AutismKB 2.0

Annotation Detail for NR4A2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NR4A2 ( HZF-3,NOT,NURR1,RNR1,TINUR )
Gene Full Name: nuclear receptor subfamily 4, group A, member 2
Band: 2q22-q23
Quick LinksEntrez ID:4929; OMIM: 601828; Uniprot ID:NR4A2_HUMAN; ENSEMBL ID: ENSG00000153234; HGNC ID: 7981
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00057Parkinson's disease
No data
Desease Name
Parkinson's disease
PSYCH
NEUROLOGICAL
schizophrenia
Desease Name
Response to statin therapy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NR4A2 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NR4A2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of NR4A2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR4A2 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of NR4A2 mRNAdecreases expression 16704987
D001151 Arsenic Arsenic results in decreased expression of NR4A2 mRNAdecreases expression 16835338
D001151 Arsenic Arsenic results in decreased expression of NR4A2 mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NR4A2 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NR4A2 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NR4A2 mRNAincreases expression 20382639
C459604 candoxin candoxin results in decreased expression of NR4A2 mRNAdecreases expression 16309724
D003024 Clozapine Clozapine results in increased expression of NR4A2 mRNAincreases expression 17266109
D003474 Curcumin Curcumin results in decreased expression of NR4A2 mRNAdecreases expression 17999991
D004958 Estradiol Estradiol results in increased expression of NR4A2 mRNAincreases expression 19153601
D005419 Flavonoids Flavonoids results in decreased expression of NR4A2 mRNAdecreases expression 18035473
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of NR4A2 mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of NR4A2 mRNAincreases expression 19153601
D008942 Mitoxantrone NR4A2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C029938 nickel sulfate nickel sulfate results in increased expression of NR4A2 mRNAincreases expression 16780908
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNAaffects cotreatment|affects expression 17715259
D010433 Pentylenetetrazole Pentylenetetrazole results in increased expression of NR4A2 mRNAincreases expression 8164692
D010622 Phencyclidine Phencyclidine results in increased expression of NR4A2 mRNAincreases expression 17266109
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNAaffects cotreatment|affects expression 17715259
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NR4A2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of NR4A2 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in decreased expression of NR4A2 mRNAdecreases expression 19013527
C017947 sodium arsenite sodium arsenite results in decreased expression of NR4A2 mRNAdecreases expression 18812580
D018038 Sodium Selenite Sodium Selenite results in increased expression of NR4A2 mRNAincreases expression 18175754
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A2 mRNAaffects cotreatment|affects expression 16979875
D013849 Thimerosal Thimerosal results in increased expression of NR4A2 mRNAincreases expression 16870260
C052342 topiramate topiramate results in decreased expression of NR4A2 mRNAdecreases expression 16979414
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNAaffects cotreatment|increases expression 17085092
C034613 triacsin C triacsin C results in decreased expression of NR4A2 mRNAdecreases expression 16704987
C025643 vinclozolin vinclozolin affects the expression of NR4A2 mRNAaffects expression 19015723
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A2 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000169 Acrodermatitis Zinc 5.1116889938 17190629 17202136
MESH:D055371 Acute Lung Injury nickel sulfate 8.2416100012 11954676 12718980 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 8.2418653653
MESH:D000230 Adenocarcinoma Estradiol 2.0311473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.583712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.1916434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.7917306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.7917306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.7714617031 12649775 16160616
MESH:D000437 Alcoholism topiramate 4.8018552399 17925516 19331489
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7817887948
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Curcumin 4.2815590663
MESH:D000544 Alzheimer Disease Zinc 4.2816580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 4.6216916123
MESH:D001008 Anxiety Disorders vinclozolin 3.4119015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5518057881 18218290 20041841
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.7812569548 16251483 18414634 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 2.9016412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4816807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4816292516
MESH:D001249 Asthma Tretinoin 4.7516456186
MESH:D001249 Asthma Zinc 4.7517085522
MESH:D050197 Atherosclerosis Arsenic 6.3312928151 19371607
MESH:D050197 Atherosclerosis Curcumin 6.3318704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.6918651412 19698954
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0618582451
MESH:D001327 Autoimmune Diseases Curcumin 4.2019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7211289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 13.8619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.8619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.8616197459 16206674
MESH:D001930 Brain Injuries Zinc 4.4017109824
MESH:D002545 Brain Ischemia Curcumin 4.0416770732
