AutismKB 2.0

Annotation Detail for NRCAM


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Basic Information Top
Gene Symbol:NRCAM ( KIAA0343,MGC138845,MGC138846 )
Gene Full Name: neuronal cell adhesion molecule
Band: 7q31.1
Quick LinksEntrez ID:4897; OMIM: 601581; Uniprot ID:NRCAM_HUMAN; ENSEMBL ID: ENSG00000091129; HGNC ID: 7994
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Axon guidance
No data
No data
Pathway IDPathway Name
500097L1CAM interactions
500102Neurofascin interactions
500103NrCAM interactions
Related Diseases/Disorders Top
No data
No data
Desease Name
autism obsessive compulsive disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRCAM mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of NRCAM mRNAincreases expression 18007998
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of NRCAM mRNAdecreases expression 17452286
D016572 Cyclosporine Cyclosporine results in increased expression of NRCAM mRNAincreases expression 20106945
C014347 decitabine decitabine affects the expression of NRCAM mRNAaffects expression 17194187
D005419 Flavonoids Flavonoids results in increased expression of NRCAM mRNAincreases expression 18035473
D007213 Indomethacin Indomethacin results in decreased expression of NRCAM mRNAdecreases expression 16984733
C024746 tobacco tar tobacco tar results in decreased expression of NRCAM mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000230 Adenocarcinoma Indomethacin 2.8316537180
MESH:D000236 Adenoma Indomethacin 3.5811497255
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.6811874814 16611668 17119214
MESH:D016301 Alveolar Bone Loss Indomethacin 5.7517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7415579461 17627676
MESH:D001014 Aortic Aneurysm Indomethacin 5.1310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1810388637
MESH:D018771 Arthralgia Indomethacin 5.552160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001321 Autistic Disorder marker/mechanism 17106428 18664314
MESH:D001477 Bartter Syndrome Indomethacin 5.2910684365
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001929 Brain Edema Indomethacin 5.4011481608
MESH:D002545 Brain Ischemia Indomethacin 4.7512524144
MESH:D001943 Breast Neoplasms marker/mechanism 18507500
MESH:D001943 Breast Neoplasms bisphenol A 2.0617123778
MESH:D001943 Breast Neoplasms decitabine 2.0618320071 19208741
MESH:D001943 Breast Neoplasms Indomethacin 2.0617401462
MESH:D002056 Burns Indomethacin 5.0110459503
MESH:D002100 Cachexia Indomethacin 5.3415141370 15625704 11239499 16537180
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 2.4716391822
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6911352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4717341418
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1719215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 5.1712636206 15482327
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5412371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.5419559774
MESH:D002764 Cholecystitis Indomethacin 5.5511181007
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003110 Colonic Neoplasms decitabine 4.1217616700
MESH:D003110 Colonic Neoplasms Indomethacin 4.1215786552 15936596 15625704 15637740 15963497 11260862
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247 18507500
MESH:D015179 Colorectal Neoplasms decitabine 2.8118981723
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8118059344 12606626 11197048 17054584
MESH:D018352 Coronavirus Infections Indomethacin 6.0917302372
MESH:D003967 Diarrhea Indomethacin 4.077907874 7237001
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4916133044 18043480 16326151 17190690 12774134 18446180
MESH:D004381 Duodenal Ulcer Indomethacin 4.4216699067 10671773 11991626 17045617 17202747 17151854 17329845 11535926 11595415 11595431 17351913
MESH:D004487 Edema Indomethacin 3.7416100529 8985016 7907874 10653021 8273558 7990266 19703484
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004715 Endometriosis Indomethacin 4.3715652904
MESH:D019446 Endotoxemia Indomethacin 4.8418509659
MESH:D004751 Enteritis Indomethacin 5.1217763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2917980183
MESH:D004802 Eosinophilia Indomethacin 4.3611298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8511005569
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005334 Fever Indomethacin 4.3517627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.2310962813
MESH:D005355 Fibrosis Cyclosporine 9.9412639820 12168785
MESH:D005355 Fibrosis Indomethacin 9.9417994277
MESH:D005499 Folliculitis Indomethacin 5.5511298111
MESH:D005756 Gastritis Indomethacin 5.1215046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Indomethacin 3.7112870263
MESH:D005910 Glioma Indomethacin 3.3018371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4811849393
MESH:D006073 Gout Indomethacin 5.6911248219
