AutismKB 2.0

Annotation Detail for NTRK1


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Basic Information Top
Gene Symbol:NTRK1 ( DKFZp781I14186,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 1
Band: 1q23.1
Quick LinksEntrez ID:4914; OMIM: 191315; Uniprot ID:NTRK1_HUMAN; ENSEMBL ID: ENSG00000198400; HGNC ID: 8031
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04722Neurotrophin signaling pathway
hsa05216Thyroid cancer
hsa04210Apoptosis
hsa05200Pathways in cancer
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200128Neurotrophic factor-mediated Trk receptor signaling
No data
Pathway IDPathway Name
500628Signalling to p38 via RIT and RIN
500632PLC-gamma1 signalling
500639PI3K/AKT signalling
500626Signalling to RAS
500643Signalling to STAT3
500645Retrograde neurotrophin signalling
500621NGF signalling via TRKA from the plasma membrane
500623TRKA activation by NGF
500631ARMS-mediated activation
500625Signalling to ERKs
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00032Thyroid cancer
Cancers of endocrine organs
H00043Neuroblastoma
Cancers of the nervous system
No data
Desease Name
CANCER
neuroblastoma
No data
Desease Name
Insensitivity to pain, congenital, with anhidrosis
Medullary thyroid carcinoma, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NTRK1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NTRK1 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of NTRK1 mRNAaffects cotreatment|affects expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK1 mRNAdecreases expression 16934159
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of NTRK1 mRNAincreases expression 18502319
D003976 Diazinon Diazinon results in increased expression of NTRK1 mRNAincreases expression 19130878
D004026 Dieldrin Dieldrin results in increased expression of NTRK1 mRNAincreases expression 19130878
D004958 Estradiol Estradiol results in increased expression of NTRK1 proteinincreases expression 16436532
C049985 K 252 K 252 results in decreased activity of NTRK1 proteindecreases activity 15973493
D008345 Manganese Manganese results in decreased expression of NTRK1 proteindecreases expression 17029596
D009532 Nickel Nickel affects the expression of NTRK1 mRNAaffects expression 19130878
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of NTRK1 mRNAaffects cotreatment|affects expression 18636392
D011374 Progesterone Progesterone results in increased expression of NTRK1 proteinincreases expression 16436532
D017975 Ruthenium Compounds Ruthenium Compounds results in decreased activity of NTRK1 proteindecreases activity 16858717
D014050 Toluene Toluene results in decreased expression of NTRK1 mRNAdecreases expression 17481687
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNAaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin affects the expression of NTRK1 mRNAaffects expression 16211290
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury Chlorine 9.7120601635
MESH:D055371 Acute Lung Injury Nickel 9.7116166738
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.2416611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.2416487989
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000756 Anemia, Sideroblastic Manganese 4.8716910769
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6716292516
MESH:D001249 Asthma Ozone 4.9617854713 16373670
MESH:D001249 Asthma Tretinoin 4.9616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001714 Bipolar Disorder marker/mechanism 14708030
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6116197459 16206674
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715380490 15665606 15845082
MESH:D001943 Breast Neoplasms Dieldrin 2.3811859874 15770527
MESH:D001943 Breast Neoplasms Estradiol 2.3819861407 16675129 14630087 17289903 17261762 12948864 18497071 17018787
MESH:D001943 Breast Neoplasms Nickel 2.3815986119
MESH:D001943 Breast Neoplasms Progesterone 2.3816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tretinoin 2.3816873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6818417511 14754758 15516495 18315731 17626835 16777450 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5816705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.581917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2916051514 16096774
MESH:D002386 Cataract Tretinoin 3.0917460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7718566989
MESH:D002547 Cerebral Palsy Toluene 5.879294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D019465 Craniofacial Abnormalities Toluene 3.049294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.048800419 9224671 9125849 17551590 9142499 9211117 9664655 10589399 14991402 16925845
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003643 Death Toluene 5.706431079
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.9617244072 19470301 17100760
MESH:D003877 Dermatitis, Contact Nickel 4.642952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 4.2217851650
MESH:D004417 Dyspnea Chlorine 10.7820016425
MESH:D004417 Dyspnea Diazinon 10.7816487989
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.4219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4216569247
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D005124 Eye Abnormalities Tretinoin 3.5816938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.5317994277
MESH:D005739 Gas Poisoning Chlorine 5.0420016425
MESH:D005909 Glioblastoma Manganese 7.4617043766
MESH:D005909 Glioblastoma Tretinoin 7.4617312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9014991402 9664655
MESH:D006505 Hepatitis Diazinon 4.5816487989
MESH:D009477 Hereditary Sensory and Autonomic Neuropathies marker/mechanism
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D015658 HIV Infections Nickel 3.8217263646
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006930 Hyperalgesia Tretinoin 3.2116870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Dieldrin 4.9410630421
MESH:D007248 Infertility, Male Diazinon 3.8212948887 16466525
MESH:D007249 Inflammation Nickel 5.5616166738
MESH:D007249 Inflammation Progesterone 5.5615869954
MESH:D007333 Insulin Resistance Estradiol 2.9716393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.5815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3716705839
MESH:D007680 Kidney Neoplasms Estradiol 7.3715610895
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0816294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1516935935 12679006 19075265 19225113 17339181 17712046 16891316 16766008 16788101 16331271 17649720 16140955 17107899 17301526 9834237 17506722 19035177 15748426 16823087 19642359 17361223 19029980 17294898 17368321 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4716248980 18397230
MESH:D008107 Liver Diseases Chlorpyrifos 3.0715991261
MESH:D008113 Liver Neoplasms Dieldrin 3.348742319 9539021
MESH:D008171 Lung Diseases Ozone 3.388266340 19066396
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Ozone 2.097614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0611408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 13.1119453300
MESH:D020149 Manganese Poisoning Manganese 13.1119453300 16551646 16568477
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Ruthenium Compounds 4.0817210701
MESH:D008545 Melanoma Tretinoin 4.0816752155
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008607 Mental Retardation Toluene 3.659294310
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D019957 Motor Skills Disorders Toluene 5.249294310
MESH:D009069 Movement Disorders Manganese 5.0216551646
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009369 Neoplasms Dieldrin 5.478820588
MESH:D009369 Neoplasms Tretinoin 5.4716946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009410 Nerve Degeneration Manganese 4.2716551646
MESH:D009421 Nervous System Malformations Estradiol 9.7011399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.709125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D009447 Neuroblastoma marker/mechanism 16989911
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1715081274
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4316049721 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 7.8919401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.8916525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8916936753
MESH:D010146 Pain Tretinoin 2.9016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4615976015
MESH:D010300 Parkinson Disease Dieldrin 5.9916809432 11181820 16112328 17291500 11445065
MESH:D010300 Parkinson Disease Manganese 5.9911181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4716140633
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D011014 Pneumonia Ozone 4.4118929643 18007984 18381685
MESH:D011041 Poisoning Diazinon 4.3617603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0916740699
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D012120 Respiration Disorders Chlorine 5.2418579056
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6511874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.9217119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012559 Schizophrenia marker/mechanism 14708030
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3118551238
MESH:D012640 Seizures Toluene 6.316431079 9294310
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.126418539
MESH:D012878 Skin Neoplasms Tretinoin 2.6116467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.3016503802 15862959
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013733 Testicular Diseases Toluene 4.9810514026 10048760
OMIM:155240 THYROID CARCINOMA, FAMILIAL MEDULLARY marker/mechanism
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2916049721
MESH:D014570 Urologic Diseases Diazinon 5.3116487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
KEGG:04210 Apoptosis
KEGG:04144 Endocytosis
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:05200 Pathways in cancer
REACT:11061 Signalling by NGF
KEGG:05216 Thyroid cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31817
    • No data
    No data
    Releated drug ID Related drug Name
    PA448497aspirin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00321 agonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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