AutismKB 2.0

Annotation Detail for ATP2A2


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Basic Information Top
Gene Symbol:ATP2A2 ( ATP2B,DAR,DD,DKFZp686P0211,FLJ20293,FLJ38063,MGC45367,SERCA2 )
Gene Full Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Band: 12q24.11
Quick LinksEntrez ID:488; OMIM: 108740; Uniprot ID:AT2A2_HUMAN; ENSEMBL ID: ENSG00000174437; HGNC ID: 812
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1779Cervical cancer
1804Chronic obstructive airway disease
1904Diabetes mellitus
1982Myopathy
2091Hypertension
2053Colon cancer
2186Achalasia and cardiospasm
Desease Name
protein quantitative trait loci
Darier's disease
Desease Name
Protein quantitative trait loci
Desease Name
Darier disease
Acrokeratosis verruciformis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]decreases reaction|increases expression 16236312
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATP2A2 mRNAaffects expression 21346803
C050147 3-(2,2,2-trimethylhydrazine)propionate 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ATP2A2 proteinincreases expression 12439634
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ATP2A2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ATP2A2 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine results in increased expression of ATP2A2 mRNAincreases expression 16084531
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
D000638 Amiodarone Amiodarone results in decreased expression of ATP2A2 mRNAdecreases expression 17535870
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP2A2 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of ATP2A2 mRNAdecreases expression 12558987
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ATP2A2 mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ATP2A2 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATP2A2 mRNAdecreases expression 19150397
C070515 bisindolylmaleimide I bisindolylmaleimide I results in decreased activity of ATP2A2 proteindecreases activity 17003265
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ATP2A2 mRNAdecreases expression 15336504
D002110 Caffeine ATP2A2 protein affects the susceptibility to Caffeineaffects response to substance 19328205
D002118 Calcium ATP2A2 protein affects the abundance of Calciumaffects abundance 19328205
D002118 Calcium ATP2A2 protein alternative form affects the export of Calciumaffects export 11679415
D002118 Calcium ATP2A2 protein alternative form affects the uptake of Calciumaffects uptake 11679415
D002118 Calcium PPP3R1 gene mutant form inhibits the reaction [ATP2A2 protein affects the transport of Calcium]affects transport|decreases reaction 19700627
D002118 Calcium ATP2A2 protein affects the transport of Calciumaffects transport 17287366
D002118 Calcium [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calciumdecreases expression|decreases transport 19244478
D002118 Calcium [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 proteinincreases activity|increases expression|increases transport 16236312
D002118 Calcium [Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calciumdecreases activity|decreases transport 19244478
D002211 Capsaicin Capsaicin affects the metabolism of ATP2A2 proteinaffects metabolic processing 18037908
D002211 Capsaicin Capsaicin results in decreased expression of ATP2A2 protein modified formdecreases expression 18037908
D016572 Cyclosporine Cyclosporine results in decreased expression of ATP2A2 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNAaffects cotreatment|decreases expression 11706060
D004041 Dietary Fats Dietary Fats results in increased expression of ATP2A2 mRNAincreases expression 18042831
D004317 Doxorubicin Doxorubicin results in decreased expression of ATP2A2 proteindecreases expression 16244372
D004317 Doxorubicin Doxorubicin results in decreased expression of ATP2A2 proteindecreases expression 17005195
D004317 Doxorubicin NRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of ATP2A2 mRNAincreases expression 16084531
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATP2A2 mRNAaffects expression 17555576
C054207 etomoxir etomoxir results in increased expression of ATP2A2 proteinincreases expression 12439634
C413355 GC 1 compound GC 1 compound results in increased expression of ATP2A2 mRNAincreases expression 11577024
C081021 Go 6976 Go 6976 results in decreased activity of ATP2A2 proteindecreases activity 17003265
D006861 Hydrogen Peroxide ATP2A2 protein affects the susceptibility to Hydrogen Peroxideaffects response to substance 19201925
D006861 Hydrogen Peroxide Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ATP2A2 proteindecreases expression 17005195
D006861 Hydrogen Peroxide NRG1 protein alternative form inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]decreases expression|decreases reaction 17005195
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNAaffects cotreatment|decreases expression 11706060
D007657 Ketone Bodies Ketone Bodies results in increased expression of ATP2A2 mRNAincreases expression 16807920
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Methamphetamine results in decreased expression of ATP2A2 mRNAdecreases expression 19149911
