315138204
MESH:D013276 Stomach Ulcer Indomethacin 22.8317918041 16169175 18543354 17977527 12077510 11595431 16252198 16934674 10423059 10878458 16397915 17895592 11906479 14567935 16755016 18193104 17627676 18299717 10750652 18181030 15104355 11523592 16150113 16631530 12500499 11595415 1323529 15255614 11145282 18087811 18431645 12787963 15138204 18237397 17135157 12498302 12467913 18726076 18209962 17654042 17657623 11729361
MESH:D013276 Stomach Ulcer Melatonin 22.8311523592 12500499 16150113
MESH:D013276 Stomach Ulcer Nitric Oxide 22.8315138204
MESH:D013276 Stomach Ulcer Plant Extracts 22.8312787963 17135157 18193104 18237397 15255614
MESH:D013610 Tachycardia Nitroprusside 4.8415306635
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.6517997062
MESH:D013733 Testicular Diseases Acrylamide 4.4315864552
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.4515821434
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.3515790496
MESH:D013964 Thyroid Neoplasms Indomethacin 2.9618791128 11352223 14736730
MESH:D013978 Tibial Fractures Estradiol 3.8619048282
MESH:D016171 Torsades de Pointes Dobutamine 4.5519353679
MESH:D014202 Tremor Tropicamide 5.3819467297 17594079
MESH:D014277 Trigeminal Neuralgia Phenol 5.6216527771 10223447
MESH:D014456 Ulcer Indomethacin 4.0810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Curcumin 6.0418593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 6.0416712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 6.0417572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 4.4518462866
MESH:D014581 Urticaria Acetaminophen 2.2410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.0511813266
MESH:D014605 Uveitis Dexamethasone 3.991336536
MESH:D014652 Vascular Diseases sodium arsenite 3.6117056641
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.3819057314
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 3.9618097624
MESH:D020257 Ventricular Remodeling marker/mechanism 16344403
MESH:D020257 Ventricular Remodeling Plant Extracts 4.5018097624
MESH:D015837 Vestibular Diseases Gentamicins 4.7418776599
MESH:D014839 Vomiting Indomethacin 3.9211897121
MESH:D014860 Warts Phenol 5.2719122958
MESH:D015430 Weight Gain Dietary Fats 3.0416723640
MESH:D014947 Wounds and Injuries Plant Extracts 3.5820213670 19894650
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:00330 Arginine and proline metabolism
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
KEGG:04730 Long-term depression
KEGG:01100 Metabolic pathways
KEGG:04145 Phagosome
KEGG:04970 Salivary secretion
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA252
    • No data
    No data
    Releated drug ID Related drug Name
    PA449412doxorubicin
    PA164743471adenosine triphosphate
    PA452229antidepressants
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00155 - L-Citrulline Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB01821 - L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
    DB01942 - Formic Acid Antibacterial Agents
    DB01997 - 3-Bromo-7-Nitroindazole
    DB02027 - N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
    DB02044 - N-(3-(Aminomethyl)Benzyl)Acetamidine Enzyme Inhibitors
    DB02077 - L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
    DB02143 - N-Isopropyl-N'-Hydroxyguanidine
    DB02644 - N-Omega-Propyl-L-Arginine
    DB02692 - (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
    DB02727 - N-Butyl-N'-Hydroxyguanidine
    DB02944 - Alpha-D-Mannose
    DB02991 - S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
    DB03014 - Heme
    DB03144 - N-Omega-Hydroxy-L-Arginine
    DB03147 - Flavin-Adenine Dinucleotide
    DB03247 - Riboflavin Monophosphate Vitamin B Complex
    DB03449 - N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03707 - S-Ethyl-N-Phenyl-Isothiourea
    DB03710 - N5-(1-Imino-3-Butenyl)-L-Ornithine
    DB03892 - 5-N-Allyl-Arginine
    DB04184 - Acetate Ion Indicators and Reagents
    DB04223 - Nitroarginine Enzyme Inhibitors
    DB08018 - N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
    DB08019 - N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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