AutismKB 2.0

Annotation Detail for YBX1


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Basic Information Top
Gene Symbol:YBX1 ( BP-8,CSDA2,CSDB,DBPB,MDR-NF1,MGC104858,MGC110976,MGC117250,NSEP-1,NSEP1,YB-1,YB1 )
Gene Full Name: Y box binding protein 1
Band: 1p34.2
Quick LinksEntrez ID:4904; OMIM: 154030; Uniprot ID:YBOX1_HUMAN; ENSEMBL ID: ENSG00000065978; HGNC ID: 8014
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of YBX1 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of YBX1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of YBX1 mRNAaffects expression 16483693
C015001 arsenite arsenite affects the localization of YBX1 proteinaffects localization 17339575
D002251 Carbon Tetrachloride YBX1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]decreases reaction|increases expression 16012952
C099555 CD 437 CD 437 results in decreased expression of YBX1 mRNAdecreases expression 12958071
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of YBX1 mRNAdecreases expression 17108234
D005472 Fluorouracil Fluorouracil promotes the reaction [YBX1 protein binds to MVP promoter]affects binding|increases reaction 15750632
D008628 Mercury Mercury results in increased expression of YBX1 mRNAincreases expression 16823088
D009151 Mustard Gas Mustard Gas results in increased expression of YBX1 mRNAincreases expression 15674843
C037219 quinoline quinoline analog results in decreased expression of YBX1 proteindecreases expression 18645022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of YBX1 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in decreased expression of YBX1 mRNAdecreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4014692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4017638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Fluorouracil 8.9415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Mustard Gas 5.0610378619
MESH:D001249 Asthma Tretinoin 5.0616456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.9816634805
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms marker/mechanism 15703814
MESH:D001943 Breast Neoplasms Fluorouracil 1.8616110121 16595493 18357371 18608205 19217205 16557594 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8616166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1110378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815700767 18705752 16192424 16011737 15721981 10355542 16227642 16097048 15673190 16124888 16050911 3786805
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.033084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0318788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0316332177 17088986 17045692 17971768 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular quinoline 9.03598648
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.031917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8018986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8016096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002386 Cataract Tretinoin 7.3817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9316919318 17110522 17681005 11677210 16105132 15861022 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8712621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D003110 Colonic Neoplasms arsenite 4.0115037631
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0117018589 16510598 17016597 17169374 15001691 17725105 17172411 18772588 16340194 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016282729 18288408 16391804 17255274 16524972 15289873 18448328 17695437 14970324 16331619 18383874 18802399 18509181 16303861 17454858 15148649 20501625 18949393 17016601 17094418 17594712 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.479125849 9224671 17551590 9211117 8800419 9142499 9664655 16925845 14991402 10589399
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.9016823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2518071297 19923254 12705907 12392966 11287661 12594235 10663392 12958197 19739265 11743745 14725611 16227642 19416960 12153990 11461765 11739529 17906064 16109766 16781746 19420014 18713872 19164858 10915739 15619225 11421492 2444490 16177239 11834606 14550746 17522070 14986274 16485898 10774834 19370779 19085960 16081117 15968718 17562736 11529661 16393943 12540782
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.254309450 10092053 15968718 3786805 11566570 6623471 16177239 6884620 9327722 15998439 16227642 17522070 19085960 7179309 7440962 3732212 7120509 15027814 19336974 10915739 2869522 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Mustard Gas 7.1111402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4018230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4716785472 16481741 17638652 16337965 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver arsenite 13.6618296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.6615959796 16239168 12795759 19224547 17595544 16045604 12631006 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis arsenite 22.1018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 22.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.1020067830
MESH:D005355 Fibrosis Tretinoin 22.1017994277
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.9715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6714991402 9664655
MESH:D006390 Hemangioendothelioma quinoline 6.04598648
MESH:D006394 Hemangiosarcoma quinoline 5.07598648
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Mustard Gas 5.1811428631 9357497 9260866 17524151 8975870 11428647 11402378 11428620 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1812200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2117551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.3912587719 15629191
MESH:D007674 Kidney Diseases Mercury 6.3917934191
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3716985049
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2017361223 17107899 16935935 12679006 16823087 17339181 17649720 16331271 17301526 17712046 17294898 19035177 16891316 16140955 19075265 19029980 16788101 9834237 15748426 19225113 17217047 16766008 19642359 17368321 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis arsenite 6.9718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9717334410 11903743 16239168 16221502 21278145 16943688 11408273 17157831 17174718
MESH:D008106 Liver Cirrhosis, Experimental therapeutic 16012952
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5016192424 15996030 12445421 12546737 17708605 17823541 16027843 12666154 12632514 15370692 18187930 14512876 12741479 18376398 15673190 12649538 12586293 14716833 17761835 16015684 18418968 18395914 16248980 17714472 18205269 16136751 18339082 18472094 15876570 15818738 17631135 12445418 15362042 18277467 18429990 17900296 18156304 15052691 13678700 18166357 15338365 15931870 18210741 16638106 18279442 14748882 15123356 16033810 17766677 15650968 15730626 15893842 12667390 18705752 17640975 11481614 10355542 15057751 12632512 18317297 17525996 18263696 17721639 16011737 17805973 18481824 12958196 17922224 17557913 12389079 12898905 17698563 20821823 18054572 18412020 16116963 17481882 15925388 12609069 17976157 17565644 18472332 14620537 18420326 18006644 16097048 14716496 14724832 17869086 15959796 18395095 17944888 18251166
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9619014921 12969438 12587719 16611625 11587558 19784758 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9615720792 17285989 16964402 15830285 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5919294768
MESH:D008113 Liver Neoplasms Fluorouracil 7.5918383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D008175 Lung Neoplasms arsenite 4.9616809336
MESH:D008175 Lung Neoplasms Fluorouracil 4.9615246190
MESH:D008175 Lung Neoplasms Mustard Gas 4.963148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6916757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009362 Neoplasm Metastasis quinoline 4.07598648
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 15703814
MESH:D009369 Neoplasms Fluorouracil 5.2818600527 16928823 18239605
MESH:D009369 Neoplasms Tretinoin 5.2816594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 4.5315738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D010051 Ovarian Neoplasms CD 437 5.2917474084
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2916936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4315113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4018626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.9215861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.9218058305
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517266442 17620002 17720292 10334151 17894541
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0816160472 15538739 18286688 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916116481 16283617
MESH:D012871 Skin Diseases Mustard Gas 2.7316961503 15451306 12880345
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5316951190 16424979 18396642 17498489 18567086 17522103 19015929 19084572 15786421 17172411
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0916280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.4116720286
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.7116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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