Gene Symbol:	NOS3 ( ECNOS,eNOS )
Gene Full Name:	nitric oxide synthase 3 (endothelial cell)
Band:	7q36.1
Quick Links	Entrez ID:4846; OMIM: 163729; Uniprot ID:NOS3_HUMAN; ENSEMBL ID: ENSG00000164867; HGNC ID: 7876
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
PWY-4983	citrulline-nitric oxide cycle
PWY-5004	superpathway of citrulline metabolism

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa00330	Arginine and proline metabolism
hsa01100	Metabolic pathways
hsa04370	VEGF signaling pathway

Pathway ID	Pathway Name
200151	VEGFR1 specific signals
200069	Thromboxane A2 receptor signaling
200066	Angiopoietin receptor Tie2-mediated signaling
200161	Signaling events mediated by VEGFR1 and VEGFR2
200044	Validated transcriptional targets of AP1 family members Fra1 and Fra2
200029	Plasma membrane estrogen receptor signaling

Pathway ID	Pathway Name
P00056	VEGF signaling pathway
P00019	Endothelin signaling pathway
P00005	Angiogenesis
P00048	PI3 kinase pathway
P00036	Interleukin signaling pathway

Pathway ID	Pathway Name
KEGG:00330	Arginine and proline metabolism
KEGG:04020	Calcium signaling pathway
REACT:604	Hemostasis
KEGG:01100	Metabolic pathways
REACT:12508	Metabolism of nitric oxide
KEGG:04370	VEGF signaling pathway

Releated disease ID	Related disease Name
PA445398	Pre-Eclampsia
PA447054	Stroke
PA443886	Diabetes Mellitus
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma
PA443324	Amenorrhea
PA443560	Breast Neoplasms
PA446852	Hot Flashes
PA445850	Thrombosis
PA443635	Cardiovascular Diseases
PA443796	Coronary Artery Disease
PA443797	Coronary Disease
PA444370	Heart Failure
PA443672	Ischemic Attack, Transient
PA444368	Heart Diseases
PA445062	Neoplasms
PA447268	tardive dyskinesia
PA443450	Asthma
PA446892	Hyperhomocysteinemia
PA444552	Hypertension
PA444606	Erectile Dysfunction
PA445019	Myocardial Infarction
PA443362	Angina Pectoris
PA165108364	Gestational hypertension
PA165108401	Acute coronary syndrome
PA444367	Heart Defects, Congenital
PA446286	Spina Bifida Cystica
PA443736	Cleft Lip

Releated drug ID	Related drug Name
PA449899	hydrochlorothiazide
PA164712308	Ace Inhibitors, Plain
PA449773	glucose
PA164778686	pyruvic acid
PA452200	antithrombotic agents
PA133950441	hmg coa reductase inhibitors
PA450877	perindopril
PA449456	enalapril
PA448976	choline
PA448547	beclomethasone
PA448681	budesonide
PA164781399	ciclesonide
PA164776996	desonide
PA449247	dexamethasone
PA449661	flunisolide
PA449686	fluticasone propionate
PA452347	glucocorticoids
PA449905	hydrocortisone
PA164754818	betamethasone
PA450466	methylprednisolone
PA450541	mometasone
PA164777035	paramethasone
PA451096	prednisolone
PA451100	prednisone
PA164752251	rimexolone
PA451749	triamcinolone
PA164744376	adenosine monophosphate
PA448478	l-arginine
PA164747225	l-citrulline
PA450635	nitric oxide
PA164743471	adenosine triphosphate
PA449509	estrogens
PA452604	xenobiotics
PA448500	atorvastatin
PA134308647	rosuvastatin
PA451581	tamoxifen
PA449688	fluvastatin
PA450428	methotrexate
PA452233	antipsychotics
PA451346	sildenafil
PA450635	nitric oxide
PA448031	acetylcholine
PA450644	nitroglycerin
PA450935	phenylephrine
PA452363	prostaglandins
PA164712600	Cardiovascular System
PA161990676	tetrahydrobiopterin
PA164712445	Antihypertensives
PA151249535	diuretics
PA449894	hydralazine
PA164712898	Methyldopa
PA450631	nifedipine
PA449165	cyclophosphamide
PA449412	doxorubicin
PA128406956	fluorouracil
PA449692	folic acid

Drugbank ID	Action	Drug Name	Description
DB00125	-	L-Arginine	Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
DB00155	-	L-Citrulline	Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB00360	cofactor	Tetrahydrobiopterin	Dietary supplement;Cofactor
DB01110	antagonist	Miconazole	Antifungal Agents
DB01686	-	N,N-dimethylarginine	Enzyme Inhibitors
DB01821	-	L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01833	-	L-2-Amino-4-(Guanidinooxy)Butyric Acid
DB01997	-	3-Bromo-7-Nitroindazole
DB02027	-	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044	-	N-(3-(Aminomethyl)Benzyl)Acetamidine	Enzyme Inhibitors
DB02048	-	1,2,4-Triazole-Carboxamidine
DB02077	-	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02141	-	S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB02207	-	7-Nitroindazole	Anti-anxiety Agents;Anticonvulsants;Analgesics;Enzyme Inhibitors;Neuroprotective Agents
DB02234	-	Ethylisothiourea	Vasoconstrictor Agents;Hypnotics and Sedatives;Enzyme Inhibitors
DB02335	-	2-Aminothiazoline
DB02589	-	Se-Ethyl-Isoselenourea
DB02692	-	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02911	-	2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
DB02979	-	N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
DB02994	-	Hydroxydimethylarsine Oxide
DB03014	-	Heme
DB03065	-	7-Nitroindazole-2-Carboxamidine
DB03100	-	6-Nitroindazole
DB03144	-	N-Omega-Hydroxy-L-Arginine
DB03305	-	N5-Iminoethyl-L-Ornithine	Enzyme Inhibitors
DB03332	-	5,6-Cyclic-Tetrahydropteridine
DB03684	-	2-Methyl-2,4-Pentanediol
DB03707	-	S-Ethyl-N-Phenyl-Isothiourea
DB03910	-	S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB03918	-	6s-5,6,7,8-Tetrahydrobiopterin
DB03963	-	S-(Dimethylarsenic)Cysteine
DB03974	-	L-Homoarginine
DB04018	-	S-Isopropyl-Isothiourea
DB04184	-	Acetate Ion	Indicators and Reagents
DB04223	-	Nitroarginine	Enzyme Inhibitors
DB04399	-	Cacodylate Ion	Herbicides
DB04402	-	2-Propanol, Isopropanol	Solvents
DB04534	-	5-Nitroindazole
DB04559	-	N-(Chlorophenyl)-N'-Hydroxyguanidine
DB07001	-	(3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
DB07244	-	5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
DB07388	-	ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB08018	-	N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019	-	N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine

Desease Name
HEMATOLOGICAL
polycystic kidney disease
Chronic renal failure
nitric oxide activity
Pseudomonas aeruginosa infection
endothelial function
ovarian cancer
Vasculitis
bipolar disorder
diabetic nephropathy
Acute Coronary Syndrome
giant cell arteritis
cardiopulmonary disease
vulvar cancer
cardiovascular disease
restenosis
Atrial Fibrillation
sickle cell anemia
AGING
Atherosclerosis
NORMALVARIATION
Skin Diseases
hypertension, cirrhotic portal
atherosclerosis, coronary
C-reactive protein
blood pressure, arterial
bone density fracture risk
renal disease
colorectal cancer
CARDIOVASCULAR
Coronary Artery Disease
myocardial infarct
diabetes, type 1
enhanced vascular responsiveness to phenylephrine
endometriosis
homocystinuria
Gram-Positive Bacterial Infections
allergy asthma
blood pressure, arterial hypertension
cholesterol, LDL

