AutismKB 2.0

Annotation Detail for NOVA1


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Basic Information Top
Gene Symbol:NOVA1 ( Nova-1 )
Gene Full Name: neuro-oncological ventral antigen 1
Band: 14q12
Quick LinksEntrez ID:4857; OMIM: 602157; Uniprot ID:NOVA1_HUMAN; ENSEMBL ID: ENSG00000139910; HGNC ID: 7886
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOVA1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NOVA1 mRNAdecreases expression 20458559
C020711 beryllium sulfate beryllium sulfate results in increased expression of NOVA1 mRNAincreases expression 16314022
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NOVA1 mRNAaffects cotreatment|increases expression 17183730
D015735 Mifepristone Mifepristone results in increased expression of NOVA1 mRNAincreases expression 17584828
C017947 sodium arsenite sodium arsenite affects the expression of NOVA1 mRNAaffects expression 19590694
D013629 Tamoxifen Tamoxifen results in decreased expression of NOVA1 mRNAdecreases expression 15590111
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NOVA1 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in decreased expression of NOVA1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 18558336 16609825 18316065 18396377 17507914 20603192 18985861 19460635 17688650 17157402 15238991 18940202 18177632 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001943 Breast Neoplasms Tamoxifen 2.1919059307 16202921 18997820 11161223 18815881 20135344 20544844 19103187 17049068 19084267 17440819 18351453 20390343 18984771 20859285 18855134 19066611 15668708 17242785 19115204 16818667 18629630 19200415 19155303 20065188 19011961 19189212 19142967 19189210 20005174 15565566 18821012 16273361 19487384 18425577 16873071 19244106 21138602 21152245 19288272 19410462 17261762 17893378 19289846 19221464
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7814691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7816924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1219524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9610525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9617688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9619769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.221733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.7819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Mifepristone 4.5616134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005234 Fatty Liver arsenic trioxide 14.4115073043
MESH:D005234 Fatty Liver Tamoxifen 14.4114986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 14.4119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007248 Infertility, Male sodium arsenite 3.1212646999 15346721
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007674 Kidney Diseases sodium arsenite 6.5520008137
MESH:D007674 Kidney Diseases Vitamin E 6.5512488133
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2118625569
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0119850784 16467208 16968895 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3417107899 17217047 19075265 17869043 16891316 16823087 15213294 19225113 9834237 12679006 15336539 16331271 16112521 15622746 16330433 12018890 19642359 16966277 11468182 17649720 19035177 11161223 17712046 15748426 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5818564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5816169303
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8914682389
MESH:D008113 Liver Neoplasms sodium arsenite 7.8915276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 7.8916684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases sodium arsenite 7.8919095001
MESH:D008171 Lung Diseases Vitamin E 7.8916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0411798837 19825857
MESH:D008175 Lung Neoplasms sodium arsenite 5.0416712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 5.0418625569
MESH:D008175 Lung Neoplasms Vitamin E 5.0411062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7419196722 11731420 16827153 19196723 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma sodium arsenite 3.4119082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.4119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2511468182 19417148 14977855 15949261 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7817596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms sodium arsenite 2.5811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009436 Neural Tube Defects arsenic trioxide 12.9210525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.9212854658
MESH:D009436 Neural Tube Defects Valproic Acid 12.928888407 16359493
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.3319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Mifepristone 8.3316525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.3317306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0519131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0515084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8711738929 1511512 15475178 11044598 16876388 3137016 14763951 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.7818572023 19524636
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 10.0712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 10.0719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7620435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7616452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7616712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31688
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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