AutismKB 2.0

Annotation Detail for ATP2B2


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Basic Information Top
Gene Symbol:ATP2B2 ( PMCA2,PMCA2a,PMCA2i )
Gene Full Name: ATPase, Ca++ transporting, plasma membrane 2
Band: 3p25.3
Quick LinksEntrez ID:491; OMIM: 108733; Uniprot ID:AT2B2_HUMAN; ENSEMBL ID: ENSG00000157087; HGNC ID: 815
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
Desease Name
METABOLIC
serum metabolites
Desease Name
Serum metabolites
Desease Name
Deafness, autosomal recessive 12, modifier of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ATP2B2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATP2B2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ATP2B2 mRNAdecreases expression 12958071
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ATP2B2 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ATP2B2 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ATP2B2 mRNAdecreases expression 15834898
17351261
17557909
C098607 JP8 aviation fuel JP8 aviation fuel affects the expression of ATP2B2 mRNAaffects expression 12539871
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ATP2B2 mRNAdecreases expression 12057914
D010126 Ozone Ozone results in decreased expression of ATP2B2 mRNAdecreases expression 16330353
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ATP2B2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ATP2B2 mRNAincreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ATP2B2 mRNAdecreases expression 19490992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9511752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.1811850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.1410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.5317162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.5317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.5316835633
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7915516495 18417511 16777450 17626835 18315731 19059883 14754758
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7416540662 20214788 20007298 20512989 21159647 19919837 18785209 20514400 18978308 19418558 20084675 18056438 3581430 20101231 19394651 16569478 19335982 18971187 19519916 16328049 16779866 16878318 16698587 10672840 16830150 18788625 19822196 18494052 16807293 16681979 20935162 19208518 18210153 20432363 19052882 19107877 3084413 20727157 19539802 18691550 19171122 17055752 16288022 16502159 20524982 17761372 19701751 17162532 17138121 18665156 17173139 19383236 17428255 10737359 18506893 18393292 17978847 16935385 11831363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.741701930 6705139 20007298 17173139 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.012727394 17174075 7505956 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817681005 16919318 11677210 16105132 17333356 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
OMIM:601386 DEAFNESS, AUTOSOMAL RECESSIVE 12 marker/mechanism
MESH:D017453 Dermatitis, Irritant JP8 aviation fuel 7.3417574719
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5917637181 15821434 15328337
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005334 Fever Lipopolysaccharides 4.149205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Phenobarbital 9.0316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.0315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16959395 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 8.7418785209
MESH:D007249 Inflammation Lipopolysaccharides 8.7412878042 9205823 17255318 17237260 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7412878042 12200463
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007970 Leukopenia Lipopolysaccharides 4.8915821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8819638242 18665156 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2117034775
MESH:D008107 Liver Diseases Phenobarbital 4.2119363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.777678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.7721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7720137499 19254457 21278145 19850985 19426721 19812893 19499222 20101389 12771043 20434301 19256749 18978307 12112319 15885732 18754104 20118626 19638242 2422723 9163691 20501860 19690152 20452335 21047994 18648771 16942905 15175105 19642983 19090486 21167192 18644402 21071580 19294768 2862719 18977376 19551842 20405173 19073162 10737359 20492335 19427195 20583210 19833225 19996281 19255062
MESH:D008113 Liver Neoplasms Phenobarbital 14.7719482888 21047994 19812893 8742319 15975961 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.576135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.5718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.5718164116 18775883 18253720 18544905 3124819 19004024 18308698 16267830 16842330 17174075 18093689 17854601 9362446 2563599 17942915 18079962 18282651 19539802 19126423 21159647 19519916 19009564
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.5717172636 1399818 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.5712151625
MESH:D008171 Lung Diseases Ozone 3.478266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 9.8321114838
MESH:D055370 Lung Injury Ozone 9.8320417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 3.498597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D011014 Pneumonia Lipopolysaccharides 11.7612224865 11605937
MESH:D011014 Pneumonia Ozone 11.7618007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.512563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11222880 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.547505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.541399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
KEGG:04972 Pancreatic secretion
KEGG:04970 Salivary secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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