Gene Symbol:	SLC11A2 ( DCT1,DMT1,FLJ37416,NRAMP2 )
Gene Full Name:	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Band:	12q13.12
Quick Links	Entrez ID:4891; OMIM: 600523; Uniprot ID:NRAM2_HUMAN; ENSEMBL ID: ENSG00000110911; HGNC ID: 10908
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000447	Aldehydes	SLC11A2 protein inhibits the reaction [Ozone results in increased abundance of Aldehydes]	decreases reaction\|increases abundance	16905637
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC11A2 mRNA	affects expression	16483693
D001151	Arsenic	Arsenic affects the expression of SLC11A2 mRNA	affects expression	18414638
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of SLC11A2 mRNA	increases expression	16272461
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of SLC11A2 protein	increases expression	16272461
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC11A2 mRNA	decreases expression	20106945
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SLC11A2 mRNA	increases expression	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of SLC11A2 mRNA	decreases expression	14729362
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of SLC11A2 mRNA	decreases expression	17720352
D002104	Cadmium	SLC11A2 protein affects the transport of Cadmium	affects transport	16552559
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLC11A2 mRNA	decreases expression	20106945
D013759	Tetrahydrocannabinol	Tetrahydrocannabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SLC11A2 mRNA	decreases expression	19061943
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SLC11A2 protein	decreases expression	19061943
D004052	Diethylnitrosamine	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]	decreases expression\|decreases reaction	19061943
C042986	ebselen	ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D004958	Estradiol	Estradiol affects the expression of SLC11A2 mRNA	affects expression	16684588
D000431	Ethanol	Ethanol results in increased expression of SLC11A2 protein	increases expression	16737972
D000431	Ethanol	HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	decreases reaction\|increases expression	16737972
D000431	Ethanol	Vitamin E inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	decreases reaction\|increases expression	16737972
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SLC11A2 mRNA	affects expression	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLC11A2 mRNA	increases expression	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC11A2 mRNA	affects cotreatment\|increases expression	17942748
C013531	ferric ammonium citrate	ferric ammonium citrate results in increased expression of SLC11A2 mRNA	increases expression	11054110
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA	decreases expression	11925462
D007501	Iron	ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D007501	Iron	[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron	affects binding\|decreases uptake	16841247
D007501	Iron	prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D007501	Iron	Tetrahydrocannabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D007501	Iron	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]	decreases expression\|decreases reaction	19061943
D007501	Iron	Iron results in increased expression of SLC11A2 mRNA	increases expression	16648237
D007501	Iron	SLC11A2 gene mutant form results in decreased transport of Iron	decreases transport	17116712
D007501	Iron	SLC11A2 protein affects the metabolism of Iron	affects metabolic processing	17194590
D007501	Iron	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]	decreases reaction\|increases uptake	17116743
D007501	Iron	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]	decreases reaction\|increases uptake	17116743
D007501	Iron	Iron results in decreased expression of SLC11A2 protein	decreases expression	17116743
D007501	Iron	Iron results in increased expression of SLC11A2 mRNA	increases expression	15908475
D007501	Iron	Iron results in increased expression of SLC11A2 protein	increases expression	15908475