C008493 methylselenic acid methylselenic acid results in increased expression of ATP2A2 mRNAincreases expression 18548127
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ATP2A2 mRNAincreases expression 17616710
D009638 Norepinephrine ATP2A2 protein affects the abundance of Norepinephrineaffects abundance 19328205
D009638 Norepinephrine Norepinephrine results in decreased expression of ATP2A2 mRNAdecreases expression 17592507
C025589 ochratoxin A ochratoxin A results in increased expression of ATP2A2 mRNAincreases expression 16251485
D010126 Ozone ATP2A2 protein affects the susceptibility to Ozoneaffects response to substance 19201925
D017239 Paclitaxel Paclitaxel results in increased expression of ATP2A2 mRNAincreases expression 15585946
C041786 palm oil palm oil results in increased expression of ATP2A2 mRNAincreases expression 18042831
D010269 Paraquat IGF1 gene mutant form inhibits the reaction [Paraquat results in increased expression of ATP2A2 protein]decreases reaction|increases expression 17979500
D010269 Paraquat Paraquat results in increased expression of ATP2A2 proteinincreases expression 17979500
D010269 Paraquat Paraquat affects the expression of ATP2A2 mRNAaffects expression 16854511
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 proteinaffects cotreatment|decreases expression 11499749
D010656 Phenylephrine 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]decreases reaction|increases expression 16236312
D010656 Phenylephrine Phenylephrine results in decreased activity of ATP2A2 proteindecreases activity 17287366
D010656 Phenylephrine Phenylephrine results in decreased expression of ATP2A2 mRNAdecreases expression 15795322
19244478
17287366
17592507
11577024
D010656 Phenylephrine Phenylephrine results in decreased expression of ATP2A2 proteindecreases expression 19244478
17287366
D010656 Phenylephrine [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calciumdecreases expression|decreases transport 19244478
D010656 Phenylephrine [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 proteinincreases activity|increases expression|increases transport 16236312
D010656 Phenylephrine Phenylephrine results in increased expression of ATP2A2 mRNAincreases expression 16236312
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 17592507
11577024
D010656 Phenylephrine THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]affects reaction|decreases expression 11577024
D010656 Phenylephrine Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 11577024
C006253 pirinixic acid pirinixic acid results in increased expression of ATP2A2 mRNAincreases expression 18445702
18301758
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 17592507
11577024
C035988 procymidone procymidone results in decreased expression of ATP2A2 mRNAdecreases expression 15686871
D014284 Triiodothyronine THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]increases expression|increases reaction 11577024
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]decreases expression|decreases reaction 11577024
D014284 Triiodothyronine Triiodothyronine results in increased expression of ATP2A2 mRNAincreases expression 11577024
D013629 Tamoxifen Tamoxifen affects the expression of ATP2A2 mRNAaffects expression 17555576
C020806 tetrabromobisphenol A tetrabromobisphenol A results in decreased activity of ATP2A2 proteindecreases activity 17784851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP2A2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP2A2 mRNAincreases expression 19465110
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]decreases reaction|increases expression 19244478
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of ATP2A2 mRNAdecreases expression 19244478
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of ATP2A2 proteindecreases expression 19244478
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of ATP2A2 proteinincreases activity 17003265
C017953 tetramethylpyrazine tetramethylpyrazine results in increased expression of ATP2A2 mRNAincreases expression 15520497
D019284 Thapsigargin ATP2A2 protein affects the susceptibility to Thapsigarginaffects response to substance 17475205
D019284 Thapsigargin Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]decreases reaction|increases expression 19244478
D019284 Thapsigargin Thapsigargin results in decreased activity of ATP2A2 proteindecreases activity 17287366
D019284 Thapsigargin [Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calciumdecreases activity|decreases transport 19244478
D019284 Thapsigargin Thapsigargin results in increased expression of and results in decreased activity of ATP2A2 proteindecreases activity|increases expression 19244478
D019284 Thapsigargin Thapsigargin results in increased expression of ATP2A2 mRNAincreases expression 19244478
D014212 Tretinoin Tretinoin results in decreased expression of ATP2A2 mRNAdecreases expression 16054129
D014241 Trichloroethylene Trichloroethylene results in decreased expression of ATP2A2 mRNAdecreases expression 17905399
D014415 Tunicamycin Tunicamycin results in increased expression of ATP2A2 mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of ATP2A2 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of ATP2A2 mRNAdecreases expression 15686871
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNAaffects cotreatment|decreases expression 11706060
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9614745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 11.117525203
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 11.1118926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.1111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 2.9918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.269612607
OMIM:101900 ACROKERATOSIS VERRUCIFORMIS marker/mechanism
MESH:D058186 Acute Kidney Injury Capsaicin 4.0318460982
MESH:D055371 Acute Lung Injury pirinixic acid 2.5918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 8.6419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.6420464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 8.6417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.6414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.306695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.0016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.0016835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.2011874814
MESH:D000419 Albuminuria Doxorubicin 4.0021441931
MESH:D000505 Alopecia Capsaicin 8.0417569567
MESH:D000505 Alopecia Tretinoin 8.0415955085
MESH:D000544 Alzheimer Disease Lithium 4.1619621015
MESH:D000544 Alzheimer Disease Ozone 4.1615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4511748828
MESH:D000799 Angioedema Acetaminophen 3.2610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.1819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.4820041841 18218290 18057881
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.4817460149
MESH:D001161 Arteriosclerosis Dietary Fats 8.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.9515885639
MESH:D001169 Arthritis, Experimental Tretinoin 5.9516412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.0915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.0916292516
MESH:D001249 Asthma epigallocatechin gallate 6.7916516891
MESH:D001249 Asthma Ozone 6.7916373670 17854713
MESH:D001249 Asthma Tretinoin 6.7916456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.4618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.3618445737
MESH:D001321 Autistic Disorder Norepinephrine 2.368570775
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.5119761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8516935849
MESH:D001714 Bipolar Disorder Lithium 4.0020338123 17594078 20046352 19153942
MESH:D001778 Blood Coagulation Disorders Amiodarone 23.3619483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 23.3616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 23.3619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 23.3612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 23.3616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.1114601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0415867366
MESH:D001919 Bradycardia Capsaicin 9.0018207255
MESH:D001919 Bradycardia Phenylephrine 9.0015306635
MESH:D002545 Brain Ischemia Capsaicin 4.4019211983
MESH:D001932 Brain Neoplasms Doxorubicin 3.3117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.0520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 5.0520435547
MESH:D001943 Breast Neoplasms Doxorubicin 5.0511325840 15994142 17426702 18382427 16115903 15634643 18234424 16935488 15668708 15939500 15567936 15136595 16322301 15993339 19526202 16595493 17369602 16826403 17983394 15692762 16264153 16096432 18695136 18628466
MESH:D001943 Breast Neoplasms ochratoxin A 5.0511921183
MESH:D001943 Breast Neoplasms Paclitaxel 5.0516244791 18234424 16273361 18223236 16115903 18323546 15136595 11325840
MESH:D001943 Breast Neoplasms Tamoxifen 5.0519200415 21138602 19289846 17049068 19288272 19410462 20859285 18855134 18425577 19189210 16273361 19115204 19059307 15668708 19103187 19011961 19244106 17893378 20390343 17440819 17261762 19487384 21152245 15565566 18984771 19221464 18997820 18351453 19066611 18815881 20005174 16873071 20135344 19189212 17242785 20544844 19155303 19084267 18629630 19142967 20065188 11161223 16202921 18821012 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.0520435547
MESH:D001943 Breast Neoplasms Tretinoin 5.0516443354 16873071 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 5.0515986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2219059883 18417511 16777450 15516495 18315731 17626835 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8011589617
MESH:D002100 Cachexia Ozone 4.1716183385
MESH:D002276 Carcinoid Tumor Doxorubicin 4.2216051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5716168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 12.1516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.153084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 12.1515073043 16217749 11135700 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 12.1518059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 12.1516313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.1516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.151917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2919014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.861485588 16201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6112490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 12.1417015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.1420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.146189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 12.1418922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.1416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1117572228
MESH:D006332 Cardiomegaly marker/mechanism 11679415
MESH:D006332 Cardiomegaly Norepinephrine 9.6111179087
MESH:D006332 Cardiomegaly Phenylephrine 9.6111754973 17124262 11179087 16170337 17287366 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.6118670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.1415811867 17351982 16278810 15505089 16952015 16269455 15792986 16731534 17007740 17519947 17974986 17382496 16612575 17924179 17928571 16651473 16242529 16109756 16364871 15476868 17131338 18627295 17329180 17308081 16455267
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.2019225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.2016243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.1116936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5118974383
MESH:D002375 Catalepsy Norepinephrine 4.968216760
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 10.2714694615
MESH:D002386 Cataract Acetaminophen 10.2710977129
MESH:D002386 Cataract Tretinoin 10.2717460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.686135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.6820889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 12.6818226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.6812371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6716835633
MESH:D002779 Cholestasis Cyclosporine 10.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.8216919318 17333356 16105132 11677210 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 10.8219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8515668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 4.859407595
MESH:D003092 Colitis Tretinoin 3.1517035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.1520501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.1518259882 18802399
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.1518802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 7.5715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.5717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6412609071
MESH:D003371 Cough Capsaicin 4.5910350223
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.7510525206
MESH:D019465 Craniofacial Abnormalities ochratoxin A 4.7520036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.759224671 17551590 14991402 10589399 9125849 16925845 8800419 9211117 9142499 9664655
MESH:D003456 Cryptorchidism vinclozolin 3.7914966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4618551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.8819747007
MESH:D007644 Darier Disease marker/mechanism 16733453 20338123
MESH:D007644 Darier Disease Lithium 5.3420338123
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5615213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1318249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.1819244398
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.0316988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 2.9919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 21.7021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.7010774834 11461765 10663392 19739265 19164858 11287661 14550746 16081117 12540782 18071297 16393943 19416960 12153990 19085960 19923254 18713872 2444490 12705907 16485898 16177239 11529661 10915739 19370779 17906064 17562736 15968718 12594235 14725611 11834606 16781746 14986274 11739529 12958197 11743745 11421492 16109766 15619225 17522070 16227642 12392966 19420014
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 21.7011287661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.7018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 21.7017416283
MESH:D056486 Drug-Induced Liver Injury Prazosin 21.7018071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.7020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 21.707120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5119426721
MESH:D004362 Drug Toxicity Doxorubicin 16.0918602426
MESH:D004362 Drug Toxicity Lamivudine 16.0915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 16.0911462148
MESH:D004362 Drug Toxicity Zidovudine 16.0915040536
MESH:D004381 Duodenal Ulcer Capsaicin 4.1510671773 11535926
MESH:D050171 Dyslipidemias Dietary Fats 3.0318367378
MESH:D004487 Edema bisindolylmaleimide I 12.348273558
MESH:D004487 Edema pirinixic acid 12.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.3411000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 12.349599246 16716910 7812673 8273558 11698051 15177302 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0016714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.1412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.1419031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.2017359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.2016202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 10.2016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.529294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5718037988
MESH:D004827 Epilepsy Norepinephrine 3.98821787
MESH:D004935 Esophageal Diseases Capsaicin 5.1319566590
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 11.8212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.8216530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 11.8216805852 15150132 15878914 15547721 15547733 15623463 15264214 16704527 16510608
MESH:D004938 Esophageal Neoplasms Paclitaxel 11.8216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3811564622
MESH:D005124 Eye Abnormalities Tretinoin 7.3816938888 9664655
MESH:D005234 Fatty Liver Amiodarone 34.3214986274
MESH:D005234 Fatty Liver arsenic trioxide 34.3215073043
MESH:D005234 Fatty Liver Cyclosporine 34.3219224547
MESH:D005234 Fatty Liver Dietary Fats 34.3217967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.3215345470
MESH:D005234 Fatty Liver pirinixic acid 34.3219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 34.3214986274 19224547
MESH:D005234 Fatty Liver Zidovudine 34.3218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9514745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.5319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.5319069698
MESH:D005355 Fibrosis Cyclosporine 16.5612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5620067830
MESH:D005355 Fibrosis Tretinoin 16.5617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7116904648
MESH:D005756 Gastritis Acetaminophen 3.0916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3616973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7116417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.648708960
MESH:D005909 Glioblastoma Capsaicin 9.7718405923
MESH:D005909 Glioblastoma Doxorubicin 9.7717150277
MESH:D005909 Glioblastoma Tretinoin 9.7717312396
MESH:D005911 Gliosis Paraquat 4.5811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.5015692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.5016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5716084493
MESH:D006356 Heartburn Capsaicin 5.1319566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.2920471113
MESH:D006330 Heart Defects, Congenital Lithium 13.2919638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.2911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.2914991402 9664655
MESH:D006331 Heart Diseases marker/mechanism 19328205
MESH:D006331 Heart Diseases Doxorubicin 3.0816244371 12587719 14766674 16330681 18674790 17888722 16879835 16707910 16495754 16144979 17875725 18006777 16244372
MESH:D006333 Heart Failure 3-(2,2,2-trimethylhydrazine)propionate 14.0412439634
MESH:D006333 Heart Failure Doxorubicin 14.0417481944
MESH:D006333 Heart Failure etomoxir 14.0412439634
MESH:D006333 Heart Failure pirinixic acid 14.0420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3915692506
MESH:D006402 Hematologic Diseases Zidovudine 4.1812579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8211000095
MESH:D006505 Hepatitis Caffeine 4.4411394713
MESH:D006509 Hepatitis B Lamivudine 4.5817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.5815274664 15631357 12044531 16476009 15309715
MESH:D006529 Hepatomegaly Amiodarone 11.1915265979
MESH:D006529 Hepatomegaly pirinixic acid 11.1918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.1915340226 12621046 16120746
MESH:D015658 HIV Infections Indinavir 9.1915388451 11363243 11141242
MESH:D015658 HIV Infections Lamivudine 9.1917530837 11141242 9296927 20032539
MESH:D015658 HIV Infections Zidovudine 9.1920032539 11141242 11698656 17358032 11363243
MESH:D006689 Hodgkin Disease Doxorubicin 2.9415147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4615340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 15.0016870215
MESH:D006930 Hyperalgesia Capsaicin 15.0017434803 17043245
MESH:D006930 Hyperalgesia Prazosin 15.0012727271
MESH:D006930 Hyperalgesia Tretinoin 15.0016870215
MESH:D006937 Hypercholesterolemia Amiodarone 7.468137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 7.4621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6820558911
MESH:D006948 Hyperkinesis Methamphetamine 4.9317658665
MESH:D006949 Hyperlipidemias Dietary Fats 3.0921332399
MESH:D006973 Hypertension Cyclosporine 7.1210903974
MESH:D006973 Hypertension Phenylephrine 7.1212717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.1218670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.0412791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2516945680 16569931
MESH:D007022 Hypotension Norepinephrine 4.476740701
MESH:D007037 Hypothyroidism Amiodarone 3.9517991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.9217937319
MESH:D007248 Infertility, Male Paraquat 8.924850670
MESH:D007248 Infertility, Male vinclozolin 8.9216467254
MESH:D007249 Inflammation bisindolylmaleimide I 15.718273558
MESH:D007249 Inflammation Capsaicin 15.7116956363
MESH:D007249 Inflammation Dietary Fats 15.7120412841
MESH:D007249 Inflammation Tamoxifen 15.7119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.7112200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 15.718273558 7812673 15177302 11698051 7562506
MESH:D007333 Insulin Resistance Dietary Fats 5.9411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 5.9416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2117994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2217551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8515604871
MESH:D007673 Kidney Cortex Necrosis tetramethylpyrazine 6.1318842672
MESH:D007674 Kidney Diseases Acetaminophen 11.5712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 11.578314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 11.5715369732 16775033 15699352
MESH:D007674 Kidney Diseases ochratoxin A 11.5711409539
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.4116707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.4116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.3912371664
MESH:D007680 Kidney Neoplasms ochratoxin A 18.3916251485
MESH:D007680 Kidney Neoplasms Tamoxifen 18.3918625569
MESH:D007680 Kidney Neoplasms Zidovudine 18.3912579204
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.4616316344
MESH:D007938 Leukemia arsenic trioxide 5.2915070760
MESH:D007938 Leukemia Tretinoin 5.2917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5716085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.1312560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.1320370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.7619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.7616932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.4316467208 17050201 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.4319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.3211161223 17649720 15748426 12679006 16331271 17712046 16966277 15622746 19225113 15213294 17217047 16823087 15336539 19075265 12018890 17869043 12712474 16891316 19035177 11468182 19642359 9834237 16112521 17107899 16330433
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.3219029980 9834237 16788101 17107899 17301526 17339181 19075265 17712046 19642359 17217047 16891316 17506722 17361223 12679006 17649720 16140955 16935935 16331271 19035177 15748426 17294898 17368321 19225113 16766008 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1616417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.889224671
MESH:D008064 Lipidoses Amiodarone 6.5015342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.5017567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.2917353645
MESH:D008103 Liver Cirrhosis Dietary Fats 2.5418296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 7.4616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 7.4617481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 7.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.4616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.7316611625 12969438 19460945 11587558 16610002 12587719 19784758 19014921
MESH:D008107 Liver Diseases Capsaicin 3.7316956363
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.647678174
MESH:D008113 Liver Neoplasms arsenic trioxide 14.6414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.6415890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 14.6416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.646135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.6420377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.6416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.6412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 14.647955063
MESH:D008133 Long QT Syndrome Amiodarone 6.7117391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 6.7115213294
MESH:D008171 Lung Diseases Acetylcysteine 10.1712815614
MESH:D008171 Lung Diseases Amiodarone 10.1712587719
MESH:D008171 Lung Diseases Ozone 10.178266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8918516814
MESH:D055370 Lung Injury Ozone 3.3020417186
MESH:D008175 Lung Neoplasms arsenic trioxide 11.2511798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.2520064080 20464547 20869020 18569708 17053015 20135361 18520028 18816296 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 11.256189445 17418594
MESH:D008175 Lung Neoplasms Ozone 11.257614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 11.2518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.2511884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 11.2511807781
MESH:D008175 Lung Neoplasms Zidovudine 11.2518800350
MESH:D008223 Lymphoma Doxorubicin 3.0416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.3917654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 7.3914749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0115621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1919428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 11.1915458769
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 11.1911921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.1916827153 19196722 19196723 11731420 14580682
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 11.198985016
MESH:D020149 Manganese Poisoning Tamoxifen 3.9619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5317453147
MESH:D008545 Melanoma Doxorubicin 8.3516827129
MESH:D008545 Melanoma epigallocatechin gallate 8.3517992120 11746506
MESH:D008545 Melanoma Paclitaxel 8.3512025231 16342250 12040289
MESH:D008545 Melanoma Tamoxifen 8.3519393235 12393984
MESH:D008545 Melanoma Tretinoin 8.3516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0119513568
MESH:D008591 Meningomyelocele Tretinoin 3.8616940565
MESH:D008654 Mesothelioma Doxorubicin 2.8017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2016801185
MESH:D008679 Metaplasia Ozone 4.5210496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.2517358032
MESH:D008850 Microphthalmos ochratoxin A 5.2520036863
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9815792986
MESH:D009041 Motion Sickness Dextroamphetamine 4.941613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7416381670
MESH:D052016 Mucositis Doxorubicin 4.2217415656
MESH:D009101 Multiple Myeloma arsenic trioxide 9.8711468182 19417148 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma Capsaicin 9.8717505005
MESH:D009101 Multiple Myeloma Paclitaxel 9.8714749477
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 4.9217962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9516239165
MESH:D009164 Mycobacterium Infections Indinavir 4.8321442799
MESH:D009181 Mycoses Amiodarone 4.3217974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.2116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.2117596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.0315857846 19429709
MESH:D009203 Myocardial Infarction Lithium 8.0316288908
MESH:D009203 Myocardial Infarction pirinixic acid 8.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5612213967
MESH:D015428 Myocardial Reperfusion Injury marker/mechanism 10734148
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 7.3315642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3316411023
MESH:D017682 Myocardial Stunning marker/mechanism 16317512
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.297678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4216624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 11.4714720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.4718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.4715867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 9.2911141357
MESH:D009369 Neoplasms pirinixic acid 9.2917405874
MESH:D009369 Neoplasms Tretinoin 9.2916594593 16946489
MESH:D009369 Neoplasms Trichloroethylene 9.2911911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4219200415 19196722 19189210
MESH:D009401 Nephrosis Doxorubicin 4.2116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.6719348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.6716889571 15640375
MESH:D009410 Nerve Degeneration Paraquat 3.2716893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.7014600291
MESH:D009421 Nervous System Malformations Tretinoin 7.709125849
MESH:D009436 Neural Tube Defects Acetylcysteine 14.2119446573
MESH:D009436 Neural Tube Defects arsenic trioxide 14.2110525206
MESH:D009436 Neural Tube Defects ochratoxin A 14.2120036863
MESH:D009436 Neural Tube Defects Tretinoin 14.219142499
MESH:D009447 Neuroblastoma Doxorubicin 2.9415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4018514411
MESH:D020078 Neurogenic Inflammation Capsaicin 4.5617961222
MESH:D009765 Obesity Capsaicin 6.4619056576
MESH:D009765 Obesity Dietary Fats 6.4621332399 11836018 20518802 17217161 18674790 20132043 18457598 16723640 19632207
MESH:D009765 Obesity pirinixic acid 6.4620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.4716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 7.4714694615
MESH:D010014 Osteolysis Paclitaxel 4.4115867366
MESH:D010024 Osteoporosis Calcium 3.4117882678
MESH:D012516 Osteosarcoma Doxorubicin 3.6515930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 6.6916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Paclitaxel 6.6911161223
MESH:D010051 Ovarian Neoplasms Tretinoin 6.6916936753
MESH:D010146 Pain Acetaminophen 8.6516870215
MESH:D010146 Pain Capsaicin 8.6516996476 19081190 17434803 18987195 17043245 17084039
MESH:D010146 Pain Tretinoin 8.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.2815580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.2815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.2815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1611578682
MESH:D010212 Papilloma Hydrogen Peroxide 7.7612065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.7618922899 8330346 12065085 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.6319927285
MESH:D010300 Parkinson Disease Paraquat 2.5815451049 15824117 12911755 16140633 11445065 16510128 11181820 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.8716190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6612520081
MESH:D010538 Peritonitis Ozone 3.5716369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5717638057
MESH:D011014 Pneumonia Ozone 9.1618007984 18381685 18929643
MESH:D011014 Pneumonia Paraquat 9.1612504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0118163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.7412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.5911118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.5918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.3618220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8715749863 15897917 16888761 16868541 16729912 18437689
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8716205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8716356831 16729912 17136230 17172428
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011472 Prostatitis vinclozolin 4.3618629315
MESH:D011507 Proteinuria Tretinoin 3.0816636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011625 Pterygium Tretinoin 4.2216723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 4.9911597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Paraquat 4.9917997886 16324872
MESH:D051437 Renal Insufficiency Doxorubicin 3.6617922066
MESH:D015427 Reperfusion Injury Capsaicin 5.7818460982 19211983
MESH:D015427 Reperfusion Injury pirinixic acid 5.7819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 7.6912210543
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.6911700416
MESH:D012135 Respiratory Sounds Paraquat 3.5011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2918990726
MESH:D012162 Retinal Degeneration Paraquat 3.4316458197
MESH:D012206 Rhabdomyolysis Lamivudine 4.969296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5716283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.4915625365 18313854 15675481 17710206 17203757 16767912
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.4716646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.4716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2217846226
MESH:D012640 Seizures 2,6-dinitrotoluene 5.0718551238
MESH:D012640 Seizures Lithium 5.0719660546
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5118724381
MESH:D012852 Sinusitis Phenylephrine 4.137327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 22.5510029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 22.5515692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 22.5512065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 22.558532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 22.5516192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 22.558330346 11807781 18404319 12065085 8985016
MESH:D012878 Skin Neoplasms Tretinoin 22.5516467112
MESH:D012893 Sleep Disorders Caffeine 4.7419395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.5217225163
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0115625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 9.6116709447
MESH:D013088 Spermatocele Tamoxifen 9.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4719457130
MESH:D013226 Status Epilepticus Lithium 5.2019430551 19570321 19951488
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.2417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.242093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 7.2412958204 17575124
MESH:D013274 Stomach Neoplasms Paclitaxel 7.2418506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 7.2417261132
MESH:D013274 Stomach Neoplasms Zidovudine 7.2417696246
MESH:D013276 Stomach Ulcer Acetylcysteine 5.9817918041
MESH:D013276 Stomach Ulcer Amiodarone 5.9818087811
MESH:D013610 Tachycardia Amiodarone 9.3011238279
MESH:D013610 Tachycardia Norepinephrine 9.303261545
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6519225199
MESH:D024801 Tauopathies Paclitaxel 4.2416930453
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.1417997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6715669648
MESH:D013959 Thyroid Diseases Amiodarone 10.1019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.1012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.4619014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.4617909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 9.4616026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.3019584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.2916051514
MESH:D016171 Torsades de Pointes Amiodarone 8.3617467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 8.3615213294
MESH:D014376 Tuberculosis Tretinoin 2.8516040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.0016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.0012973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.0017053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 13.0017653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.0016712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7410091137
MESH:D014581 Urticaria Acetaminophen 2.4510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.1816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0216752155
MESH:D014605 Uveitis Cyclosporine 3.401336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.2012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.6616364871 17334414 17638931 17678736
MESH:D014820 Vitiligo Tretinoin 3.5116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6615886252
MESH:D015430 Weight Gain Dietary Fats 3.2516723640
MESH:D009396 Wilms Tumor Tretinoin 3.4816287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8517120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04020 Calcium signaling pathway
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:04972 Pancreatic secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA71
    • No data
    No data
    Releated drug ID Related drug Name
    PA165291922doxorubicinol
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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