AutismKB 2.0

Annotation Detail for ROR2


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Basic Information Top
Gene Symbol:ROR2 ( BDB,BDB1,MGC163394,NTRKR2 )
Gene Full Name: receptor tyrosine kinase-like orphan receptor 2
Band: 9q22.31
Quick LinksEntrez ID:4920; OMIM: 602337; Uniprot ID:ROR2_HUMAN; ENSEMBL ID: ENSG00000169071; HGNC ID: 10257
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200016Noncanonical Wnt signaling pathway
200055Wnt signaling network
No data
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Related Diseases/Disorders Top
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Desease Name
Brachydactyly, type B1
Robinow syndrome, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A results in decreased expression of ROR2 mRNAdecreases expression 15223131
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ROR2 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ROR2 mRNAincreases expression 17586704
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7315322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001862 Bone Resorption bisphenol A 4.4111985600
OMIM:113000 BRACHYDACTYLY, TYPE B1 marker/mechanism 12815588
MESH:D001943 Breast Neoplasms bisphenol A 2.0117123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002278 Carcinoma in Situ bisphenol A 5.8817123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2616354765 15340226 15668235 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9716714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.539294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.1216959395 15340226 8697196 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.5816393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009421 Nervous System Malformations bisphenol A 11.9316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.9314600291
MESH:D010049 Ovarian Diseases bisphenol A 5.8811985600
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 12.6810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.6811118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.7620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3316740699
MESH:D011629 Puberty, Precocious bisphenol A 5.6710548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:C535863 Robinow syndrome, autosomal recessive marker/mechanism 12815588 15952209
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2316192470
MESH:D019966 Substance-Related Disorders bisphenol A 4.8716684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D014591 Uterine Diseases bisphenol A 6.0814652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34629
    • No data
    Releated disease ID Related disease Name
    PA152530793Brachydactyly type B
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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