AutismKB 2.0

Annotation Detail for NTRK3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NTRK3 ( TRKC,gp145(trkC) )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 3
Band: 15q25.3
Quick LinksEntrez ID:4916; OMIM: 191316; Uniprot ID:NTRK3_HUMAN; ENSEMBL ID: ENSG00000140538; HGNC ID: 8033
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04722Neurotrophin signaling pathway
No data
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00043Neuroblastoma
Cancers of the nervous system
No data
Desease Name
PSYCH
panic disorder
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of NTRK3 mRNAdecreases expression 20406850
D000638 Amiodarone Amiodarone results in increased expression of NTRK3 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NTRK3 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of NTRK3 mRNAdecreases expression 18687144
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of NTRK3 mRNAdecreases expression 18502319
D003976 Diazinon Diazinon affects the expression of NTRK3 mRNAaffects expression 18502319
D003976 Diazinon Diazinon results in decreased expression of NTRK3 mRNAdecreases expression 19130878
D004026 Dieldrin Dieldrin results in decreased expression of NTRK3 mRNAdecreases expression 19130878
D002117 Calcitriol Calcitriol results in decreased expression of NTRK3 mRNAdecreases expression 16002434
D004391 Dust Dust results in decreased expression of NTRK3 mRNAdecreases expression 17805423
D009532 Nickel Nickel results in decreased expression of NTRK3 mRNAdecreases expression 19130878
D010424 Pentobarbital Pentobarbital results in decreased expression of NTRK3 mRNAdecreases expression 9191102
C025299 polyphenols polyphenols results in decreased expression of NTRK3 mRNAdecreases expression 16293270
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NTRK3 mRNAdecreases expression 20055451
D014212 Tretinoin [NTF3 protein co-treated with Tretinoin] results in increased expression of NTRK3 mRNAaffects cotreatment|increases expression 16996685
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNAaffects cotreatment|increases expression 17085092
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury Nickel 4.6416166738
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.4511874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.4516487989
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001008 Anxiety Disorders Pentobarbital 4.7718313124 11141031
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8518218290 20041841 18057881
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.9419698954 18651412
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.7019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.7016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Calcitriol 2.3911237771
MESH:D001943 Breast Neoplasms Dieldrin 2.3915770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.3915986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3916443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0316705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.031917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8311237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8316096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.816135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315668235 16354765 8697196 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469142499 9664655 9224671 10589399 9211117 17551590 8800419 14991402 9125849 16925845
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.0219470301 17244072 17100760
MESH:D003877 Dermatitis, Contact Nickel 4.692952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.1515265979 18218290
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.1519370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004417 Dyspnea Diazinon 4.9016487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0015138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.979664655 16938888
MESH:D005234 Fatty Liver Amiodarone 3.5714986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8620067830
MESH:D005355 Fibrosis Tretinoin 8.8617994277
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6214991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis Diazinon 4.6416487989
MESH:D006529 Hepatomegaly Amiodarone 8.7815265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7815340226 12621046 16120746
MESH:D015658 HIV Infections Nickel 3.8417263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.939751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 4.5918020914 17991464
MESH:D007247 Infertility, Female Dieldrin 5.0010630421
MESH:D007248 Infertility, Male Diazinon 3.8512948887 16466525
MESH:D007249 Inflammation Nickel 8.6616166738
MESH:D007249 Inflammation polyphenols 8.6616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6612200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0216705839
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917339181 16140955 15748426 16788101 19642359 16823087 19035177 17506722 17712046 19225113 17368321 17217047 9834237 19029980 16331271 17301526 19075265 16935935 17107899 17294898 16891316 17649720 17361223 12679006 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008064 Lipidoses Amiodarone 3.5515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3216248980 18397230
MESH:D008107 Liver Diseases Chlorpyrifos 4.7315991261
MESH:D008107 Liver Diseases polyphenols 4.7316698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.647678174
MESH:D008113 Liver Neoplasms Dieldrin 7.649539021 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.842876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6211989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0917365036
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2018303189 16966607 16166281
MESH:D009181 Mycoses Amiodarone 5.0017974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009369 Neoplasms Dieldrin 5.558820588
MESH:D009369 Neoplasms Tretinoin 5.5516594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2015081274
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4815976015
MESH:D010300 Parkinson Disease Dieldrin 3.5411445065 11181820 17291500 16112328 16809432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011041 Poisoning Diazinon 4.4117603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11399792 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5415754350 16289102 12479363 16644109 18247401
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.9512490602 11597910 12832656
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.9517365031 17322281 17975199 15814490
MESH:D012021 Reflex, Abnormal Pentobarbital 6.1010930210
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.7116611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.9916611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4918551238
MESH:D012640 Seizures Pentobarbital 6.499754883 10087439
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.196418539
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6416467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.3718087811
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 5.039754883 11529278
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3517997062
MESH:D013959 Thyroid Diseases Amiodarone 12.3819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0616026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.9319584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3116049721
MESH:D014570 Urologic Diseases Diazinon 5.3716487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
KEGG:04722 Neurotrophin signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved