AutismKB 2.0

Annotation Detail for NTHL1


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Basic Information Top
Gene Symbol:NTHL1 ( NTH1,OCTS3 )
Gene Full Name: nth endonuclease III-like 1 (E. coli)
Band: 16p13.3
Quick LinksEntrez ID:4913; OMIM: 602656; Uniprot ID:NTHL1_HUMAN; ENSEMBL ID: ENSG00000065057; HGNC ID: 8028
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03410Base excision repair
Pathway IDPathway Name
DNA Repair
No data
No data
Pathway IDPathway Name
500031Depyrimidination
501000Displacement of DNA glycosylase by APE1
501015Cleavage of the damaged pyrimidine
500926Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NTHL1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NTHL1 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA]decreases reaction|increases expression 16137721
D001629 Bezafibrate Bezafibrate results in increased expression of NTHL1 mRNAincreases expression 15447978
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 12634122
D016572 Cyclosporine Cyclosporine results in decreased expression of NTHL1 mRNAdecreases expression 20106945
D002945 Cisplatin Folic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA]affects expression|affects reaction 16898872
D004391 Dust Dust results in decreased expression of NTHL1 mRNAdecreases expression 17805423
D004958 Estradiol Estradiol affects the expression of NTHL1 mRNAaffects expression 16684588
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NTHL1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 17942748
D005492 Folic Acid Folic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA]affects expression|affects reaction 16898872
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 12634122
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTHL1 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of NTHL1 mRNAincreases expression 12634122
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNAaffects cotreatment|increases expression 17942748
D014028 Tobacco Smoke Pollution Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA]decreases reaction|increases expression 16137721
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of NTHL1 mRNAincreases expression 16137721
D014212 Tretinoin Tretinoin results in decreased expression of NTHL1 mRNAdecreases expression 16140955
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D058186 Acute Kidney Injury Cisplatin 8.8512690470 17670903 15814532
MESH:D058186 Acute Kidney Injury Folic Acid 8.8516316344 17003819 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Cisplatin 7.0111798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 7.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0114692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.4715814487
MESH:D000236 Adenoma Folic Acid 3.7516963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8517306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000544 Alzheimer Disease Folic Acid 3.0317116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.8519898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.9116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8314601052
MESH:D001943 Breast Neoplasms Cisplatin 2.3319526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.3317289903 18497071 19861407 17261762 16675129 14630087 17018787 12948864
MESH:D001943 Breast Neoplasms Folic Acid 2.3316777985
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.263084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.2617982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.2615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.261917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.8712023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.8711212258
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 14.1817015178
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 14.1818337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.1818572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 14.1811212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.1816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 3.9016755160
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.626135515
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 20.6218226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.6212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.6218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.6220056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Cyclosporine 13.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.0516105132 15861022 17333356 11677210 17681005 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 13.0519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002971 Cleft Lip Folic Acid 3.9421254359
MESH:D002972 Cleft Palate Folic Acid 9.748946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.7416354765 15340226 12621046 15668235 8697196
MESH:D002972 Cleft Palate Tretinoin 9.749407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9615273666
MESH:D015179 Colorectal Neoplasms Folic Acid 2.9617116713 17245555 16985020 17087956 16963246
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities lead acetate 3.8919769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8917551590 9211117 10589399 9224671 8800419 14991402 16925845 9125849 9142499 9664655
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.3119747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.5116886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8311743745 16485898 2444490 11421492 12392966 17906064 12540782 12705907 19739265 19416960 15619225 12594235 12153990 19370779 10774834 16393943 10915739 18071297 19420014 16109766 10663392 19085960 14550746 11834606 18713872 17562736 11287661 12958197 11529661 16177239 19923254 16227642 11739529 16781746 15968718 19164858 17522070 16081117 14986274 11461765 14725611
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 8.8311287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Cisplatin 8.0115033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0111462148
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D016889 Endometrial Neoplasms Estradiol 12.3011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 12.3017301261
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7615464296 16785472 15173087 16481741 17638652
MESH:D017889 Exfoliation Syndrome Folic Acid 5.4316504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.6716938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 12.6419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.6415345470
MESH:D005234 Fatty Liver pirinixic acid 12.6419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.3219769572
MESH:D005355 Fibrosis Cyclosporine 14.3512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3520067830
MESH:D005355 Fibrosis Tretinoin 14.3517994277
MESH:D005756 Gastritis Acetaminophen 11.0916983495
MESH:D005756 Gastritis Folic Acid 11.0917171786
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005901 Glaucoma Folic Acid 5.0116504073
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.7615102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7616096774
MESH:D034381 Hearing Loss Cisplatin 4.2419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3615464296
MESH:D006330 Heart Defects, Congenital Folic Acid 11.0417286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.0410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.049664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly pirinixic acid 8.0516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006679 HIV Seropositivity Folic Acid 5.4317209195
MESH:D006689 Hodgkin Disease Cisplatin 7.3516200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 7.3512676792
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 18606429 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.4416870215
MESH:D006930 Hyperalgesia Tretinoin 7.4416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.4416433478 16755160 16395265 16865747 16397167
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4917937319
MESH:D007248 Infertility, Male sodium arsenite 6.4912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.1318590791
MESH:D007333 Insulin Resistance Estradiol 7.0516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.0516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0815464296
MESH:D007674 Kidney Diseases Acetaminophen 23.3815629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 23.3816962696
MESH:D007674 Kidney Diseases Cisplatin 23.3818289764 12231392 12649298 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 23.3818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 23.3815618244
MESH:D007674 Kidney Diseases sodium arsenite 23.3820008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.0416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0412371664
MESH:D007680 Kidney Neoplasms Estradiol 12.0415610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7411231351
MESH:D007938 Leukemia Tretinoin 2.7417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1117107899 17368321 19642359 17301526 17217047 19029980 16331271 19075265 15748426 16788101 17712046 12679006 19035177 17506722 17649720 16140955 16823087 19225113 17339181 16935935 16766008 17294898 16891316 17361223 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8518397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.1919460945 11587558 19014921 12587719 19784758 16611625 12969438 16610002
MESH:D008107 Liver Diseases Folic Acid 4.1916877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.477678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.4720007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 10.4716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.592876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5912151625
MESH:D008171 Lung Diseases Acetylcysteine 7.6112815614
MESH:D008171 Lung Diseases sodium arsenite 7.6119095001
MESH:D008175 Lung Neoplasms Cisplatin 4.8517225452 11798837 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 4.8515276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8519555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 4.853440675 16288123 11091918 12111688
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3217718048
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5211408345 16891317 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.6316832597
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Cisplatin 5.1112883367 16432458 18176117 16248763 11135225 17761969 18332650 15577323 12393984 17023156 16809738 12374674 18505091
MESH:D008545 Melanoma sodium arsenite 5.1116487513 19082730
MESH:D008545 Melanoma Tretinoin 5.1116752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.7115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008654 Mesothelioma Cisplatin 3.2217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3015006635
MESH:D009135 Muscular Diseases Bezafibrate 10.5216239165
MESH:D009135 Muscular Diseases pirinixic acid 10.5216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.807678174 18551238
MESH:D009362 Neoplasm Metastasis Acetylcysteine 3.5514720322
MESH:D009369 Neoplasms Cisplatin 11.6116773208
MESH:D009369 Neoplasms pirinixic acid 11.6117405874
MESH:D009369 Neoplasms sodium arsenite 11.6111559025
MESH:D009369 Neoplasms Tretinoin 11.6116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4415464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.9611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.969125849
MESH:D009436 Neural Tube Defects Acetylcysteine 17.0719446573
MESH:D009436 Neural Tube Defects Folic Acid 17.0717438019
MESH:D009436 Neural Tube Defects sodium arsenite 17.0712854658
MESH:D009436 Neural Tube Defects Tretinoin 17.079142499
MESH:D009447 Neuroblastoma Cisplatin 3.418761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.648761367
MESH:D009503 Neutropenia Folic Acid 4.4416322990
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3716049721
MESH:D010051 Ovarian Neoplasms Cisplatin 11.1415464296 19769630 6897625 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 11.1419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.1415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 11.1416936753
MESH:D010146 Pain Acetaminophen 6.4016870215
MESH:D010146 Pain Tretinoin 6.4016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.3819003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2516039940
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D051437 Renal Insufficiency Cisplatin 10.3715464296
MESH:D051437 Renal Insufficiency Folic Acid 10.3715728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.4612210543
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.5618410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3614601052
MESH:D012559 Schizophrenia Folic Acid 2.8916641680
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4918551238
MESH:D012871 Skin Diseases Folic Acid 3.2318709164
MESH:D012878 Skin Neoplasms sodium arsenite 13.3519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.3516192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 13.3518590791
MESH:D012878 Skin Neoplasms Tretinoin 13.3516467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.4316361298
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013274 Stomach Neoplasms Cisplatin 3.5217522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Folic Acid 3.5217171786
MESH:D013274 Stomach Neoplasms Tretinoin 3.5217261132
MESH:D013276 Stomach Ulcer Acetylcysteine 3.9417918041
MESH:D020521 Stroke Folic Acid 4.2716517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.5715464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9717045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.7916049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.7915464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.7916452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 11.7912846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.5616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.5611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.5616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D014839 Vomiting Cisplatin 4.6611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:03410 Base excision repair
REACT:216 DNA Repair
KEGG:03050 Proteasome
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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