AutismKB 2.0

Annotation Detail for NPY


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Basic Information Top
Gene Symbol:NPY ( PYY4 )
Gene Full Name: neuropeptide Y
Band: 7p15.3
Quick LinksEntrez ID:4852; OMIM: 162640; Uniprot ID:NPY_HUMAN; ENSEMBL ID: ENSG00000122585; HGNC ID: 7955
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
cholesterol
cholesterol, HDL
body mass leptin obesity, localized
diabetes, type 2 ghrelin insulin
atherosclerosis, coronary
CARDIOVASCULAR
diabetes, type 1
atherosclerosis, carotid
CHEMDEPENDENCY
cholesterol, LDL
alcohol withdrawal
blood pressure
PSYCH
PHARMACOGENOMIC
lipids
alcoholism
body mass
bone density
nephropathy in other diseases
birth weight and serum triglyceride concentration
glucose tolerance
vascular disease
hypertension
lipoprotein, LDL
alcohol abuse
Edema rosiglitazone or pioglitazone
alcohol dependence
schizophrenia
METABOLIC
triglycerides
obesity
insulin
cholesterol, total
coronary heart disease
progression of carotid atherosclerosis blood pressure and serum lipids
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NPY mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of NPY mRNAdecreases expression 19497417
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of NPY proteindecreases expression 19497417
D000661 Amphetamine NPY protein results in decreased susceptibility to Amphetaminedecreases response to substance 12183048
D000661 Amphetamine Amphetamine affects the expression of NPY proteinaffects expression 16896163
D000661 Amphetamine Amphetamine results in decreased expression of NPY mRNAdecreases expression 16896163
16101753
16084549
15680483
D000661 Amphetamine Amphetamine results in decreased expression of NPY proteindecreases expression 15680483
12005258
D000661 Amphetamine Amphetamine results in increased expression of NPY mRNAincreases expression 15183010
D000661 Amphetamine FOS protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]decreases expression|increases reaction 16084549
D000661 Amphetamine JUN protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]decreases expression|increases reaction 16084549
D000661 Amphetamine NPY protein affects the susceptibility to Amphetamineaffects response to substance 16101753
D000661 Amphetamine NPY protein results in increased susceptibility to Amphetamineincreases response to substance 12005258
D000661 Amphetamine PRKCA protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]decreases expression|increases reaction 16101753
D001218 Aspartame Aspartame results in decreased expression of NPY proteindecreases expression 11890951
C074212 bis(maltolato)oxovanadium(IV) bis(maltolato)oxovanadium(IV) results in increased expression of NPY mRNAincreases expression 11398143
C006780 bisphenol A bisphenol A results in increased expression of NPY mRNAincreases expression 18180321
D002211 Capsaicin Capsaicin inhibits the reaction [NPY protein affects the susceptibility to Potassium]affects response to substance|decreases reaction 18055875
D002217 Carbachol NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]decreases reaction|increases secretion 3329090
D003024 Clozapine Clozapine results in decreased expression of NPY mRNAdecreases expression 16516965
D003345 Corticosterone Corticosterone results in decreased expression of NPY mRNAdecreases expression 15755911
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNAaffects cotreatment|increases expression 18606552
D003847 Deoxyglucose Deoxyglucose results in increased expression of NPY mRNAincreases expression 10683841
D019422 Dietary Sucrose Dietary Sucrose results in decreased expression of NPY mRNAdecreases expression 18627777
D000431 Ethanol Ethanol results in decreased expression of NPY mRNAdecreases expression 11095510
D005632 Fructose Fructose results in decreased expression of NPY mRNAdecreases expression 18627777
D005947 Glucose Glucose deficiency results in increased expression of NPY mRNAincreases expression 11177238
D005947 Glucose Glucose results in decreased expression of NPY mRNAdecreases expression 18627777
D005947 Glucose Glucose results in decreased expression of NPY proteindecreases expression 16210367
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNAaffects cotreatment|increases expression 18606552
D006220 Haloperidol Haloperidol results in decreased expression of NPY mRNAdecreases expression 16516965
D016627 Oxidopamine Oxidopamine results in increased expression of NPY mRNAincreases expression 15303306
D007649 Ketamine NPY protein results in increased susceptibility to Ketamineincreases response to substance 11454027
D008094 Lithium Lithium results in increased expression of NPY mRNAincreases expression 17572454
D008094 Lithium Lithium results in increased expression of NPY proteinincreases expression 17572454
D008713 Methimazole Methimazole results in decreased expression of NPY mRNAdecreases expression 17403546
D008713 Methimazole Methimazole results in increased expression of NPY mRNAincreases expression 17403546
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPY mRNAdecreases expression 19285098
D009020 Morphine Morphine results in increased expression of NPY mRNAincreases expression 20144693
C076029 olanzapine olanzapine results in decreased expression of NPY mRNAdecreases expression 16516965
D010126 Ozone Ozone results in increased expression of NPY mRNAincreases expression 16716893
C076213 PD 142893 PD 142893 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]decreases reaction|decreases secretion 12234805
D010424 Pentobarbital NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]affects reaction|increases response to substance 11454027
D010424 Pentobarbital NPY protein results in increased susceptibility to Pentobarbitalincreases response to substance 11454027
C494474 perchlorate perchlorate results in decreased expression of NPY mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in increased expression of NPY mRNAincreases expression 17403546
D010615 Phenacetin Phenacetin results in increased expression of NPY mRNAincreases expression 17082564
D010656 Phenylephrine NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]affects reaction|increases phosphorylation|increases reaction 10660688
D010656 Phenylephrine NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]affects reaction|increases phosphorylation|increases reaction 10660688
D010656 Phenylephrine NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]increases phosphorylation|increases reaction 10660688
D010656 Phenylephrine NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]increases phosphorylation|increases reaction 10660688
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY proteinaffects cotreatment|decreases expression 11499749
D010656 Phenylephrine Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]decreases reaction|increases phosphorylation|increases reaction 10660688
D010656 Phenylephrine Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]decreases reaction|increases phosphorylation|increases reaction 10660688
C030299 phenylhydrazine phenylhydrazine results in increased expression of NPY mRNAincreases expression 17082564
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of NPY mRNAdecreases expression 17684035
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of NPY proteindecreases expression 17684035
C006253 pirinixic acid pirinixic acid results in decreased expression of NPY mRNAdecreases expression 17426115
D011188 Potassium NPY protein inhibits the reaction [CALCA protein affects the susceptibility to Potassium]affects response to substance|decreases reaction 18055875
D011188 Potassium Capsaicin inhibits the reaction [NPY protein affects the susceptibility to Potassium]affects response to substance|decreases reaction 18055875
D011188 Potassium NPY protein inhibits the reaction [CALCA protein affects the susceptibility to Potassium]affects response to substance|decreases reaction 18055875
D011188 Potassium NPY protein results in increased susceptibility to Potassiumincreases response to substance 18055875
D011374 Progesterone Progesterone results in increased expression of NPY mRNAincreases expression 18070364
D011441 Propylthiouracil Propylthiouracil results in decreased expression of NPY mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in increased expression of NPY mRNAincreases expression 17403546
D019257 Quinpirole NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]affects cotreatment|decreases response to substance 12183048
C087120 RES 701-1 RES 701-1 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]decreases reaction|decreases secretion 12234805
D013311 Streptozocin INS protein inhibits the reaction [Streptozocin results in increased expression of NPY mRNA]decreases reaction|increases expression 20219977
D013311 Streptozocin Streptozocin results in increased expression of NPY mRNAincreases expression 20219977
D013549 Sweetening Agents Sweetening Agents results in decreased expression of NPY mRNAdecreases expression 18627777
D013726 Terbutaline NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]decreases reaction|increases secretion 3329090
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NPY mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NPY mRNAaffects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NPY mRNAincreases expression 15093705
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]decreases reaction|increases phosphorylation|increases reaction 10660688
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]decreases reaction|increases phosphorylation|increases reaction 10660688
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]affects cotreatment|decreases response to substance 12183048
C052342 topiramate topiramate results in increased expression of NPY proteinincreases expression 17572454
C062527 tribromoethanol NPY protein results in increased susceptibility to tribromoethanolincreases response to substance 11454027
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of NPY mRNAincreases expression 11294500
D020888 Vigabatrin Vigabatrin results in increased expression of NPY mRNAincreases expression 16194568
D020888 Vigabatrin Vigabatrin results in increased expression of NPY proteinincreases expression 16194568
C022189 zonisamide zonisamide results in increased expression of NPY proteinincreases expression 16194568
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 16.1618926900
MESH:D000014 Abnormalities, Drug-Induced Ethanol 16.1618926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 16.1614610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.1615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.7218287403
MESH:D000138 Acidosis Ethanol 8.7211192467
MESH:D058186 Acute Kidney Injury Capsaicin 4.0718460982
MESH:D055371 Acute Lung Injury pirinixic acid 2.6318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.1516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.1516835633
MESH:D000380 Agranulocytosis Clozapine 4.5412649775 14617031 16160616
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7815451039 15451040
MESH:D000437 Alcoholism marker/mechanism 17572454
MESH:D000437 Alcoholism topiramate 4.6219331489 18552399 17925516
MESH:D000505 Alopecia Capsaicin 4.3117569567
MESH:D000544 Alzheimer Disease Lithium 4.2219621015
MESH:D000544 Alzheimer Disease Ozone 4.2215513908
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.5316459022 18475255 15010207 16916582
MESH:D000686 Amyloidosis Terbutaline 5.127986221
MESH:D000740 Anemia Phenacetin 12.492444515
MESH:D000740 Anemia phenylhydrazine 12.492444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 12.4911748828
MESH:D000743 Anemia, Hemolytic Phenacetin 9.4817698508 17082564 1949026
MESH:D000743 Anemia, Hemolytic phenylhydrazine 9.4817084956 17082564 17698508
MESH:D000755 Anemia, Sickle Cell Aspartame 5.5511372003
MESH:D000853 Anophthalmos Ethanol 4.3015513904
MESH:D000855 Anorexia marker/mechanism 16084549 16101753
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 25.7612183048
MESH:D000855 Anorexia Amphetamine 25.7612183048 16084549 16101753 12005258
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 25.7615146954
MESH:D000855 Anorexia Phenylpropanolamine 25.7617684035
MESH:D000855 Anorexia Quinpirole 25.7612183048
MESH:D001008 Anxiety Disorders Ethanol 8.0111141031
MESH:D001008 Anxiety Disorders Pentobarbital 8.0118313124 11141031
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6617460149
MESH:D001169 Arthritis, Experimental bis(maltolato)oxovanadium(IV) 4.9717696279
MESH:D001172 Arthritis, Rheumatoid Aspartame 4.8010777254
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8015570426
MESH:D001249 Asthma Ozone 2.4617854713 16373670
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.2914699433
MESH:D001321 Autistic Disorder Haloperidol 2.5519368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.5517069543 18685284
MESH:D001321 Autistic Disorder Terbutaline 2.5517400887 16417856
MESH:D001714 Bipolar Disorder Lithium 7.2617594078 19153942 20338123 20046352
MESH:D001714 Bipolar Disorder zonisamide 7.2615383137 16855456
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.6219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 12.6219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.6212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D001862 Bone Resorption bisphenol A 3.3911985600
MESH:D001919 Bradycardia Capsaicin 14.8718207255
MESH:D001919 Bradycardia Carbachol 14.8712411408
MESH:D001919 Bradycardia Phenylephrine 14.8715306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8017868700
MESH:D001930 Brain Injuries Progesterone 3.7415665606 15845082 15380490
MESH:D002545 Brain Ischemia Capsaicin 9.1319211983
MESH:D002545 Brain Ischemia Morphine 9.1319211983
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Deoxyglucose 1.9718985042
MESH:D001943 Breast Neoplasms Progesterone 1.9716175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2618315731 16777450 15516495 19059883 18417511 14754758 17626835
MESH:D002056 Burns Ethanol 4.1416374292
MESH:D002100 Cachexia Ozone 4.2116183385
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.3211713377 9428835
MESH:D002276 Carcinoid Tumor Streptozocin 5.0616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3816835633
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.3418788625 15763234 15289165
MESH:D002278 Carcinoma in Situ bisphenol A 4.4617123778
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 2.7918922899
MESH:D006332 Cardiomegaly Ethanol 9.6719332462
MESH:D006332 Cardiomegaly Phenylephrine 9.6711754973 17287366 17124262 16170337 15728586 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.6718850075 18670907 16120746
MESH:D009202 Cardiomyopathies Zalcitabine 4.3510591146
MESH:D002375 Catalepsy Haloperidol 4.381977408 15215559
MESH:D002389 Catatonia olanzapine 5.7116772815 18071103
MESH:D002544 Cerebral Infarction marker/mechanism 11821007
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.8815650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002779 Cholestasis pirinixic acid 2.4319176532
MESH:D002971 Cleft Lip Ethanol 3.2915513904
MESH:D002972 Cleft Palate Ethanol 5.1315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1316354765 15340226 15668235 12621046 8697196
MESH:D003072 Cognition Disorders Clozapine 4.4517123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D003327 Coronary Disease Fructose 4.1218504504
MESH:D003371 Cough Capsaicin 9.8710350223
MESH:D003371 Cough Terbutaline 9.8719679606
MESH:D019465 Craniofacial Abnormalities Ethanol 2.4315513904 11198716 15451039 11873399 15451040 19302082 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 10048152 20055451
MESH:D007644 Darier Disease Lithium 5.3820338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3620210726
MESH:D003704 Dementia Haloperidol 4.1111575062
MESH:D003731 Dental Caries Aspartame 6.398955999
MESH:D003866 Depressive Disorder therapeutic 17572454
MESH:D003866 Depressive Disorder zonisamide 4.5316855456
MESH:D017449 Dermatitis, Allergic Contact Aspartame 4.2314996049
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1618249437
MESH:D002658 Developmental Disabilities olanzapine 4.3217069543
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.2319244398
MESH:D003920 Diabetes Mellitus Streptozocin 4.2816285004
MESH:D003921 Diabetes Mellitus, Experimental bis(maltolato)oxovanadium(IV) 16.4912083368
MESH:D003921 Diabetes Mellitus, Experimental Fructose 16.4918603373
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 16.498740154 19960420 12093613 7637645 17874149 15862027 19586609 19298542 15831366 15298345 18715473 12644472 11055810 12446591 12083368 17442507 1374869 16684804 16286809 2177838 19496084 6379147 18603373 11260395
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 16.4916684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4518603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 11.9716402076
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 11.9718603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 11.9719647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.9717107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 11.9716979414
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.2016025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.2319682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 3.9817187935
MESH:D003930 Diabetic Retinopathy Streptozocin 4.9217662242
MESH:D003967 Diarrhea Morphine 4.032540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.0215331141
OMIM:607208 DRAVET SYNDROME zonisamide 5.5411748493
MESH:D056486 Drug-Induced Liver Injury Ethanol 3.3411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2211462148
MESH:D004362 Drug Toxicity Zalcitabine 7.227515130
MESH:D004381 Duodenal Ulcer Capsaicin 4.2011535926 10671773
MESH:D050171 Dyslipidemias Clozapine 3.8016402076
MESH:D004487 Edema pirinixic acid 8.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.7712711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.7711698051 9599246 16716910 8113982 15177302 8273558 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3615322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.2817692515
MESH:D004715 Endometriosis Progesterone 7.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.4110568697 9294722
MESH:D004831 Epilepsies, Myoclonic zonisamide 5.313659116 3691417
MESH:D004828 Epilepsies, Partial zonisamide 5.0515140322 11558140 3691417
MESH:D004827 Epilepsy topiramate 6.8319148780
MESH:D004827 Epilepsy zonisamide 6.8320196486
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.7416499746
MESH:D004830 Epilepsy, Tonic-Clonic zonisamide 5.213659116 3691417
MESH:D004893 Erythema Nodosum Aspartame 6.399324739
MESH:D004935 Esophageal Diseases Capsaicin 5.1819566590
MESH:D004938 Esophageal Neoplasms Ethanol 2.6116704527
MESH:D020329 Essential Tremor zonisamide 5.6617149715 18297619
MESH:D005076 Exanthema zonisamide 5.5515140322
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6111564622
MESH:D005141 Eyelid Diseases Aspartame 5.8414996049
MESH:D005221 Fatigue Amphetamine 11.0219890266
MESH:D005221 Fatigue zonisamide 11.0217149715
MESH:D005234 Fatty Liver Dietary Sucrose 19.7617967931
MESH:D005234 Fatty Liver Ethanol 19.7616409862 19236843 18620774
MESH:D005234 Fatty Liver Fructose 19.7618395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 19.7620131406 19236843
MESH:D005234 Fatty Liver Zalcitabine 19.7618299183
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7710194807 15513904 16946407 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005334 Fever Aspartame 4.879630831
MESH:D005355 Fibrosis Fructose 12.1618504504
MESH:D005355 Fibrosis Terbutaline 12.1615467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.1620067830
MESH:D005756 Gastritis Ethanol 4.1615046732
MESH:D005909 Glioblastoma Capsaicin 3.7718405923
MESH:D018149 Glucose Intolerance Fructose 4.8419165636
MESH:D006042 Goiter perchlorate 4.8218801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006261 Headache Ketamine 10.1011554966
MESH:D006261 Headache zonisamide 10.1017149715
MESH:D006356 Heartburn Capsaicin 5.1819566590
MESH:D006330 Heart Defects, Congenital Lithium 6.0219638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0210048152 11294989
MESH:D006331 Heart Diseases Streptozocin 3.9012093613
MESH:D006333 Heart Failure pirinixic acid 2.2020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006529 Hepatomegaly pirinixic acid 6.5616221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.5615340226 16120746 12621046
MESH:D015658 HIV Infections Zalcitabine 4.0417457083
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5118606429 16354765 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Capsaicin 7.0217434803 17043245
MESH:D006930 Hyperalgesia Ethanol 7.0218783367
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006946 Hyperinsulinism Fructose 4.4618360027 14757778 15752949 18563319 19008412
MESH:D006948 Hyperkinesis Amphetamine 10.051977408 14960337
MESH:D006948 Hyperkinesis Clozapine 10.0516046005
MESH:D006949 Hyperlipidemias Fructose 4.2715752949
MESH:D006963 Hyperphagia olanzapine 5.7017933447
MESH:D006973 Hypertension Aspartame 10.6318708962
MESH:D006973 Hypertension Fructose 10.6314633139 19008412 16843071 14573337 14568997
MESH:D006973 Hypertension Phenylephrine 10.638949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.6318670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.1114678291
MESH:D015228 Hypertriglyceridemia Fructose 4.6219799862 19342510
MESH:D006984 Hypertrophy Phenylephrine 4.0812791704 18502941
MESH:D006985 Hyperventilation Terbutaline 5.5510895896
MESH:D007008 Hypokalemia Terbutaline 5.5617292646
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.3319822448
MESH:D007037 Hypothyroidism Methimazole 10.2418031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.248137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8915869954
MESH:D007249 Inflammation Capsaicin 9.5916956363
MESH:D007249 Inflammation Progesterone 9.5915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.5912200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 9.597562506 8273558 11698051 7812673 15177302
MESH:D007333 Insulin Resistance bisphenol A 10.4116393666
MESH:D007333 Insulin Resistance Fructose 10.4114573337 14757778 18981581 19342510 18563319 17133782 14633139 19008412 18057795 19799862 19586609
MESH:D007333 Insulin Resistance pirinixic acid 10.4116306350
MESH:D002546 Ischemic Attack, Transient zonisamide 6.369372210
MESH:D007569 Jaw Abnormalities Ethanol 8.5415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5416580747
MESH:D007674 Kidney Diseases Aspartame 6.1211409539
MESH:D007674 Kidney Diseases Streptozocin 6.1212093613
MESH:D007859 Learning Disorders Ethanol 3.7015451040
MESH:D053609 Lethargy Terbutaline 5.7810895896
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4317676605
MESH:D008064 Lipidoses Clozapine 3.5817567588
MESH:D008103 Liver Cirrhosis Ethanol 3.0715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5718295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.0318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.0312878042
MESH:D008107 Liver Diseases Capsaicin 3.1216956363
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1417207112 17347304
MESH:D008113 Liver Neoplasms pirinixic acid 3.5120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.7812151625
MESH:D008133 Long QT Syndrome olanzapine 4.3220210726
MESH:D008171 Lung Diseases Ozone 3.0119066396 8266340
MESH:D017563 Lung Diseases, Interstitial zonisamide 5.3917228818
MESH:D055370 Lung Injury Ozone 3.3420417186
MESH:D008175 Lung Neoplasms Ozone 3.098597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.0911884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.0911807781
MESH:D008223 Lymphoma Zalcitabine 4.268764131 17941976 8840982 9205081 11980663 9488045 18798262
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 8.1712807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.1711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.178985016
MESH:D008545 Melanoma Glucose 2.9914993021
MESH:D008569 Memory Disorders Ethanol 3.6915451040 18411066
MESH:D001523 Mental Disorders Clozapine 10.4216856516
MESH:D001523 Mental Disorders Haloperidol 10.4216856516
MESH:D001523 Mental Disorders olanzapine 10.4216856516
MESH:D008659 Metabolic Diseases olanzapine 4.9219142110
MESH:D024821 Metabolic Syndrome X Clozapine 8.6019142101
MESH:D024821 Metabolic Syndrome X Fructose 8.6016815490 17098227 19165636 18497449 17261469
MESH:D008679 Metaplasia Ozone 4.5710496685
MESH:D008708 Methemoglobinemia Phenacetin 4.471949026 16296465 3537620 4834387
MESH:D008881 Migraine Disorders Aspartame 7.3918627677 10792367
MESH:D008881 Migraine Disorders topiramate 7.3918765137 18759728 18803445 16942474
MESH:D009041 Motion Sickness Dextroamphetamine 4.981613127
MESH:D009101 Multiple Myeloma Capsaicin 7.0117505005
MESH:D009101 Multiple Myeloma zonisamide 7.0111868602
MESH:D009135 Muscular Diseases pirinixic acid 2.9916239165
MESH:D009203 Myocardial Infarction Lithium 5.2516288908
MESH:D009203 Myocardial Infarction pirinixic acid 5.2519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.5416411023
MESH:D020191 Myoclonic Epilepsies, Progressive zonisamide 5.669477142
MESH:D009325 Nausea zonisamide 5.4716855456
MESH:D009369 Neoplasms Aspartame 4.6316507461
MESH:D009369 Neoplasms pirinixic acid 4.6317405874
MESH:D009374 Neoplasms, Experimental Zalcitabine 4.598764131 9488045 9205081
MESH:D009421 Nervous System Malformations bisphenol A 7.9216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.9214600291
MESH:D009437 Neuralgia Zalcitabine 5.7917292584
MESH:D019636 Neurodegenerative Diseases Amphetamine 7.9215183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 7.9218514411
MESH:D020078 Neurogenic Inflammation Capsaicin 4.6017961222
MESH:D009765 Obesity Capsaicin 12.4719056576
MESH:D009765 Obesity Clozapine 12.4718515891 19142110
MESH:D009765 Obesity Fructose 12.4718585860 17707055
MESH:D009765 Obesity olanzapine 12.4718515891
MESH:D009765 Obesity pirinixic acid 12.4720558911
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.5714998686
MESH:D010003 Osteoarthritis Aspartame 4.549630831
MESH:D010049 Ovarian Diseases bisphenol A 4.4611985600
MESH:D010051 Ovarian Neoplasms Progesterone 2.3516525653 17393432
MESH:D010146 Pain Aspartame 12.889630831
MESH:D010146 Pain Capsaicin 12.8817084039 19081190 18987195 16996476 17434803 17043245
MESH:D010146 Pain Morphine 12.8816273134 6776300 15275824 18699797 20225289 15215642
MESH:D010146 Pain zonisamide 12.8817666864 16217643 15140322
MESH:D010149 Pain, Postoperative Ketamine 5.5911554966
MESH:D010190 Pancreatic Neoplasms Ethanol 4.9712384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 4.9715976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.7812065085 18922899 8330346 18404319
MESH:D010292 Paresthesia zonisamide 6.3617149715
MESH:D010300 Parkinson Disease zonisamide 3.9917200492 11755227 20196486 19594199 13677302
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 4.9411771942 15893579
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 9.2718606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 9.2718606552
MESH:D010538 Peritonitis Ozone 3.6216369182
MESH:D011014 Pneumonia Ozone 3.8718007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7611222880 11399792 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 4.2716740699
MESH:D011471 Prostatic Neoplasms Deoxyglucose 4.2718985042
MESH:D011595 Psychomotor Agitation Haloperidol 10.1011575062
MESH:D011595 Psychomotor Agitation olanzapine 10.1018685284
MESH:D011618 Psychotic Disorders Clozapine 7.8615331141
MESH:D011618 Psychotic Disorders Haloperidol 7.8611575062
MESH:D011629 Puberty, Precocious bisphenol A 4.2610548101
MESH:D011654 Pulmonary Edema Terbutaline 4.9810903255
MESH:D012021 Reflex, Abnormal Pentobarbital 5.4910930210
MESH:D015427 Reperfusion Injury Capsaicin 9.5418460982 19211983
MESH:D015427 Reperfusion Injury Morphine 9.5419211983
MESH:D015427 Reperfusion Injury pirinixic acid 9.5419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 4.572878809
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012220 Rhinitis marker/mechanism 12746121
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012559 Schizophrenia Clozapine 7.2217667964 20521326 18855531 11763009 18806925 17726453 20107430 19369910 20168265 11151749 16141801 20580759 20521320 17123785 20452607
MESH:D012559 Schizophrenia Haloperidol 7.2219369910 20107430 18513383 1830565
MESH:D012559 Schizophrenia Ketamine 7.2220000043
MESH:D012559 Schizophrenia olanzapine 7.2220521326 20107430 17726453
MESH:D012640 Seizures marker/mechanism 16194568
MESH:D012640 Seizures Deoxyglucose 22.5217978042
MESH:D012640 Seizures Ethanol 22.529754883
MESH:D012640 Seizures Lithium 22.5219660546
MESH:D012640 Seizures Pentobarbital 22.5210087439 9754883
MESH:D012640 Seizures topiramate 22.5216499746
MESH:D012640 Seizures Vigabatrin 22.5210454489 9844417
MESH:D012640 Seizures zonisamide 22.5216938433 11755227 16180713 11879338 9806000 9844417 11442880 11518630 15946322 11044598 10029267 9046859 18455367 12941455 16876388
MESH:D012772 Shock, Septic Terbutaline 4.973431524
MESH:D012852 Sinusitis Phenylephrine 4.187327846
MESH:D012859 Sjogren's Syndrome Aspartame 6.0416800424
MESH:D012878 Skin Neoplasms Glucose 8.0714993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.0716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.0718404319 8985016 8330346 11807781 12065085
MESH:D013119 Spinal Cord Injuries Progesterone 3.7516503802 15862959
MESH:D013226 Status Epilepticus Lithium 11.4919430551 19951488 19570321
MESH:D013226 Status Epilepticus zonisamide 11.4912833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.881977408
MESH:D013262 Stevens-Johnson Syndrome zonisamide 5.3112239465
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.0817918041 16755016 17189318 9211565 9562338 11906479
MESH:D019966 Substance-Related Disorders bisphenol A 3.4616684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 8.739754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.7311529278 9754883
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.02978859
MESH:D013610 Tachycardia Terbutaline 5.0010895896
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.2920210726
MESH:D017180 Tachycardia, Ventricular olanzapine 9.2920210726
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.1917997062
MESH:D013921 Thrombocytopenia Aspartame 5.0217534100
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.2815710170
MESH:D020194 Unverricht-Lundborg Syndrome zonisamide 5.6611814737
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 3.6011144890
MESH:D014591 Uterine Diseases bisphenol A 4.4714652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D018487 Ventricular Dysfunction, Left Dietary Sucrose 5.3918551017
MESH:D014839 Vomiting zonisamide 5.3917157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D015430 Weight Gain Clozapine 8.8620564506 17502770 16402076 20521320 16141801 20107430
MESH:D015430 Weight Gain olanzapine 8.8619434072 17933447 20107430
MESH:D015431 Weight Loss Clozapine 4.5517933447
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA255
    • Releated gene ID Related gene Name
    PA255NPY
    Releated disease ID Related disease Name
    PA443994Edema
    PA445752Stress
    PA445019Myocardial Infarction
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444516Hypercholesterolemia
    Releated drug ID Related drug Name
    PA452631thiazolidinediones
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02952 - Alpha-Aminoisobutyric Acid
    DB03380 - L-Tyrosinamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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