D007501	Iron	Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]	increases reaction\|increases transport	15908475
D007501	Iron	Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]	affects binding\|increases reaction\|increases uptake	16908409
D007501	Iron	SLC11A2 gene mutant form results in decreased uptake of Iron	decreases uptake	17116712
D007501	Iron	SLC11A2 protein affects the metabolism of Iron	affects metabolic processing	17194590
D007501	Iron	SLC11A2 protein mutant form results in decreased uptake of Iron	decreases uptake	17116743
D019266	Iron, Dietary	Iron, Dietary affects the expression of SLC11A2 mRNA	affects expression	15637178
D007608	Kainic Acid	Kainic Acid results in increased expression of SLC11A2	increases expression	16552559
D007854	Lead	SLC11A2 protein affects the transport of Lead	affects transport	16552559
D001556	Lindane	Lindane results in increased expression of SLC11A2 mRNA	increases expression	17785943
D008070	Lipopolysaccharides	IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of SLC11A2 mRNA]	increases expression\|increases reaction	11054110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLC11A2 mRNA	increases expression	16648237 11054110
D008345	Manganese	Manganese results in increased expression of SLC11A2 mRNA	increases expression	17175027
D008345	Manganese	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]	decreases reaction\|increases uptake	17116743
D008345	Manganese	Manganese results in increased expression of SLC11A2 mRNA	increases expression	16729984
D008345	Manganese	Manganese results in increased expression of SLC11A2 protein	increases expression	16729984 16705042
D008345	Manganese	Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]	affects binding\|increases stability	16729984
D008345	Manganese	SLC11A2 protein mutant form results in decreased metabolism of Manganese	decreases metabolic processing	17116743
D008345	Manganese	SLC11A2 protein mutant form results in decreased uptake of Manganese	decreases uptake	17116743
C025340	manganese chloride	manganese chloride results in increased expression of SLC11A2 mRNA	increases expression	17175027
C025340	manganese chloride	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]	decreases reaction\|increases uptake	17116743
C025340	manganese chloride	SLC11A2 protein mutant form results in decreased uptake of manganese chloride	decreases uptake	17116743
D008670	Metals	Metals inhibits the reaction [SLC11A2 protein results in increased transport of Vanadium]	decreases reaction\|increases transport	15908475
D008670	Metals	Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]	increases reaction\|increases transport	15908475
D008670	Metals	SLC11A2 protein results in increased transport of Metals	increases transport	15908475
D009569	Nitric Oxide	Nitric Oxide affects the expression of SLC11A2 protein alternative form	affects expression	16232120
D009569	Nitric Oxide	Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]	affects binding\|increases reaction\|increases uptake	16908409
D010126	Ozone	SLC11A2 protein inhibits the reaction [Ozone results in increased abundance of Aldehydes]	decreases reaction\|increases abundance	16905637
D010126	Ozone	SLC11A2 protein inhibits the reaction [Ozone results in increased secretion of IL8 protein]	decreases reaction\|increases secretion	16905637
D010634	Phenobarbital	Phenobarbital results in decreased methylation of SLC11A2 promoter	decreases methylation	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC11A2 mRNA	increases expression	19482888
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	decreases reaction\|increases uptake	16984886
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of SLC11A2 mRNA	affects cotreatment\|decreases expression	19244175
D013629	Tamoxifen	Tamoxifen affects the expression of SLC11A2 mRNA	affects expression	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC11A2 mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC11A2 mRNA	decreases expression	19465110
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC11A2 mRNA	increases expression	17942748
D014212	Tretinoin	Tretinoin affects the expression of SLC11A2 mRNA alternative form	affects expression	16232120
D014212	Tretinoin	Tretinoin affects the expression of SLC11A2 protein alternative form	affects expression	16232120
D014212	Tretinoin	Tretinoin affects the reaction [RELA protein binds to SLC11A2 promoter]	affects binding\|affects reaction	16232120
D014639	Vanadium	Metals inhibits the reaction [SLC11A2 protein results in increased transport of Vanadium]	decreases reaction\|increases transport	15908475
D014639	Vanadium	Vanadium results in decreased expression of SLC11A2 mRNA	decreases expression	15908475
D014639	Vanadium	Vanadium results in decreased expression of SLC11A2 protein	decreases expression	15908475
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of SLC11A2 mRNA	affects cotreatment\|decreases expression	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of SLC11A2 mRNA	decreases expression	19244175
D014810	Vitamin E	Vitamin E inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	decreases reaction\|increases expression	16737972
D015032	Zinc	Zinc results in increased expression of SLC11A2 mRNA	increases expression	16614402
D015032	Zinc	Zinc results in increased expression of SLC11A2 protein	increases expression	16614402

Pathway ID	Pathway Name
KEGG:04142	Lysosome
KEGG:04978	Mineral absorption
REACT:15518	Transmembrane transport of small molecules

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms		Tamoxifen	4.16	14745880
MESH:D000014	Abnormalities, Drug-Induced		Ethanol	12.05	17676605 18926900
MESH:D000014	Abnormalities, Drug-Induced		Phenobarbital	12.05	6195326
MESH:D000014	Abnormalities, Drug-Induced		Tetrachlorodibenzodioxin	12.05	11752688 14514962 15322242
MESH:D000138	Acidosis		Ammonium Chloride	9.20	18287403
MESH:D000138	Acidosis		Ethanol	9.20	11192467
MESH:D000152	Acne Vulgaris		Ethinyl Estradiol	3.55	17505938
MESH:D000169	Acrodermatitis		Zinc	5.02	16889938 17202136 17190629
MESH:D055371	Acute Lung Injury		Lipopolysaccharides	3.68	11850527 18653653
MESH:D000230	Adenocarcinoma		Benzo(a)pyrene	6.36	20127859 20464547
MESH:D000230	Adenocarcinoma		Estradiol	6.36	11473722
MESH:D000230	Adenocarcinoma		Ethinyl Estradiol	6.36	14692618
MESH:D000236	Adenoma		Benzo(a)pyrene	5.88	6695378
MESH:D000236	Adenoma		Diethylnitrosamine	5.88	10737359 6695378
MESH:D018248	Adenoma, Liver Cell		Diethylnitrosamine	15.13	16434500 19061943 17162532 19052882 18056438 17620307
MESH:D018248	Adenoma, Liver Cell		Phenobarbital	15.13	17620307
MESH:D018248	Adenoma, Liver Cell		Tetrachlorodibenzodioxin	15.13	16835633
MESH:D018246	Adrenocortical Adenoma		Arsenic	4.82	17306315
MESH:D000382	Agricultural Workers' Diseases		Lindane	4.00	12661182
MESH:D020268	Alcohol-Induced Disorders, Nervous System		Ethanol	4.93	15451040 15451039
MESH:D000505	Alopecia		Tretinoin	3.32	15955085
MESH:D019896	alpha 1-Antitrypsin Deficiency		Iron	5.27	16640825
MESH:D000544	Alzheimer Disease		Iron	8.73	16640825 16563566
MESH:D000544	Alzheimer Disease		Nitric Oxide	8.73	17556102
MESH:D000544	Alzheimer Disease		Ozone	8.73	15513908
MESH:D000544	Alzheimer Disease		Zinc	8.73	16325427 16580781 17119284 16410023
MESH:D000690	Amyotrophic Lateral Sclerosis		Tetrahydrocannabinol	4.59	15204022
MESH:D000740	Anemia		Iron	7.83	16434484 16566752
MESH:D000740	Anemia		Tetrachlorodibenzodioxin	7.83	11748828
OMIM:206100	ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD	marker/mechanism
MESH:D018798	Anemia, Iron-Deficiency	marker/mechanism			17116712
MESH:D018798	Anemia, Iron-Deficiency		Iron	4.32	17162259 17163184 16569441 17375513 17147795
MESH:D000755	Anemia, Sickle Cell		Zinc	4.54	16916123
MESH:D000756	Anemia, Sideroblastic		Iron	15.93	16910769
MESH:D000756	Anemia, Sideroblastic		Manganese	15.93	16910769
MESH:D000756	Anemia, Sideroblastic		manganese chloride	15.93	16910769
MESH:D000853	Anophthalmos		Ethanol	4.45	15513904
MESH:D001008	Anxiety Disorders		Ethanol	3.71	11141031
MESH:D017544	Aortic Aneurysm, Abdominal		Benzo(a)pyrene	3.70	19183758
MESH:D001145	Arrhythmias, Cardiac		Iron	4.04	16604332

AutismKB 2.0

Annotation Detail for SLC11A2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics