AutismKB 2.0

Annotation Detail for ATP2A1


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Basic Information Top
Gene Symbol:ATP2A1 ( ATP2A,SERCA1 )
Gene Full Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Band: 16p11.2
Quick LinksEntrez ID:487; OMIM: 108730; Uniprot ID:AT2A1_HUMAN; ENSEMBL ID: ENSG00000196296; HGNC ID: 811
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1804Chronic obstructive airway disease
1831Prostate cancer
1832Congenital abnormality
Desease Name
Body mass index
weight
METABOLIC
No data
Desease Name
Brody myopathy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ATP2A1 mRNAaffects expression 17562736
C014949 acetylhydrazine acetylhydrazine results in decreased expression of ATP2A1 mRNAdecreases expression 15282401
D001241 Aspirin Aspirin results in increased expression of ATP2A1 mRNAincreases expression 11906190
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein]decreases activity|decreases reaction 12870653
D002118 Calcium Calcium binds to and affects the folding of ATP2A1 proteinaffects binding|affects folding 16618114
D002118 Calcium ATP2A1 protein affects the transport of Calciumaffects transport 11230109
C100106 dicarbine dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ATP2A1 mRNAdecreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ATP2A1 mRNA]decreases expression|decreases reaction 17942915
D004317 Doxorubicin Doxorubicin affects the activity of ATP2A1 proteinaffects activity 15937726
D004317 Doxorubicin Tamoxifen inhibits the reaction [Doxorubicin affects the activity of ATP2A1 protein]affects activity|decreases reaction 15937726
D004492 Edetic Acid Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
D004492 Edetic Acid dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
D004492 Edetic Acid [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 proteinaffects cotreatment|decreases activity 12870653
C020748 ferrous sulfate Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
C020748 ferrous sulfate dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]affects cotreatment|decreases activity|decreases reaction 12870653
C020748 ferrous sulfate [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 proteinaffects cotreatment|decreases activity 12870653
D005609 Free Radicals Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein]decreases activity|decreases reaction 12870653
D005609 Free Radicals Free Radicals results in decreased activity of ATP2A1 proteindecreases activity 12870653
C029424 hydrazine hydrazine results in decreased expression of ATP2A1 mRNAdecreases expression 15282401
D008274 Magnesium Magnesium binds to and affects the folding of ATP2A1 proteinaffects binding|affects folding 16618114
D008713 Methimazole Methimazole results in decreased expression of ATP2A1 mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in decreased expression of ATP2A1 mRNAdecreases expression 17403546
D010710 Phosphates Phosphates binds to and affects the folding of ATP2A1 proteinaffects binding|affects folding 16618114
D011441 Propylthiouracil Propylthiouracil results in decreased expression of ATP2A1 mRNAdecreases expression 17403546
D013467 Sulindac Sulindac results in decreased expression of ATP2A1 mRNAdecreases expression 11906190
D013629 Tamoxifen Tamoxifen inhibits the reaction [Doxorubicin affects the activity of ATP2A1 protein]affects activity|decreases reaction 15937726
C020806 tetrabromobisphenol A tetrabromobisphenol A results in decreased activity of ATP2A1 proteindecreases activity 18329244
C020806 tetrabromobisphenol A tetrabromobisphenol A results in decreased activity of ATP2A1 proteindecreases activity 17784851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP2A1 mRNAincreases expression 15716485
D014212 Tretinoin Tretinoin results in decreased expression of ATP2A1 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.5914745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.5914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Sulindac 4.197897758
MESH:D000230 Adenocarcinoma Doxorubicin 4.7617418594
MESH:D000230 Adenocarcinoma Sulindac 4.7611910360
MESH:D000236 Adenoma Diethylnitrosamine 11.0910737359 6695378
MESH:D000236 Adenoma Magnesium 11.0917823441
MESH:D000236 Adenoma Sulindac 11.0910223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6219052882 16434500 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4819003578 17611924 11535846 15623613 12394442 11874996 16460482
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.5920485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 2.4318445737
MESH:D001321 Autistic Disorder Magnesium 2.4316846101
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 21.096421970
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 21.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.0912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.0916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5714601052
MESH:D001913 Bowen's Disease Sulindac 5.2211207687
MESH:D001932 Brain Neoplasms Aspirin 8.7515481559
MESH:D001932 Brain Neoplasms Doxorubicin 8.7517150277
MESH:D001943 Breast Neoplasms Aspirin 3.6915161893
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6917474063
MESH:D001943 Breast Neoplasms Doxorubicin 3.6919526202 17426702 15939500 16935488 15136595 15567936 16826403 16595493 15993339 16264153 16096432 18382427 16115903 15994142 18628466 16322301 18234424 15634643 15692762 18695136 15668708 17983394 17369602 11325840
MESH:D001943 Breast Neoplasms Sulindac 3.6916642371
MESH:D001943 Breast Neoplasms Tamoxifen 3.6915565566 16273361 19011961 19142967 20390343 20135344 20544844 19059307 19155303 16202921 19084267 19103187 19288272 18351453 17893378 18855134 17261762 18997820 19200415 18821012 19221464 20005174 18629630 20065188 19189210 19066611 11161223 19487384 21152245 17049068 20859285 17242785 19189212 17440819 18815881 19244106 15668708 16818667 19115204 18425577 16873071 19410462 19289846 21138602 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6920435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6916166294 16443354 16873071
MESH:C536607 Brody myopathy marker/mechanism
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.643084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6419208518 19171122 16569478 17761372 20432363 17055752 16328049 17978847 17162532 19539802 21159647 10672840 16935385 20514400 19383236 17173139 16779866 16288022 16830150 18788625 19418558 19919837 16540662 16878318 10737359 18506893 20214788 17138121 16502159 19701751 19107877 3581430 20727157 19519916 20512989 20007298 18971187 19052882 18494052 3084413 11831363 17428255 18056438 18785209 19822196 20524982 20101231 18393292 18665156 18210153 16681979 20935162 16698587 19394651 18691550 20084675 18978308 16807293 19335982
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.6416234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.6416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.641917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.656189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4416651473 16612575 15811867 17519947 17131338 15476868 18627295 17308081 17928571 17007740 16731534 16455267 16952015 16242529 16109756 17924179 16278810 17382496 16364871 17974986 17351982 17329180 15505089 16269455 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9016243910 17334414
MESH:D002386 Cataract Acetaminophen 6.9710977129
MESH:D002386 Cataract Tretinoin 6.9717460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7721159647 17174075 2727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5815340226 8697196 15668235 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 5.589407595
MESH:D003092 Colitis Tretinoin 3.5717035595
MESH:D003110 Colonic Neoplasms Aspirin 4.2812411196
MESH:D003110 Colonic Neoplasms Sulindac 4.2812902858 12458338
MESH:D003111 Colonic Polyps Magnesium 5.9317823441
MESH:D015179 Colorectal Neoplasms Aspirin 4.8517047198
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8518802399 18259882
MESH:D015179 Colorectal Neoplasms Magnesium 4.8517823441
MESH:D015179 Colorectal Neoplasms Sulindac 4.8511197048 11076880 10666051 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4116925845 9125849 9211117 10589399 9142499 8800419 9224671 9664655 14991402 17551590
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D002658 Developmental Disabilities Magnesium 4.8216846101
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3619279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.0517621415 12861449
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6416227642 16109766 12153990 19085960 11529661 16485898 19739265 12958197 10663392 2444490 12540782 19923254 11461765 19370779 19416960 11421492 12705907 17562736 16781746 16177239 14550746 16393943 14725611 15968718 11834606 16081117 18071297 17522070 17906064 12392966 14986274 12594235 10915739 19164858 11287661 18713872 11739529 11743745 19420014 15619225 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.6417416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7911462148
MESH:D004487 Edema Aspirin 6.6617259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5116714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.4119031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.0017359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0020544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0016569247
MESH:D004715 Endometriosis Sulindac 8.8015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.809294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms Sulindac 3.1012235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.519664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 7.4321071580 20387270
MESH:D005234 Fatty Liver Tamoxifen 7.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.5214745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.5214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 18.7919069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 18.7919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 18.7919069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1920067830
MESH:D005355 Fibrosis Tretinoin 8.1917994277
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8811910360
MESH:D005909 Glioblastoma Aspirin 11.5312870263
MESH:D005909 Glioblastoma Doxorubicin 11.5317150277
MESH:D005909 Glioblastoma Tretinoin 11.5317312396
MESH:D006042 Goiter perchlorate 5.1818801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006261 Headache Aspirin 4.8315240983
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.5515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.3114991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.3914766674 16144979 16495754 16244371 16879835 16330681 17875725 18674790 16244372 17888722 18006777 12587719 16707910
MESH:D006333 Heart Failure Doxorubicin 3.2617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7612621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.3017606976 15147373 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 15340226 16959395 18606429 16354765
MESH:D012001 Hyperacusis Aspirin 5.6315240983
MESH:D006930 Hyperalgesia Acetaminophen 7.2816870215
MESH:D006930 Hyperalgesia Tretinoin 7.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3917604070
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8618670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.4914678291
MESH:D007037 Hypothyroidism Methimazole 11.5218031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.5218031379 8137927
MESH:D007249 Inflammation Diethylnitrosamine 11.4318785209
MESH:D007249 Inflammation Sulindac 11.433291741
MESH:D007249 Inflammation Tamoxifen 11.4319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4312200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.5212351151 10213222 12584176 10223192 12663524 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.8611245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 5.8115629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 5.8115699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0316707910
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9216316344
MESH:D007938 Leukemia Tretinoin 2.7117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0719642359 17506722 17107899 16891316 17217047 19075265 17368321 16788101 17339181 17361223 9834237 17649720 19035177 16823087 17712046 17294898 19225113 12679006 15748426 16935935 16331271 19029980 17301526 16766008 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008064 Lipidoses Tamoxifen 3.0617567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7518407596 18522880 19638242 20032147 18665156
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1412468960
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.4016611625 16610002 19460945 12587719 19784758 11587558 19014921 12969438
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4017034775
MESH:D008107 Liver Diseases Sulindac 6.4016867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1217185352 16871587
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 10.3418177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.3418648771 18754104 19073162 9163691 19551842 16942905 15885732 20405173 19427195 21047994 15175105 10737359 19996281 19256749 2422723 19833225 19255062 19426721 2862719 20492335 20434301 18644402 18977376 19690152 20118626 12112319 19254457 19812893 19850985 20137499 20501860 12771043 18978307 20452335 20101389 19499222 19090486 19638242 19642983 21278145 21167192 20583210 21071580 19294768
MESH:D008113 Liver Neoplasms Tamoxifen 10.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.3416984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.3818308698 19009564 17854601 18079962 19004024 18544905 18253720 16267830 2563599 18775883 18164116 19539802 17174075 17942915 9362446 19126423 21159647 3124819 18282651 18093689 19519916 16842330
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.3817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3812151625
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 8.3611246140 15390079 19359593 18597497 19925653 16337739 11696405
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3621163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 8.3617418594 6189445
MESH:D008175 Lung Neoplasms Sulindac 8.3619359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 8.3618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4415621674
MESH:D008275 Magnesium Deficiency Magnesium 6.3117823441
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.671500032
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.6715458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.6711731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.4219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Doxorubicin 7.1516827129
MESH:D008545 Melanoma Sulindac 7.1516642371
MESH:D008545 Melanoma Tamoxifen 7.1519393235 12393984
MESH:D008545 Melanoma Tretinoin 7.1516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D001523 Mental Disorders Phosphates 4.8812686366
MESH:D008654 Mesothelioma Doxorubicin 3.0117638057
MESH:D008881 Migraine Disorders Aspirin 8.1315240983
MESH:D008881 Migraine Disorders Magnesium 8.1318803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0117596541
MESH:D009203 Myocardial Infarction Aspirin 6.0512692751
MESH:D009203 Myocardial Infarction Doxorubicin 6.0519429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D009325 Nausea Aspirin 5.0915240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.229029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.2218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Tretinoin 2.3516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719200415 19189210 19196722
MESH:D009401 Nephrosis Doxorubicin 4.6416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8916889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0914600291
MESH:D009421 Nervous System Malformations Tretinoin 9.099125849
MESH:D009436 Neural Tube Defects Tretinoin 2.979142499
MESH:D009447 Neuroblastoma Doxorubicin 3.2015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.4920387270
MESH:D019636 Neurodegenerative Diseases Sulindac 13.4916850258 17266991
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D010003 Osteoarthritis Aspirin 3.987009135
MESH:D010024 Osteoporosis Calcium 3.7017882678
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3116936753
MESH:D010146 Pain Acetaminophen 15.2816870215
MESH:D010146 Pain Aspirin 15.286995502 6363464
MESH:D010146 Pain Sulindac 15.283291741
MESH:D010146 Pain Tretinoin 15.2816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4516540662
MESH:D010190 Pancreatic Neoplasms Sulindac 8.4516820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.4515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.4111156591
MESH:D020795 Photophobia Aspirin 5.6315240983
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0317638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.0311893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.442563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3915749863 15897917 16729912 16868541 18437689 16888761
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3915067354
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.0917922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9816116481 16283617
MESH:D012220 Rhinitis Aspirin 4.2612372130
MESH:D012509 Sarcoma Doxorubicin 3.8717203757 15675481 16767912 15625365 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.1312269725
MESH:D012878 Skin Neoplasms Doxorubicin 9.1115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.1116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4416767912 15625365 17203757
MESH:D013088 Spermatocele Tamoxifen 4.1616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9119457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3918456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3917261132
MESH:D020521 Stroke Aspirin 4.2716403987
MESH:D013927 Thrombosis Aspirin 4.4017672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.327505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.3217909728 16010429
MESH:D013964 Thyroid Neoplasms Propylthiouracil 16.3215710170
MESH:D013964 Thyroid Neoplasms Tretinoin 16.3217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0417653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.0417572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 8.4910982225
MESH:D014581 Urticaria Aspirin 8.4910982225 20485159
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014594 Uterine Neoplasms Sulindac 4.4718645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917678736 17334414 17638931 16364871
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
KEGG:04972 Pancreatic secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25105
    • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03431 - Adenosine-5'-Diphosphate
    DB03909 - Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
    DB04444 - Tetrafluoroaluminate Ion
    DB04638 - 2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONE Antioxidants;Enzyme Inhibitors
    DB07604 - (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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