AutismKB 2.0

Annotation Detail for NRF1


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Basic Information Top
Gene Symbol:NRF1 ( ALPHA-PAL )
Gene Full Name: nuclear respiratory factor 1
Band: 7q32.2
Quick LinksEntrez ID:4899; OMIM: 600879; Uniprot ID:NRF1_HUMAN; ENSEMBL ID: ENSG00000106459; HGNC ID: 7996
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C095284 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]decreases reaction|increases expression 17179207
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]affects binding|decreases reaction|increases reaction 17179207
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]decreases reaction|increases expression 17179207
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of NRF1 mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRF1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene promotes the reaction [NRF1 protein binds to GSTA1 gene]affects binding|increases reaction 11961136
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRF1 mRNAdecreases expression 19150397
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of NRF1 mRNAincreases expression 17179207
D002248 Carbon Monoxide 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]decreases reaction|increases expression 17179207
D002248 Carbon Monoxide 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]affects binding|decreases reaction|increases reaction 17179207
D002248 Carbon Monoxide 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]decreases reaction|increases expression 17179207
D002248 Carbon Monoxide Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]affects binding|increases reaction 17179207
D002248 Carbon Monoxide Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]affects binding|increases reaction 17179207
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of NRF1 proteinincreases expression 17179207
D002248 Carbon Monoxide CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]affects binding|decreases reaction|increases reaction 17179207
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NRF1 mRNAincreases expression 16934159
D018119 Stavudine Stavudine results in increased expression of NRF1 mRNAincreases expression 17926646
D019297 2,4-Dinitrophenol 2,4-Dinitrophenol results in increased expression of NRF1 mRNAincreases expression 11784294
D004958 Estradiol ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of NRF1 mRNA]decreases reaction|increases expression 20302909
D004958 Estradiol Estradiol results in increased expression of NRF1 mRNAincreases expression 20302909
D004958 Estradiol [Estradiol co-treated with Norepinephrine] results in decreased expression of NRF1 mRNAaffects cotreatment|decreases expression 16954335
D019469 Indinavir Indinavir results in increased expression of NRF1 mRNAincreases expression 17926646
D009638 Norepinephrine [Estradiol co-treated with Norepinephrine] results in decreased expression of NRF1 mRNAaffects cotreatment|decreases expression 16954335
C422648 pluronic block copolymer p85 pluronic block copolymer p85 results in decreased expression of NRF1 mRNAdecreases expression 16579640
D012643 Selenium NRF1 protein promotes the reaction [Selenium results in increased expression of TFAM mRNA]increases expression|increases reaction 17936198
D012643 Selenium Selenium results in increased expression of NRF1 mRNAincreases expression 17936198
D014501 Uranium Uranium affects the expression of NRF1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of NRF1 mRNAaffects expression 15672453
D015215 Zidovudine Zidovudine results in increased expression of NRF1 mRNAincreases expression 17926646
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.799612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001321 Autistic Disorder Norepinephrine 3.378570775
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0717474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.0714630087 19861407 12948864 16675129 18497071 17261762 17289903 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.937296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Norepinephrine 4.3411179087
MESH:D002375 Catalepsy Norepinephrine 5.508216760
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.997505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.9920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.9918566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.119022650 19486331
MESH:D003092 Colitis Carbon Monoxide 10.0816365149
MESH:D003092 Colitis Selenium 10.0817936198
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.772524372 12868966 18759878 8156756 8970840 11298694 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.319328219 9022650 18692083 7440962 18289764 6482804 6679447 8291058 1440618 18648102 11289319 16192314 9653073
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.3117851650
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3115131321
MESH:D004362 Drug Toxicity Stavudine 8.9315040536
MESH:D004362 Drug Toxicity Zidovudine 8.9315040536
MESH:D016889 Endometrial Neoplasms Estradiol 2.9511473722 18566989 19148513
MESH:D004827 Epilepsy Norepinephrine 4.27821787
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D005234 Fatty Liver Stavudine 8.5818299183
MESH:D005234 Fatty Liver Zidovudine 8.5818299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6320471113
MESH:D006333 Heart Failure Selenium 3.0517162251
MESH:D006402 Hematologic Diseases Zidovudine 4.6712579204
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D015658 HIV Infections Indinavir 11.0815388451 11141242 11363243
MESH:D015658 HIV Infections Stavudine 11.0811141242
MESH:D015658 HIV Infections Zidovudine 11.0811141242 20032539 17358032 11363243 11698656
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D007022 Hypotension Norepinephrine 4.956740701
MESH:D007251 Influenza, Human Selenium 4.1716624496
MESH:D007333 Insulin Resistance Estradiol 2.9416393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.999022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.5615618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.8416518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.296582329
MESH:D007680 Kidney Neoplasms Estradiol 12.2915610895
MESH:D007680 Kidney Neoplasms Zidovudine 12.2912579204
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.7812970779
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3720370541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.179327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6714716833 14659978
MESH:D008107 Liver Diseases Carbon Monoxide 4.0717173083
MESH:D017093 Liver Failure Stavudine 5.8218299183
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0321137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.50598648 3712494 6587162 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6318569708 20135361 18816296 18520028 20464547 20064080 6695378 20869020 17053015
MESH:D008175 Lung Neoplasms Zidovudine 2.6318800350
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9216891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.9215318939
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009164 Mycobacterium Infections Indinavir 5.3821442799
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8316810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 8.8315642760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.453581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1511141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009421 Nervous System Malformations Estradiol 3.6116427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.886679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.386482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5.1416211241
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1216740699
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3510029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.592093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 2.5917696246
MESH:D013610 Tachycardia Norepinephrine 5.393261545
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.851399818 6582329 3712494 7505956 6587162
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.918074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7212579204
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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