AutismKB 2.0

Annotation Detail for NTRK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NTRK2 ( GP145-TrkB,TRKB )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 2
Band: 9q21.33
Quick LinksEntrez ID:4915; OMIM: 600456; Uniprot ID:NTRK2_HUMAN; ENSEMBL ID: ENSG00000148053; HGNC ID: 8032
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00043Neuroblastoma
Cancers of the nervous system
No data
Desease Name
CHEMDEPENDENCY
nicotine dependence
PSYCH
anorexia nervosa
bulimia
No data
Desease Name
Obesity, hyperphagia, and developmental delay
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NTRK2 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of NTRK2 mRNAincreases expression 18681898
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of NTRK2 mRNAincreases expression 15305145
C006780 bisphenol A bisphenol A results in increased expression of NTRK2 mRNAincreases expression 12075121
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NTRK2 mRNAdecreases expression 15336504
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of NTRK2 mRNAdecreases expression 18502319
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative formaffects cotreatment|increases expression 18606552
C014347 decitabine decitabine results in increased expression of NTRK2 mRNAincreases expression 19151715
D003976 Diazinon Diazinon affects the expression of NTRK2 mRNAaffects expression 19130878
18502319
D004026 Dieldrin Dieldrin affects the expression of NTRK2 mRNAaffects expression 19130878
D004041 Dietary Fats Dietary Fats results in increased expression of NTRK2 mRNAincreases expression 18721800
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NTRK2 mRNAincreases expression 15901920
12075121
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of NTRK2 geneincreases mutagenesis 16495775
D005419 Flavonoids Flavonoids results in increased expression of NTRK2 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of NTRK2 proteindecreases expression 15352031
D005472 Fluorouracil NTRK2 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005473 Fluoxetine Fluoxetine results in increased expression of NTRK2 mRNAincreases expression 8601816
D019833 Genistein Genistein results in increased expression of NTRK2 mRNAincreases expression 12075121
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative formaffects cotreatment|increases expression 18606552
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of NTRK2 mRNAdecreases expression 17997286
D006861 Hydrogen Peroxide Sodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA]decreases expression|increases reaction 17997286
D008713 Methimazole Methimazole results in decreased expression of NTRK2 mRNAdecreases expression 17403546
D009151 Mustard Gas Mustard Gas results in decreased expression of NTRK2 mRNAdecreases expression 15674843
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FGF2 protein results in increased expression of NTRK2 mRNA]decreases reaction|increases expression 16269011
D009532 Nickel Nickel results in decreased expression of NTRK2 mRNAdecreases expression 19130878
D010208 Papaverine Papaverine results in increased expression of NTRK2 mRNAincreases expression 8601816
C494474 perchlorate perchlorate results in decreased expression of NTRK2 mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in decreased expression of NTRK2 mRNAdecreases expression 17403546
D020889 Rolipram Rolipram results in increased expression of NTRK2 mRNAincreases expression 8601816
D018038 Sodium Selenite Sodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA]decreases expression|increases reaction 17997286
D013739 Testosterone Testosterone results in increased expression of NTRK2 proteinincreases expression 17131419
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NTRK2 mRNAincreases expression 19465110
D014191 Tranylcypromine Tranylcypromine results in increased expression of NTRK2 mRNAincreases expression 8601816
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNAaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin results in increased expression of NTRK2 mRNAincreases expression 16051641
D014212 Tretinoin Tretinoin results in increased expression of NTRK2 proteinincreases expression 16150056
C025643 vinclozolin vinclozolin affects the expression of NTRK2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury Nickel 4.2916166738
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5914692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.5917638652
MESH:D000230 Adenocarcinoma Genistein 6.5911473722
MESH:D000236 Adenoma Ethylnitrosourea 3.536695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0516835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.0917119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.0916487989
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000740 Anemia Fluorouracil 7.7517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7511748828
MESH:D000987 Antisocial Personality Disorder Testosterone 5.527506515
MESH:D001008 Anxiety Disorders Fluoxetine 8.5118083778
MESH:D001008 Anxiety Disorders vinclozolin 8.5119015723
MESH:D001161 Arteriosclerosis Dietary Fats 8.8515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.5416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Mustard Gas 4.6310378619
MESH:D001249 Asthma Tretinoin 4.6316456186
MESH:D001321 Autistic Disorder marker/mechanism 20662941
MESH:D001321 Autistic Disorder Fluoxetine 3.3918775368 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001714 Bipolar Disorder marker/mechanism 19018715
MESH:D001768 Blister Mustard Gas 4.8319167455