Desease Name
Coronary artery spasm 1, susceptibility to
Placental abruption
Hypertension, susceptibility to
Ischemic stroke, susceptibility to
Hypertension, pregnancy-induced
Alzheimer disease, late-onset, susceptibility to

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C032405	11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1	11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]	decreases expression\|decreases reaction	10525081
C032405	11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1	11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 results in increased expression of NOS3 mRNA	increases expression	10525081
C034008	11-deoxyprostaglandin E1	11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]	decreases expression\|decreases reaction	10525081
C040168	19-oxo-11-deoxycorticosterone acetate	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein	affects cotreatment\|decreases expression	18823320
C040168	19-oxo-11-deoxycorticosterone acetate	atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of NOS3 protein]	affects cotreatment\|decreases expression\|decreases reaction	18823320
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NOS3 mRNA	increases expression	19933214
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in decreased expression of NOS3 mRNA	decreases expression	19426978
C028358	24,25-epoxycholesterol	24,25-epoxycholesterol results in decreased expression of NOS3 mRNA	decreases expression	19426978
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]	decreases reaction\|increases phosphorylation	19906781
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GW0742 results in increased phosphorylation of NOS3 protein]	decreases reaction\|increases phosphorylation	19906781
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased expression of NOS3 mRNA	decreases expression	19426978
C076996	27-hydroxycholesterol	27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]	decreases reaction\|increases expression	17873880
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of NOS3 mRNA	decreases expression	17873880
C076996	27-hydroxycholesterol	ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]	affects reaction\|decreases expression	17873880
C076996	27-hydroxycholesterol	ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]	affects reaction\|decreases expression	17873880
C437043	2-butylamino-2-demethoxy-hypocrellin B	2-butylamino-2-demethoxy-hypocrellin B results in increased activity of NOS3 protein	increases activity	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 mRNA	increases expression	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 protein	increases expression	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 mRNA]	decreases reaction\|increases expression	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 protein]	decreases reaction\|increases expression	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	Sodium Azide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 mRNA]	decreases reaction\|increases expression	17045927
C437043	2-butylamino-2-demethoxy-hypocrellin B	Sodium Azide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 protein]	decreases reaction\|increases expression	17045927
C528575	2-ethyl-2-thiopseudourea	2-ethyl-2-thiopseudourea results in decreased expression of NOS3 mRNA	decreases expression	18192589
C528575	2-ethyl-2-thiopseudourea	2-ethyl-2-thiopseudourea results in decreased expression of NOS3 protein	decreases expression	18192589
C528575	2-ethyl-2-thiopseudourea	[2-ethyl-2-thiopseudourea results in decreased expression of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide	decreases chemical synthesis\|decreases expression	18192589
C079391	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 mRNA]	decreases reaction\|increases expression	17045927
C079391	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [2-butylamino-2-demethoxy-hypocrellin B results in increased expression of NOS3 protein]	decreases reaction\|increases expression	17045927
C506282	3,5-dimethoxy-4'-hydroxystilbene	[3,5-dimethoxy-4'-hydroxystilbene co-treated with Quercetin] results in increased expression of NOS3 mRNA	affects cotreatment\|increases expression	17135264
C506282	3,5-dimethoxy-4'-hydroxystilbene	3,5-dimethoxy-4'-hydroxystilbene results in increased expression of NOS3 mRNA	increases expression	17135264
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3]	decreases expression\|decreases reaction	16891912
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]	decreases reaction\|increases phosphorylation	19906781
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein	increases phosphorylation	19906781
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	GSK0660 inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]	decreases reaction\|increases phosphorylation	19906781
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	PPARD protein promotes the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]	increases phosphorylation\|increases reaction	19906781
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]	decreases activity\|decreases reaction	16225752
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]	decreases reaction\|increases expression	16225752
C032171	4-coumaric acid	4-coumaric acid results in increased expression of NOS3 mRNA	increases expression	15740983
C085754	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]	decreases reaction\|increases expression	15477225
D000082	Acetaminophen	Acetaminophen affects the expression of NOS3 mRNA	affects expression	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of NOS3 mRNA	decreases expression	16172162

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms		Tamoxifen	3.35	14745880
MESH:D000014	Abnormalities, Drug-Induced		Capsaicin	11.01	18926900
MESH:D000014	Abnormalities, Drug-Induced		Ethanol	11.01	18926900 17676605
MESH:D000014	Abnormalities, Drug-Induced		Tetrachlorodibenzodioxin	11.01	11752688 14514962 15322242
MESH:D000014	Abnormalities, Drug-Induced		Trinitrotoluene	11.01	7525203
MESH:D000038	Abscess		Drugs, Chinese Herbal	5.11	15043669
MESH:D000138	Acidosis		Ammonium Chloride	16.02	18287403
MESH:D000138	Acidosis		Ethanol	16.02	11192467
MESH:D000138	Acidosis		Hydrochloric Acid	16.02	11574821 20872349 15920416 19262391 16144966 12771618
MESH:D000138	Acidosis		Lactic Acid	16.02	20872349 18406487
MESH:D000141	Acidosis, Renal Tubular		Hydrochloric Acid	4.61	17183249
MESH:D000142	Acidosis, Respiratory		Hydrochloric Acid	4.61	20597076
MESH:D000152	Acne Vulgaris		Ethinyl Estradiol	2.75	17505938
MESH:D058186	Acute Kidney Injury		Capsaicin	19.62	18460982
MESH:D058186	Acute Kidney Injury		Desoxycorticosterone	19.62	19564549
MESH:D058186	Acute Kidney Injury		Gentamicins	19.62	11274264
MESH:D058186	Acute Kidney Injury		Ibuprofen	19.62	6375363
MESH:D058186	Acute Kidney Injury		resveratrol	19.62	16538975
MESH:D058186	Acute Kidney Injury		Superoxides	19.62	18460982
MESH:D055371	Acute Lung Injury		Hydrochloric Acid	17.00	19060228 15970105 19760209 16759491 11850527 11953099 19094174
MESH:D055371	Acute Lung Injury		Lipopolysaccharides	17.00	11850527 18653653
MESH:D055371	Acute Lung Injury		Oxygen	17.00	16759491
MESH:D055371	Acute Lung Injury		Particulate Matter	17.00	12396868
MESH:D055371	Acute Lung Injury		pirinixic acid	17.00	18653653
MESH:D000210	Acute-Phase Reaction		Thioglycolates	5.17	9464241
MESH:D000230	Adenocarcinoma	marker/mechanism			21472143
MESH:D000230	Adenocarcinoma		arsenic trioxide	21.20	11798837 19825857
MESH:D000230	Adenocarcinoma		daidzein	21.20	11473722
MESH:D000230	Adenocarcinoma		Dimethylnitrosamine	21.20	16033868
MESH:D000230	Adenocarcinoma		Doxorubicin	21.20	17418594
MESH:D000230	Adenocarcinoma		Estradiol	21.20	11473722
MESH:D000230	Adenocarcinoma		Ethinyl Estradiol	21.20	14692618
MESH:D000230	Adenocarcinoma		Genistein	21.20	11473722
MESH:D000230	Adenocarcinoma		Ibuprofen	21.20	10697514
MESH:D000230	Adenocarcinoma		Indomethacin	21.20	16537180
MESH:D000230	Adenocarcinoma		Urethane	21.20	18316556
MESH:D002282	Adenocarcinoma, Bronchiolo-Alveolar		Urethane	4.51	15814487
MESH:D000236	Adenoma		2-Acetylaminofluorene	12.21	10737359
MESH:D000236	Adenoma		Dimethylnitrosamine	12.21	19555203
MESH:D000236	Adenoma		Indomethacin	12.21	11497255

AutismKB 2.0

Annotation Detail for NOS3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics