AutismKB 2.0

Annotation Detail for CNOT3


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Basic Information Top
Gene Symbol:CNOT3 ( KIAA0691,LENG2,NOT3,NOT3H )
Gene Full Name: CCR4-NOT transcription complex, subunit 3
Band: 19q13.42
Quick LinksEntrez ID:4849; OMIM: 604910; Uniprot ID:CNOT3_HUMAN; ENSEMBL ID: ENSG00000088038; HGNC ID: 7879
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of CNOT3 mRNAaffects expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CNOT3 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CNOT3 mRNAdecreases expression 20018196
D008727 Methotrexate CNOT3 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C030110 oxaliplatin oxaliplatin results in increased expression of CNOT3 mRNAincreases expression 17762391
D010634 Phenobarbital Phenobarbital results in decreased expression of CNOT3 mRNAdecreases expression 19270015
C004648 testosterone enanthate testosterone enanthate affects the expression of CNOT3 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 10.1612039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.166195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1517286800
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms Methotrexate 2.3816978400
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.123581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.126705139 20007298 20935162 1701930 17173139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.267505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3519486331 9022650
MESH:D003110 Colonic Neoplasms oxaliplatin 3.2116004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9417401013 17255274 17695437 18448328 18509181 17594712
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.669562676 12039119
MESH:D003550 Cystic Fibrosis Methotrexate 4.5019747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.152524372 18759878 14531868 12868966 8970840 11906362 11298694 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003882 Dermatomyositis Methotrexate 5.4520191521
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0218289764 7440962 9653073 8291058 11289319 16192314 6482804 9328219 18648102 1440618 18692083 9022650 6679447
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.533581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5316530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006086 Graft vs Host Disease Methotrexate 5.5116518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1917440010
MESH:D006930 Hyperalgesia oxaliplatin 4.5717418472
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D007805 Language Development Disorders Methotrexate 5.419562676
MESH:D008103 Liver Cirrhosis Methotrexate 7.4214986274
MESH:D008103 Liver Cirrhosis Phenobarbital 7.4221047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8421137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 4.8419073162 21047994 15975961 8742319 19812893 19482888
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.496587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4917172636 1399818 2563599 6150874 18308698
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4618516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720135361 20064080 6695378 20869020 18520028 18816296 20464547 18569708 17053015
MESH:D008223 Lymphoma Methotrexate 4.1417352296
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D052016 Mucositis Methotrexate 5.6817488658
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Methotrexate 3.5117410198
MESH:D051437 Renal Insufficiency Methotrexate 5.0717352296
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures Phenobarbital 2.8711442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013576 Syndactyly Methotrexate 5.369562676
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.857505956 3712494 6587162 6582329 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.851399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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