MESH:D001932 Brain Neoplasms Curcumin 3.6817596214
MESH:D001943 Breast Neoplasms Curcumin 1.9718593918 19250217 18462866 16243823
MESH:D001943 Breast Neoplasms Estradiol 1.9719861407 18497071 17289903 14630087 17261762 12948864 16675129 17018787
MESH:D001943 Breast Neoplasms Tretinoin 1.9716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002277 Carcinoma Curcumin 3.6118593918
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4315504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 10.713581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.7112619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Arsenic 10.7116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.7116924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.7117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.711917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8718414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 16.9115504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Curcumin 16.9118462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.9118572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 16.9118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.9116051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 16.9116543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8218640142
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7919225199 15710769
MESH:D002318 Cardiovascular Diseases Arsenic 6.9617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Zinc 6.9616936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.0616973168 18022660
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7918974383
MESH:D002386 Cataract Tretinoin 2.9217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.377505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.3720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.3719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.9915650499
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.1319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.1319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4615894690
MESH:D002972 Cleft Palate Tretinoin 2.549407595
MESH:D003072 Cognition Disorders Clozapine 4.6817123785
MESH:D003092 Colitis Curcumin 8.6818200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 8.6817035595
MESH:D003103 Coloboma Curcumin 4.2818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4616340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 4.6118497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.789142499 10589399 9211117 8800419 9224671 9125849 9664655 17551590 14991402 16925845
MESH:D019465 Craniofacial Abnormalities Zinc 2.7819302082
MESH:D003456 Cryptorchidism vinclozolin 4.0614966744
MESH:D003643 Death Pentylenetetrazole 6.446431079
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 10.178970840 12868966 11298694 2524372 11906362 18759878 14531868 8156756
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 10.1711298694 16823706 16780908
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 10.1716958921 15932584
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.223621924 2952479
MESH:D002658 Developmental Disabilities Thimerosal 4.6515764492
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.5716285004
MESH:D003920 Diabetes Mellitus Zinc 8.5716479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.0516402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.0518403477
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 7.0516979414
MESH:D003928 Diabetic Nephropathies Curcumin 8.2218204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.2219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2515331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.791440618 18289764 9022650 16192314 6679447 7440962 8291058 9328219 6482804 18648102 9653073 11289319 18692083
MESH:D056486 Drug-Induced Liver Injury Amiodarone 5.7918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 5.7915131321
MESH:D004381 Duodenal Ulcer Curcumin 3.7717351913
MESH:D050171 Dyslipidemias Clozapine 3.9716402076
MESH:D004487 Edema Arachidonic Acid 10.189831321 16716910 7990266 15177302 11698051 9599246
MESH:D004487 Edema pirinixic acid 10.1812083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.1816716910 8113982 11698051 8273558 15177302 9599246 7812673
MESH:D004489 Edema, Cardiac Tretinoin 4.1718230668
MESH:D016889 Endometrial Neoplasms Estradiol 6.7811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7816569247
MESH:D004827 Epilepsy topiramate 4.1719148780
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 5.406426943
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.9716499746
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.823581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8220426865
MESH:D004938 Esophageal Neoplasms Zinc 6.8216543248
MESH:D005124 Eye Abnormalities Tretinoin 3.3616938888 9664655
MESH:D005234 Fatty Liver Amiodarone 11.6914986274
MESH:D005234 Fatty Liver Curcumin 11.6919297423
MESH:D005234 Fatty Liver pirinixic acid 11.6919236843 20131406
MESH:D005334 Fever Arachidonic Acid 4.4011852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D005355 Fibrosis Curcumin 8.0418705752
MESH:D005355 Fibrosis Tretinoin 8.0417994277
MESH:D005534 Foot Diseases Arsenic 5.266392382
MESH:D005756 Gastritis Zinc 4.5017241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4018462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0016417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005909 Glioblastoma Curcumin 6.6517596214
MESH:D005909 Glioblastoma Tretinoin 6.6517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006130 Growth Disorders Zinc 3.7717217573
