AutismKB 2.0

Annotation Detail for NUMA1


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Basic Information Top
Gene Symbol:NUMA1 ( NUMA )
Gene Full Name: nuclear mitotic apparatus protein 1
Band: 11q13.4
Quick LinksEntrez ID:4926; OMIM: 164009; Uniprot ID:NUMA1_HUMAN; ENSEMBL ID: ENSG00000137497; HGNC ID: 8059
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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No data
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200148Caspase cascade in apoptosis
No data
Pathway IDPathway Name
500382Recruitment of NuMA to mitotic centrosomes
Related Diseases/Disorders Top
No data
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Desease Name
Leukemia, acute promyelocytic, NUMA/RARA type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014347 decitabine decitabine results in decreased expression of NUMA1 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of NUMA1 mRNA]affects reaction|decreases expression 19363521
D002117 Calcitriol Calcitriol results in decreased expression of NUMA1 mRNAdecreases expression 12798352
D005576 Forskolin Forskolin results in decreased expression of NUMA1 mRNAdecreases expression 16751804
C030110 oxaliplatin oxaliplatin results in increased expression of NUMA1 mRNAincreases expression 17762391
C006253 pirinixic acid pirinixic acid results in decreased expression of NUMA1 mRNAdecreases expression 18445702
C017947 sodium arsenite sodium arsenite results in decreased expression of NUMA1 mRNAdecreases expression 19822182
C025643 vinclozolin vinclozolin affects the expression of NUMA1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of NUMA1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2816712894 17306315
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Calcitriol 2.4011237771
MESH:D001943 Breast Neoplasms decitabine 2.4018320071 19208741
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.9811237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.9819215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.9818572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1420056578 19524636
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003110 Colonic Neoplasms decitabine 4.3417616700
MESH:D003110 Colonic Neoplasms oxaliplatin 4.3416510598 16004971 16024531
MESH:D015179 Colorectal Neoplasms decitabine 3.0318981723
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.0317695437 17255274 18509181 17594712 18448328 17401013
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D005234 Fatty Liver pirinixic acid 3.0119236843 20131406
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia oxaliplatin 4.5417418472
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007248 Infertility, Male decitabine 12.2117581917
MESH:D007248 Infertility, Male sodium arsenite 12.2112646999 15346721
MESH:D007248 Infertility, Male vinclozolin 12.2116467254
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases sodium arsenite 6.6120008137
MESH:D007674 Kidney Diseases Vitamin E 6.6112488133
MESH:D007938 Leukemia decitabine 3.1819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 19387464 18460780 18206229 19010910 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4416169303
MESH:D008113 Liver Neoplasms pirinixic acid 4.7520007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 4.7516712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 7.9619095001
MESH:D008171 Lung Diseases Vitamin E 7.9616863852
MESH:D008175 Lung Neoplasms sodium arsenite 2.6017077188 16712894 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Vitamin E 2.6011062179
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008545 Melanoma decitabine 3.5616505122 17785578
MESH:D008545 Melanoma sodium arsenite 3.5619082730 16487513
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5116882708 18608210 19010910 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms decitabine 8.9117925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 8.9117405874
MESH:D009369 Neoplasms sodium arsenite 8.9111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2912854658
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms decitabine 5.2119259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2115276417 17306315
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 19015723 18220299
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5916289102 16644109 18247401 12479363 15754350
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.7919524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013964 Thyroid Neoplasms decitabine 3.5117967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5211723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9911813266
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31844
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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