AutismKB 2.0

Annotation Detail for NPTX2


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Basic Information Top
Gene Symbol:NPTX2 ( NARP,NP-II,NP2 )
Gene Full Name: neuronal pentraxin II
Band: 7q22.1
Quick LinksEntrez ID:4885; OMIM: 600750; Uniprot ID:NPTX2_HUMAN; ENSEMBL ID: ENSG00000106236; HGNC ID: 7953
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NPTX2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NPTX2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of NPTX2 mRNAincreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NPTX2 mRNAincreases expression 20106945
D003024 Clozapine Clozapine results in decreased expression of NPTX2 mRNAdecreases expression 18208916
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of NPTX2 mRNAaffects cotreatment|increases expression 17404688
C419708 gefitinib gefitinib results in decreased expression of NPTX2 mRNAdecreases expression 16685379
D006220 Haloperidol Haloperidol results in decreased expression of NPTX2 mRNAdecreases expression 18208916
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of NPTX2 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of NPTX2 mRNAincreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NPTX2 mRNAincreases expression 20106945
D014635 Valproic Acid Valproic Acid results in increased expression of NPTX2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9715322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.978875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.2511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000380 Agranulocytosis Clozapine 5.2312649775 14617031 16160616
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Haloperidol 2.3418080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3415238991 17688650 20603192 16609825 18985861 17157402 18558336 18316065 18940202 18177632 17507914 18775368 19460635 18396377 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.318888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315380490 15845082 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9416675129 17289903 18497071 12948864 19861407 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Progesterone 1.9416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7212619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7216217749 11135700 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7216924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9918347146 20005069 15496427 16230376 19233551 17290066
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 5.101977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 8697196 15668235 15340226 12621046
MESH:D003072 Cognition Disorders Clozapine 5.1417123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.0320501625
MESH:D015179 Colorectal Neoplasms gefitinib 3.0317594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.848888407 17688650 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 11.4315213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.4320210726
MESH:D003704 Dementia Haloperidol 4.7211575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6116402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.7715331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.8919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Clozapine 4.2816402076
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0718566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 9.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 8.3915073043
MESH:D005234 Fatty Liver Valproic Acid 8.3919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16959395 16354765
MESH:D006948 Hyperkinesis Clozapine 5.1016046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D006976 Hypertension, Pulmonary gefitinib 4.7918424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.4318424623
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Progesterone 5.2015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 8.3315610895
MESH:D007680 Kidney Neoplasms gefitinib 8.3318625569
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9817050201 16968895 19850784 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3016891316 15622746 15213294 15748426 17649720 16331271 9834237 17869043 16823087 15336539 19225113 12679006 19642359 16330433 19035177 12712474 11468182 12018890 16112521 11161223 19075265 17107899 16966277 17712046 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008064 Lipidoses Clozapine 4.0617567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.102125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1020195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.328603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.3220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9514755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9511798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9517053015 18816296 18520028 18569708 6695378 20869020 20135361 20064080 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 10.6918375820
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.6911408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D001523 Mental Disorders Clozapine 9.0216856516
MESH:D001523 Mental Disorders Haloperidol 9.0216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5319142101
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019417148 14977855 19549372 15949261 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 10.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6210525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.628888407 16359493
MESH:D009765 Obesity Clozapine 3.0418515891 19142110
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1312452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 8.1319401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.1316525653 17393432
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1211896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.1220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms gefitinib 2.1115651060 16685379 17914592
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Clozapine 9.4915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4911575062
MESH:D011658 Pulmonary Fibrosis gefitinib 4.0518424623
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Clozapine 5.8317726453 17123785 11763009 11151749 18855531 18806925 16141801 19369910 20107430 20168265 20580759 20521320 20521326 20452607 17667964
MESH:D012559 Schizophrenia Haloperidol 5.8318513383 19369910 1830565 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.8315737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8311044598 15475178 14763951 16876388 3137016 11738929 1511512 17978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8720210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.1019014326
MESH:D013964 Thyroid Neoplasms gefitinib 8.1016940797
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2112973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2117053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Clozapine 4.5916402076 20107430 16141801 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 5.2717933447
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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