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.7419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.7412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.7416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6014991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0116651633 16357521 18412241 15144691 16436596
MESH:D001943 Breast Neoplasms Ascorbic Acid 7.8816443354
MESH:D001943 Breast Neoplasms bisphenol A 7.8817123778
MESH:D001943 Breast Neoplasms decitabine 7.8818320071 19208741
MESH:D001943 Breast Neoplasms Dieldrin 7.8811859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 7.8820435547
MESH:D001943 Breast Neoplasms Fluorouracil 7.8818357371 18608205 16595493 16557594 16110121 15136595 19217205
MESH:D001943 Breast Neoplasms Genistein 7.8816541309 16873071 17200150
MESH:D001943 Breast Neoplasms Nickel 7.8815986119
MESH:D001943 Breast Neoplasms Testosterone 7.8817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 7.8816166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2616813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3416051944
MESH:D002277 Carcinoma Fluorouracil 7.3417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.3517045692 17088986 16332177 18930000 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.3516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.351917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8618695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.0019215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.0018986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0016096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Zalcitabine 4.5010591146
MESH:D002318 Cardiovascular Diseases Genistein 6.7816332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.7816936243
MESH:D002386 Cataract Tretinoin 2.9017460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.5116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5620678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6415861022 17681005 17110522 16105132 11677210 16919318 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3015668235 8697196 12621046 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.309407595
MESH:D003092 Colitis Tretinoin 3.3917035595
MESH:D003110 Colonic Neoplasms decitabine 5.4817616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4815001691 17172411 17725105 17287894 16510598 16340194 17169374 18772588 17018589 17016597
MESH:D003110 Colonic Neoplasms Genistein 5.4817182828
MESH:D015179 Colorectal Neoplasms decitabine 2.5518981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5520501625 17016601 16331619 17594712 17094418 14970324 16303861 16391804 17255274 18448328 17401013 15289873 18383874 18949393 18288408 16524972 18509181 17454858 15148649 16282729 18802399 17695437
MESH:D003139 Common Cold Ascorbic Acid 5.1417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.348800419 10589399 9224671 16925845 9664655 17551590 14991402 9142499 9211117 9125849
MESH:D003456 Cryptorchidism vinclozolin 4.0314966744
MESH:D003556 Cystitis Rolipram 5.8718710439
MESH:D007644 Darier Disease Fluorouracil 4.4716733453
MESH:D003866 Depressive Disorder Fluoxetine 4.3715014590
MESH:D003872 Dermatitis Rolipram 5.7716442096
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.6519470301 17244072 17100760
MESH:D003877 Dermatitis, Contact Nickel 4.342952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5116285004
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.7116506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7117107852
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.4815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7511462148
MESH:D004362 Drug Toxicity Zalcitabine 7.757515130
MESH:D050171 Dyslipidemias Dietary Fats 3.2218367378
MESH:D004417 Dyspnea Diazinon 4.4716487989
MESH:C538011 Eales disease Ascorbic Acid 5.149068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6518357618
MESH:D004487 Edema Fluoxetine 10.0212798668
MESH:D004487 Edema Mustard Gas 10.0211428647 9260866 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7819294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.2616402032
MESH:D016889 Endometrial Neoplasms Genistein 6.8511473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D004890 Erythema Mustard Gas 4.839357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3716785472 15173087 16481741 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.049664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 11.6419551842 18296743 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.6415345470
MESH:D005234 Fatty Liver Zalcitabine 11.6418299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005355 Fibrosis Dietary Fats 12.9318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9320067830
MESH:D005355 Fibrosis Tretinoin 12.9317994277
MESH:D005391 Firesetting Behavior Testosterone 5.527506515
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9716417039
MESH:D005909 Glioblastoma Ethylnitrosourea 15.2916436596
MESH:D005909 Glioblastoma Genistein 15.2916598420
MESH:D005909 Glioblastoma Testosterone 15.2917162496
MESH:D005909 Glioblastoma Tretinoin 15.2917312396
MESH:D005910 Glioma Ethylnitrosourea 5.9016651633 18412241 16357521
MESH:D005910 Glioma Fluorouracil 5.9016145905
MESH:D006042 Goiter perchlorate 5.0018801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms decitabine 11.7119215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.7115162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.7116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.2316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.2314991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis Diazinon 4.2716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5816120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3616490937 16863852
