AutismKB 2.0

Annotation Detail for NOTCH1


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Basic Information Top
Gene Symbol:NOTCH1 ( TAN1,hN1 )
Gene Full Name: notch 1
Band: 9q34.3
Quick LinksEntrez ID:4851; OMIM: 190198; Uniprot ID:NOTC1_HUMAN; ENSEMBL ID: ENSG00000148400; HGNC ID: 7881
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway
hsa05020Prion diseases
Pathway IDPathway Name
Gene Expression
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
200196Notch-mediated HES/HEY network
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00045Notch signaling pathway
Pathway IDPathway Name
500520Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
500112Maturation of Notch precursor via proteolytic cleavage
500111Transport of Notch receptor precursor to golgi
500110Signaling by Notch
500117NICD trafficks to nucleus
500116A third proteolytic cleavage releases NICD
500115Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
500113Mature Notch receptor trafficks to plasma membrane
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00002Acute lymphoblastic leukemia (ALL) (Precursor T lymphoblastic leukemia)
No data
Desease Name
CANCER
leukemia
No data
Desease Name
Leukemia, T-cell acute lymphoblastic
Aortic valve disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of NOTCH1 mRNAaffects expression 18343893
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 proteindecreases activity 20348013
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine [2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of ACTA2 proteinaffects expression|decreases activity 20348013
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine [2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of CDH1 proteinaffects expression|decreases activity 20348013
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine [2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of MMP2 proteinaffects expression|decreases activity 20348013
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine [2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of MMP9 proteinaffects expression|decreases activity 20348013
C028145 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine [2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of SNAI1 proteinaffects expression|decreases activity 20348013
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NOTCH1 mRNAincreases expression 18042819
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOTCH1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of NOTCH1 protein modified formdecreases expression 18633435
C015001 arsenite tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]decreases expression|decreases reaction 18633435
C006680 baicalein baicalein results in increased activity of NOTCH1 proteinincreases activity 19160421
C006680 baicalein baicalein results in increased expression of NOTCH1 mRNAincreases expression 19160421
C038044 baicalin baicalin results in increased activity of NOTCH1 proteinincreases activity 19160421
C038044 baicalin baicalin results in increased expression of NOTCH1 mRNAincreases expression 19160421
D002101 Cacodylic Acid Cacodylic Acid affects the expression of NOTCH1 mRNAaffects expression 17720352
D002392 Catechin Catechin results in increased expression of NOTCH1 mRNAincreases expression 15465739
D003474 Curcumin [Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 proteinaffects cotreatment|decreases expression 18640131
D003474 Curcumin Curcumin results in decreased expression of NOTCH1 mRNAdecreases expression 17927689
D003474 Curcumin Curcumin results in decreased expression of NOTCH1 proteindecreases expression 18640131
D003474 Curcumin Curcumin results in decreased expression of NOTCH1decreases expression 18462866
D016047 Zalcitabine Zalcitabine results in increased mutagenesis of NOTCH1 geneincreases mutagenesis 18798262
C014347 decitabine [decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNAaffects cotreatment|decreases expression 17185465
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NOTCH1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NOTCH1 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol promotes the reaction [NOTCH1 protein binds to CCND1 promoter]affects binding|increases reaction 19838210
D004958 Estradiol Estradiol affects the expression of NOTCH1 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NOTCH1 mRNAdecreases expression 17557909
D007529 Isoflavones [Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 proteinaffects cotreatment|decreases expression 18640131
D007529 Isoflavones Isoflavones results in decreased expression of NOTCH1 proteindecreases expression 18640131
D009534 Niclosamide Niclosamide results in decreased activity of NOTCH1 proteindecreases activity 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified formdecreases expression 18633435
C030110 oxaliplatin NOTCH1 protein affects the susceptibility to oxaliplatinaffects response to substance 19147571
C030110 oxaliplatin oxaliplatin results in increased expression of NOTCH1 protein modified formincreases expression 19147571
C030110 oxaliplatin Sulfonamides inhibits the reaction [oxaliplatin results in increased expression of NOTCH1 protein modified form]decreases reaction|increases expression 19147571
C006253 pirinixic acid pirinixic acid results in increased expression of NOTCH1 mRNAincreases expression 18301758
C059514 resveratrol resveratrol results in decreased expression of NOTCH1 proteindecreases expression 17868649
C009166 retinol acetate retinol acetate results in increased expression of NOTCH1 mRNAincreases expression 16772331
C017947 sodium arsenite sodium arsenite affects the expression of NOTCH1 mRNAaffects expression 20056578
C017947 sodium arsenite sodium arsenite results in increased expression of NOTCH1 mRNAincreases expression 17879257
D013449 Sulfonamides Sulfonamides inhibits the reaction [oxaliplatin results in increased expression of NOTCH1 protein modified form]decreases reaction|increases expression 19147571
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NOTCH1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of NOTCH1 mRNA]decreases reaction|increases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNAdecreases expression 17586704
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNAincreases expression 16611356
15800033
18796159
16960034
15328365
19684285
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNAaffects cotreatment|decreases expression 17185465
C030665 triphenyltin triphenyltin results in decreased expression of NOTCH1 mRNAdecreases expression 12788061
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]decreases expression|decreases reaction 18633435
C101044 tyrphostin AG 1478 tyrphostin AG 1478 results in increased expression of NOTCH1 protein modified formincreases expression 18633435
C025643 vinclozolin vinclozolin affects the expression of NOTCH1 mRNAaffects expression 19015723
D002762 Cholecalciferol Cholecalciferol results in increased expression of NOTCH1 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6016538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Estradiol 3.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9714692618
MESH:D000236 Adenoma Diethylnitrosamine 6.3410737359 6695378
MESH:D000236 Adenoma resveratrol 6.3415688382
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 22.6116628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6119061943 18056438 19052882 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6216712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8017887948
MESH:D000505 Alopecia Isoflavones 4.5017569567
MESH:D000544 Alzheimer Disease Curcumin 4.2215590663
MESH:D000544 Alzheimer Disease resveratrol 4.2216183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4219015723
OMIM:109730 AORTIC VALVE DISEASE marker/mechanism
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7915885639
MESH:D001169 Arthritis, Experimental resveratrol 6.7917115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6716807698
MESH:D050197 Atherosclerosis Curcumin 6.3718704882
MESH:D050197 Atherosclerosis resveratrol 6.3716873680 17967414
MESH:D001327 Autoimmune Diseases Cholecalciferol 10.1816142846
MESH:D001327 Autoimmune Diseases Curcumin 10.1819761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D002545 Brain Ischemia Curcumin 9.3916770732
MESH:D002545 Brain Ischemia resveratrol 9.3917600658
MESH:D001932 Brain Neoplasms Curcumin 3.7017596214
MESH:D001943 Breast Neoplasms Cacodylic Acid 3.5817474063
MESH:D001943 Breast Neoplasms Curcumin 3.5819250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms decitabine 3.5818320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5817474063
MESH:D001943 Breast Neoplasms Estradiol 3.5812948864 18497071 17289903 19861407 14630087 16675129 17261762 17018787
MESH:D001943 Breast Neoplasms resveratrol 3.5817651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5820435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.6712794006
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002277 Carcinoma Curcumin 7.5618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.2119208518 20432363 18788625 19418558 17162532 16779866 19052882 19519916 17138121 19701751 20512989 16288022 20514400 18691550 17055752 16681979 16328049 20084675 16540662 19335982 16830150 19394651 19919837 19822196 18494052 3581430 16878318 18056438 19171122 18978308 19383236 18971187 20214788 20524982 20101231 16807293 19107877 18506893 18210153 17173139 16935385 20007298 10672840 18785209 18393292 11831363 17978847 10737359 16569478 17428255 20727157 20935162 3084413 18665156 16502159 21159647 16698587 17761372 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2116924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.2119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.2115276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8818414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.1418462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.1419215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.1416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.1418572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 16120746 18670907
MESH:D009202 Cardiomyopathies Zalcitabine 4.5310591146
MESH:D002318 Cardiovascular Diseases Isoflavones 7.1917689850
MESH:D002318 Cardiovascular Diseases resveratrol 7.1915458977
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.1117174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.1118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.1119524636 20056578
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 14.8716628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.8719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.8716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0617333356 16919318 17110522 15861022 11677210 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 7.0619176532
MESH:D016770 Ciliophora Infections Niclosamide 5.4512113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 15668235 16354765 15340226 8697196
MESH:D003092 Colitis Curcumin 8.8918200517 16804969 16782535
MESH:D003092 Colitis resveratrol 8.8916474422
MESH:D003103 Coloboma Curcumin 4.3018809619
MESH:D003110 Colonic Neoplasms marker/mechanism 19147571
MESH:D003110 Colonic Neoplasms arsenite 10.5215037631
MESH:D003110 Colonic Neoplasms Curcumin 10.5216340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 10.5217616700
MESH:D003110 Colonic Neoplasms oxaliplatin 10.5216024531 16004971 16510598
MESH:D003110 Colonic Neoplasms resveratrol 10.5216338953
MESH:D015179 Colorectal Neoplasms decitabine 4.6818981723
MESH:D015179 Colorectal Neoplasms Isoflavones 4.6817116718
MESH:D015179 Colorectal Neoplasms oxaliplatin 4.6817401013 18509181 17695437 17255274 17594712 18448328
MESH:D015179 Colorectal Neoplasms resveratrol 4.6816550006
MESH:D000013 Congenital Abnormalities marker/mechanism 17849441
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6218497527
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D019465 Craniofacial Abnormalities marker/mechanism 17849441
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 2.8317686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8315322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.0714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.7018403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.7518204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.7519279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.7516286809
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.4519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8711462148
MESH:D004362 Drug Toxicity Zalcitabine 7.877515130
MESH:D004381 Duodenal Ulcer Curcumin 3.7817351913
MESH:D004487 Edema pirinixic acid 10.0012083418
MESH:D004487 Edema resveratrol 10.008985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0011000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 11.4717686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.4715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.2417872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.0819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.0819294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.8011473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver arsenite 27.4818296743
MESH:D005234 Fatty Liver Curcumin 27.4819297423
MESH:D005234 Fatty Liver Diethylnitrosamine 27.4821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.4815345470
MESH:D005234 Fatty Liver pirinixic acid 27.4820131406 19236843
MESH:D005234 Fatty Liver Zalcitabine 27.4818299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005355 Fibrosis arsenite 24.9118296743
MESH:D005355 Fibrosis baicalein 24.9119474275
MESH:D005355 Fibrosis baicalin 24.9119474275
MESH:D005355 Fibrosis Curcumin 24.9118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.9120067830
MESH:D005393 Fish Diseases Niclosamide 5.4112113305
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4218462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005909 Glioblastoma baicalein 11.2319804834
MESH:D005909 Glioblastoma Curcumin 11.2317596214
MESH:D005909 Glioblastoma trichostatin A 11.2318801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.3818829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 7.3819215824
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 10.6111294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.6120471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006529 Hepatomegaly pirinixic acid 7.3519176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3515340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7717701891
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006561 Herpes Simplex resveratrol 3.9016876885
MESH:D015658 HIV Infections Zalcitabine 4.1917457083
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Estradiol 9.4817088409
MESH:D019584 Hot Flashes Isoflavones 9.4817290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7616354765 16959395 8697196 15340226 18606429
MESH:D006930 Hyperalgesia oxaliplatin 4.1417418472
MESH:D006937 Hypercholesterolemia Curcumin 8.5618704882
MESH:D006937 Hypercholesterolemia resveratrol 8.5617188708
MESH:D006943 Hyperglycemia pirinixic acid 9.0420558911
MESH:D006943 Hyperglycemia triphenyltin 9.0410522495
MESH:D020138 Hyperhomocysteinemia Catechin 4.7417292331
MESH:D006949 Hyperlipidemias resveratrol 3.7716873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D015228 Hypertriglyceridemia triphenyltin 5.7110522495
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3717600658
MESH:D007246 Infertility triphenyltin 5.7615205045
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male decitabine 14.5317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.5317937319
MESH:D007248 Infertility, Male sodium arsenite 14.5312646999 15346721
MESH:D007248 Infertility, Male vinclozolin 14.5316467254
MESH:D007249 Inflammation Curcumin 10.7818403477 17151092 16956363
MESH:D007249 Inflammation Diethylnitrosamine 10.7818785209
MESH:D007249 Inflammation resveratrol 10.7816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7812878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018596194 18200517
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007333 Insulin Resistance Estradiol 6.5916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.5916306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.9810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007674 Kidney Diseases Estradiol 5.5715618244
MESH:D007674 Kidney Diseases sodium arsenite 5.5720008137
MESH:D007680 Kidney Neoplasms Estradiol 2.7615610895
MESH:D007889 Leiomyoma Curcumin 4.3118555241
MESH:D007938 Leukemia Curcumin 6.1418462866
MESH:D007938 Leukemia decitabine 6.1419235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9616106398
MESH:D007951 Leukemia, Myeloid decitabine 3.7519117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0918206229 17679729 18704418 18460780 19387464 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.0918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4016087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.5016106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D008103 Liver Cirrhosis arsenite 6.3218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3219638242 20032147 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental baicalin 6.3718187930
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.3718006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3712878042
MESH:D008107 Liver Diseases Curcumin 6.4516956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4517034775
MESH:D008107 Liver Diseases Sulfonamides 6.4514986274
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.0719090486 18648771 21278145 12771043 20405173 12112319 20492335 20101389 19499222 20583210 10737359 18644402 19638242 15885732 19073162 15175105 19551842 18754104 2862719 19850985 21047994 19254457 21071580 20434301 21167192 20452335 16942905 19255062 2422723 19690152 19427195 20137499 20501860 19812893 9163691 18977376 19833225 19996281 19642983 19294768 19256749 20118626 18978307 19426721
MESH:D008113 Liver Neoplasms pirinixic acid 13.0720007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 13.0719812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 13.0715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.0716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.1918093689 19009564 16842330 18775883 2563599 17854601 19004024 18079962 9362446 19539802 17942915 21159647 3124819 18544905 18308698 16267830 19519916 18282651 18253720 19126423 17174075 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1912151625
MESH:D008171 Lung Diseases sodium arsenite 2.9919095001
MESH:D008175 Lung Neoplasms arsenite 6.2116809336
MESH:D008175 Lung Neoplasms Curcumin 6.2118462866 19359593 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 6.2116712894 17306315 17077188 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2119555203 11884234
MESH:D008223 Lymphoma marker/mechanism 18798262
MESH:D008223 Lymphoma Curcumin 11.6718462866
MESH:D008223 Lymphoma decitabine 11.6719470736
MESH:D008223 Lymphoma Zalcitabine 11.6711980663 17941976 9488045 18798262 9205081 8840982 8764131
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4216173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9715688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5617203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.5611606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.2019453300
MESH:D008545 Melanoma Curcumin 9.2417885582 18462866
MESH:D008545 Melanoma decitabine 9.2417785578 16505122
MESH:D008545 Melanoma resveratrol 9.2417992120
MESH:D008545 Melanoma sodium arsenite 9.2419082730 16487513
MESH:D008545 Melanoma trichostatin A 9.2416505122
MESH:D008569 Memory Disorders Curcumin 3.8917263510
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D009101 Multiple Myeloma Curcumin 15.7219372569
MESH:D009101 Multiple Myeloma decitabine 15.7218172295
MESH:D009101 Multiple Myeloma resveratrol 15.7217049120 17935668 16490592 14749477 16267019 17164350
MESH:D009101 Multiple Myeloma trichostatin A 15.7218172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.4817962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.4817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2219157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 5.3519151258
MESH:D009203 Myocardial Infarction resveratrol 5.3517188708 16456233 16525036 17125593 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.2817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5516411023
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.463581430 9029167
MESH:D009369 Neoplasms decitabine 7.4719470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 7.4717405874
MESH:D009369 Neoplasms sodium arsenite 7.4711559025
MESH:D009374 Neoplasms, Experimental resveratrol 13.918985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.9120056578
MESH:D009374 Neoplasms, Experimental Zalcitabine 13.918764131 9205081 9488045
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2512497104
MESH:D009389 Neovascularization, Pathologic arsenite 9.2215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.2217289903
MESH:D009421 Nervous System Malformations Estradiol 8.5816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5814600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3518462866
MESH:D009437 Neuralgia Zalcitabine 6.0417292584
MESH:D009436 Neural Tube Defects sodium arsenite 2.9612854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7820387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.7817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D009765 Obesity Curcumin 4.3619297423
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D010024 Osteoporosis Curcumin 7.1018719352
MESH:D010024 Osteoporosis Isoflavones 7.1016562857
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0017513867
MESH:D010051 Ovarian Neoplasms Curcumin 14.0219020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 14.0219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.0219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.0217306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 14.0219331143
MESH:D010190 Pancreatic Neoplasms Curcumin 11.5517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 11.5519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.5516540662
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.5519294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 5.0418606552
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.322563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 14.6616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.6611222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.6619015723 18042343 18220299
MESH:D055728 Primary Myelofibrosis decitabine 11.5117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.5117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6320887781
MESH:D011471 Prostatic Neoplasms baicalin 2.3915714805
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.3917024972
MESH:D011471 Prostatic Neoplasms Curcumin 2.3911398177 15129424 18226269 12497104 18156803 18769126 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.3916740699
MESH:D011471 Prostatic Neoplasms Isoflavones 2.3916365062 17571952 17219775 17374662
MESH:D011471 Prostatic Neoplasms resveratrol 2.3915767336 17636462 17804756 17718901 17675339 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3916039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.3919789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.2819168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1119058328
MESH:D015427 Reperfusion Injury resveratrol 6.1116317513 16314181 17520802 17058453 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7710666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1419155313
MESH:D012509 Sarcoma Curcumin 3.8818462866
MESH:D012600 Scoliosis marker/mechanism 17849441
MESH:D012640 Seizures Sulfonamides 4.6420420384
MESH:D018805 Sepsis Curcumin 3.8518389075
MESH:D012878 Skin Neoplasms resveratrol 8.7115837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 8.7118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms decitabine 2.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4618456281
MESH:D013276 Stomach Ulcer Curcumin 3.2616631530 19188055
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms decitabine 6.5917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.597505956
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms resveratrol 3.9716227395
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 11.1115537745
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.1118593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.1119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.1116712894 17306315 11723127 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.9818462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.7617473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6114692618
MESH:D014594 Uterine Neoplasms resveratrol 8.6117044934
MESH:D014604 Uveal Neoplasms decitabine 4.6317785578
MESH:D014652 Vascular Diseases sodium arsenite 4.1417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
Pathway ID Pathway Name
KEGG:04320 Dorso-ventral axis formation
REACT:71 Gene Expression
KEGG:04330 Notch signaling pathway
KEGG:05020 Prion diseases
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31683
    • Releated gene ID Related gene Name
    PA31683NOTCH1
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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