AutismKB 2.0

Annotation Detail for NUP98


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Basic Information Top
Gene Symbol:NUP98 ( ADIR2,NUP196,NUP96 )
Gene Full Name: nucleoporin 98kDa
Band: 11p15.4
Quick LinksEntrez ID:4928; OMIM: 601021; Uniprot ID:NUP98_HUMAN; ENSEMBL ID: ENSG00000110713; HGNC ID: 8068
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of carbohydrates
Cell Cycle, Mitotic
DNA Replication
Transmembrane transport of small molecules
HIV Infection
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Leukemia, lymphocytic, acute T-cell
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NUP98 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NUP98 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUP98 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUP98 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in increased expression of NUP98 mRNAincreases expression 17198877
C107676 deguelin deguelin results in decreased expression of NUP98 mRNAdecreases expression 17490514
C107676 deguelin deguelin results in decreased expression of NUP98 proteindecreases expression 17490514
D000431 Ethanol Ethanol results in decreased expression of NUP98 mRNAdecreases expression 15353170
D018038 Sodium Selenite Sodium Selenite results in increased expression of NUP98 mRNAincreases expression 18175754
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.2018926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 11.4418287403
MESH:D000138 Acidosis Ethanol 11.4411192467
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 4.1711141031
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7716807698
MESH:D050197 Atherosclerosis Curcumin 3.4318704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.7519761891
MESH:D002545 Brain Ischemia Curcumin 4.6116770732
MESH:D001932 Brain Neoplasms Curcumin 4.1317596214
MESH:D001943 Breast Neoplasms Curcumin 2.9316243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms deguelin 2.9318593368 17035597
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D002277 Carcinoma Curcumin 4.0018593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular deguelin 6.8918575727
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.8918788625 15289165 15763234
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8118462866
MESH:D006332 Cardiomegaly Ethanol 7.8619332462
MESH:D006332 Cardiomegaly valsartan 7.8619597038
MESH:D009202 Cardiomyopathies valsartan 4.5616247790
MESH:D002318 Cardiovascular Diseases valsartan 4.4411230374
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 3.2515513904
MESH:D003092 Colitis Curcumin 4.4316804969 18200517 16782535
MESH:D003103 Coloboma Curcumin 4.7618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.1618497527
MESH:D003324 Coronary Artery Disease valsartan 3.9617719468
MESH:D003384 Coxsackievirus Infections valsartan 6.1320392896
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3315451039 15513904 19302082 10194807 15451040 11873399 11198716
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.7711508273
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7418403477
MESH:D003928 Diabetic Nephropathies Curcumin 10.1618204486
MESH:D003928 Diabetic Nephropathies valsartan 10.1611427623 18630688
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4512540782 14986274 19923254 10663392 16177239 11421492 11529661 11287661 2444490 17522070 14550746 14725611 10774834 19739265 15619225 19085960 12392966 16781746 12594235 15968718 16485898 10915739 17562736 12705907 19370779 19416960 11739529 11834606 16081117 12958197 19164858 18071297 11743745 18713872 16393943 11461765 19420014 16227642 16109766 12153990 17906064
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.4511566570
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.4515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004381 Duodenal Ulcer Curcumin 4.2817351913
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7720426865
MESH:D004938 Esophageal Neoplasms Ethanol 4.7716704527
MESH:D005234 Fatty Liver Curcumin 8.9219297423
MESH:D005234 Fatty Liver Ethanol 8.9216409862 18620774 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15513904 15451040 10194807
MESH:D005355 Fibrosis Curcumin 10.3418705752
MESH:D005355 Fibrosis valsartan 10.3416893502
MESH:D005756 Gastritis Acetaminophen 12.2116983495
MESH:D005756 Gastritis Ethanol 12.2115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9518462866
MESH:D005909 Glioblastoma Curcumin 3.6017596214
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.7816928621
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7918829502 18462866
MESH:D006333 Heart Failure valsartan 4.3719027736
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3017701891
MESH:D006930 Hyperalgesia Acetaminophen 8.3616870215
MESH:D006930 Hyperalgesia Ethanol 8.3618783367
MESH:D006937 Hypercholesterolemia Curcumin 4.2618704882
MESH:D006973 Hypertension valsartan 3.7918390891 10903974 12850387 18344623 20102058 16475468 12692753 11427623
MESH:D006974 Hypertension, Malignant valsartan 6.7311560862
MESH:D007249 Inflammation Curcumin 2.9817151092 18403477 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2818200517 18596194
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.4110783313
MESH:D007569 Jaw Abnormalities Ethanol 4.6115513904
MESH:D007674 Kidney Diseases Acetaminophen 6.7615629191 12587719
MESH:D007674 Kidney Diseases valsartan 6.7616893502 10903974 12164870
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D007889 Leiomyoma Curcumin 4.7918555241
MESH:D007938 Leukemia Curcumin 3.3318462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4116106398
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 21441929
MESH:D015458 Leukemia, T-Cell Curcumin 5.0016106398
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.9417355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.9418166357
MESH:D008106 Liver Cirrhosis, Experimental valsartan 3.9415504291 16872305 15619341
MESH:D008107 Liver Diseases Acetaminophen 4.2419014921 11587558 19784758 12587719 19460945 16611625 16610002 12969438
MESH:D008107 Liver Diseases Curcumin 4.2416956363
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008175 Lung Neoplasms Curcumin 3.2816243823 19359593 18462866
MESH:D008175 Lung Neoplasms deguelin 3.2816288123 19336726
MESH:D008223 Lymphoma Curcumin 3.7318462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9516173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008569 Memory Disorders Curcumin 10.5617263510
MESH:D008569 Memory Disorders Ethanol 10.5618411066 15451040
MESH:D009101 Multiple Myeloma Curcumin 3.6519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2017962980
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6118495463
MESH:D009369 Neoplasms deguelin 4.0717764071
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8512497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.9518462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Curcumin 2.7919297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010024 Osteoporosis Curcumin 3.5918719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8718462866 19020741
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.8419196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Ethanol 5.8412384795
MESH:D011471 Prostatic Neoplasms Curcumin 3.4411398177 18226269 18156803 18769126 10851300 15129424 12497104
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4418760546
MESH:D011507 Proteinuria valsartan 5.0818344623 17664856 12164870
MESH:D011656 Pulmonary Emphysema Curcumin 4.7219168576
MESH:D011658 Pulmonary Fibrosis valsartan 3.8817241526
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2510666014 18379247
MESH:D012509 Sarcoma Curcumin 4.3118462866
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5518551238
MESH:D012640 Seizures Ethanol 6.559754883
MESH:D018805 Sepsis Curcumin 4.2518389075
MESH:D012878 Skin Neoplasms deguelin 4.2716041863
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Curcumin 8.2419188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 8.2411906479 16755016 17918041 17189318 9211565 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4716049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5518462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D020257 Ventricular Remodeling valsartan 5.9819027736
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:474 Metabolism of carbohydrates
KEGG:03013 RNA transport
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31856
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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