MESH:D006628 Hirsutism Testosterone 5.3217019078
MESH:D015658 HIV Infections Nickel 6.8217263646
MESH:D015658 HIV Infections Zalcitabine 6.8217457083
MESH:D019584 Hot Flashes Fluoxetine 4.9814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Tretinoin 2.9616870215
MESH:D017588 Hyperandrogenism Testosterone 4.9817019078
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.3221332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.3114678291
MESH:D007006 Hypogonadism Testosterone 4.3612002444
MESH:D007018 Hypopituitarism Testosterone 5.8717426086
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007037 Hypothyroidism Methimazole 10.8918031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.898137927 18031379
MESH:D007077 Ileal Diseases Rolipram 6.0718306037
MESH:D007174 Impulse Control Disorders Testosterone 5.527506515
MESH:D007247 Infertility, Female Dieldrin 9.2910630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.2912013081
MESH:D007248 Infertility, Male decitabine 14.3117581917
MESH:D007248 Infertility, Male Diazinon 14.3116466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.3117937319
MESH:D007248 Infertility, Male vinclozolin 14.3116467254
MESH:D007249 Inflammation Dietary Fats 17.7420412841
MESH:D007249 Inflammation Flavonoids 17.7417296493
MESH:D007249 Inflammation Fluoxetine 17.7412798668
MESH:D007249 Inflammation Mustard Gas 17.749357497 11428647 11428631 9260866 8975870 11428620 17524151 11402378 16001271
MESH:D007249 Inflammation Nickel 17.7416166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.7412200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.1916393666
MESH:D007333 Insulin Resistance Dietary Fats 11.1911836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 11.1914714311
MESH:D007410 Intestinal Diseases Tretinoin 3.4517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9717551590 15992940
MESH:D007579 Jejunal Diseases Rolipram 6.0718306037
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9816518626
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 6.9717379185
MESH:D007680 Kidney Neoplasms Fluorouracil 6.9716985049
MESH:D007938 Leukemia decitabine 9.5719235587 18980019
MESH:D007938 Leukemia Genistein 9.5718980019 17468513
MESH:D007938 Leukemia Tretinoin 9.5717143497
MESH:D007951 Leukemia, Myeloid decitabine 8.6017236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7518704418 17679729 18206229 19010910 19387464 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7517596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.949834237 17506722 17301526 15748426 16935935 17107899 19225113 16140955 19035177 16766008 16891316 12679006 19642359 16331271 17361223 17339181 17294898 17368321 19029980 17217047 17649720 17712046 16788101 16823087 19075265
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4116417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.089224671
MESH:D008064 Lipidoses Fluoxetine 4.4215342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.7018296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.2617823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.2618397230 16248980
MESH:D008107 Liver Diseases Chlorpyrifos 2.9915991261
MESH:D008113 Liver Neoplasms Dieldrin 6.838742319 9539021
MESH:D008113 Liver Neoplasms Fluorouracil 6.8316603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8316984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 5.4318544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4312151625
MESH:D008171 Lung Diseases Ascorbic Acid 7.1016863852
MESH:D008171 Lung Diseases Mustard Gas 7.1018161513 18702808
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.1516401635
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.156695378 16271038 16019985 17703301
MESH:D008175 Lung Neoplasms Fluorouracil 6.1515246190
MESH:D008175 Lung Neoplasms Mustard Gas 6.158781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4715086387
MESH:D008223 Lymphoma decitabine 11.5219470736
MESH:D008223 Lymphoma Ethylnitrosourea 11.5215790496
MESH:D008223 Lymphoma Zalcitabine 11.529488045 9205081 8840982 11980663 18798262 8764131 17941976
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7614737004
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7315375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 5.7518041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.7512929590 14578162
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma decitabine 3.2216505122 17785578
MESH:D008545 Melanoma Tretinoin 3.2216752155
MESH:D008579 Meningioma Ethylnitrosourea 5.6517943659
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D001523 Mental Disorders Fluoxetine 4.3216856516
MESH:D009041 Motion Sickness Dextroamphetamine 5.191613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3916757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.1218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 6.8619157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8617596541
MESH:D009203 Myocardial Infarction Genistein 2.7217141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.4117141266
MESH:D009207 Myoclonus Fluoxetine 5.558041377
MESH:D009369 Neoplasms decitabine 10.5919116145 17925555 19470736
MESH:D009369 Neoplasms Dieldrin 10.598820588
MESH:D009369 Neoplasms Fluorouracil 10.5918600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 10.5916594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.8516707424
MESH:D009374 Neoplasms, Experimental Zalcitabine 8.858764131 9488045 9205081
MESH:D009421 Nervous System Malformations bisphenol A 20.9011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.9016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 20.909125849
MESH:D009437 Neuralgia Zalcitabine 5.9917292584
MESH:D009436 Neural Tube Defects Tretinoin 2.849142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0916651423 16003739 17160924
MESH:D009447 Neuroblastoma marker/mechanism 16051641
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.5815081274
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 7.5816436463
OMIM:600456 NEUROTROPHIC TYROSINE KINASE, RECEPTOR, TYPE 2 marker/mechanism
MESH:D009503 Neutropenia Mustard Gas 3.677688884 16761898
MESH:D009765 Obesity Ascorbic Acid 4.6317217161
MESH:D009765 Obesity Dietary Fats 4.6319632207 17217161 18674790 21332399 11836018 20518802 16723640 20132043 18457598
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1520418887
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6517160924
MESH:D010024 Osteoporosis Genistein 3.0519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7916169203
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms decitabine 7.3219259094 19331143
MESH:D010051 Ovarian Neoplasms Genistein 7.3219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.3216936753
MESH:D010146 Pain Fluoxetine 6.4412798668
MESH:D010146 Pain Tretinoin 6.4416870215
MESH:D010190 Pancreatic Neoplasms decitabine 7.9619294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.9616500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.9615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7712065085
MESH:D010300 Parkinson Disease Dieldrin 3.4017291500 11445065 11181820 16112328 16809432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 9.9118606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 9.9118606552
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.688041377
MESH:D011041 Poisoning Diazinon 8.0317603234
MESH:D011041 Poisoning Mustard Gas 8.0315727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.3610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3611222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.3618042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.4117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6118220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 10.0120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1719082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.1715378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1718760546
MESH:D011472 Prostatitis vinclozolin 4.6118629315
MESH:D011507 Proteinuria Tretinoin 3.3116636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.4415861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.4418058305
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0014606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8017620002 17266442 17720292 17894541 10334151
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7416160472 18286688 18722050 15538739
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.3217119214 16611668 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.5617119214 16611668
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012208 Rhabdomyosarcoma decitabine 9.9519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9516116481 16283617
MESH:D020230 Serotonin Syndrome Fluoxetine 5.578704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.766418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.8716631401
MESH:D012871 Skin Diseases Ascorbic Acid 5.0118709164
MESH:D012871 Skin Diseases Mustard Gas 5.0116961503 12880345 15451306
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2812065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.288532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2816192470
MESH:D012878 Skin Neoplasms Tretinoin 12.2816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013272 Stomach Diseases Rolipram 5.4715038085
MESH:D013274 Stomach Neoplasms decitabine 3.2419037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2418396642 19015929 17172411 19084572 17498489 18567086 16424979 15786421 17522103 16951190
MESH:D013274 Stomach Neoplasms Tretinoin 3.2417261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.2718726076
MESH:D013276 Stomach Ulcer Rolipram 7.2714567935
MESH:D020521 Stroke Ascorbic Acid 4.0416517955 16403987
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.8315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms decitabine 10.6917967635
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.6915710170
MESH:D013964 Thyroid Neoplasms Tretinoin 10.6916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.8916280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.6017616700 19087683
MESH:D014570 Urologic Diseases Diazinon 4.9516487989
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.5216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.5216129372
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D014604 Uveal Neoplasms decitabine 11.7217785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.7216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020301 Vasospasm, Intracranial Papaverine 6.2619057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2515869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Dietary Fats 3.4716723640
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31818
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA446879Alcohol-Related Disorders
    Releated drug ID Related drug Name
    PA450243lithium
    PA450626nicotine
    PA448073ethanol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00321 agonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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