AutismKB 2.0

Annotation Detail for DDR2


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Basic Information Top
Gene Symbol:DDR2 ( MIG20a,NTRKR3,TKT,TYRO10 )
Gene Full Name: discoidin domain receptor tyrosine kinase 2
Band: 1q23.3
Quick LinksEntrez ID:4921; OMIM: 191311; Uniprot ID:DDR2_HUMAN; ENSEMBL ID: ENSG00000162733; HGNC ID: 2731
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Spondylometaepiphyseal dysplasia, short limb-hand type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DDR2 mRNAincreases expression 19933214
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNAdecreases expression 12419474
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDR2 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of DDR2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DDR2 mRNAaffects expression 17555576
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of DDR2 mRNAdecreases expression 12419474
C006253 pirinixic acid pirinixic acid results in increased expression of DDR2 mRNAincreases expression 12832660
D013629 Tamoxifen Tamoxifen affects the expression of DDR2 mRNAaffects expression 17555576
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNAaffects cotreatment|decreases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.089612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.2210965797
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1919103187 19142967 20005174 18629630 17440819 19155303 17261762 18815881 19066611 19289846 19244106 19115204 16818667 18351453 18984771 18855134 18821012 20135344 18997820 11161223 20065188 20544844 20390343 15668708 19410462 18425577 21138602 16202921 19288272 19221464 16273361 15565566 17049068 17893378 19059307 19084267 17242785 19200415 19487384 19189212 20859285 19011961 19189210 21152245 16873071
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6516936243
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002779 Cholestasis Cyclosporine 14.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2317333356 16919318 15861022 16105132 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 14.2319176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D004362 Drug Toxicity Zidovudine 4.1515040536
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 16202921 20544844 19155303
MESH:D005234 Fatty Liver Cyclosporine 27.0219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.0215345470
MESH:D005234 Fatty Liver pirinixic acid 27.0220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 27.0219224547 14986274
MESH:D005234 Fatty Liver Zidovudine 27.0218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006402 Hematologic Diseases Zidovudine 4.9312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19176532 19772884 18467677
MESH:D015658 HIV Infections Zidovudine 3.5920032539 17358032 11698656 11141242 11363243
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4418776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.5118625569
MESH:D007680 Kidney Neoplasms Zidovudine 13.5112579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6220370541
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3718564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.6615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.6616684651
MESH:D008175 Lung Neoplasms Tamoxifen 2.7518625569
MESH:D008175 Lung Neoplasms Zidovudine 2.7518800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7419196723 19196722 11731420 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1617358032
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.3412065085
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.8211550810
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.1512065085
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
OMIM:271665 SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE marker/mechanism
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.428653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0212579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27196
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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