MESH:D006258 Head and Neck Neoplasms Curcumin 7.2418829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.7414991402 9664655
MESH:D006331 Heart Diseases Mitoxantrone 3.9516019553
MESH:D006333 Heart Failure pirinixic acid 6.5520558911
MESH:D006333 Heart Failure Zinc 6.5517162251
MESH:D006335 Heart Injuries Zinc 5.4717074742
MESH:D016481 Helicobacter Infections Zinc 4.2617241300
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.236705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4017276780
MESH:D006529 Hepatomegaly Amiodarone 7.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 7.6219772884 18467677 19176532 16221962
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7517701891
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006930 Hyperalgesia Tretinoin 2.9816870215
MESH:D006937 Hypercholesterolemia Amiodarone 8.468137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 8.4618704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2017050553
MESH:D006948 Hyperkinesis Clozapine 4.6116046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6515034207
MESH:D006973 Hypertension Arsenic 2.7616076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 5.2616093927
MESH:D007037 Hypothyroidism Amiodarone 4.2218020914 17991464
MESH:D007248 Infertility, Male sodium arsenite 6.2012646999 15346721
MESH:D007248 Infertility, Male vinclozolin 6.2016467254
MESH:D007249 Inflammation Arachidonic Acid 10.8215177302 17371808 9831321
MESH:D007249 Inflammation Curcumin 10.8216956363 18403477 17151092
MESH:D007249 Inflammation Flavonoids 10.8217296493
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.8211698051 8273558 7812673 15177302 7562506
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0918596194 18200517
MESH:D007333 Insulin Resistance Estradiol 11.2016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.2016306350
MESH:D007333 Insulin Resistance Sodium Selenite 11.2014714311
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9610783313
MESH:D007511 Ischemia Zinc 4.3416584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.728074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 3.6417551590 15992940
MESH:D007642 Keratosis Arsenic 4.6912749816 16930632
MESH:D007674 Kidney Diseases Estradiol 9.2015618244
MESH:D007674 Kidney Diseases sodium arsenite 9.2020008137
MESH:D007674 Kidney Diseases Zinc 9.2016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.576582329
MESH:D007680 Kidney Neoplasms Estradiol 6.5715610895
MESH:D007889 Leiomyoma Curcumin 4.3018555241
MESH:D007938 Leukemia Curcumin 6.0018462866
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6618172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9416106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.1217339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1217107899 17506722 16331271 17368321 16766008 16891316 15748426 12679006 19642359 16140955 17712046 16935935 9834237 17217047 19035177 19075265 17649720 19225113 16788101 17301526 17339181 17361223 16823087 19029980 17294898
MESH:D015458 Leukemia, T-Cell Curcumin 4.4816106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4416417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008064 Lipidoses Amiodarone 7.5215342952 17567588
MESH:D008064 Lipidoses Clozapine 7.5217567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.019327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.6518705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.6518397230 16248980
MESH:D008107 Liver Diseases Arsenic 4.1611134558
MESH:D008107 Liver Diseases Curcumin 4.1616956363
MESH:D008113 Liver Neoplasms Aflatoxin B1 9.7718177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Arsenic 9.7716368122
MESH:D008113 Liver Neoplasms pirinixic acid 9.7716377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 9.7716712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.361399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.368603461
MESH:D008133 Long QT Syndrome Amiodarone 3.3611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.8612587719
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1818516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7417365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.2014755239
MESH:D008175 Lung Neoplasms Arsenic 6.2017306315 17976673 19168569
MESH:D008175 Lung Neoplasms Curcumin 6.2019359593 18462866 16243823
MESH:D008175 Lung Neoplasms sodium arsenite 6.2019931552 17306315 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.2011807781
MESH:D008223 Lymphoma Curcumin 3.3818462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7914737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4016173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0316891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.038985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.0312773700
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Curcumin 4.8417885582 18462866
MESH:D008545 Melanoma sodium arsenite 4.8416487513 19082730
MESH:D008545 Melanoma Tretinoin 4.8416752155
MESH:D008569 Memory Disorders Curcumin 3.8717263510
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D001523 Mental Disorders Clozapine 3.6616856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0716166281 16966607 18303189
MESH:D024821 Metabolic Syndrome X Clozapine 4.1719142101
MESH:D008881 Migraine Disorders topiramate 4.3716942474 18765137 18759728 18803445
MESH:D009101 Multiple Myeloma Curcumin 3.3119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009181 Mycoses Amiodarone 4.6017974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Arsenic 3.7515371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0918495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.353581430
