AutismKB 2.0

Annotation Detail for NOTCH4


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Basic Information Top
Gene Symbol:NOTCH4 ( FLJ16302,INT3,MGC74442,NOTCH3 )
Gene Full Name: notch 4
Band: 6p21.32
Quick LinksEntrez ID:4855; OMIM: 164951; Uniprot ID:NOTC4_HUMAN; ENSEMBL ID: ENSG00000204301; HGNC ID: 7884
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway
Pathway IDPathway Name
Gene Expression
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00045Notch signaling pathway
Pathway IDPathway Name
500112Maturation of Notch precursor via proteolytic cleavage
500111Transport of Notch receptor precursor to golgi
500110Signaling by Notch
500117NICD trafficks to nucleus
500116A third proteolytic cleavage releases NICD
500115Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
500113Mature Notch receptor trafficks to plasma membrane
Related Diseases/Disorders Top
No data
No data
Desease Name
Alzheimer's disease
PSYCH
HIV-1 control
NEUROLOGICAL
schizophrenia
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NOTCH4 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NOTCH4 mRNAaffects expression 17331233
D002945 Cisplatin Folic Acid affects the reaction [Cisplatin affects the expression of NOTCH4 mRNA]affects expression|affects reaction 16898872
D005492 Folic Acid Folic Acid affects the reaction [Cisplatin affects the expression of NOTCH4 mRNA]affects expression|affects reaction 16898872
D008345 Manganese Manganese results in decreased expression of NOTCH4 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of NOTCH4 mRNAdecreases expression 17175027
D014212 Tretinoin Tretinoin results in decreased expression of NOTCH4 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 10.0217670903 15814532 12690470
MESH:D058186 Acute Kidney Injury Folic Acid 10.0216316344 17003819 16595132
MESH:D000230 Adenocarcinoma Cisplatin 2.8111798837 17638652
MESH:D000236 Adenoma Folic Acid 3.9416963246
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000544 Alzheimer Disease Folic Acid 3.0917116317
MESH:D000756 Anemia, Sideroblastic Manganese 11.9916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.9916910769
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.3314601052
MESH:D001943 Breast Neoplasms Cisplatin 2.1119526202 18382427
MESH:D001943 Breast Neoplasms Folic Acid 2.1116777985
MESH:D001943 Breast Neoplasms Tretinoin 2.1116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.823084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8217982673
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.821917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0717066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0716096774 16051514
MESH:D002318 Cardiovascular Diseases Folic Acid 4.1316755160
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002971 Cleft Lip Folic Acid 4.1021254359
MESH:D002972 Cleft Palate Folic Acid 6.6321254359 8946559
MESH:D002972 Cleft Palate Tretinoin 6.639407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D015179 Colorectal Neoplasms Cisplatin 3.0315273666
MESH:D015179 Colorectal Neoplasms Folic Acid 3.0317116713 16963246 16985020 17087956 17245555
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 9125849 17551590 9142499 10589399 9664655 14991402 8800419 9211117 9224671
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1816886840
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6515619225 10915739 18071297 17522070 10663392 19085960 19420014 17906064 16485898 12594235 11743745 19416960 16781746 15968718 11461765 19739265 12392966 12958197 11529661 11834606 16393943 16081117 12705907 16109766 14725611 16177239 18713872 2444490 12153990 11421492 12540782 19923254 10774834 19164858 11739529 14986274 14550746 11287661 19370779 16227642 17562736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Cisplatin 4.0612231392 15033597 19839026 12649298
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Folic Acid 8.3617301261
MESH:D016889 Endometrial Neoplasms Tretinoin 8.3616569247
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8316785472 15173087 17638652 16481741 15464296
MESH:D017889 Exfoliation Syndrome Folic Acid 5.8916504073
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005756 Gastritis Acetaminophen 12.8016983495
MESH:D005756 Gastritis Folic Acid 12.8017171786
MESH:D005901 Glaucoma Folic Acid 5.3816504073
MESH:D005909 Glioblastoma Manganese 8.0217043766
MESH:D005909 Glioblastoma Tretinoin 8.0217312396
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.5115102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5116096774
MESH:D034381 Hearing Loss Cisplatin 4.5519898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6515464296
MESH:D006330 Heart Defects, Congenital Folic Acid 7.5117286298 16524890
MESH:D006330 Heart Defects, Congenital Tretinoin 7.519664655 14991402
MESH:D006679 HIV Seropositivity Folic Acid 5.8917209195
MESH:D006689 Hodgkin Disease Cisplatin 3.8416200630 16170182
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.7416397167 16865747 16433478 16755160 16395265
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.5815464296
MESH:D007674 Kidney Diseases Acetaminophen 6.6112587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 6.6118289764 15190930 12649298 12231392 19839026
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.2411231351
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3216935935 17712046 16140955 17217047 17301526 19642359 19029980 17294898 17649720 15748426 16891316 9834237 17506722 17368321 12679006 16788101 19225113 16766008 16331271 19035177 17361223 19075265 17107899 16823087 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.4516611625 12587719 19014921 19460945 12969438 16610002 19784758 11587558
MESH:D008107 Liver Diseases Folic Acid 4.4516877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D008175 Lung Neoplasms Cisplatin 2.3417225452 6189445 11798837
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.4017718048
MESH:D020149 Manganese Poisoning Manganese 5.9616551646 19453300 16568477
MESH:D019767 Maxillofacial Abnormalities Folic Acid 6.0916832597
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Cisplatin 3.6318332650 17023156 15577323 16809738 11135225 18505091 12393984 17761969 12374674 16248763 12883367 16432458 18176117
MESH:D008545 Melanoma Tretinoin 3.6316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.8116966607 18303189 16166281
MESH:D008654 Mesothelioma Cisplatin 6.8117638057
MESH:D009069 Movement Disorders Manganese 5.3116551646
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009369 Neoplasms Cisplatin 5.6816773208
MESH:D009369 Neoplasms Tretinoin 5.6816946489 16594593
MESH:D009395 Nephritis, Interstitial Cisplatin 4.9315464296
MESH:D009410 Nerve Degeneration Manganese 4.4816551646
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects Folic Acid 8.1817438019
MESH:D009436 Neural Tube Defects Tretinoin 8.189142499
MESH:D009447 Neuroblastoma Cisplatin 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.098761367
MESH:D009503 Neutropenia Folic Acid 4.8116322990
MESH:D010051 Ovarian Neoplasms Cisplatin 5.2917225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2916936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.7419003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7415976015
MESH:D010300 Parkinson Disease Manganese 3.4511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7316140633
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6415464296
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.7917638057
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1117322281 17365031 15814490 17975199
MESH:D051437 Renal Insufficiency Cisplatin 11.8115464296
MESH:D051437 Renal Insufficiency Folic Acid 11.8115728788
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7614601052
MESH:D012559 Schizophrenia Folic Acid 2.9216641680
MESH:D012871 Skin Diseases Folic Acid 3.3018709164
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7915464296
MESH:D013118 Spinal Cord Diseases Folic Acid 5.8916361298
MESH:D013274 Stomach Neoplasms Cisplatin 3.6717522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Folic Acid 3.6717171786
MESH:D013274 Stomach Neoplasms Tretinoin 3.6717261132
MESH:D020521 Stroke Folic Acid 4.5516517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.9317225452 15464296
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0312973940 17225452 15464296
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.4716803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9715577323
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D014839 Vomiting Cisplatin 5.1611897121
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
KEGG:04320 Dorso-ventral axis formation
REACT:71 Gene Expression
KEGG:04330 Notch signaling pathway
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31686
    • No data
    Releated disease ID Related disease Name
    PA443464Autoimmune Diseases
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA452233antipsychotics
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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