MESH:D006258 Head and Neck Neoplasms decitabine 8.5519215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.5515482327
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9615135802
MESH:D006930 Hyperalgesia Indomethacin 3.9612727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0917883296
MESH:D006940 Hyperemia Indomethacin 5.3412524144
MESH:D006949 Hyperlipidemias Indomethacin 4.4217546600
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007077 Ileal Diseases Indomethacin 5.4010574470 18306037
MESH:D007079 Ileitis Indomethacin 5.6910647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.7516133044
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Flavonoids 5.7817296493
MESH:D007249 Inflammation Indomethacin 5.787812673 3291741 12568917
MESH:D007333 Insulin Resistance bisphenol A 3.4416393666
MESH:D007410 Intestinal Diseases Indomethacin 4.6317329856 11855677 11713966 18236018 17994277 10210152 15831440 11686837 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.7515241188
MESH:D007579 Jejunal Diseases Indomethacin 5.4018306037 10574470 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.618314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 6.6117190690
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1012228301 11703811 10320625
MESH:D007938 Leukemia decitabine 3.1818980019 19235587
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1010785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3019387464 19010910 18704418 18460780 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.3018360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D007964 Leukocytosis Indomethacin 5.7516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.3718194892
MESH:D008107 Liver Diseases Chlorpyrifos 3.1215991261
MESH:D008175 Lung Neoplasms Indomethacin 2.3616537180 11497255 11053908
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Indomethacin 3.8411903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.1712636206
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 16882708 19157545 18608210
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2511239499 16537180 11053908
MESH:D009369 Neoplasms decitabine 2.8119470736 19116145 17925555
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4415625704 10663608
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.2516427766 11399458
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.1412349958
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3215081274
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.556374098
MESH:D010003 Osteoarthritis Indomethacin 3.807009135
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010051 Ovarian Neoplasms decitabine 2.7119259094 19331143
MESH:D010146 Pain Indomethacin 3.6617627676 3291741 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 5.0618702446 12538197
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D010195 Pancreatitis Indomethacin 4.1815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0911903285
MESH:D010437 Peptic Ulcer Indomethacin 5.4911148446
MESH:D010518 Periodontitis Indomethacin 5.2917225004
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D047928 Premature Birth Indomethacin 5.4317000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2910548101
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3716740699
MESH:D011507 Proteinuria Indomethacin 4.4211849393
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.9416611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.2717119214 16611668
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.476418539
MESH:D013272 Stomach Diseases Indomethacin 4.7515472012 16113693 15038085 16184426 10486359 18545984 17160473 10192188 10215738 17638125 16280098 17207306 18209964
MESH:D013274 Stomach Neoplasms decitabine 2.8019037991
MESH:D013274 Stomach Neoplasms Indomethacin 2.8015609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8212498302 16631530 17135157 18209962 16755016 12787963 17895592 17654042 12467913 15255614 16397915 11595415 12077510 18193104 18543354 11145282 11729361 18726076 11906479 18181030 1323529 10878458 15104355 12500499 18299717 10423059 14567935 16169175 17918041 17657623 15138204 17977527 17627676 18087811 10750652 11523592 16150113 11595431 18431645 16252198 16934674 18237397
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216684133 16045194
MESH:D013964 Thyroid Neoplasms decitabine 8.1217967635
MESH:D013964 Thyroid Neoplasms Indomethacin 8.1211352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 5.2310574470 17380554
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8017616700 19087683
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014839 Vomiting Indomethacin 5.1211897121
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31773
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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