MESH:D009369 Neoplasms Mitoxantrone 10.6816640825
MESH:D009369 Neoplasms pirinixic acid 10.6817405874
MESH:D009369 Neoplasms sodium arsenite 10.6811559025
MESH:D009369 Neoplasms Tretinoin 10.6816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009410 Nerve Degeneration Rotenone 3.6618619942 15790535 17356569
MESH:D009421 Nervous System Malformations Estradiol 8.7416427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 8.749125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3318462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 15.776679447
MESH:D009436 Neural Tube Defects Arsenic 15.7716620997
MESH:D009436 Neural Tube Defects sodium arsenite 15.7712854658
MESH:D009436 Neural Tube Defects Tretinoin 15.779142499
MESH:D020078 Neurogenic Inflammation Arsenic 4.1017056641
MESH:D009765 Obesity Clozapine 7.0719142110 18515891
MESH:D009765 Obesity Curcumin 7.0719297423
MESH:D009765 Obesity pirinixic acid 7.0720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.174026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010024 Osteoporosis Curcumin 3.2918719352
MESH:D010051 Ovarian Neoplasms Arsenic 13.9417306315
MESH:D010051 Ovarian Neoplasms Curcumin 13.9418462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 13.9419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.9417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 13.9416936753
MESH:D010146 Pain Tretinoin 2.6716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.1219196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.1215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.437296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.4318922899 12065085 18404319 8330346
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010300 Parkinson Disease Rotenone 2.8719114014 16412576 11535288 19232380 16140633 18619942 15451049 18191903 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 3.8218197244 15927086 15574749 15795934
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6916905509 6392382 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6010923243
MESH:D011225 Pre-Eclampsia Zinc 3.9517114810
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.6019015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Curcumin 1.8810851300 18226269 18156803 12497104 15129424 11398177 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8818760546
MESH:D011471 Prostatic Neoplasms Zinc 1.8816517595 16606632 16700911 12429649
MESH:D011472 Prostatitis vinclozolin 4.6418629315
MESH:D011507 Proteinuria Arsenic 8.3721343184
MESH:D011507 Proteinuria Tretinoin 8.3716636307
MESH:D011618 Psychotic Disorders Clozapine 3.9715331141
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2719168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.5011597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.5015814490 17322281 17365031 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7618379247 10666014
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.293692021
MESH:D012162 Retinal Degeneration Zinc 8.2916584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316283617 16116481
MESH:D012509 Sarcoma Curcumin 3.8618462866
MESH:D012559 Schizophrenia Clozapine 2.7018806925 18855531 20168265 20452607 19369910 20521326 20521320 11763009 16141801 20107430 17123785 20580759 17667964 11151749 17726453
MESH:D012640 Seizures Pentylenetetrazole 6.6318657176 18164287 19660546 16054440 3037702 8954991 2616065 15475178 3352866 6431079
MESH:D012640 Seizures topiramate 6.6316499746
MESH:D018805 Sepsis Curcumin 3.8418389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7918724381
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.6719834688 16702368 16759981 17050553 6392382 17453740 15952646 18709164 16353154 17938729 17548696
MESH:D012878 Skin Neoplasms Arsenic 12.4817029826 17050553 17976673 19538983 16251483 15504454
MESH:D012878 Skin Neoplasms sodium arsenite 12.4818572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.4818404319 12065085 11807781 8985016 8330346
MESH:D012878 Skin Neoplasms Tretinoin 12.4816467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Amiodarone 6.6118087811
MESH:D013276 Stomach Ulcer Curcumin 6.6119188055 16631530
MESH:D013610 Tachycardia Amiodarone 4.0111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9119225199
MESH:D013959 Thyroid Diseases Amiodarone 4.4619731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.403712494 1399818 6582329 6587162 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4017045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.5719584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.1316051514
MESH:D014062 Tongue Neoplasms Zinc 9.1316543248
MESH:D016171 Torsades de Pointes Amiodarone 3.9017467628 11989578
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.998074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.9918640142 11144890 19429237 17976673 15987713 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.9918593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.9916712894 16452187 17306315 11723127
MESH:D014565 Urogenital Neoplasms Curcumin 4.9718462866
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.5611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.5616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014652 Vascular Diseases Arsenic 10.8617056641
MESH:D014652 Vascular Diseases sodium arsenite 10.8617056641
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D015430 Weight Gain Clozapine 4.2220107430 16402076 16141801 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 4.7817933447
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
Pathway ID Pathway Name
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31762
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved