AutismKB 2.0

Annotation Detail for NOTCH2


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Basic Information Top
Gene Symbol:NOTCH2 ( AGS2,hN2 )
Gene Full Name: notch 2
Band: 1p12
Quick LinksEntrez ID:4853; OMIM: 600275; Uniprot ID:NOTC2_HUMAN; ENSEMBL ID: ENSG00000134250; HGNC ID: 7882
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway
Pathway IDPathway Name
Gene Expression
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00045Notch signaling pathway
Pathway IDPathway Name
500112Maturation of Notch precursor via proteolytic cleavage
500111Transport of Notch receptor precursor to golgi
500110Signaling by Notch
500117NICD trafficks to nucleus
500116A third proteolytic cleavage releases NICD
500115Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
500114Notch receptor binds with a ligand
500113Mature Notch receptor trafficks to plasma membrane
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
No data
Desease Name
METABOLIC
type 2 diabetes
diabetes, type 2
Desease Name
Type 2 diabetes
Desease Name
Alagille syndrome 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOTCH2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NOTCH2 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NOTCH2 mRNAincreases expression 19181443
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOTCH2 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NOTCH2 proteinincreases expression 12500195
D002251 Carbon Tetrachloride FOXF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of NOTCH2 protein]affects reaction|increases expression 12500195
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of NOTCH2 mRNAincreases expression 15829613
D002945 Cisplatin NOTCH2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOTCH2 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NOTCH2 mRNAincreases expression 17606305
D019833 Genistein Genistein results in decreased expression of NOTCH2 mRNAdecreases expression 17341692
D008044 Linuron Linuron results in decreased expression of NOTCH2 mRNAdecreases expression 12730624
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate results in increased expression of NOTCH2 mRNAincreases expression 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate [sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of NOTCH2 mRNAaffects cotreatment|decreases expression 19615344
D009151 Mustard Gas IL10 protein affects the reaction [Mustard Gas affects the expression of NOTCH2 mRNA]affects expression|affects reaction 16173061
D009151 Mustard Gas Mustard Gas results in decreased expression of NOTCH2 mRNAdecreases expression 15674843
C006253 pirinixic acid pirinixic acid results in decreased expression of NOTCH2 mRNAdecreases expression 17426115
18445702
D011374 Progesterone Progesterone results in decreased expression of NOTCH2 mRNAdecreases expression 18070364
C009166 retinol acetate retinol acetate results in increased expression of NOTCH2 mRNAincreases expression 16772331
C017947 sodium arsenite sodium arsenite affects the expression of NOTCH2 mRNAaffects expression 19590694
C017947 sodium arsenite [sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of NOTCH2 mRNAaffects cotreatment|decreases expression 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of NOTCH2 mRNAdecreases expression 19615344
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NOTCH2 mRNAincreases expression 18796159
D014501 Uranium Uranium affects the expression of NOTCH2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of NOTCH2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.8817670903 15814532 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0120127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 10.0117638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0114692618
MESH:D000230 Adenocarcinoma Genistein 10.0111473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.466695378
MESH:D000236 Adenoma Diethylnitrosamine 6.466695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.7918056438 19061943 17162532 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.7916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D016738 Alagille Syndrome marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001768 Blister Mustard Gas 5.0719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8014601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9217474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 2.9218382427 19526202
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9217474063
MESH:D001943 Breast Neoplasms Genistein 2.9216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Progesterone 2.9217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9017687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6915700767 3786805 16227642 16011737 15721981 16192424 15673190 10355542 18705752 16050911 16097048 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7418788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.7417982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7420727157 18210153 18056438 19519916 18393292 18785209 19383236 20512989 18506893 20084675 18665156 16830150 16328049 16779866 16502159 19701751 18494052 19822196 19171122 21159647 20514400 11831363 19208518 20007298 17978847 20935162 20432363 17428255 19919837 18971187 18788625 3581430 17162532 19539802 17138121 10737359 17761372 16540662 10672840 16698587 16878318 19335982 18691550 20524982 16935385 19394651 20214788 19418558 20101231 18978308 17173139 16807293 19107877 3084413 16288022 19052882 17055752 16681979 16569478
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.7416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7415276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.4317066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.4318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.2416332659
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.572727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5720056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5211677210 16105132 17333356 16919318 15861022 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 7.5219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0712621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2717182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.3616037377
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 18372903
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9817107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.0421278145 7120509 9327722 3732212 7179309 19336974 10915739 15027814 6884620 16177239 4309450 15998439 16227642 19085960 2869522 10092053 7440962 3786805 17522070 15968718 6623471 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.0419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0420420201
MESH:D004362 Drug Toxicity Cisplatin 7.9612649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9611462148
MESH:D004487 Edema Mustard Gas 10.9511428631 11402378 11428647 9260866
MESH:D004487 Edema pirinixic acid 10.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.7517692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3011473722
MESH:D004715 Endometriosis Progesterone 8.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6610568697 9294722
MESH:D004890 Erythema Mustard Gas 5.079357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5316530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.5316785472 16481741 17638652 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.0712795759 15959796 12631006 16239168 19224547 16045604 61145 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 18.0720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.0715345470
MESH:D005234 Fatty Liver pirinixic acid 18.0720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Genistein 3.2016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D031845 Hajdu-Cheney Syndrome marker/mechanism 21378989 21378985
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.2219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3415464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.9716221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9715340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cisplatin 7.2916200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 7.2912676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 15340226 16959395 16354765 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male sodium arsenite 6.4415346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 11.6018785209
MESH:D007249 Inflammation Mustard Gas 11.609260866 11428631 9357497 11402378 17524151 11428647 11428620 16001271 8975870
MESH:D007249 Inflammation Progesterone 11.6015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6012878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5716306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.5110783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0615464296
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 10.0115369732
MESH:D007674 Kidney Diseases Cisplatin 10.0112649298 12231392 18289764 15190930 19839026
MESH:D007674 Kidney Diseases sodium arsenite 10.0120008137
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7111231351
MESH:D007938 Leukemia Genistein 2.9818980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9316766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4521278145 11903743 16239168 11408273 16221502 16943688 17157831 17334410 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4518522880 18407596 18665156 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8512649538 12586293 17708605 15123356 18418968 17944888 17721639 18420326 18412020 12741479 12389079 17631135 12632514 17900296 15818738 18166357 14620537 15362042 17761835 17976157 18006644 18429990 17922224 18187930 18205269 12667390 17481882 12609069 17869086 17640975 15925388 17525996 12445418 17565644 16638106 16015684 18210741 11481614 15370692 18156304 12898905 16027843 14512876 18472332 13678700 15052691 17823541 15650968 12666154 18317297 16248980 15893842 18251166 12958196 10355542 18263696 18376398 16097048 17805973 18705752 18395914 15959796 14716496 16033810 18472094 17766677 18054572 14724832 17714472 16192424 12546737 18481824 15730626 15996030 15931870 15057751 17557913 18339082 16136751 18277467 18279442 12632512 17698563 16011737 15673190 18395095 15338365 20821823 14748882 14716833 15876570 12445421 16116963
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.8517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0017285989 16246199 15720792 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6114706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.5516942905 20118626 18644402 18648771 20492335 20101389 19642983 21278145 2422723 19254457 19426721 18978307 20583210 15885732 19073162 19812893 20434301 15175105 21071580 20137499 19090486 12771043 18754104 19499222 10737359 19294768 20405173 18977376 19427195 19638242 19256749 20452335 21167192 12112319 19833225 20501860 19996281 19255062 9163691 19551842 2862719 19850985 19690152 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 17.5520007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 17.5516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.4712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.4717942915 19009564 18253720 18079962 16842330 19004024 19126423 21159647 9362446 16267830 2563599 19539802 18093689 17174075 3124819 17854601 19519916 18544905 18308698 18775883 18282651 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4712151625
MESH:D008171 Lung Diseases Mustard Gas 7.3418161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.3419095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9417365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.4218569708 20064080 20464547 20135361 18520028 6695378 18816296 20869020 17053015
MESH:D008175 Lung Neoplasms Cisplatin 8.4211798837 17225452 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.4220970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 8.428781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 8.4215276417 16712894 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.4219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.0114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0117203775 11408345
MESH:D008545 Melanoma Cisplatin 3.4918505091 12393984 17023156 15577323 16809738 11135225 16248763 18332650 16432458 12883367 17761969 12374674 18176117
MESH:D008545 Melanoma sodium arsenite 3.4916487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6915990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.3916966607 18303189 16166281
MESH:D008654 Mesothelioma Cisplatin 6.3917638057
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009203 Myocardial Infarction Genistein 5.5617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.5619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1616411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.539029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 11.5111141357
MESH:D009369 Neoplasms Cisplatin 11.5116773208
MESH:D009369 Neoplasms pirinixic acid 11.5117405874
MESH:D009369 Neoplasms sodium arsenite 11.5111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4115464296
MESH:D009421 Nervous System Malformations Genistein 9.3216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0812854658
MESH:D009447 Neuroblastoma Cisplatin 3.408761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.618761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009503 Neutropenia Mustard Gas 3.8916761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D010051 Ovarian Neoplasms Cisplatin 11.116897625 15464296 17225452 19769630
MESH:D010051 Ovarian Neoplasms Genistein 11.1119005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.1116525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.1117306315 15276417
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.3419003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2215464296
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8110923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.2617638057
MESH:D011041 Poisoning Mustard Gas 3.7115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.472563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Genistein 2.6015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6016039940
MESH:D011537 Pruritus Ethinyl Estradiol 9.2416919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.2418058305
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.8015814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8017894541 17620002 17266442 10334151 17720292
MESH:D051437 Renal Insufficiency Cisplatin 4.3215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3414601052
MESH:D012871 Skin Diseases Mustard Gas 2.6916961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1619755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.1619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1616192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1915862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3520155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 3.3518396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3518456281
MESH:D013736 Testicular Neoplasms Cisplatin 4.5517225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.927505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1817053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.1815464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1811723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.3416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5215577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
Pathway ID Pathway Name
KEGG:04320 Dorso-ventral axis formation
REACT:71 Gene Expression
KEGG:04330 Notch signaling pathway
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31684
    • Releated gene ID Related gene Name
    PA31684NOTCH2
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA446376Alagille Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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