AutismKB 2.0

Annotation Detail for ROR1


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Basic Information Top
Gene Symbol:ROR1 ( MGC99659,NTRKR1,dJ537F10.1 )
Gene Full Name: receptor tyrosine kinase-like orphan receptor 1
Band: 1p31.3
Quick LinksEntrez ID:4919; OMIM: 602336; Uniprot ID:ROR1_HUMAN; ENSEMBL ID: ENSG00000185483; HGNC ID: 10256
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
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Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ROR1 mRNAdecreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ROR1 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROR1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ROR1 mRNAaffects expression 17484886
D002117 Calcitriol Calcitriol results in decreased expression of ROR1 mRNAdecreases expression 16002434
C029424 hydrazine hydrazine results in decreased expression of ROR1 mRNAdecreases expression 15282401
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ROR1 mRNAdecreases expression 20713471
C009166 retinol acetate retinol acetate results in increased expression of ROR1 mRNAincreases expression 16772331
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ROR1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ROR1 mRNAdecreases expression 19933214
D014415 Tunicamycin Tunicamycin results in decreased expression of ROR1 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.186695378
MESH:D000236 Adenoma Methylcholanthrene 7.186695378 10545420
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9911237771
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9917474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915721981 16097048 16192424 3786805 15673190 15700767 16227642 16124888 16011737 10355542 18705752 16050911
MESH:D002277 Carcinoma Methylcholanthrene 8.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8016835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8320419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8311237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3020889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.3016192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 16354765 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8710915739 15998439 15968718 16227642 2869522 6884620 7179309 3786805 7440962 7120509 19085960 9327722 21278145 4309450 15027814 10092053 3732212 6623471 16177239 11566570 17522070 19336974
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3412795759 16239168 16045604 61145 12631006 17595544 15959796 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1810962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16354765 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916239168 11903743 17334410 16943688 11408273 16221502 17174718 17157831 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3318279442 18205269 18472332 17698563 17823541 18412020 17721639 17766677 20821823 15338365 17900296 18376398 17640975 12958196 15893842 16638106 15052691 15925388 15959796 17805973 16097048 18251166 15876570 12632512 16027843 15996030 16116963 15362042 14748882 17922224 17976157 15818738 17525996 18006644 15650968 18187930 14716496 18210741 10355542 14620537 18166357 12586293 14724832 17714472 15057751 15123356 12667390 12741479 18705752 16192424 18317297 16248980 18277467 17631135 12609069 15931870 11481614 18395914 18395095 18054572 18420326 12649538 18481824 12546737 18156304 17481882 17565644 13678700 12666154 15730626 18429990 17761835 16033810 17869086 18418968 16136751 18263696 17708605 16011737 12445418 17944888 15673190 14716833 18472094 16015684 18339082 12445421 15370692 14512876 17557913 12389079 12632514 12898905
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16964402 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7019294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.48598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5220464547 17053015 18569708 20869020 18816296 6695378 18520028 20064080 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.5216271038 20512841 1399818 6695378 20970405 17909032 7750092 15390079 9230183 10545420 21163286 16337739 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5211884234 19555203
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11399792 11896295 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2416644109 15754350 12479363 18247401 16289102
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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