AutismKB 2.0

Annotation Detail for NPAS2


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Basic Information Top
Gene Symbol:NPAS2 ( FLJ23138,MGC71151,MOP4,PASD4,bHLHe9 )
Gene Full Name: neuronal PAS domain protein 2
Band: 2q11.2
Quick LinksEntrez ID:4862; OMIM: 603347; Uniprot ID:NPAS2_HUMAN; ENSEMBL ID: ENSG00000170485; HGNC ID: 7895
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
Pathway IDPathway Name
200068Circadian rhythm pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NPAS2 mRNAdecreases expression 19933214
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NPAS2 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of NPAS2 mRNAdecreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NPAS2 mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of NPAS2 mRNAdecreases expression 16934159
D004610 Ellagic Acid Ellagic Acid results in increased expression of NPAS2 mRNAincreases expression 12002526
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NPAS2 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in increased expression of NPAS2 mRNAincreases expression 12002526
12569576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NPAS2 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NPAS2 mRNAincreases expression 20159946
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D058186 Acute Kidney Injury resveratrol 4.0616538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma resveratrol 3.4215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000544 Alzheimer Disease resveratrol 2.6016162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001169 Arthritis, Experimental resveratrol 3.6217115116
MESH:D050197 Atherosclerosis resveratrol 3.3817967414 16873680
MESH:D001321 Autistic Disorder marker/mechanism 17264841
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D002545 Brain Ischemia resveratrol 4.5717600658
MESH:D001943 Breast Neoplasms bisphenol A 1.9217123778
MESH:D001943 Breast Neoplasms resveratrol 1.9217651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416050911 15700767 15673190 16011737 15721981 16124888 18705752 16192424 16227642 3786805 10355542 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2718788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.2716227395 19321006
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7616227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.6115458977
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 15668235 8697196 12621046
MESH:D003092 Colitis resveratrol 4.3916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8716507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.1416286809
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6215027814 16227642 3786805 9327722 7179309 19085960 4309450 10092053 3732212 21278145 15998439 10915739 6623471 2869522 19336974 7440962 6884620 16177239 17522070 15968718 7120509 11566570
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.6217851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 12.6612083418
MESH:D004487 Edema resveratrol 12.668985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.6611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2617872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1117923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3712795759 16045604 19224547 17595544 12631006 16239168 15959796 61145
MESH:D005234 Fatty Liver pirinixic acid 8.3719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 9.1418467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.4616876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16959395 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006937 Hypercholesterolemia resveratrol 4.2117188708
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias resveratrol 4.2516873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5017488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9117600658
MESH:D007249 Inflammation resveratrol 5.3916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3912878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.8616624496
MESH:D007333 Insulin Resistance bisphenol A 7.7416393666
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7016087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9111408273 21278145 17157831 16239168 16943688 11903743 17334410 17174718 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5014620537 18395914 18481824 18277467 17640975 17761835 16638106 12546737 15959796 15730626 15925388 12586293 17766677 12666154 14716833 14716496 15650968 12649538 15057751 17823541 18705752 15673190 15876570 18376398 18187930 17481882 18156304 18251166 18420326 17708605 11481614 12958196 15370692 12632514 14724832 12898905 15893842 12741479 15052691 17557913 18418968 16136751 18205269 14748882 16033810 15818738 17631135 17714472 16116963 18412020 17922224 15338365 18054572 17805973 18395095 15996030 12632512 17869086 16027843 18472332 17976157 18210741 20821823 18472094 16097048 16248980 18429990 16015684 18317297 12667390 17944888 17900296 18166357 16192424 10355542 17565644 17698563 17721639 15931870 12445421 14512876 18263696 18339082 18006644 13678700 18279442 12609069 17525996 15123356 15362042 12389079 16011737 12445418
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2719294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.2720007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 11.2719812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.2311606380 8985016
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008659 Metabolic Diseases resveratrol 4.5817112576
MESH:D009101 Multiple Myeloma resveratrol 3.6117935668 16267019 14749477 16490592 17049120 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9919151258
MESH:D009203 Myocardial Infarction resveratrol 5.9917188708 17015251 16525036 16456233 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.5617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009205 Myocarditis resveratrol 5.0417322642
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.268985016
MESH:D009421 Nervous System Malformations bisphenol A 10.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3914600291
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6217929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4817513867
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.0410548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.0416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.0411896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4216740699
MESH:D011471 Prostatic Neoplasms resveratrol 3.4217804756 15767336 17675339 16731767 17636462 17718901
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.8719058328
MESH:D015427 Reperfusion Injury resveratrol 6.8715827377 16314181 16317513 17520802 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms resveratrol 6.0015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6716321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014062 Tongue Neoplasms resveratrol 4.4116227395
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2917473185
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms resveratrol 4.3717044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5617488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31696
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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